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A field study was conducted to evaluate control efficacy of ground ultra-low-volume (ULV applications (Aquareslin® against a natural population of Culex pipiens pallens in three different vegetation areas (dense, open (grassland, and sparsely vegetated in Changping county, Beijing City, China. Over 80% population decline rates (PDRs were achieved from the different vegetation levels. Significantly higher PDR was achieved in the sparsely vegetated habitat compared to the dense and open habitats. Significant higher reduction (% of parity in female mosquitoes was found in the open grassland and sparse vegetation level, compared with the dense vegetation level. Control efficacy of ground ULV spray against a natural population of Cx. pipiens pallens was impacted by the different vegetation levels.

In previous studies, pulse signals have been analysed primarily to standardise and objectify pulse diagnosis, but the influence of TCM constitution on pulse signals and disease has been neglected. Our study links the wrist pulse wave signal to TCM constitution to find TCM constitution factors that predispose to disease while improving the accuracy of disease classification. Our specific approach is set out below. A wrist pulse signal sampler based on a piezoelectric sensor was designed and 95 healthy subjects and 20 hypertensive patients were invited to complete the CCMQ (Constitution in the Chinese Medicine Questionnaire), of which 48 completed the pulse wave signal. Meanwhile, we improved the Butterworth filtering algorithm to denoise the pulse wave signals, and after smoothing and period segmentation, we finally extracted 27 time-domain features and 8 wavelet packet energy features. Then, we used the independent sample t-test and binary logistic regression analysis to analyze the correlation between the prevalence of hypertension and TCM constitution and found that the three constitutions of YaD (Yang-deficiency), YiD (Yin-deficiency), and PW (Phlegm-wet) were significantly associated with whether the subjects suffered from hypertension. The final classification results showed that the fusion features after adding the three constitution features with a high correlation with hypertension had a 17.46% higher F-score than the classification model without the constitution features. It can be seen that the incorporation of constitution characteristics into pulse characteristics in this paper has important implications for disease classification. This also provides a basis for studying the correlation between TCM physical characteristics and certain diseases, and patients can adopt targeted TCM management techniques to prevent diseases in advance.

What is known and objective A large proportion of recurrent cervical cancer (RCC) patients present with poor performance status (PS) after comprehensive treatments, which usually prevents them from opting for clinical trials. We retrospectively analysed the effect and safety of low-dose apatinib and tegafur-gimeracil-oteracil (TGO) in the treatment of these patients. Case summary Six patients treated with low-dose apatinib and TGO showed a disease control rate of 83.3% and grade 1-2 adverse events (AEs). What is new and conclusion This case series indicates that low-dose apatinib and TGO could be considered as palliative therapy for RCC patients with poor PS.

IntroductionDysregulated angiogenesis is a critical characteristic for endothelial dysfunction disorders. This study aimed to determine functions of microRNA-126 in formation of tube and investigated the potential mechanisms.Material and methodsThe synthesized microRNA-126 control and microRNA-126 inhibitor plasmids were transfected into human umbilical-vein endothelial cells (HUVECs) using lipofectamine 2000 reagent. Cell counting kit-8 (CCK-8) was employed to measure proliferative capability of HUVECs. Transwell analysis was used to evaluate HUVECs invasive ability. Real time PCR (RT-PCR) was utilized to access epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 mRNA transcription. Tube-forming capability in HUVECs was determined. Dual-luciferase assay and linear-regression analysis were conducted to measure interaction between EGFL7 and microRNA-126 molecule. Phosphoinositide-3-kinase/protein kinase-B (PI3K/AKT) signaling pathway associated molecules were evaluated using western blot assay.ResultsSilencing of microRNA-126 significantly enhanced proliferative capability and invasive ability of HUVECs compared to those of microRNA-126 control group (pConclusionsmicroRNA-126 modulated angiogenesis and tube formation through increasing EGFL7 expression and phosphorylating PI3K/AKT signaling pathway.

