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Your search keyword '"Zhou, Longyuan"' showing total 19 results
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19 results on '"Zhou, Longyuan"'

6. Intestinal strictures in Crohn's disease: An update from 2023

Author

Liu, Zishan, primary, Huang, Zhuoyan, additional, Wang, Yu, additional, Xiong, Shanshan, additional, Lin, Sinan, additional, He, Jinshen, additional, Tan, Jinyu, additional, Liu, Caiguang, additional, Wu, Xiaomin, additional, Nie, Jing, additional, Huang, Weidong, additional, Zhang, Yao, additional, Zhou, Longyuan, additional, and Mao, Ren, additional

Published
2024
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8. sj-docx-1-tag-10.1177_17562848231170947 – Supplemental material for Early transmural healing and its predictors assessed by magnetic resonance enterography in patients with Crohn’s disease receiving ustekinumab

Author

Zhou, Longyuan, Hu, Cicong, Zhang, Ruonan, Qiu, Yun, Wang, Yu, Liu, Zishan, Chen, Baili, He, Yao, Zeng, Zhirong, Li, Xuehua, Mao, Ren, and Chen, Minhu

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tag-10.1177_17562848231170947 for Early transmural healing and its predictors assessed by magnetic resonance enterography in patients with Crohn’s disease receiving ustekinumab by Longyuan Zhou, Cicong Hu, Ruonan Zhang, Yun Qiu, Yu Wang, Zishan Liu, Baili Chen, Yao He, Zhirong Zeng, Xuehua Li, Ren Mao and Minhu Chen in Therapeutic Advances in Gastroenterology

Published
2023
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10. Ulcerative colitis increases risk of hypertension in a UK biobank cohort study

Author

He, Jinshen, primary, Zhang, Shaozhao, additional, Qiu, Yun, additional, Liu, Fen, additional, Liu, Zishan, additional, Tan, Jinyu, additional, Hu, Fan, additional, Wu, Xiaomin, additional, Wang, Yu, additional, Zhou, Longyuan, additional, Hu, Shixian, additional, Chen, Minhu, additional, Liao, Xinxue, additional, Zhuang, Xiaodong, additional, and Mao, Ren, additional

Published
2022
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17. Ulcerative colitis increases risk of hypertension in a UK biobank cohort study

Author

He, Jinshen, Zhang, Shaozhao, Qiu, Yun, Liu, Fen, Liu, Zishan, Tan, Jinyu, Hu, Fan, Wu, Xiaomin, Wang, Yu, Zhou, Longyuan, Hu, Shixian, Chen, Minhu, Liao, Xinxue, Zhuang, Xiaodong, and Mao, Ren

Abstract

Inflammatory bowel disease (IBD) is not only a chronic inflammatory disorder of the gastrointestinal tract but also accompanied by systemic inflammation. The onset of hypertension is closely related to systemic inflammation. However, the relationship between IBD and hypertension has not been investigated. We aimed to investigate the potential association between IBD and the incidence of hypertension. We retrieved IBD onset and the incidence of hypertension from a public database UK Biobank. The association between the onset of IBD and subsequent incidence of hypertension was analyzed using a multivariate Cox regression analysis, and propensity score matching was performed for sensitivity analysis. Of a total of 281,064 participants included in the study, 2376 (0.8%) were diagnosed with IBD at baseline, and 20,129 (7.2%) in the whole cohort developed hypertension with a median follow‐up duration of 8.1 years (interquartile range [IQR] 7.3–8.8 years). Patients with IBD had a higher cumulative risk of hypertension compared with general population (10.9% in ulcerative colitis [UC], 7.7% in Crohn's disease [CD], and 9.3% in IBD unclassified [IBD‐U] vs. 7.1% in non‐IBD, p< 0.001). Multivariate Cox regression analysis identified that UC, rather than CD or IBD‐U, was independently associated with subsequent occurrence of hypertension (HR 1.30, 95% CI: 1.11–1.52, p= 0.001). In propensity matching analysis, UC also showed its robustness as a risk factor for the prediction of hypertension (HR 1.56, 95% CI: 1.21–2.03, p= 0.001). In IBD patients, UC rather than CD is associated with a higher risk for the incidence of hypertension compared with general population. Close monitoring of hypertension might be required in clinical practice.

Published
2023
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19. Multi-Omics Biomarkers for Predicting Efficacy of Biologic and Small-Molecule Therapies in Adults With Inflammatory Bowel Disease: A Systematic Review.

Author

Chen L, Zhang C, Niu R, Xiong S, He J, Wang Y, Zhang P, Su F, Liu Z, Zhou L, Mao R, Hu S, Chen M, Qiu Y, and Feng R

Abstract

The heterogeneity and suboptimal efficacy of biological treatments and small molecule drugs necessitate their precise selection based on biomarkers that predict therapeutic responses in inflammatory bowel disease. Recent studies have identified numerous novel biomarkers predictive of responses to biologics and small molecule modulators, utilizing a variety of omics approaches in inflammatory bowel disease. In this review, we systematically examine baseline omics biomarkers that predict responses to biological therapies and small molecule drugs, drawing on literature from PubMed. Our analysis spans multiple omics disciplines, including genomics, transcriptomics (both bulk RNA and single-cell RNA sequencing), proteomics, microbiomics, and metabolomics, with particular emphasis on the impact of models integrating multiple omics datasets. Additionally, to further the field of precision medicine, we evaluated specific biomarkers that may exhibit distinct effects on responses to multiple therapeutic interventions., (© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.)

Published
2024
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