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Your search keyword '"Zhou, Guangshuai"' showing total 17 results
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17 results on '"Zhou, Guangshuai"'

7. An Anthracene Carboxamide-Based Fluorescent Probe for Rapid and Sensitive Detection of Mitochondrial Hypochlorite in Living Cells.

Author

Liu, Xueling, Wang, Yali, Zhou, Guangshuai, and Zhang, Wenzhou

Subjects
FLUORESCENT probes, BIOLOGICAL systems, MITOCHONDRIA, ANTHRACENE, DETECTION limit, OPTICAL properties
Abstract

Mitochondrial hypochlorite (ClO−) plays important and often contradictory roles in maintaining the redox balance of mitochondria. Abnormal ClO− levels can induce mitochondrial inactivation and further cause cell apoptosis. Herein, we have developed an anthracene carboxyimide-based fluorescent probe mito-ACS for imaging mitochondrial ClO− in living cells. This probe exhibits some distinctive features as excellent resistance to photobleaching, high selectivity and sensitivity, as well as good water solubility. Mito-ACS showed a noticeable fluorescence response toward ClO− with a fast response (within 6 s) and a low detection limit (23 nM). Moreover, the introduction of triphenylphosphonium makes the probe soluble in water and selectively localizes to mitochondria. Furthermore, mito-ACS was successfully applied to image mitochondria ClO− in living cells with low toxicity. Remarkably. the less used fluorophore anthracene carboxyimide exhibiting excellent photostability and desirable optical properties provides a promising application prospect in biological systems. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Development of a Risk Scoring System for Predicting Anastomotic Leakage Following Laparoscopic Rectal Cancer Surgery

Author

Han,Zhongbo, Chen,Dawei, Li,Yan, Zhou,Guangshuai, Wang,Meng, Zhang,Chao, Han,Zhongbo, Chen,Dawei, Li,Yan, Zhou,Guangshuai, Wang,Meng, and Zhang,Chao

Abstract

Zhongbo Han,1,* Dawei Chen,2,* Yan Li,3 Guangshuai Zhou,3 Meng Wang,1 Chao Zhang1 1Department of Gastrointestinal Surgery, Zibo Central Hospital, Shandong University, Zibo, Shandong, People’s Republic of China; 2Department of General Surgery, Jiangyin People′s Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu, People’s Republic of China; 3Department of Quality and Safety Management, Zibo Central Hospital, Shandong University, Zibo, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chao ZhangDepartment of Gastrointestinal Surgery, Zibo Central Hospital, Shandong University, 54 West Gongqingtuan Road, Zibo, 255000, Shandong, People’s Republic of ChinaTel +86 05333570671Fax +86 05333570672Email zhangchao20202021@163.comPurpose: To develop a risk scoring system that can predict the incidence of anastomotic leakage after laparoscopic rectal cancer surgery.Patients and Methods: The clinical data of 387 patients with rectal cancer who underwent laparoscopic low anterior resection were retrospectively collected. Univariable and multivariable logistic regression analyses were used to evaluate independent risk factors for postoperative anastomotic leakage. A simplified points system was then developed based on the corresponding regression coefficient β of each risk factor. Receiver operating characteristic (ROC) analysis was used to evaluate the performance and the optimal cut-off value in predicting anastomotic leakage. The performance of the points system was then externally validated in an independent cohort of 192 patients based in another institution.Results: Anastomotic leakage occurred in 36 of 387 patients with rectal cancer (9.30%). Logistic multivariable regression analysis showed that males, maximum tumor diameter (≥ 5cm), operation time (≥ 180min), preoperative chemoradiation, intraoperative blood transfusion and the anastom

Published
2021

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