To understand the status and dynamics of macrozoobenthos community in Sanmen Bay, we collected benthos samples by Agassiz trawl in November 2015, and February, May and August in 2016. The results showed that: 1) A total of 119 macrozoobenthos species were recorded, with main groups of fishes, crustaceans and molluscs, accounting for 79% of the total number of species. 2) The dominant species of macrozoobenthos throughout the year were为了解三门湾大型底栖动物群落的现状和动态变化,分别于2015年11月、2016年2月、5月和8月在三门湾海域用阿氏拖网对大型底栖动物进行调查。结果表明: 经鉴定,大型底栖动物有119种,主要类群为鱼类、甲壳类和软体动物,占种类总数的79%。大型底栖动物全年优势种为细螯虾、长额超刺糠虾和六丝钝尾虾虎鱼,不同季节优势种的变化明显,种类差异性较大。大型底栖动物的年平均生物量和平均栖息密度分别为0.025 g·m

Background/Objective: This is a multicentre, randomised, double-blind, placebo-controlled clinical trial to investigate the safety and efficacy of Chinese herbal Fufang Xian Ling Gu Bao (XLGB) with antiadipogenic compounds for the prevention of corticosteroid (CS)-induced osteonecrosis of femoral head (ONFH). Methods: Patients of both genders, aged between 18 and 65 years, with diseases such as systemic lupus erythematosus, nephrosis, dermatosis and rheumatoid arthritis indicated for CS treatment and who did not show magnetic resonance imaging of ONFH at baseline were recruited into the study and then randomised into either XLGB group (n = 129) with daily oral administration of XLGB or placebo group (n = 146). Results: Magnetic resonance imaging revealed a total of 30 ONFH cases at 6 months after CS treatment, with 6.98% (9 of 129 cases) and 14.4% (21 of 146 cases) in the XLGB group and placebo group, respectively, (p

Defects in autophagy-mediated clearance of α-synuclein may be one of the key factors leading to progressive loss of dopaminergic neurons in the substantia nigra. Moxibustion therapy for Parkinson's disease has been shown to have a positive effect, but the underlying mechanism remains unknown. Based on this, we explored whether moxibustion could protect dopaminergic neurons by promoting autophagy mediated by mammalian target of rapamycin (mTOR), with subsequent elimination of α-syn. A Parkinson's disease model was induced in rats by subcutaneous injection of rotenone at the back of their necks, and they received moxibustion at Zusanli (ST36), Guanyuan (CV4) and Fengfu (GV16), for 10 minutes at every point, once per day, for 14 consecutive days. Model rats without any treatment were used as a sham control. Compared with the Parkinson's disease group, the moxibustion group showed significantly greater tyrosine hydroxylase immunoreactivity and expression of light chain 3-II protein in the substantia nigra, and their behavioral score, α-synuclein immunoreactivity, the expression of phosphorylated mTOR and phosphorylated ribosomal protein S6 kinase (p-p70S6K) in the substantia nigra were significantly lower. These results suggest that moxibustion can promote the autophagic clearance of α-syn and improve behavioral performance in Parkinson's disease model rats. The protective mechanism may be associated with suppression of the mTOR/p70S6K pathway.

Accumulating researches reported that particulate matter (PM2.5) is a risk factor for developing various diseases, including metabolic syndrome. Recently, inactive rhomboid protein 2 (iRhom2) was considered as a necessary modulator for shedding of tumor necrosis factor-α (TNF-α) in immune cells. TNF-α, a major pro-inflammatory cytokine, was linked to various pathogenesis of diseases, including dyslipidemia. Here, wild type (WT) and iRhom2-knockout (iRhom2−/−) mice were used to investigate the effects of iRhom2 on PM2.5-induced hepatic dyslipidemia. The hepatic histology, inflammatory response, glucose tolerance, serum parameters and gene expressions were analyzed. We found that long-term inhalation of PM2.5 resulted in hepatic steatosis. And a significant up-regulation of iRhom2 in liver tissues was observed, accompanied with elevated TNF-α, TNF-α converting enzyme (TACE), TNFα receptor (TNFR)2 and various inflammatory cytokines expressions. Additionally, PM2.5 treatment caused TG and TC accumulation in serum and liver, probably attributed to changes of genes modulating lipid metabolism. Intriguingly, hepatic injury and dyslipidemia were attenuated by iRhom2−/− in mice with PM2.5 challenge. In vitro, iRhom2-knockdwon reduced TNF-α expressions and its associated inflammatory cytokines in Kupffer cells, implying that liver-resident macrophages played an important role in regulating hepatic inflammation and lipid metabolism in cells treated with PM2.5. The findings indicated that long-term PM2.5 exposure caused hepatic steatosis and dyslipidemia through triggering inflammation, which was, at least partly, dependent on iRhom2/TNF-α pathway in liver-resident macrophages.

