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Your search keyword '"Zhou, Rongxing"' showing total 146 results
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146 results on '"Zhou, Rongxing"'

11. Construction of a streptavidin-based dual-localized DNAzyme walker for disease biomarker detection.

Author

Xia, Lingying, Chen, Junbo, Hou, Xiandeng, Zhou, Rongxing, and Cheng, Nansheng

Subjects
DEOXYRIBOZYMES, BIOMARKERS, STREPTAVIDIN, GOLD nanoparticles, CLINICAL medicine, DIAGNOSIS
Abstract

A dual-localized DNAzyme walker (dlDW) was constructed by utilizing multiple split DNAzymes with probes, and their substrates are separately localized on streptavidin and AuNPs, serving as walking pedals and tracks, respectively. Based on dlDW, biosensing platform was successfully constructed and showed great potential application in clinical disease diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Biomolecule-guided co-localization of intermolecular G-rich strands for the construction of a tetramolecular G-quadruplex sensing strategy.

Author

Hu, Changjia, Jin, Yanwen, Yang, Peng, Zhou, Rongxing, Xia, Lingying, Du, Lijie, Chen, Junbo, Cheng, Nansheng, and Hou, Xiandeng

Subjects
SENSES, QUADRUPLEX nucleic acids, BIOMOLECULES
Abstract

We herein introduce the principle of proximity assay into tetramolecular G-quadruplexes guided by various biomolecules for the construction of a sensing strategy. Our strategy is based on the co-localization of intermolecular G-rich strands guided by a recognition event of a specific biomolecule to its corresponding affinity ligand. In such case, the local concentration among intermolecular strands is significantly increased to trigger the following self-assembly that served as the peroxidase-mimicking activity. This strategy is versatile, homogenous and adaptable to different types of biomolecules. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Protein-Controlled Split DNAzyme to Enhance Catalytic Activity: Design and Performance

Author

Xia, Lingying, Du, Lijie, Hou, Xiandeng, Zhou, Rongxing, Cheng, Nansheng, and Chen, Junbo

Abstract

In this study, we utilized proteins to control the assembly of split DNAzyme to establish protein-controlled split DNAzymes (Pc SD), with the aim of enhancing its catalytic activity. To achieve this, simultaneous recognition of protein by affinity ligands at both ends of split DNAzyme fragments induced an increased local concentration of each split fragment, leading to reassembly of the split catalytic core with a rigid conformation and higher affinity to its cofactor. As a result, under protein control, Pc SD exhibits unexpected cleavage efficiency compared to free split DNAzyme. To further explore the catalytic features, we then systematically positioned split sites within the catalytic core of three popular DNAzyme-based Pc SDs, thus revealing the important nucleic acids that influence Pc SDs activity. Based on the excellent analytical performance of Pc SD for streptavidin (with a LOD of 0.1 pM in buffer),we equipped Pc SD with antibodies as rapid diagnostic tools for inpatient care (AFP as biomarker) with a minimized workflow (with a LOD of 2 pM in 5% human serum). The results of this study offer fundamental insights into external factors for boosting DNAzyme catalysis and will be promising for applications that utilize split DNAzymes.

Published
2024
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46. An Experimental and Numerical Study on the Impact Energy Absorption Characteristics of the Multiaxial Warp Knitted (MWK) Reinforced Composites

Author

H. U. Hong, Chen Nan-liang, Zhou Rongxing, and Feng Xun-wei

Subjects
Double loop, Materials science, business.industry, Mechanical Engineering, Pillar, 02 engineering and technology, Structural engineering, Dissipation, 021001 nanoscience & nanotechnology, 020303 mechanical engineering & transports, 0203 mechanical engineering, Low speed, Mechanics of Materials, Energy absorption, Materials Chemistry, Ceramics and Composites, Impact energy absorption, Composite material, 0210 nano-technology, business
Abstract

In this paper, an experimental and numerical study on the energy absorption characteristics due to the low-velocity impact of the composites reinforced by the multiaxial warp knitted (MWK) structures with double loop pillar stitch and common tricot stitch are presented. The influences of the MWK structural parameters on the impact behavior and energy absorption properties are discussed. A good agreement between the experimental results and simulation is obtained.

Published
2005

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