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Novel coronavirus pneumonia was first detected in Wuhan, China, in late December 2019. Its widespread infectivity and strong pathogenicity has posed a great threat to public health, seriously affecting social production and life. The disease caused by this virus has been officially named COVID-19 (coronavirus disease 2019) by the World Health Organization (WHO). Tuina (massage) therapy is 1 of the widely employed complementary and alternative medicine interventions in the world. As a useful therapy implemented on human's skin, muscles and joints, tuina (massage) has unique advantages in the field of medicine. This systematic review and meta-analysis will summarize the current evidence of tuina (massage) used as an intervention for COVID-19.We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating all patients recovering from COVID-19: Wanfang and Pubmed Database, china national knowledge infrastructure database, cochrane central register of controlled trials, cumulative index of nursing and allied health literature and excerpta medica database. Each database will be searched from inception to October 2022. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses.This proposed study will evaluate the effectiveness and safety of massage therapy for patients recovering from COVID-19.This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients recovering from COVID-19.

Autism Spectrum Disorder (ASDs) are a group of extensive developmental disorders with neurological basis, including self Autism, Asperger's Syndrome Subcategories such as syndrome, Rett syndrome, child disintegrating mental disorder, and generalized developmental disorder unspecified type. Each subcategory is on a continuous spectrum from mild to severe in terms of severity of symptoms, with autism being the most severe One end. Their common characteristics are the widespread existence of social communication barriers, verbal and non-verbal communication defects, narrow interests, and behavioral stereotypes.

Background: Metatarsalgia refers to localized or generalized forefoot pain in the region of the metatarsal heads. Often this pain is plantar, beneath the metatarsal heads, and arises from either mechanical or iatrogenic causes. The treatment of metatarsalgia remains controversial. A thorough understanding of the biomechanics of the forefoot and the underlying pathology of the particular type of metatarsalgia affecting the patient is a prerequisite to selecting the proper treatment. In recent years, massage therapy has been increasingly accepted by patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with metatarsal pain. Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating metatarsal pain: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL and EMBASE. Each database will be searched from inception to October 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses. Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with metatarsal pain. The outcomes will include changes in metatarsal pain relief and adverse effect. Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with metatarsalgia.

Background: Functional constipation (FC) is a common gastrointestinal disorder characterized by slow bowel movement and defecation difficulties, significantly impacting patients’ quality of life and exerting heavy financial burden to whole society. However, more than 50% FC patients are not completely satisfied with current therapies and alternative therapies are urgently required. Increasing evidences have demonstrated that traditional Chinese medicine (TCM) has a good therapeutic effect on FC, which is well known for its multitarget and multimode effects on diverse diseases as well as less side effects. Furthermore, studies proved that Qi Di Laxative Decoction was an effective treatment for functional constipation. Its safety and effectiveness should be verified by further studies. Methods: We will search the following electronic databases for randomized controlled trials to evaluate the clinical efficacy of Qi Di Laxative Decoction in treating functional constipation: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL and EMBASE. Each database will be searched from inception to November 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses. Result: This proposed study will evaluate the clinical efficacy of Qi Di Laxative Decoction for patients with functional constipation. The outcomes will include changes in FC relief and adverse effect. Conclusion: This proposed systematic review will evaluate the existing evidence on the clinical efficacy of Qi Di Laxative Decoction in treating functional constipation.

Background: Thoracic facet joint disorder is a common thoracic disorder in clinic, inducing pain and discomfort at the dislocated thoracic vertebrae, radiating to pain of the neck and back. The incidence of thoracic facet joint disorder is higher than the facet disorder of the cervical and lumbar vertebrae. Therefore, an ideal strategy to relieve thoracic facet joint disorder is urgently needed. In recent years, massage therapy has been increasingly accepted by thoracic facet joint disorder patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with thoracic facet joint disorder. Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating thoracic facet joint disorder: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL and EMBASE. Each database will be searched from inception to October 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses. Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with thoracic facet joint disorder. Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with thoracic facet joint disorder

Background: Chronic atrophic gastritis (CAG) is an established precursor of gastric carcinoma with high prevalence worldwide. It is a typical complex gastro-intestinal disease with multiple influence factors, of which exact mechanisms remain unelucidated. Therefore, an ideal strategy to relieve CAG is urgently needed. In recent years, massage therapy has been increasingly accepted by CAG patients due to its lower costs, fewer unwanted side effects and safety for clinical use. In this systematic review, we aim to evaluate the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis. Methods: We will search the following electronic databases for randomized controlled trials to evaluate the effectiveness and safety of massage therapy in treating chronic atrophic gastritis: Wanfang and Pubmed Database, CNKI, CENTRAL, CINAHL and EMBASE. Each database will be searched from inception to September 2020. The entire process will include study selection, data extraction, risk of bias assessment and meta-analyses. Results: This proposed study will evaluate the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis. The outcomes will include changes in CAG relief and adverse effect. Conclusions: This proposed systematic review will evaluate the existing evidence on the effectiveness and safety of massage therapy for patients with chronic atrophic gastritis.

With the rapid development of the global economy, changes in lifestyle and the acceleration of the aging process, the number of patients with diabetes mellitus (DM) in the world in 2017 was approximately 425 million (20 to 79 years old). According to data from the United Nations Population Division, it is estimated that by 2045, the number of people with diabetes in the world will increase to 629 million, of which China's adult population will reach about 120 million. The pain and disease burden caused by diabetes and its complications are major health problems and socio-economic problems that plague people all over the world. Therefore, it is particularly important to find a treatment method with obvious curative effect and small side effects for the treatment of T2DM, and to explain its possible mechanism of action, which has become an urgent problem to be solved in contemporary medicine.

Major depressive disorder (MDD) is one of the typical affective disorders with a high morbidity, high suicide rate and high recurrence rate. Depression is estimated to affect more than 300 million people of all ages globally (World Health Organization (WHO), 2019), causing heavy financial burden on families and the society. Therefore, it is particularly important to find a therapy with curative effect and small side effects for the treatment of MDD, and to explain its possible mechanism of action, which has become an urgent problem to be solved in contemporary medicine.