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In order to investigate the aging behavior of acrylic polyurethane coatings in environments with high ultraviolet radiation intensity and large temperature differences， the aging processes of water-based and solvent-based acrylic polyurethane coatings were studied using UV-high and low-temperature artificial accelerated aging methods.Techniques such as super depth-of-field imaging， attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and energy-dispersive spectroscopy (EDS) were employed to analyze the changes in microscopic morphology， molecular structure and elemental atomic fraction on the surfaces of the coatings.The performance changes and aging patterns of solvent-based and water-based coatings during the aging process were examined through electrochemical impedance spectroscopy (EIS)， water contact angle measurements， adhesion strength tests and glossiness assessments.Results showed that the water-based acrylic polyurethane coating system exhibited cracking， whereas the solvent-based coating system exhibited layering.Both coatings experienced significant reductions in glossiness， water contact angle and adhesion strength.The aging rate of the two coating systems initially increased rapidly and then slowed down， with an early appearance of the rate transition inflection point.Infrared spectroscopy analysis indicated that both coatings shared similar aging mechanisms， while EDS analysis demonstrated a faster aging rate for the water-based coating.Additionally， the weight of each performance index was calculated by entropy method， and the comprehensive aging grade under the test was obtained， which verified that the solventbased acrylic polyurethane coating system had relatively good weather resistance.

In order to study the initial soil corrosion behavior of Q235 steel and hot-dip galvanized steel， which are commonly used metallic materials for grounding grid equipment， in a brown loam soil environment， four soil corrosion experimental sites-both inside and outside of Dongjin and Qiaoying stations were chosen in the Xiangyang area of Hubei province.Macro-morphological analysis，micro-morphological analysis，corrosion product analysis and electrochemical testing were employed to analyze the specimens.The morphology analysis results showed that the surface of the carbon steel sample corroded for 1 a in the soil environment of Xiangyang was non-uniform corrosion with obvious pockmarked corrosion pits visible， while the galvanized steel material exhibited no obvious red rust without the obvious damage on the surface galvanized layer.The analysis of corrosion products showed that the brown soil in Xiangyang area was an alkaline soil with high moisture content.The main components of the rust layer on the surface of Q235 steel soil buried sample 1 a were iron oxides and trace amounts of SiO2， while the corrosion products on the surface of galvanized steel were mainly zinc oxides and trace amounts of SiO2.The correlation analysis between corrosion rate and soil physicochemical properties displayed that in the soil environment of Xiangyang， the corrosion rate of the two samples was positively correlated with soil physicochemical properties.Specifically， the soil pH value had the most significant impact on soil corrosion rate.The electrochemical results indicated that the galvanized layer on the surface of galvanized steel provided good protection for the substrate， and the corrosion current density of galvanized steel was 1～2 orders of magnitude lower than that of Q235 steel.Overall， galvanized steel materials exhibited superior corrosion resistance compared to Q235 steel materials in the brown soil environment of Xiangyang region.Notably，the pH of the local soil had a major impact on the galvanized steel material’s rate of corrosion in the soil.

The effect of process conditions on the co-processing technology of crude oil and coal was investigated. Crude oil/coal matching performance, swelling degree, crude oil/coal slurry viscosity-temperature characteristics and process parameters were obtained via the laboratory scale and pilot scale studies. The optimum reaction temperature of the co-processing was 445~450 oC, the pressure was 19 MPa, the catalyst addition was 3 wt.%, the reaction time was 2 h, and the ratio of hydrogen to crude oil was 1500 (V/V). Furthermore, the co-processing technology including catalyst and corresponding equipment based on the slurry bed hydrogenation were developed. By using this co-processing technology, the feed ratio of crude oil and coal can be 1:1, the coal conversion rate can be over 99%, the light oil (oil and aromatics) yield was over 70%, and the end products were gasoline, diesel, jet fuel, aromatics and LPG. The product quality meets the Euro V standard, whilst aromatics accounted for 48% of the light oil. So it was proved to be feasible to co-refine crude oil and coal at a ratio of 1:1. What’s more, the slurry bed hydrogenation plant and its equipment were tested for long-term operation, and it has been proved that this co-processing technology could be deployed as large-scale industrial application.

In order to study the corrosion behavior of a new type of 439 ferritic stainless steel in marine atmospheric environment,439 stainless steel samples were put into two test stations in typical marine atmospheric environment (Wenchang test station and Qingdao test station) and one inland urban atmospheric environment (Wuhan test station) for atmospheric exposure test.After two years of exposure,the samples were tested by electrochemical test and analyzed by ultra depth of field microscope,scanning electron microscope (SEM) and energy dispersive spectrometer (EDS).Results showed that the main corrosion form of 439 stainless steel in atmospheric environment was pitting corrosion,and the corrosion degree in Wenchang area was the highest.Meanwhile,the corrosion products were mainly composed of iron oxides,and the samples still had passivation ability in 3.5% (mass fraction) NaCl solution after exposure.The electrochemical test results were consistent with the macro and micro morphology judgment results,i.e.,the samples in Wenchang area corroded most seriously and had the lowest corrosion potential,revealing that the stability of the passive film on those samples was the worst.The samples in Qingdao test station also corroded seriously,while those in Wuhan test station had the lowest corrosion degree.

Background: Triple-negative breast cancer (TNBC) is a poor prognostic subtype of breast cancer due to limited treatment. Macrophage plays a critical role in tumor growth and survival. Our study intends to explore the heterogeneity of macrophage in TNBC and establish a macrophage-related prognostic model for TNBC prognostic stratification. Materials and Methods: Seurat package was conducted to analyze the single-cell RNA expression profilers. The cell types were identified by the markers derived from public research and online database. The cell-cell interactions were calculated by the CellChat package. Monocle package was used to visualize the cell trajectory of macrophages. The prognostic model was constructed by six macrophage-related genes after a series of selections. The expression of six genes were validated in normal and TNBC tissues. And several potential agents for high-risk TNBC patients were analyzed by Connectivity Map analysis. Results: Nine cell types were identified, and the macrophages were highly enriched in TNBC samples. five distinct subgroups of macrophage were identified. Notably, SPP1+ tumor-associated macrophages exhibited a poor prognosis. The prognostic model was constructed by HSPA6 , LPL , IDO1 , ALDH2 , TK1 , and QPCT with good predictive accuracy at 3-, 5- years overall survival for TNBC patients in both training and external test cohorts. Finally, several drugs were identified for the high-risk TNBC patients decided by model. Conclusion: Our study provides a valuable source for clarifying macrophage heterogeneity in TNBC, and a promising tool for prognostic risk stratification of TNBC., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)