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3. Successful secukinumab treatment of generalized pustular psoriasis

Author

Guo, Heng-Shan, Zhou, Xiu-Lian, Chen, Hong-Hui, Hu, Ting, Liu, Min-Hong, Liu, Fang-Yan, Ma, Li-Li, and Li, Wei-Quan

Subjects
generalized, pustular psoriasis, secukinumab
Abstract

Generalized pustular psoriasis is a rare variant of psoriasis. Evidence recommending generalized pustular psoriasis treatment with secukinumab is limited. This report aims to evaluate the use of secukinumab in two patients with generalized pustular psoriasis. The standard treatment regimen for secukinumab was as follows: 300mg subcutaneously once weekly in weeks 0-4, followed by 300mg every four weeks. The efficacy was evaluated by analyzing the psoriasis area and severity index (PASI) and dermatology life quality index (DLQI). One patient had generalized pustular psoriasis, which had developed from palmoplantar pustulosis over 12 years. The second patient was an adolescent with recurrent generalized pustular psoriasis. The first patient achieved PASI-75 response by week 3 and both PASI-90 and a DLQI score of 0 were observed by week 8. The second patient achieved PASI-75 response by week 4 and complete clinical resolution, except for nail changes, and a DLQI of 0 by week 8, without any adverse events.

Published
2024

6. Analysis on Causes of an Arrester Anomaly Based on Electric-Temperature Field Simulation

Author

Zhou, Xiu, Yu, Jiaying, Chang, Wenzhi, Yang, Haitao, Si, Wenrong, Tian, Tian, Bai, Jin, Chen, Lei, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Yang, Qingxin, editor, Li, Zewen, editor, and Luo, An, editor

Published
2024
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7. Abnormal Analysis and Preventive Measures of Arrester on Middle Voltage Side of Main Transformer

Author

Tian, Lu, Zhou, Xiu, Chen, Lei, Chang, Wenzhi, Yang, Haitao, Tian, Tian, Bai, Jin, Ni, Hui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Yang, Qingxin, editor, Li, Zewen, editor, and Luo, An, editor

Published
2024
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8. Analysis of Cathinone Alkaloids in Khat by HPLC-Q-TOF In-source Fragmentation Multistage Mass Spectrometry

Author

SHI Hong-fei1, XU Bo-peng1, QUAN Yang-ke2, XU Cheng-xin1, ZHOU Xiu-qi

Subjects
high performance liquid chromatography-quadrupole-time of flight mass spectrometry (hplc-q-tof ms) / in-source fragmentation multistage mass spectrometry / khat / cathinone alkaloids / analysis of unknown compounds, Chemistry, QD1-999
Abstract

Khat is a kind of common drug plant. Many experiments have shown that the content of cathinone norpseudoephedrine and norephedrine in some varieties of Khat are similar. However, some studies showed that there are differences in the intensity of psychoactivity between these varieties. Therefore, it is speculated that other substances in Khat may affect the psychoactive strength of Khat. But currently there are some difficulties in non-targeted screening of unknown compounds without mass spectrometry database information and standard solutions. In this paper, the unknown cathinone alkaloids in Khat were discovered and resolved by HPLC-Q-TOF MS in-source fragmentation multistage mass spectrometry. The separation was carried out on a ZORBAX Eclipse Plus Phenyl-Hexyl column (3.0 mm×100 mm×1.8 μm) with a gradient elution using 0.1% formic acid in water (A)-acetonitrile (B) as the mobile phase. The mobile phase flow rate was 0.3 mL/min, and the column temperature was 30 ℃. The screening of unknown cathinone alkaloid components was realized by the in-source cleavage characteristics of cathinone alkaloids in single-stage mass spectrometry under full-scan mode using an ESI ion source, and then the molecular structures of the unknown cathinone alkaloid components were deduced from the multi-stage MS cleavage patterns of the unknown cathinone alkaloid components in the target ion acquisition mode. The results showed that this method can effectively realize the screening and resolution of the unknown alkaloid components in Khat. A total of three cathinone alkaloid components, including methcathinone, ethcathinone and 2-amino-1-phenyl-1-butanone, were identified in Khat. Methcathinone and ethcathinone were corroborated using standard substances, and 2-amino-1-phenyl-1-butanone needs to be further corroborated due to the lack of corresponding standard substances. The work provides a guideline for the further study of the psychoactive components in Khat, and a reference for the analysis of unknown compounds in other fields.

