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315 results on '"Zhou, Xiaoxue"'

4. EllipseNet: Anchor-Free Ellipse Detection for Automatic Cardiac Biometrics in Fetal Echocardiography

Author

Chen, Jiancong, Zhang, Yingying, Wang, Jingyi, Zhou, Xiaoxue, He, Yihua, and Zhang, Tong

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Artificial Intelligence, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

As an important scan plane, four chamber view is routinely performed in both second trimester perinatal screening and fetal echocardiographic examinations. The biometrics in this plane including cardio-thoracic ratio (CTR) and cardiac axis are usually measured by sonographers for diagnosing congenital heart disease. However, due to the commonly existing artifacts like acoustic shadowing, the traditional manual measurements not only suffer from the low efficiency, but also with the inconsistent results depending on the operators' skills. In this paper, we present an anchor-free ellipse detection network, namely EllipseNet, which detects the cardiac and thoracic regions in ellipse and automatically calculates the CTR and cardiac axis for fetal cardiac biometrics in 4-chamber view. In particular, we formulate the network that detects the center of each object as points and regresses the ellipses' parameters simultaneously. We define an intersection-over-union loss to further regulate the regression procedure. We evaluate EllipseNet on clinical echocardiogram dataset with more than 2000 subjects. Experimental results show that the proposed framework outperforms several state-of-the-art methods. Source code will be available at https://git.openi.org.cn/capepoint/EllipseNet ., Comment: MICCAI 2021

Published
2021

7. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID‐19 Therapy

Author

Xie, Feng, Su, Peng, Pan, Ting, Zhou, Xiaoxue, Li, Heyu, Huang, Huizhe, Wang, Aijun, Wang, Fangwei, Huang, Jun, Yan, Haiyan, Zeng, Linghui, Zhang, Long, and Zhou, Fangfang

Subjects
Prevention, Pneumonia, Vaccine Related, Lung, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Animals, Extracellular Vesicles, Mice, Protein Binding, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Thiolester Hydrolases, COVID-19 Drug Treatment, ACE2, extracellular vesicles, palmitoylation, Physical Sciences, Chemical Sciences, Engineering, Nanoscience & Nanotechnology
Abstract

Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces that directly interacts with the viral spike (S) protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It is proposed that inhibiting this interaction can be promising in treating COVID-19. Here, the presence of ACE2 in extracellular vesicles (EVs) is reported and the EV-ACE2 levels are determined by protein palmitoylation. The Cys141 and Cys498 residues on ACE2 are S-palmitoylated by zinc finger DHHC-Type Palmitoyltransferase 3 (ZDHHC3) and de-palmitoylated by acyl protein thioesterase 1 (LYPLA1), which is critical for the membrane-targeting of ACE2 and their EV secretion. Importantly, by fusing the S-palmitoylation-dependent plasma membrane (PM) targeting sequence with ACE2, EVs enriched with ACE2 on their surface (referred to as PM-ACE2-EVs) are engineered. It is shown that PM-ACE2-EVs can bind to the SARS-CoV-2 S-RBD with high affinity and block its interaction with cell surface ACE2 in vitro. PM-ACE2-EVs show neutralization potency against pseudotyped and authentic SARS-CoV-2 in human ACE2 (hACE2) transgenic mice, efficiently block viral load of authentic SARS-CoV-2, and thus protect host against SARS-CoV-2-induced lung inflammation. The study provides an efficient engineering protocol for constructing a promising, novel biomaterial for application in prophylactic and therapeutic treatments against COVID-19.

Published
2021

25. Phospholipids with two polyunsaturated fatty acyl tails: an important driver of ferroptosis.

Author

Lu, Chu, Zhou, Xiaoxue, and Zhang, Long

Subjects
PHOSPHOLIPIDS, OXYGEN consumption, REACTIVE oxygen species, ELECTRON transport, ENDOPLASMIC reticulum, BIOCHEMICAL substrates
Abstract

We highlight the latest work of Qiu et al. on the core mechanism of ferroptosis induced by rare phospholipids with two polyunsaturated fatty acyl tails (PL‐PUFA2s), which has been published in Cell. It has long been acknowledged that PLs containing one PUFA tail (PL‐PUFA1s) serve as substrates for phospholipid peroxidation during the process of ferroptosis, owing to their susceptibility to oxidation and prevalence in vivo. However, the authors note that PL‐PUFA2s, rather than PL‐PUFA1s, represent critical lipid classes involved in the pro‐ferroptosis process. Exogenous phosphatidylcholine‐PUFA2s accumulate in mitochondria and combine with Complex I within the electron transport chain, thereby potentially resulting in an elevation of mitochondrial reactive oxygen species levels. Then, these mitochondrial peroxides prompt the substantial accumulation of peroxides within the endoplasmic reticulum, ultimately culminating in ferroptosis. These findings shed light on the potential molecular mechanisms underlying the induction of ferroptosis by dietary PL‐PUFA2s and offer novel insights for both the evaluation of cellular iron death sensitivity and the treatment of cancer. This article will provide a more comprehensive elucidation of the paper and facilitate an enhanced understanding of the underlying mechanisms for readers. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Types and Trends Of Prenatally Diagnosed Fetal Heart Disease Over the Past Decade: A Multicenter Study

Author

Ruan, Yanping, primary, Liu, Tingting, additional, Han, Jiancheng, additional, Zhou, Xiaoxue, additional, Gu, Xiaoyan, additional, Zhang, Ye, additional, sun, lin, additional, zhao, Ying, additional, liu, Xiaowei, additional, Hao, Xiaoyan, additional, Man, Tingting, additional, Wang, Jingyi, additional, Wang, Chenyu, additional, Deng, Hanyu, additional, and He, Yihua, additional

Published
2023
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47. Association of Preimplantation Genetic Testing and Twin Pregnancy with Prenatally Diagnosed Congenital Heart Defects Among High-Risk Pregnant Women

Author

Ruan, Yanping, primary, Ma, Sheng, additional, Wang, Huan, additional, Hao, Xiaoyan, additional, Man, Tingting, additional, Wang, Yaqi, additional, Wang, Jingyi, additional, Wan, Xiaoyu, additional, Gu, Xiaoyan, additional, Han, Jiancheng, additional, Zhou, Xiaoxue, additional, Deng, Hanyu, additional, Wang, Chenyu, additional, Zou, Zhiyong, additional, He, Yihua, additional, and Li, Jing, additional

Published
2023
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