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387 results on '"Zhou, Junmei"'

13. Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: A cohort study of a rural adult Chinese population

Author

Wang, Bingyuan, Zhang, Ming, Wang, Shu, Wang, Chongjian, Wang, Jinjin, Li, Linlin, Zhang, Lu, Ren, Yongcheng, Han, Chengyi, Zhao, Yang, Zhou, Junmei, Wang, Guo’an, Shen, Yanxia, Wu, Dongting, Pang, Chao, Yin, Lei, Feng, Tianping, Zhao, Jingzhi, Luo, Xinping, and Hu, Dongsheng

Published
2018
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23. Comparison of body mass index, waist circumference, conicity index, and waist-to-height ratio for predicting incidence of hypertension: the rural Chinese cohort study

Author

Chen, Xu, Liu, Yu, Sun, Xizhuo, Yin, Zhaoxia, Li, Honghui, Deng, Kunpeng, Cheng, Cheng, Liu, Leilei, Luo, Xinping, Zhang, Ruiyuan, Liu, Feiyan, Zhou, Qionggui, Wang, Chongjian, Li, Linlin, Zhang, Lu, Wang, Bingyuan, Zhao, Yang, Zhou, Junmei, Han, Chengyi, Zhang, Hongyan, Yang, Xiangyu, Pang, Chao, Yin, Lei, Feng, Tianping, Zhao, Jingzhi, Zhang, Ming, and Hu, Dongsheng

Published
2018
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33. Efficient Evaluation in XML to XML Transformations

Author

Wang, Qing, Zhou, Junmei, Wu, Hongwei, Wu, Yizhong, Yuan, Yang, Zhou, Aoying, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Zhou, Xiaofang, editor, Orlowska, Maria E., editor, and Zhang, Yanchun, editor

Published
2003
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34. Additional file 1 of Forsythiaside A improves Influenza A virus infection through TLR7 signaling pathway in the lungs of mice

Author

Zheng, Xiao, Chen, Ziqi, Shi, Shanshan, Yan, Huijun, Zhou, Junmei, Jiang, Lifang, Wang, Hongli, Hou, Guanghui, and Jiang, Zhenyou

Abstract

Additional file 1: Supplementary Figure 1. This figure represents the original picture of GAPDH in the WT mice of Fig. 5A in the manuscript. Supplementary Figure 2. This figure represents the original picture of TLR7 in the WT mice of Fig. 5A in the manuscript. Supplementary Figure 3. This figure represents the original picture of Myd88 in the WT mice of Fig. 5A in the manuscript. Supplementary Figure 4. This figure represents the original picture of NF-κB in the WT mice of Fig. 5A in the manuscript. Supplementary Figure 5. This figure represents the original picture of GAPDH in the TLR7−/− mice of Fig. 5A in the manuscript. Supplementary Figure 6. This figure represents the original picture of TLR7 in the TLR7−/− mice of Fig. 5A in the manuscript. Supplementary Figure 7. This figure represents the original picture of Myd88 in the TLR7−/− mice of Fig. 5A in the manuscript. Supplementary Figure 8. This figure represents the original picture of NF-κB in the TLR7−/− mice of Fig. 5A in the manuscript.

Published
2022
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43. Advances in Female Germ Cell Induction from Pluripotent Stem Cells

Author

Gulimiheranmu, Maisumu, Wang, Xinjie, and Zhou, Junmei

Subjects
endocrine system, Article Subject
Abstract

Germ cells are capable of maintaining species continuity through passing genetic and epigenetic information across generations. Female germ cells mainly develop during the embryonic stage and pass through subsequent developmental stages including primordial germ cells, oogonia, and oocyte. However, due to the limitation of using early human embryos as in vivo research model, in vitro research models are needed to reveal the early developmental process and related mechanisms of female germ cells. After birth, the number of follicles gradually decreases with age. Various conditions which damage ovarian functions would cause premature ovarian failure. Alternative treatments to solve these problems need to be investigated. Germ cell differentiation from pluripotent stem cells in vitro can simulate early embryonic development of female germ cells and clarify unresolved issues during the development process. In addition, pluripotent stem cells could potentially provide promising applications for female fertility preservation after proper in vitro differentiation. Mouse female germ cells have been successfully reconstructed in vitro and delivered to live offspring. However, the derivation of functional human female germ cells has not been fully achieved due to technical limitations and ethical issues. To provide an updated and comprehensive information, this review centers on the major studies on the differentiation of mouse and human female germ cells from pluripotent stem cells and provides references to further studies of developmental mechanisms and potential therapeutic applications of female germ cells.