Published
2024
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11. Condition assessment method of GIS disconnector based on vibration- thermal-electrical multi-parameter signal characteristics

Author

ZHOU Xiu, WU Xutao, TIAN Tian, BAI Jin, ZHANG Zhaoyu, and LI Junhao

Subjects
gas insulated switchgear (gis), disconnector, vibration signal, temperature variation, partial discharge, health index, improved analytic hierarchy process, Applications of electric power, TK4001-4102
Abstract

The disconnector fault in gas insulated switchgear (GIS) is commonly caused by the combined effects of mechanical, thermal, and electrical factors. Throughout the progression from defect development to a severe fault, various signals, including abnormal vibration, temperature changes, and partial discharge, are generated. The simultaneous measurement and analysis of multi-parameter information pertaining to the GIS disconnector are crucial for accurately determining its operating condition. This study focuses on simulating typical defects in a 220 kV GIS disconnector to investigate the evolution patterns of vibration signals, temperature variations, and partial discharge signals under different contact states. The aim is to establish the correlation between these signals and the condition of the GIS disconnector. Additionally, the study proposes a comprehensive evaluation method for GIS disconnector by incorporating the health index theory and an improved analytic hierarchy process. The proposed method is subsequently applied to practical GIS, demonstrating consistency between the identified fault and the analysis results obtained through the multi-parameter comprehensive evaluation approach. Overall, this research introduces a highly feasible new method for the detection of GIS disconnector conditions.

Published
2024
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18. Evaluation of Operation State of 750 kV Main Transformer Bushing

Author

Zhou, Xiu, Bai, Jin, Tian, Tian, Yang, Weidong, Chen, Lei, Wei, Ying, Luo, Yan, Zhang, Heng, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Li, Jian, editor, Xie, Kaigui, editor, Hu, Jianlin, editor, and Yang, Qingxin, editor

Published
2023
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19. Abnormal Analysis and Treatment of a ±660 kV Converter Station Main Transformer

Author

Zhou, Xiu, Bai, Jin, Tian, Tian, Ni, Hui, Chen, Lei, Sun, Shangpeng, Li, Xiuguang, Yu, Jiaying, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Yang, Qingxin, editor, Li, Jian, editor, Xie, Kaigui, editor, and Hu, Jianlin, editor

Published
2023
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28. Research and Application of Partial Discharge Inspection Instrument for Converter Transformer Based on High Frequency Coupling Method

Author

Zhou, Xiu, Zhang, Qingping, Luo, Yan, Ma, Yunlong, Li, Xiuguang, Bai, Jin, Tian, Lu, Xu, Yuhua, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Yang, Qingxin, editor, Liang, Xidong, editor, Li, Yaohua, editor, and He, Jinghan, editor

Published
2022
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29. Analysis of a Local Overheating Fault of UHV Converter

Author

Zhou, Xiu, Zhang, Qing-ping, Wu, Xu-tao, Liu, Wei-feng, Luo, Yan, Li, Xiu-guang, He, Ning-hui, Wu, Yang, Wei, Ying, Tian, Tian, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Yang, Qingxin, editor, Liang, Xidong, editor, Li, Yaohua, editor, and He, Jinghan, editor

Published
2022
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30. Research on Transformer Fault Diagnosis Technology Based on Adaboost-Decision Tree and DGA

Author

Zhou, Xiu, Tian, Tian, Zhang, Pengcheng, Wang, Yi, Luo, Yan, Ma, Yunlong, Li, Xiuguang, He, Ninghui, Sun, Jun, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Yang, Qingxin, editor, Liang, Xidong, editor, Li, Yaohua, editor, and He, Jinghan, editor

Published
2022
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47. Higher Cumulative Live Birth Rate but Also Higher Late Miscarriage Risk in Non-Obese Women with Polycystic Ovary Syndrome Undergoing the First IVF/ICSI Cycle

Author

Liu,Simin, Zhou,Xiu, Jie,Huiying, Zheng,Zetong, Cai,Bing, Mai,Qingyun, Zhou,Canquan, Liu,Simin, Zhou,Xiu, Jie,Huiying, Zheng,Zetong, Cai,Bing, Mai,Qingyun, and Zhou,Canquan

Abstract

Simin Liu,1,2 Xiu Zhou,1,2 Huiying Jie,1,2 Zetong Zheng,1,2 Bing Cai,1,2 Qingyun Mai,1– 3 Canquan Zhou1– 3 1Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, People’s Republic of China; 3Guangdong Provincial Clinical Research Center for Obstetrical and Gynecological Diseases, Guangzhou, People’s Republic of ChinaCorrespondence: Canquan Zhou, Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, No. 1 Zhongshan Second Road, Guangzhou, 510080, People’s Republic of China, Fax +86 87330736, Email zhoucanquan@mail.sysu.edu.cnPurpose: To determine the impact of polycystic ovary syndrome on in vitro fertilization/intracytoplasmic sperm injection and embryo transfer outcomes while analyzing the influencing factors.Patients and Methods: A retrospective cohort study comprised 4839 patients who underwent their first cycle of IVF/ICSI treatment from January 2016 to December 2021. Cumulative pregnancy rates, cumulative live birth rates, and late miscarriage rates compared between the PCOS group and control group. Subgroup analysis and binary regression were used to analyze the influence of BMI on clinical outcomes among individuals diagnosed with PCOS.Results: Non-obese PCOS patients exhibited higher cumulative pregnancy rates, cumulative live birth rates, and late miscarriage rates compared to the control group with the normal BMI population (84.7% vs71.2%, P < 0.001; 74.1% vs 61.6%, P < 0.001; 4.1% vs 2.0%, P = 0.002), but there was no significant difference in early miscarriage rates between the two groups.Conclusion: Non-obese PCOS patients demonstrated a notably higher cumulative live birth rate but also a higher risk of late miscarriage compared to non-PCOS females with a normal BMI.Keywords: body mass index, cumulative live birth rate, in vitro fertilization, intracytoplasmic sp

