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Regarding the goal of "carbon peaking and carbon neutrality," an urgent practical problem is how green finance decreases carbon emissions. This paper uses the dynamic spatial Durbin model and China's provincial panel data to empirically test the impact of green credit on carbon emissions. The results show that green credit effectively curbs carbon emissions, and has significant spatial spillover effects on the carbon emissions. In the short run, the spillover effects of green credit on carbon emissions are greater than the direct effects, but in the long run, the direct effects of green credit on carbon emissions are greater than the spillover effects. The mechanism test finds that upgrading industrial structure is an important transmission channel for green credit to affect carbon emissions, and energy consumption only plays a part of the intermediary role in the direct impact of green credit on carbon emissions. However, green credit has not achieved the goal of carbon emission reduction by promoting low-carbon technology innovation.

Purpose Climate change not only causes serious economic losses but also influences financial stability. The related research is still at the initial stage. This paper aims to examine and explore the impact of climate change on financial stability in China. Design/methodology/approach This paper first uses vector autoregression model to study the impact of climate change to financial stability and applies NARDL model to assess the nonlinear asymmetric effect of climate change on China’s financial stability using monthly data from 2002 to 2018. Findings The results show that both positive and negative climate shocks do harm to financial stability. In the short term, the effect of positive climate shocks on financial stability is greater than the negative climate shocks in the current period, but less in the lag period. In the long term, negative climate shocks bring larger adjustments to financial stability relative to positive climate shocks. Moreover, compared with the short-term effect, climate change is more destructive to financial stability in the long run. Originality/value The paper provides a quantitative reference for assessing the nexus between climate change and financial stability from a nonlinear and asymmetric perspective, which is beneficial for understanding climate-related financial risks.

Background Previous investigations indicated that transmembrane protein 16A (TMEM16A) mediates the pathogenesis and malignant of many tumors through regulating multiple pathways. However, whether TMEM16A could regulate autophagy via mammalian target of rapamycin (mTOR) pathway to modulate hypopharyngeal squamous cell carcinoma (HSCC) occurrence and development or not is still unclear. Methods The expression of TMEM16A in HSCC and metastatic lymph nodes was detected by immunohistochemistry and western blot. TMEM16A was overexpressed or knocked down in FaDu cell line to evaluate its effects on the biological function by cell colony formation experiment, wound healing assay, trans well assay, and invasion assay. TMEM16A was knocked down or over expression in FaDu cells to test apoptosis and autophagy related protein and autophagosome formation by western blot, transmission electron microscopy and immunofluorescence. Results In the present study, we observe that the expression level of TMEM16A in HSCC and metastatic lymph nodes are significantly higher than that in normal tissues. The results of in-vitro experiments showed that silencing TMEM16A significantly inhibited the proliferation, invasion and migration of HSCC cells. Silencing TMEM16A inhibited tumor formation in xenografted mice. Further experiments demonstrated that knocking down TMEM16A in HSCC cells could block the activation of mTOR, and thus promote the initiation of the autophagic death by activating sequestosome-1 (SQSTM1/P62) and protein light chain 3II (LC3II). Conclusion Therefore, TMEM16A displays an important effect on autophagy in HSCC, which may provide a potential therapeutic target for the treatment of HSCC.

With the data of Chinese A-share-listed companies from 2004 to 2017, this paper builds a difference-in-differences model to investigate the impact of air pollution collaborative governance on green technology innovation. The main results show that air pollution collaborative governance promotes green technology innovation, and a series of robustness tests also verify this conclusion. Patent heterogeneity analysis suggests that air pollution collaborative governance increases the number of green utility model patents, but has no obvious impact on green invention patents. In terms of enterprise heterogeneity, air pollution collaborative governance can effectively stimulate the non-heavy-polluting enterprises to innovate green technology, but the incentive effect on heavy-polluting enterprises is not evident. Moreover, by constructing a mediating effect model and a moderating effect model, mechanism analysis reveals that RD investment plays a positive mediating role in the impact of air pollution collaborative governance on green technology innovation, and the increase of government subsidy also enhances the promotion effect of air pollution collaborative governance on green technology innovation.

