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187 results on '"Zhou, Suna"'

14. MicroRNA-381 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma by Targeting X-Linked Inhibitor of Apoptosis Protein [Retraction]

Author

Zhou,Suna, Cui,Yaoyou, Yu,Dequan, Liang,Jun, Zhang,Mingxin, Wenguang,Ye, Zhou,Suna, Cui,Yaoyou, Yu,Dequan, Liang,Jun, Zhang,Mingxin, and Wenguang,Ye

Abstract

Zhou S, Cui Y, Yu D, Liang J, Zhang M, Ye W. Onco Targets Ther. 2017;10:2527–2538. The Editor and Publisher of OncoTargets and Therapy are retracting the published article. Concerns were raised regarding the duplication of western blot images and an investigation found duplicated images in Figures 3 and 6. Specifically, The image in Figure 3D, TE10, c-caspase-3, has been duplicated with the same image from Figure 6C, TE10, c-PARP. The image in Figure 3D, TE10, c-PARP has been duplicated with the same image from Figure 3D, TE11, c-PARP. The image in Figure 3D, TE10/miR-381(+), c-caspase-3, has been duplicated with the same image from Figure 3D, TE11/miR-NC(-), Total PARP. The image in Figure 3D, TE11, Total PARP, has been duplicated with the same image from Figure 6C, TE11, Total caspase-3. The image from Figure 6C, TE10/shXIAP(+), c-PARP has been duplicated with the same image from Figure 6C, TE11/shcontrol(-), Total caspase-3. The authors cooperated with the investigation but were unable to provide a satisfactory explanation regarding the duplicated images and were unable to verify the published work. Therefore, the Editor and Publisher are retracting the article and the authors have been notified. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Published
2023

35. A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

Author

Luo, Qiuyun, primary, Pan, Wentao, additional, Zhou, Suna, additional, Wang, Guangfeng, additional, Yi, Hanjie, additional, Zhang, Lin, additional, Yan, Xianglei, additional, Yuan, Luping, additional, Liu, Zhenyi, additional, Wang, Jing, additional, Chen, Haibo, additional, Qiu, MiaoZhen, additional, Yang, DaJun, additional, and Sun, Jian, additional

Published
2020
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39. Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2

Author

Zhang Lingmin, Wang Ning, Zhou Suna, Ye Wenguang, Jing Guixia, and Zhang Mingxin

Subjects
Propofol, NF-E2-related factor 2 (Nrf2), Gallbladder cancer, Proliferation, Invasion, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear. NF-E2-related factor 2 (Nrf2) is abundantly expressed in cancer cells and relates to proliferation, invasion, and chemoresistance. The aims of the current study were to evaluate effects of propofol on the behavior of human GC cells and role of Nrf2 in these effects. Method The effects of propofol on cell proliferation, apoptosis, and invasion were detected by MTT assays, flow cytometry, and transwell assay. Also, activation of Nrf2 was determined by western blot, RT-PCR, and immunofluorescence assays. Nrf2 was knocked-down in GBC-SD cells by shRNA before evaluating the role of Nrf2 in the influence of propofol on biological behaviors. Results Propofol promoted the proliferation of GBC-SD cells in a dose- and time- dependent manner. After exposure to propofol for 48 h, GBC-SD cells showed decreased apoptosis and increased invasion. Also, propofol over-expressed Nrf2 at both the protein and mRNA levels and induced translocation of Nrf2 into the nucleus. Finally, loss of Nrf2 by shRNA reversed the effect of propofol on cell proliferation, apoptosis, and invasion. Conclusion Propofol induces proliferation and promotes invasion of GC cells through activation of Nrf2.