Published
2024

48. Inflection Point Effect of Interturn Insulation for Transformer under Preload Stress.

Author

Zhou, Xiu, Bai, Jin, Zhu, Lin, Tian, Tian, Zhao, Xinyang, Wang, Yibo, and Li, Xiaonan

Subjects
TRANSFORMER insulation, STRUCTURAL optimization, X-ray diffraction, INFLECTION (Grammar), PARTIAL discharges, VOLTAGE
Abstract

The current research mainly focuses on the influence of different voltage forms on partial discharge for the interturn insulation of a transformer, and the discharge characteristics and its mechanism of interturn insulation under the action of preload are unclear. Therefore, a partial discharge test platform under the synergistic action of preloading force and electrical stress is constructed based on the actual operation conditions of the interturn insulation of a 750 kV transformer. Then, the partial discharge characteristics and its mechanism is explored by using (OM, SEM, FTIR, XRD, EDS, FEA). It is found that the statistical parameters and damage degree of interturn insulation decrease first and then increase with the increase in preload. Moreover, there is an inflection point at 1000 N. The reason is that the preload causes the deformation of the holes and air gaps between the layers of insulating paper and in the insulating paper. As a result, the contact area and volume of partial discharge are changed, which further changes the characteristics of partial discharge for interturn insulation. This study can provide a reference for the maintenance and structural optimization of 750 kV transformers. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Transformer oil electrical–thermal characteristics analysis and evaluation.

Author

Luo, Yan, Zhou, Xiu, Zhu, Lin, Bai, Jin, Tian, Tian, Liu, Bo, and Zhang, Heng

Subjects
*INSULATING oils, *BREAKDOWN voltage, *POWER transformers, *QUALITY factor, *TRANSFORMER insulation
Abstract

Transformer oil plays the role of heat dissipation and insulation in power transformers, and its electrical and thermal characteristics are directly related to the stable operation of the transformer. At the same time, it is important to master the electric–thermal characteristics of transformer oil for transformer state evaluation, latent fault prediction, and maintenance planning. Based on this, the gas production rule and electrical characteristics of transformer oil under accelerated aging are studied in this paper. First, the experimental platform for power transformer aging is established to accelerate the aging of power transformers. Second, the accelerated aging transformer oil is taken as the research object, and the power frequency, DC, lightning, and gas chromatography are measured and analyzed. Finally, a transformer oil aging evaluation model is established, which takes into account four factors: carbon and oxygen gas factors in transformers, life loss factors calculated by hotspot temperature, hydrocarbon gas factors dissolved in transformer oil, and oil quality factors, and conducts aging evaluation. The conclusion shows that the T parameter proposed in this paper can effectively evaluate the quality of transformer oil. When T is less than or equal to 0.6, there is no aging of the oil. When T is greater than 0.6 and less than 1, the transformer oil has been aging, but it is not manifested. Those are parameters whose chromatography and breakdown voltage are not far beyond the IEEE standard. When T = 1, the aging of oil with significant changes in gas content and breakdown voltage can be observed. When T is greater than 1, the oil has undergone serious aging. [ABSTRACT FROM AUTHOR]

Published
2024
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50. GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway

Author

Wang Jian, Xu Min, Li Dan-Dan, Abudukelimu Wujikenayi, and Zhou Xiu-Hong

Subjects
lung adenocarcinoma, gpr37, tgf-β/smad pathway, Medicine
Abstract

This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to the poor outcomes. Furthermore, biological function experiments in vitro were utilized to assess whether GPR37 impacts malignant phenotype of LUAD cells. Gain- or loss-of-function assays indicated that the upregulation of GPR37 contributed to improving the proliferation, migration, and invasion of LUAD cells in vitro, while knockdown of GPR37 can inhibit the malignant biological behaviors. Then, we found that depletion of GPR37 resulted in a decrease in the expression of TGF-β1 as well as the extents of Smad2 and Smad3 phosphorylation, while overexpression of GPR37 presented opposite outcomes. Altogether, our findings indicated that GPR37 is a potential oncogene of LUAD, and its promoting effects on the malignant progression of LUAD may be realized via TGF-β/Smad pathway.

Published
2020
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