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20. Diterpenoids from Sauropus spatulifoliusLeaves with Antimicrobial Activities

Author

Wu, Pei-Qian, Cui, Yong-Sheng, Han, Xiao-Ying, Wang, Chen, An, Pei-Pei, Zhou, Jun-Su, Ren, Yu-Hao, Liu, Zhen-Long, Lin, Rong-Tuan, Zhou, Bin, and Yue, Jian-Min

Abstract

As a plant used in both food and medicine, Sauropus spatulifoliusis consumed widely as a natural herbal tea, food source, and Chinese medicine. Inspired by its extensive applications, we conducted a systematic phytochemical study of the leaves of S. spatulifolius. Thirteen new diterpenoids, sauspatulifols A–M (1–13), including four ent-cleistanthane-type diterpenoids (1–4), eight 15,16-di-nor-ent-cleistanthane-type diterpenoids (5–12), and one 17-nor-ent-pimarane-type diterpenoid (13) as well as one known diterpenoid, cleistanthol (14), were isolated. All of these diterpenoids feature a 2α,3α-dihydroxy unit within the A ring, and their structures were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. Compound 14displayed moderate inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Shigella flexneriwith the same minimum inhibitory concentration value of 12 μg/mL as well as activity against vesicular stomatitis virus and influenza A virus.

Published
2022
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