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Your search keyword '"Zhou, Liang-Fu"' showing total 456 results
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456 results on '"Zhou, Liang-Fu"'

1. Double-modified oncolytic adenovirus armed with a recombinant interferon-like gene enhanced abscopal effects against malignant glioma

Author

Jiang, Shan, primary, Chai, Hui-hui, additional, Fang, Xian-long, additional, Xu, Hou-shi, additional, Li, Tian-wen, additional, Tang, Qi-sheng, additional, Gu, Jin-fa, additional, Zhang, Kang-jian, additional, Liu, Xin-yuan, additional, Shi, Zhi-feng, additional, Cao, Xue-ping, additional, Wu, Zan-yi, additional, and Zhou, Liang-fu, additional

Published
2023
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8. The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor.

Author

Zhang, Jie, Yao, Ye, Wu, Jin‐song, Rolls, Edmund T., Sun, Ce‐chen, Bu, Ling‐hao, Lu, Jun‐feng, Lin, Ching‐po, Feng, Jian‐feng, Mao, Ying, and Zhou, Liang‐fu

Subjects
WHITE matter (Nerve tissue), BRAIN tumors, TEMPORAL lobe, DIFFUSION tensor imaging, AUDITORY cortex
Abstract

The comprehension of spoken language is one of the most essential language functions in humans. However, the neurological underpinnings of auditory comprehension remain under debate. Here we used multi‐modal neuroimaging analyses on a group of patients with low‐grade gliomas to localize cortical regions and white matter tracts responsible for auditory language comprehension. Region‐of‐interests and voxel‐level whole‐brain analyses showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity assessed with diffusion tensor imaging of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with both auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri. Together, our findings provide direct evidence for an integrated network of auditory comprehension whereby the superior temporal gyrus and sulcus, the posterior parts of the middle and inferior temporal gyri serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide critical evidence on the neural underpinnings of language comprehension. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Histopathological classification and location of consecutively operated meningiomas at a single institution in China from 2001 to 2010

Author

WANG, Dai-jun, XIE, Qing, GONG, Ye, MAO, Ying, WANG, Yin, CHENG, Hai-xia, ZHONG, Ping, CHE, Xiao-ming, JIANG, Cheng-chuan, HUANG, Feng-ping, ZHENG, Kang, LI, Shi-qi, GU, Yu-xiang, BAO, Wei-min, YANG, Bo-jie, WU, Jing-song, XIE, Li-qian, ZHENG, Ming-zhe, TANG, Hai-liang, ZHU, Hong-da, CHEN, Xian-cheng, and ZHOU, Liang-fu

Published
2013
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41. The nucleation and growth of Helium hubbles at grain boundaries of bcc tungsten: a molecular dynamics simulation

Author

Li Yu-Hong, He Wen-Hao, Su Xue, Wang Dong, Yang Dong-Yang, Zhou Liang-Fu, and Zhang Jing

Subjects
Materials science, Condensed matter physics, chemistry, Bubble, Atom, Nucleation, General Physics and Astronomy, chemistry.chemical_element, Grain boundary, Radius, Dislocation, Tungsten, Helium
Abstract

Tungsten (W) is a potential candidate for plasma facing materials (PFMs) of fusion reactor. The helium (He) produced in fusion reaction is insoluble and easy to gather and form to He bubbles in W, resulting in embrittlement and degradation of the performance of the W matrix. In this paper, based on molecular dynamics, the nucleation and growth of helium bubbles in the bulk and at ∑3[211](110) and ∑9[110](411) grain boundaries of W was studied. As a result, the growth mechanism of Helium bubbles at grain boundary of W was different from in bulk. Helium bubbles in bulk W grow up by extruding dislocation rings. The growth mechanism of helium bubbles at ∑3[211](110) grain boundary was as follows: Firstly, a small amount of W interstitial atoms were extruded and emitted. And then the 1/2\begin{document}$\left\langle {111} \right\rangle $\end{document} dislocation line was extruded. Finally, the 1/2\begin{document}$\left\langle {111} \right\rangle $\end{document} dislocation line would migrate along the direction of [111] of the grain boundary interface. Moreover, the emission of W interstitial atoms and dislocation extrusion of the helium bubble were not observed in our simulated time scale at the ∑9[110](411) grain boundary. Then we used the NEB method to calculate the diffusion barrier of self-gap atoms in the bulk and at ∑3[211](110) and ∑9[110](411) grain boundaries of W, which explained the simulation results. The migration energy barrier of W self-gap atoms in the bulk and at ∑3[211](110) grain boundary was only a few to a few millielectron volts. So as long as W self-gap atoms dissociated from the surface of the He bubble in the thermal relaxation process, they can be easily migrated out. However, The migration energy of the W self-gap atom at the ∑9[110](411) grain boundary can be from a few tenths to a few electron volts. Even during the thermal relaxation process, the W self-gap atoms dissociated from the surface of the He bubble. It was difficult for the W self-gap atoms migrated out. Finally, the correlation between He bubble size and stress released was given. Either in bulk or at ∑3[211](110) and ∑9[110](411) grain boundaries of W, after the pressure of the helium bubble becomes stable with time, the radius of the helium bubble would increase rapidly whenever the pressure dropped sharply. So there was a small step on the curve of the evolution of the radius of the helium bubble with time. Thus, helium bubbles in W could promote growth by releasing pressure intermittently.