Cobalt-impregnated activated carbon (GAC/Co) was used to produce sulfate radical (SO4·-) from peroxymonosulfate (PMS) in aqueous solution (hereafter called PMS activation). We evaluated its effectiveness by examining the degradation of orange acid 7 (AO7). GAC/Co exhibited high activity to activate PMS to degrade AO7. The degradation efficiency of AO7 increased with increasing dosage of GAC/Co or PMS and elevated temperatures. pH 8 was most favorable for the degradation of AO7 by GAC/Co-activated PMS. The radical quenching experiments indicated that the reactions most likely took place both in the bulk solution and on the surface of GAC/Co. We found that SO4·- played a dominant role in AO7 degradation. Sodium chloride (NaCl) which presents in most dye wastewater had a significant impact on AO7 degradation. Low dosages (

Objective To determine the difference in blood microcirculation recovery between normal frostbite and high-altitude frostbite during the wound healing. Methods Twenty four male rats were randomly divided into control group (n=8), normal frostbite group (n=8), and high-altitude group (n=8). The normal frostbite group rats were frozen to produce mid-degree frostbite models by controlling the freezing time with liquid nitrogen penetration equipment. The high-altitude frostbite group rats were acclimated to a hypoxic and low-pressure environment for 1 week, and then the high-altitude frostbite models were constructed by the same way with liquid nitrogen penetration apparatus. On days 3, 7, 11, 15, 19, and 23 after modeling, the recovery situation of blood circulation of each group was observed with contrast ultrasonography by injecting SonoVue micro-bubble into rats' tail. Finally, the micro-bubble concentration (MC) was calculated to confirm the blood circulation recovery with software Image Pro. Results At different time points, the wound area of the high-altitude frostbite group was bigger than that of the normal frostbite group, and the MC of control group was always about (27±0.2)×109/ml. On day 3, 7, 11, 15, 19, and 23, the MC was significantly lower in the high-altitude frostbite group than in the control group and normal frostbite group (P

Carbon nanotube (CNT) has been shown to effectively activate peroxymonosulfate (PMS) to remove contaminants, whereas controversial activation mechanisms (radical vs non-radical mechanism) were previously proposed. Here we report that radical-induced decolorization of acid orange 7 (AO7) dominated in the CNT activated PMS system, but non-radical mechanism was also involved at high Cl- concentration. CNT exhibited high activity in activating PMS to decolorize AO7. The decolorization rate of AO7 increased with increasing PMS dosages and CNT loadings, rising temperature and higher pH. Radical quenching and photoluminescence techniques confirmed the decolorization of AO7 in the CNT/PMS system was caused by the radical oxidation, which dominantly took place on the surface of CNT, rather than the bulk solution. The presence of Cl- exhibited a dual effect on AO7 decolorization. Low concentration of Cl- slightly inhibited AO7 decolorization, but further raising the concentration to above 0.1M significantly accelerated its decolorizaition. Cl- was confirmed to react with PMS to generate HClO, which effectively bleached AO7 through non-radical process rather than radical process. The decolorization of AO7 induced from the non-radical process exhibited different degradation products and less mineralization in comparison to that derived from radical process.

Background Re-irradiation (re-RT) has the active effect of relieving clinical symptoms and prolonging the survival of patients with recurrent esophageal squamous cell carcinoma (ESCC). However, the optimal re-RT dose is still uncertain. Here, we analyzed the prognostic factors associated with survival and explored the optimal re-RT dose for patients with recurrent ESCC following definitive radiotherapy. Patients and methods The data of 47 patients with recurrent ESCC who were retreated between 2010 and 2014 were retrospectively analyzed. All patients received a radiation dose > 50 Gy during the primary treatment. The median time to recurrence after primary radiotherapy was 26 months (range 6–120 months). All patients had in-field recurrence in the esophagus. Recurrence within the local site was observed in 37 patients (78.7%), and recurrence in both the local site and regional nodes were observed in 10 patients (21.3%). All patients received 3D conformal re-RT with a median dose of 58 Gy (range 26–64 Gy). Chemotherapy was sequentially used in 27.7% of the patients. Survival curves were constructed according to the Kaplan-Meier method and were compared by log-rank tests. The factors predictive of survival were identified with univariate and multivariate analyses. Results Dysphagia relief after re-RT was achieved in 20 of the 35 symptomatic patients (57.1%). The median survival time (MST) of all patients was 17 months, and the 1-, 2-, 3- and 5-year overall survival (OS) rates were 72.3, 25.5, 17.0 and 2.1%, respectively. In the univariate analysis, an Eastern Cooperative Oncology Group Performance Status (ECOG-PS) of 0–1 (P = 0.014), recurrence at the local site (P = 0.048), time to recurrence ≥24 months (P = 0.006) and re-RT dose ≥50 Gy (P P = 0.007). Severe complications were observed in 7 patients, two of whom received a re-RT dose > 60 Gy. Conclusion Our results demonstrated that patients with recurrent ESCC following definitive radiotherapy had unfavorable OS. Re-RT could be considered a feasible and effective treatment modality. A re-RT dose > 50 Gy could improve the survival outcomes, and a dose > 60 Gy should be administered with caution due to the risk of severe complications.

