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7 results on '"Zhou, Jeffrey O."'

1. Identification and Characterization of a B-Raf Kinase α-Helix Critical for the Activity of MEK Kinase in MAPK Signaling

Author

Nguyen, Diep, primary, Lin, Linda Yingqi, additional, Zhou, Jeffrey O., additional, Kibby, Emily, additional, Sia, Twan W., additional, Tillis, Tiara D., additional, Vapuryan, Narine, additional, Xu, Ming-Ray, additional, Potluri, Rajiv, additional, Shin, YongJoon, additional, Erler, Elizabeth A., additional, Bronkema, Naomi, additional, Boehlmer, Daniel J., additional, Chung, Christopher D., additional, Burkhard, Caroline, additional, Zeng, Shirley H., additional, Grasso, Michael, additional, Acevedo, Lucila A., additional, Marmorstein, Ronen, additional, and Fera, Daniela, additional

Published
2020
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3. Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

Author

Nguyen, Diep, primary, Lin, Linda Yingqi, additional, Zhou, Jeffrey O., additional, Kibby, Emily, additional, Sia, Twan W., additional, Tillis, Tiara D., additional, Vapuryan, Narine, additional, Xu, Ming-Ray, additional, Potluri, Rajiv, additional, Shin, YongJoon, additional, Erler, Elizabeth A., additional, Bronkema, Naomi, additional, Boehlmer, Daniel J., additional, Chung, Christopher D., additional, Burkhard, Caroline, additional, Zeng, Shirley H., additional, Grasso, Michael, additional, Acevedo, Lucila A., additional, Marmorstein, Ronen, additional, and Fera, Daniela, additional

Published
2020
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6. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, primary, Lee, Matthew S., additional, Wiehe, Kevin, additional, Meyerhoff, R. Ryan, additional, Piai, Alessandro, additional, Bonsignori, Mattia, additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Ton, Therese, additional, Zhou, Jeffrey O., additional, Danishefsky, Samuel, additional, Haynes, Barton F., additional, and Harrison, Stephen C., additional

Published
2018
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7. HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

Author

Fera, Daniela, Lee, Matthew S., Wiehe, Kevin, Meyerhoff, R. Ryan, Piai, Alessandro, Bonsignori, Mattia, Aussedat, Baptiste, Walkowicz, William E., Ton, Therese, Zhou, Jeffrey O., Danishefsky, Samuel, Haynes, Barton F., and Harrison, Stephen C.

Abstract

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide (“Man9-V3”) for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage (“DH270”), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3 mimetics, Man9-V3 encompasses two key features of the V3 region recognized by V3-glycan bnAbs—the conserved GDIR motif and the N332 glycan. In our structure of an antibody fragment of a lineage member, DH270.6, in complex with the V3 glycopeptide, the conformation of the antibody-bound glycopeptide conforms closely to that of the corresponding segment in an intact HIV-1 Env trimer. An additional structure identifies roles for two critical mutations in the development of breadth. The results suggest a strategy for use of a V3 glycopeptide as a vaccine immunogen.

Published
2018
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