Published
2012
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44. Smac Mimetic APG-1387 Has Synergistic Effect with anti-PD1 Antibody via Increasing NK Cells Recruitment by Inducing Multiple Cytokines from Tumor Cells

Author

Pan, Wentao, primary, Luo, Qiuyun, additional, Fang, Douglas D., additional, Wang, Guangfeng, additional, Shi, Mude, additional, Sun, Jian, additional, Shen, Huimin, additional, Lu, Zhenhai, additional, Zhang, Lin, additional, Yan, Xianglei, additional, Yuan, Luping, additional, Zhou, Suna, additional, Yi, Hanjie, additional, Zhang, Yuxin, additional, Pan, Mengxian, additional, Zhai, Yi-Fan, additional, Qiu, Miao-Zhen, additional, and Yang, Da-Jun, additional

Published
2019
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49. RETRACTED ARTICLE: MicroRNA-381 enhances radiosensitivity in esophageal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein

Author

Zhou,Suna, Cui,Yaoyou, Yu,Dequan, Liang,Jun, Zhang,Mingxin, Wenguang,Ye, Zhou,Suna, Cui,Yaoyou, Yu,Dequan, Liang,Jun, Zhang,Mingxin, and Wenguang,Ye

Abstract

This paper has been retracted. Zhou S, Cui Y, Yu D, Liang J, Zhang M, Ye W. Onco Targets Ther. 2017;10:2527–2538. The Editor and Publisher of OncoTargets and Therapy are retracting the published article. Concerns were raised regarding the duplication of western blot images and an investigation found duplicated images in Figures 3 and 6. Specifically, The image in Figure 3D, TE10, c-caspase-3, has been duplicated with the same image from Figure 6C, TE10, c-PARP. The image in Figure 3D, TE10, c-PARP has been duplicated with the same image from Figure 3D, TE11, c-PARP. The image in Figure 3D, TE10/miR-381(+), c-caspase-3, has been duplicated with the same image from Figure 3D, TE11/miR-NC(-), Total PARP. The image in Figure 3D, TE11, Total PARP, has been duplicated with the same image from Figure 6C, TE11, Total caspase-3. The image from Figure 6C, TE10/shXIAP(+), c-PARP has been duplicated with the same image from Figure 6C, TE11/shcontrol(-), Total caspase-3. The authors cooperated with the investigation but were unable to provide a satisfactory explanation regarding the duplicated images and were unable to verify the published work. Therefore, the Editor and Publisher are retracting the article and the authors have been notified. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Published
2017

50. miR-144 reverses chemoresistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway

Author

Zhou, Suna, Ye, Wenguang, Zhang, Yanjun, Yu, Dequan, Shao, Qiuju, Liang, Jun, and Zhang, Mingxin

Subjects
Original Article
Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Chemoresistance occurrence is a major cause of treatment failure in HCC. Currently, extensive research has revealed diverse mechanisms for chemoresistance, but the molecular mechanisms underlying the role of miRNAs in resistance to 5-FU are not confirmed in HCC cells. By quantitative real-time polymerase chain reaction (qRT-PCR) analysis, we found that miR-144 was significantly decreased in HCC cell lines. It has been further demonstrated that miR-144 were significantly down-regulated in Bel-7402/5-FU cells compared with parental Bel-7402 cells by qRT-PCR and western blot. The expression of Nrf2 was reversely correlated to that of miR-144 in HCC cells. Moreover, Enhancement of 5-FU-induced cytotoxicity and apoptosis are resulted from the transfection with miR-144 mimics in Bel-7402/5-FU cells. Mechanically, miR-144 promoted nuclear factor erythroid-2-related factor-2 (Nrf2) mRNA degradation by directly targeting the Nrf2 3'untranslated region (3'UTR). In addition, ectopic expression of miR-144 in Bel-7402/5-FU cells reduced the levels of Nrf2 and inhibited the transcription of Nrf2-dependent HO-1 gene, thus contributing to 5-FU sensibilization. Conversely, re-expression of Nrf2 partly attenuated the chemosensibilization of miR-144. Our study showed that miR-144 serves as a potential chemoresistance-reversal agent in hepatocellular carcinoma cells, which is at least partly due to the down-regulation of Nrf2-dependent antioxidant pathway.

Published
2016

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