This article reports on experiments aimed at modifying nanosilica powder by adding a silane coupling agent, KH570, to achieve high dispersibility and strengthen the compatibility and interface bonding between it and the organic phases. Experiments were first done to prepare the common nanosilica powder, dried at 120°C for 4 h in a drying oven; second, an ethanol/water solution (volume ratio 11:1, total volume not more than two-thirds of the capacity of the flask) was blended in a three-necked flask with a reflux condenser and magnetic stirring; third, appropriate amount of dried nanosilica powder and appropriate mass fraction ratio of the silane coupling agent KH570 were added into the ethanol/water solution, and the pH of the mixture was adjusted to about 4–5 by adding acetic acid solution; fourth, the three-necked flask was placed in a water bath, and the modification reaction of the above mixing solution was sustained for an appropriate time in the appropriate temperature with magnetic stirring; fifth, the above mixing solution was separated by using a centrifuge (10,000 rpm) for 3 min, and the precipitate at the bottom of the flask was obtained after the supernatant was poured out; sixth, the precipitate was dried at 120°C for 48 h in a drying oven after it was washed with acetone several times, finally yielding the high-dispersibility nanosilica powder. The orthogonal test method was adopted to optimize three key test parameters: mass fraction ratio of the silane coupling agent KH570, modification reaction temperature, and modification reaction time. The dispersion effect of the high-dispersibility nanosilica powder was characterized by using infrared, X-ray diffraction, and scanning electron microscopic analyses from different views. The results revealed that the best dispersibility effect was achieved when the mass fraction ratio of the silane coupling agent KH570 was 3%, the modification reaction temperature was 80°C, and the modification reaction time was 2 h. Furthermore, the modification reaction resulted in chemical bonding, but not simple physical adsorption, owing to the presence of organic bond groups in the nanosilica modified by the silane coupling agent. The crystal structure of the nanosilica powder remained amorphous after the modification reaction.

A new tongue sole, Cynoglossus nanhaiensis, described from 21 specimens (101.0–133.7 mm SL) collected in coastal waters of the South China Sea, is distinguished from congeners by the following combination of characters: 3 ocular-side lateral lines; no blind-side lateral lines; 2 ocular-side nostrils; 8 caudal-fin rays; 49–51 total vertebrae; 64–73 scales in the midlateral line; 11–12 scales in diagonal series between midlateral and dorsal lateral lines; 99–108 dorsal-fin rays; 77–82 anal-fin rays; pores of lateral-line scales tubular, with conspicuously black tips posteriorly; and with light- to medium-brown ocular-side background coloration overlain by numerous, small, irregular, dark blotches forming a series of narrow, interrupted, longitudinal stripes, with many specimens also featuring two large, brown spots on their caudal region. Among congeners, C. nanhaiensis is most similar to C. maccullochi Norman, 1926, described from specimens taken off Queensland, Australia, but differs in its ocula...

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Carbon nanotube (CNT) was used as an activator to activate peroxymonosulfate (PMS) to degrade azo dye orange G (OG) in aqueous solution. The results indicated that CNT exhibited a much better performance in activating PMS to decolorize OG than activated carbon (GAC), with 99% decolorization of OG achieved within 45 min. Afterwards, the degradation mechanism of OG in CNT activated PMS system was explored, and SO

Objective: Discussing whether occurs reperfusion malignant ventricular arrhythmia by intravenous injecting metoprolol before the intervention treatment of Left Anterior Descending (LAD) of Acute Myocardial Infarction (AMI) and observing the change of heart rate.