OBJECTIVE: The aim of this study is to explore the diagnosis, clinical manifestations and surgical treatment experience of acute sinusitis complicated with orbital subperiosteal abscess. METHODS: The clinical data of 11 patients with acute sinusitis complicated by orbital subperiosteal abscess from 1 year and 8 months to 50 years were retrospectively analyzed, including clinical manifestations, imaging manifestations, bacteriological examinations, surgical methods and therapeutic effects. All patients were given antibacterial drugs, glucocorticoids, and surgery. RESULTS: All 11 patients had unilateral lesions. The imaging examinations all supported the appearance of orbital subperiosteal abscess. Nine patients underwent nasal endoscopic sinus opening+SPOA incision and drainage, 2 patients underwent nasal endoscopic sinus opening+ultrasound guided abscess puncture. Eyelid swelling and exophthalmia of all patients were alleviated when discharged. Ten of the 11 patients had no visual acuity change, and one patient had light perception only when she came to the hospital and recovered to 0.05 when discharged, there was no change in visual acuity after 3 months follow-up. The bacterial cultures of nasal secretion or pus were positive in 7 cases, the main pathogenic bacteria were Staphylococcus aureus(3 cases, includes one case of MRSA), Streptococcus anginosus(2 cases), and Streptococcus intermedius(2 cases). CONCLUSION: Rhinogenous orbital subperiosteal abscess has a rapid onset and progresses quickly. Once an abscess is formed, patients with poor conservative treatment should choose surgical treatment as soon as possible. The most common surgical method is nasal endoscopic sinus opening+SPOA incision and drainage. If the abscess is located above or above the eyeball, puncture or incision and drainage should be combined with ultrasound guidance.

Circular RNA zinc finger protein 609 (circZNF609) has been reported to involve in nasopharyngeal carcinoma (NPC) tumorigenesis regulation. However, the role and the molecular mechanism of circZNF609 in NPC remain unclear. Levels of circZNF609, microRNA (miR)-338-3p, and GTPase HRas (HRAS) were detected by quantitative real-time polymerase chain reaction or Western blot. Cell proliferation, migration, and invasion were analyzed using cell counting kit-8 assay, colony formation assay, and transwell assay, respectively. Glucose metabolism was calculated by measuring glucose consumption, lactate production, adenosine triphosphate (ATP) levels, and HK2 activity. The interaction between miR-338-3p and circZNF609 or HRAS was analyzed by the dual-luciferase reporter assay. In vivo experiment was conducted using the murine xenograft model. CircZNF609 was elevated in NPC tissues and cell lines, and high circZNF609 expression had a poor prognosis. CircZNF609 knockdown suppressed NPC progression in vitro by inhibiting cell proliferation, migration, invasion, and glycolysis and hindered tumor growth in vivo. MiR-338-3p directly bound to circZNF609 and HRAS, and circZNF609 knockdown repressed NPC cell malignant properties by binding to miR-338-3p. MiR-338-3p was low in NPC, and miR-338-3p restoration performed anti-tumor effects in cells of NPC by targeting HRAS. Importantly, circZNF609 acted as a competing endogenous RNA of miR-338-3p to regulate HRAS. CircZNF609 knockdown suppressed cell tumorigenesis in NPC via regulating miR-338-3p/HRAS axis, suggesting a novel therapeutic strategy for NPC.

The objective of this study is to analyze the expression of ILC2 cells (type 2 innate lymphoid cells) in nasal mucosa based on animal model of allergic bacterial infection rhinitis. 45 female BALB/c mice were selected as research subject. They were randomly divided into control group (group A), sensitization group (group B) and inhibitor group (group C) to establish a mouse model of allergic rhinitis. The pathological changes of mouse nasal mucosa were observed by HE (hematoxylin-eosin) staining. The number of ILC2 cells in mouse nasal mucosa was detected by immunofluorescence double staining assay. Real-time quantitative Polymerase Chain Reaction (PCR) was used to detect the expression of ILC2 cell-associated factor in mouse nasal mucosa. The expression of cytokine protein in serum was detected by enzyme linked immunosorbent assay. The results showed that there was no inflammatory cell infiltration in the nasal mucosa of group A, and the number of ILC2 cells was small. Inflammatory cell infiltration and obvious ILC2 cells were observed in the nasal mucosa of group B and C, and the number of ILC2 cells in group B and C was significantly increased compared with that in group A. Compared with group A, ROR α, Thy-1, ST2, and CD90 genes were significantly increased in nasal mucosa tissues of group B and C, and protein levels of IL-4, IL-5, IL-13, and IgE in serum were significantly increased. Compared with group B, the protein expression levels of IL-13 and IgE in serum of group C mice were significantly increased, while the expression levels of IL-4 and IL-5 were not significantly different. In conclusion, in the pathogenesis of allergic rhinitis, ILC2 cells play a role in promoting the development of inflammation, and its expression is related to RORα, Thy-1, ST2 and CD90. Meanwhile, ILC2 cells are also important cells for the synthesis and secretion of IL-13. The study on the pathogenesis of allergic rhinitis provides a new target for its treatment.

Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are the common treatment to relieve it. Polysacharides of Citrus grandis L. Osbeck (PCG) and luteolin have been reported to have anti-inflammatory activities. In this study, the protective effects of PCG and luteolin on chronic pharyngitis are evaluated and the underlying mechanisms are explored. PCG and luteolin are administrated to animal models with granuloma, ear edema and chronic pharyngitis and the effects of PCG and luteolin on disease severity are evaluated. We also evaluate the effects of PCG and luteolin on inflammatory cytokine production in macrophages stimulated with lipopolysaccharides (LPS)/interferon-gamma (IFN-γ) and detect the effects of PCG and luteolin on macrophage polarization. Finally, we evaluate the effects of PCG and luteolin on activations of LPS-induced downstream signaling pathways. PCG and luteolin alleviate the disease severity of granuloma, ear edema and chronic pharyngitis. PCG and luteolin suppress the productions of pro-inflammatory cytokines interlukin-6 (IL-6), interlukin-12 (IL-12) and tumor necrosis factor alpha (TNF-α) in macrophages. Luteolin promotes macrophage M2 polarization by enhancing expressions of arginase (Arg1) and mannose receptor C type 1 (Mrc1). PCG and luteolin suppress nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation and interferon regulatory factor 1 (IRF1), interferon regulatory factor 5 (IRF5) expression. PCG together with luteolin relieves chronic pharyngitis by anti-inflammatory via suppressing NF-κB pathway and the polarization of M1 macrophage.

To investigate the minimally invasive ablation of giant osteoma of the ethmoid sinuses endonasally with the assistance of an image-guidance system.A retrospective analysis was carried out on 12 patients with osteomas of ethmoid sinuses treated by endoscopic surgery with the help of a navigation system from April 2005 to October 2013.Osteomas in all 12 patients were giant and connected extensively with the anterior skull base, lamina papyracea, or orbital apex, and were removed successfully with the help of an endoscope and image navigation system under general anaesthesia. In two cases (one through superciliary arch incision and the other one through labiogingival incision), the procedure was combined with an external procedure to remove osteomas. All patients were followed-up for 8 to 64 months. No recurrences were found. All symptoms gradually vanished or reduced dramatically after surgery. One case of frontal mucocele was observed and was successfully removed 5 years after removal of the osteoma. Anosmia occurred in both patients who underwent crista galli resection, and no recovery was noted 9 and 26 months later. Cerebrospinal fluid rhinorrhea was found in one case during surgery and was repaired with mucosa of inferior nasal concha immediately, and primary healing was successful.Endoscopic ablation of giant osteomas of the ethmoid sinuses with the guidance of a navigation system is an accurate, secure, minimally invasive procedure. A careful study of the preoperative computed tomographic scan is necessary for the success of the operation. If the lesion extensively affects the frontal sinus and maxillary sinus, a combination of superciliary arch incision and labiogingval groove incision is a simple, easy and elegant option.

Research for surgical methods and experience of sinus fibrous dysplasia treatment by auxiliary nasal endoscopy image navigation.Retrospective analysis of the records of 4 patients from March 2006 to December 2011 who were diagnosed as fibrous dysplasia of nasal sinuses, 2 male and 2 female, aged from 19 yrs to 55 yrs and average age was 38 yrs; 3 of them were destroyed of sinus floor, the other who had the bone fiber of sphenoidal sinus. By using 16 multi slice spiral CT and 3D reconstruction, the 4 cases were all treated by drill grinding abnormal fibrous tissue in the nasal sinus cavities with auxiliary nasal endoscopy image navigation, to achieve contour in the bone fiber cavities.Lesions of 4 cases were accurately found and grinded under auxiliary nasal endoscopy image navigation. For 3 patients, headache, nasal congestion, facial discomfort and other symptoms have gradually disappeared after operation. However, one patient with sinus floor destroyed suffered facial swelling and pain 3 month after operation, with ineffective conservation treatment outcomes. After CT re-scan, it showed that there were a large number of bone residue in maxillary sinus during the re-operation. The reason was that the surgical cavity was not rinsed off which leaded to maxillary sinus congestion. With the methods of expansion of the maxillary sinus, flushing the cavity, and postoperative nasal and maxillary sinus rinse, symptoms disappeared 1 month later without recurrence.Patients with fibrous dysplasia of nasal sinuses are treated thoroughly, securely, and effectually, by drill grinding abnormal fibrous tissue in the nasal sinus cavities with auxiliary nasal endoscopy image navigation, to achieve contour in the bone fiber cavities.