Published
2020

44. Application of Keyhole Microneurosurgery in China

Author

Chen, Li-Gang, primary, Chen, Shu-Da, additional, Huang, Guang-Fu, additional, Huang, Ying, additional, Kang, De-Zhi, additional, Lan, Qing, additional, Li, Gang, additional, Li, Xin-Gang, additional, Liu, Zhi-Xiong, additional, Qi, Song-Tao, additional, Tian, Xin-Hua, additional, Wang, Guo-Liang, additional, Wang, Shuo, additional, Wang, Xiang-Yu, additional, Wang, Yong-Fei, additional, Wang, Yun-Jie, additional, You, Chao, additional, Yu, Yan-Bing, additional, Yue, Shu-Yuan, additional, Zhang, Dong, additional, Zhang, Jian-Min, additional, Zhang, Jian-Ning, additional, Zhang, Jun-Ting, additional, Zhang, Shi-Zhong, additional, Zhang, Xian, additional, Zhang, Ya-Zhuo, additional, Zhao, Ji-Zong, additional, Zhao, Wei-Guo, additional, Zhao, Yuan-Li, additional, Zhou, Ding-Biao, additional, and Zhou, Liang-Fu, additional

Published
2017
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47. Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy

Author

Tang, Chao, Guo, Jun, Chen, Hong, Yao, Cheng-Jun, Zhuang, Dong-Xiao, Wang, Yin, Tang, Wei-Jun, Ren, Guang, Yao, Yu, Wu, Jin-Song, Mao, Ying, and Zhou, Liang-Fu

Subjects
Adult, Image-Guided Biopsy, Male, Aspartic Acid, Adolescent, Brain Neoplasms, Gene Expression Profiling, Proton Magnetic Resonance Spectroscopy, DNA Mutational Analysis, Mutation, Missense, Middle Aged, Magnetic Resonance Imaging, Choline, Young Adult, Phenotype, Codon, Nonsense, Biomarkers, Tumor, Humans, Original Article, Female, Genetic Predisposition to Disease, Neoplasm Grading, Glioblastoma
Abstract

Genetic mutation has served as the biomarkers for the diagnosis and treatment of glioblastoma multiforme (GBM). However, intra-tumor heterogeneity may interfere with personalized treatment strategies based on mutation analysis. This study aimed to characterize somatic mutation profiling of GBM. We collected 33 samples from 7 patients with the primary GBM associated with different Choline (Cho) to N-acetylaspartate (NAA) index (CNI) through the frameless proton magnetic resonance spectroscopy (1H-MRS) guided biopsies and investigated multiple somatic mutations profi ling using the AmpliSeq cancer hotspot panel V2. We identifi ed 53 missense or nonsense mutations in 27 genes including some novel mutations such as APC and IDH2. The mutations in EGFR, TP53, PTEN, PIK3CA genes were presented with different frequency and the majority of the mutated gene was only shared by 1-2 samples from one patient. Moreover, we found the association of CNI with histological grade, but there was no signifi cant change of CNI in the presence of TP53, EGFR and PTEN mutations. These data suggest that gene mutations constitute a heterogeneous marker for primary GBM which may be independent of intra-tumor morphological phenotypes of GBM; therefore, gene mutation markers could not be determined from a small number of needle biopsies or only confi ned to the high-grade region.

Published
2015

48. The genome-wide mutational landscape of pituitary adenomas

Author

Song, Zhi-Jian, primary, Reitman, Zachary J, additional, Ma, Zeng-Yi, additional, Chen, Jian-Hua, additional, Zhang, Qi-Lin, additional, Shou, Xue-Fei, additional, Huang, Chuan-Xin, additional, Wang, Yong-Fei, additional, Li, Shi-Qi, additional, Mao, Ying, additional, Zhou, Liang-Fu, additional, Lian, Bao-Feng, additional, Yan, Hai, additional, Shi, Yong-Yong, additional, and Zhao, Yao, additional

Published
2016
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