This article mainly aims at experiments used for modifying unsaturated polyester resin (UPR), and trying to enhance the strengthening and toughening performance of nano-silica/UPR polymer composite in order to improve its integrated mechanical properties and to expand its field of application. Experiments were initially used to get high dispersibility nano-silica powder by adding silane coupling agent KH570 as a dispersant into commonly and commercially available nano-silica powder. Then, high dispersibility nano-silica powder was added as a filling with different mass fraction ratios into UPR and nano-silica/UPR polymer composite samples were fabricated. Infrared spectroscopy analysis, X-ray diffraction analysis, and scanning electron microscopy (SEM) analysis were conducted for high dispersibility nano-silica powder. Mechanical properties test and SEM observation of fracture morphology were investigated for nano-silica/UPR polymer composite samples. The results revealed that adding silane coupling agent KH570 with a mass fraction ratio 3% into nano-silica powder made nano-silica best dispersed after the modification reaction at a temperature of 80°C for 2 h. When the high dispersibility nano-silica powder was added into UPR with a mass fraction ratio 1.5%, the impact strength of nano-silica/UPR polymer composite improved greatly by 9.6%. However, when the high dispersibility nano-silica powder was added into UPR with a mass fraction ratio 2%, the tensile strength, bending strength and extension rate of nano-silica/UPR polymer composite improved greatly by 152%, 102%, and 167%, respectively.

The so-called zebra sole includes a group of small flatfishes characterized by transverse band pairs on the ocular side and distributed throughout shallow waters along the coast of the Indo-West Pacific Ocean. Several species of the zebra sole have been recorded from the coastal waters of China. Morphological analysis of 1 107 specimens of the zebra sole from 15 successive localities along the China’s coast demonstrated that no significant variations among these localities were found on the basis of meristic counts and morphometric characters. Phylogenetic analysis based on COI gene sequences of 14 individuals and D-loop of 22 individuals from eight localities showed that they were indistinguishable among these localities. Therefore, both morphological and molecular evidence supported the occurrence of a single species of the zebra sole along the China’s coast. The available name for this species is Zebrias zebrinus (Temminck and Schlegel, 1846) instead of Z. zebra (Bloch, 1787). Zebrias fasciatus (Basilewsky, 1855) and Solea ommatura (Richardson, 1846) are considered here as two synonyms of Z. zebrinus.

In this paper, the mineral processing experimental study on the flotation tailings which are stored in the tailings pond of a copper-molybdenum mine is conducted, with a large content of slimes and kaolinite in the tailings and the fine particle sizes and poor locked particles of most of valuable minerals disseminated in the gangue minerals taken into consideration. Based on the mineralogical characteristics of the ore, a combined process is adopted in order to recover copper, molybdenum, sulfur and iron minerals from the ore, this process contains a series of steps in a particular sequence, which are pre-desliming of the ore, bulk flotation of copper and molybdenum of the coarse fraction, separation of Cu-Mo, separating sulfur from bulk flotation tailings and low-intensity magnetic separation of iron from sulfur flotation tailings. The results of the closed circuit test show that it can be obtained copper concentrate with a Cu grade of 20.61% and a recovery rate of 28.52%, molybdenum concentrate with a Mo grade of 36.00% (containing 20% C) and a recovery rate of 43.35%, sulfur concentrate with a S grade of 35.66% and a recovery rate of 42.58%, and iron concentrate with a Fe grade of 68.40% and a recovery rate of 6.85% (75% of phase recovery of magnetite).

The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01–12:00, n=53) and non-morning onset (12:01–06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P

In order to eliminate the negative effect of temperature to resistive pressure sensor of automobile, a calibration circuit is required based on ZMD chip or MAX1452. The traditional calibration way of ZMD is four-point calibration that has the defects such as inefficiencies and complexity. Thus, a simplified calibration way, named as three-point calibration, is provided which is able to simplify the calibration equipment in practical manufacturing. Considerably, the calibration efficiency is improved from about one hour into 5 minutes every time. After calibrated, the output of pressure sensor change only with pressure and the deviation value is from -0.48%FSO to +0.84%FSO，in the designing range ±2%FSO.