Published
2021
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45. MVP interacts with YPEL4 and inhibits YPEL4-mediated activities of the ERK signal pathway

Author

Liang, Pei, Wan, Yongqi, Yan, Yan, Wang, Yuequn, Luo, Na, Deng, Yun, Fan, Xiongwei, Zhou, Junmei, Li, Yongqing, Wang, Zequn, Yuan, Wuzhou, Tang, Ming, Mo, Xiaoyang, and Wu, Xiushan

Subjects
Binding proteins -- Properties -- Research, Molecular biology -- Research, Protein kinases -- Properties -- Research, Biochemical assays -- Research, Biological sciences
Abstract

Human YPEL4 is a member of YPEL family. II contains a Yippee domain, which is a putative zinc-finger-like, metal-binding domain. The human YPEL4 gene maps to chromosome 11q12.1, is ubiquitously expressed in adult tissues, and encodes a nuclear protein of 127 amino acids, the function of which remains unknown. To gain insights into the cellular function of this protein, we searched for YPEL4-interacting proteins using a yeast two-hybrid screen. The major vault protein (MVP), a lung resistance associated protein, was identified as a binding partner of YPEL4. The interaction between YPEL4 and MVP in mammalian cells was further demonstrated by a series of biochemical assays including the mammalian two-hybrid assay. GST pull-down assay, co-immunoprecipilation assay, and immunocyiochemistry. Using a reporter system, we found that MVP can inhibit YPEL4's ability to activate Elk-1 in the MAPK signaling pathway. This study provides new clues for understanding the molecular mechanism of YPEL4 in cell division and signal transduction pathways and should be helpful for understanding molecular functions of the YPEL family. Key words: YPEL4, MVP, interaction, MAPK signaling pathway. La proteine humaine YPEL4 appartient a la famille YPEL. Elle contient un domaine Yippee, un domaine presume de liaison des metaux de type << doigt de zinc >>. Le gene codant YPEL4 se situe sur le chromosome 11q12,l, est exprime de facon ubiquiste dans les tissus adultes et code une proteine nucleaire de 127 acides amines; sa fonetion demeure cependant inconnue. Attn d'en apprendre davantage sur la fonetion cellulaire de cette proteine, nous avons recherche les proteines qui interagissent avec YPEL4 par un criblage en double hybride. La proteine majeure vault (MVP), une proteine associee a la resistance du poumon, etait un partenaire de liaison de YPEL4. L'interaction entre YPEL4 et MVP dans les cellules mammileres a ete plus amplemeni demontree par une serie d'essais biochimiques, noiamment par un systeme en double hybride mammilere, par un essai de co-precipitation par GST, par co-immunoprecipiialion, et par immunocylochimie. A l'aide d'un systeme rapporteur, nous avons trouve que MVP peut inhiber la capacite de YPEL4 a activer Elk-1 dans la voie de signalisation de MAPK. Cette etude fournit de nouvelle pistes dans la comprehension du mecanisme moleculaire d'action de YPEL4 dans la division cellulaire et la transduction de signaux, et devrait pouvoir etre utile pour comprendre les fonctions moleculaires de la famille YPEL. Mots-cles : YPEL4, MVP, interaction, voie de signalisation de MAPK. [Traduit par la Redaction], Introduction The YPEL gene family was characterized as the first highly conserved family of genes coding for proteins containing putative zinc-finger-like metal-binding domains, and is found in a wide spectrum [...]

Published
2010
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