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23. Association of background-level arsenic exposure with sperm quality and sex hormones in Chongqing males

Author

LI Lili, YANG Huan, CHEN Qing, ZHOU Niya, and ZHOU Wenzheng

Subjects
semen quality, sex hormones, low dose arsenic exposure, young men population, piecewise linear model, threshold dose, Medicine (General), R5-920
Abstract

Objective To study the relationship of urinary total arsenic exposure level with sperm quality and sex hormone levels in young male population, and evaluate the potential impact of background arsenic exposure on parameters of sperm quality and sex hormone levels in Chongqing. Methods Generalized additive model and recursive algorithm were used to analyze the correlation of the baseline urine arsenic concentration with semen parameters and sex hormone levels in 703 male college students volunteers (18~22 years old) in the cohort of Chongqing college students constructed in 2013-2015. The inflection point of the nonlinear relationship was explored, and the threshold effect of arsenic exposure was analyzed. The median of urinary arsenic in this study was compared with the data from other reports at home and abroad. Results There was a nonlinear relationship of urine arsenic level with sperm concentration, sperm total number, sperm DNA fragment index, and levels of prolactin, follicle-stimulating hormone and progesterone. Further threshold effect analysis showed that there were inflection points of urine arsenic concentration with the above indicators, and the key points were 15.17, 14.17, 50.97, 57.51, 11.36, and 70.44 μg/L, respectively (Log-likelihood ratio test P < 0.05). Compared with relevant literature, the urine arsenic level was at a relatively lower level in this cohort population. Conclusion Compared with some regions at home and abroad, the background urine arsenic level of this study population is quite lower, and significant correlation is found in the background level with the decline of sperm quality parameters and changes in sex hormone levels.

Published
2023
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24. Association between exposure to air pollutants and risk of infertility in men of childbearing age: a PREBIC cohort study in Chongqing

Author

GUO Ying, CHEN Qing, WANG Tong, and ZHOU Wenzheng

Subjects
air pollutants, infertility, joint effect, interaction, window time, reproductive health, Medicine (General), R5-920
Abstract

Objective To investigate the association between exposure levels of air pollutants (PM10, PM2.5, SO2, O3, NO2, and CO) and infertility risk in men of childbearing age. Methods Preconception Reproductive Health and Birth Outcomes Cohort (PREBIC) was subjected by recruiting men of childbearing age who taking pre-pregnancy health examination in Chongqing Maternal and Child Health Hospital since November 2018. The baseline indicators were collected and established after their enrollment. Then they were followed up every 3 months, and failure to achieve a clinical pregnancy after 12 months of unprotected intercourse was defined as infertility. The individualized air pollution exposure levels of the subjects in 3 months prior to enrollment (spermatogenic cycle) were assessed by machine learning algorithm. Logistic regression model was established to determine the effect of air pollutant exposure on infertility and the potential susceptibility windows induced by single pollutant. Sensitivity analysis was carried out using two-pollutant model. The joint effects and interaction of air pollutants on infertility were analyzed by Bayesian kernel machine regression. Results A total of 2 297 male subjects were included in the study. After multiple test adjustment, the relative risk of infertility was increased by 29.3% (OR=1.293, 95%CI: 1.022-1.636, P=0.008) in the highest and lowest quartiles of PM10 exposure during the 90 d prior to enrollment. In the analysis of susceptibility windows, PM10 was associated with infertility at all stages from 0 to 90 d, and no significant susceptibility window was observed. No significant results were observed in the analysis of the joint effects and interactions of air pollutants. Conclusion Male exposure to PM10 may increase the risk of infertility.

Published
2023
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