Granular activated carbon with silver loaded as activator (Ag/GAC) was prepared using impregnation method. N2 adsorption, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) were adopted to characterize the Ag/GAC, showing that silver was successfully loaded on granular activated carbon. The oxidation degradation of acid orange 7 (AO7) by the Ag/GAC activated by persulfate (PS) was investigated at ambient temperature. The influences of factors such as Ag loading, PS or Ag/GAC dosages and initial pH on the degradation of AO7 were evaluated. The results demonstrated that the degradation rate of AO7 could reach more than 95.0% after 180 min when the Ag loading content, PS/AO7 molar ratio, the Ag/GAC dosage were 12.7 mg x g(-1), 120: 1, 1.0 g x L(-1), respectively. The initial pH had significant effect on the AO7 degradation, with pH 5.0 as the optimal pH for the degradation of AO7. The possible degradation pathway was proposed for the AO7 degradation by using UV-visible spectroscopy and gas chromatography-mass spectrometry (GG/MS). The azo bond and naphthalene ring in the AO7 were destroyed during the degradation, with phthalic acid and acetophenone as the main degradation products.

To observe the action of electroacupuncture (EA) intervention on the expression of gap junction protein connexin 43 (Cx 43) and content of glutamate (Glu) in the striatum in Parkinson's disease (PD) rats, so as to reveal its mechanism underlying improvement of PD.Forty male SD rats were randomly divided into normal control, sham operation, model and EA groups (n = 10 in each group). The PD model was duplicated by microinjection of 6-hydroxyldopamine (6-OHDA, 15 µg/rat) into the right striatum of rats (AP: 1.0, 1.0; R: 3.0, 4.5; H: 4.5, 6.0), and for control, the same dose of normal saline was injected into the right striatum for rats in the sham operation group. EA (2 Hz, 1 mA) was applied to "Fengfu" (GV 16) "Taichong" (LR 3) for 30 min, once a day for 2 weeks. The PD rats' rotational behavior changes (the numbers of rotations in 30 min) were detected following subcutaneous injection of apomorphine (0.5 mg/kg). The Glu concentration and the expression of Cx 43 in the striatum were detected by using high performance liquid chromatography (HPLC) and Western blot, respectively.No significant differences were found between the model group and EA group in the number of rotations before the treatment, between the control and sham operation groups in the levels of Glu content and Cx 43 protein expression in the striatum (P0.05). Compared with the control group, the Glu content and Cx 43 protein expression level were significantly increased in the model group (P0.01), while in comparison with the model group, the number of rotations was significantly reduced in the EA group (P0.05). Following EA intervention, both Glu content and Cx 43 expression were considerably down-regulated in the EA group compared with the model group (P0.05, P0.01).EA can improve PD rats' rotation behavior, which may be associated with its effects in down-regulating the level of Glu and Cx 43 protein expression in the striatum.

Reconfigurable SRAM-based FPGAs are highly susceptible to radiation induced single-event upsets (SEUs) in space applications. The bit flip in FPGAs configuration memory may alter user circuit permanently without proper bitstream reparation, which is a completely different phenomenon from upsets in traditional memory devices. It is important to find the relationship between a programmable resource and corresponding control bit in order to understand the impact of this effect. In this paper, a method is proposed to decode the bitstream of FPGAs from Xilinx Corporation, and then an analysis program is developed to parse the netlist of a specific design to get the configuration state of occupied programmable logic and routings. After that, an SEU propagation rule is established according to the resource type to identify critical logic nodes and paths, which could destroy the circuit topological structure. The decoded relationship is stored in a database. The database is queried to get the sensitive bits of a specific design. The result can be used to represent the vulnerability of the system and predict the on orbit system failure rate. The analysis tool was validated through fault injection and accelerator irradiation experiment.

Polyphenylene sulfide-intercalated layered manganese oxide (PPS-MnO2) nanocomposite is synthesized via the delamination/reassembling process. SEM images and XRD analysis indicate that the surface of the nanocomposite material is layered and the basal spacing of PPS-MnO2 was 1.69 nm. The maximum specific capacitance as obtained from cyclic voltammetry was 524.0 F•g−1. The specific capacitance decreases by 6% of the initial value over 1000 cycles at a high current density of 2mA•cm-2.

