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Suppressing tumor metastasis is a crucial strategy for improving survival rates in patients with colorectal cancer (CRC), with cancer stem cells (CSCs) being the primary drivers of metastasis. Current therapeutic approaches targeting CSCs are limited, and their molecular mechanisms remain unclear. To address this challenge, a biomimetic nanoparticle delivery system, CMD-BHQ3-PTL/DOX@RBCM is developed, to deliver the stem cell regulator, piceatannol (PTL). This system used carboxymethyl dextran (CMD) and Black Hole Quencher 3 (BHQ3) to encapsulate PTL and the cytotoxic drug doxorubicin (DOX) within a red blood cell membrane (RBCm), enhancing stability and biocompatibility while allowing gradual drug release under hypoxic conditions. The effects of PTL are investigated on CSCs using molecular biology experiments, plasmid construction, and high-throughput sequencing and elucidated the molecular mechanisms underlying this biomimetic nanoparticle delivery system. The therapeutic efficacy of PTL is validated at the tissue level using subcutaneous and metastatic tumor models in human and murine systems. The results demonstrated that CMD-BHQ3-PTL/DOX@RBCM effectively addressed the challenges of specificity and biocompatibility in vivo, significantly inhibiting CSC-related tumor metastasis. This inhibitory effect is closely associated with the Hippo/YAP1/SOX9 pathway. This study highlights the effectiveness of the pH-responsive biomimetic nanoparticle system CMD-BHQ3-PTL/DOX@RBCm in delivering PTL to tumor sites, with SOX9 and its upstream Hippo/YAP1 pathway playing a critical role in the underlying mechanism., (© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)

As a result of the absence of solid-state diffusion limitation, intercalation pseudocapacitance behavior is emerging as an attractive charge-storage mechanism that can greatly facilitate the ion kinetics to boost the rate capability and cycle stability of batteries; however, related research in the field of zinc-ion batteries (ZIBs) is still in the initial stage and only found in limited cathode materials. In this study, a novel V 2 O 5- x @rGO hybrid aerogel consisting of ultrathin V 2 O 5 nanosheets (∼1.26 nm) with abundant oxygen vacancies (Vö) and a three-dimensional (3D) graphene conductive network was specifically designed and used as a freestanding and binder-free electrode for ZIBs. As expected, the ideal microstructure of both the material and the electrode enable fast electron/ion diffusion kinetics of the electrode, which realize a typical intercalation pseudocapacitance behavior as demonstrated by the simulation calculation of cyclic voltammetry (CV), ex situ X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and first-principles density functional theory (DFT) calculation. Thanks to the elimination of solid-state diffusion limitation, the V 2 O 5- x @rGO electrode delivers a high reversible rate capacity of 153.9 mAh g -1 at 15 A g -1 and 90.6% initial capacity retention at 0.5 A g -1 after 1050 cycles in ZIBs. The intercalation pseudocapacitance behavior is also realized in the assembled soft-pack battery, showing promising practical application prospects.