In order to eliminate the negative effect of temperature to automobile pressure sensor whose environment temperature changes from-40°C to 130°C, a calibration circuit is designed based on ZMD chip. The temperature characters of this pressure sensor are: zero point linearly change with temperature at the rate-0.07mV/20°C; strain coefficient linearly change with temperature at the rate 3.27e-4/°C. After calibrated, the output of pressure sensor change only with pressure and the deviation value is from-0.48%FSO to +0.84%FSO，in the designing range ±2%FSO.

The theory of sheet model is used to design the elastic cell of pressure sensor. In this model, the elastic cell shapes like a disk; the ratio of diameter to thickness is in the range from 0.01 to 0.2. According to the calculating result, an elastic cell made by 40CrNiMo with diameter 11mm and thickness 1.6mm can test the pressure form 0 to 100MPa. It is similar with features of calculating result and works well in test.

A pressure sensor used in the Common Rail System is designed to monitor the oil pressure changing form 0 to 200MPa in the temperature from -40 to 130°C. It is composed of elastic cell, strain gage and signal processing circuit. Elastic cell produces liner strain with the oil pressure; strain gage transforms this strain into electrical signal that is enlarged and processed by signal processing circuit. To describe the relation of oil pressure with the strain, the stress distribution and strain of elastic cell with different shape is simulated, applying ANSYS tool in the 200MPa pressure. Then, an acceptable shape is produced and tested. It has the similar features with simulated result and works well.

Cobalt oxide-Polyaniline (Co3O4/PANI) nanocomposites were prepared via inverted emulsion polymerization. The structure of the obtained composites were characterized by X-ray diffraction (XRD). The electrochemical behavior was studied by cyclic voltammetry(CV) and electrochemical impedance spectrometry(EIS) experiments. The Co3O4/PANI(1:2) composite calcined at 400°C exhibits the highest capacitance value of 357 F/g at the scan rate of 5mV/s.

CVC mills are generally used in the whole stands of CSP (Compact Strip Product). Their special “s” curve of work roll contour and shifting strategy aimed at controlling strip shape, and the characteristics of continuous casting and rolling production, which make the work roll wear in downstream stands seriously uneven, and easily form abnormal transverse profile at the rolling end. As a result, CVC mill configuration in the downstream stands can not meet the profile and flatness control requirement for schedule free rolling, and bring some difficulties in profile and flatness control for the subsequent cold rolling. Based on the characteristics of the shape control system of CSP production line, and combined with the theory of flat roll technology, a kind of technology solution of using flat roll in the downsteam stands for CSP hot strip mills was proposed. At last, industrial test was carried out in the last stand of Masteel CSP, and good results were obtained.

The endoplasmic/sarcoplasmic reticulum (ER/SR) plays a crucial role in cytoplasmic signalling in a variety of cells. It is particularly relevant to skeletal muscle fibres, where this organelle constitutes the main Ca2+ store for essential functions, such as contraction. In this work, we expressed the cameleon biosensor D1ER by in vivo electroporation in the mouse flexor digitorum brevis (FDB) muscle to directly assess SR Ca2+ depletion in response to electrical and pharmacological stimulation. The main conclusions are: (1) D1ER is expressed in the SR of FDB fibres according to both di-8-(amino naphthyl ethenyl pyridinium) staining experiments and reductions in the Förster resonance energy transfer signal consequent to SR Ca2+ release; (2) the amplitude of D1ER citrine/cyan fluorescent protein (CFP) ratio evoked by either 4-chloro-m-cresol (4-CmC) or electrical stimulation is directly proportional to the basal citrine/CFP ratio, which indicates that SR Ca2+ modulates ryanodine-receptor-isoform-1-mediated SR Ca2+ release in the intact muscle fibre; (3) SR Ca2+ release, measured as D1ER citrine/CFP signal, is voltage-dependent and follows a Boltzmann function; and (4) average SR Ca2+ depletion is 20% in response to 4-CmC and 6.4% in response to prolonged sarcolemmal depolarization. These results indicate that significantly depleting SR Ca2+ content under physiological conditions is difficult.

The objective of the study is to report a case of atrial myxoma with bloodstream metastasis misdiagnosed to be Takayasu arteritis. A 23-year-old woman manifested with fever, repetitive vasocerebral events and extremities ischemic signs (claudication, difference of BP in arms and absence of pulse) for 5 years. Imaging studies revealed multiple cerebral infarction, bilateral iliac artery stenosis and as thrombosis formation. Takayasu arteritis was diagnosed according to American College of Rheumatology criteria. Glucosteroids and immunosuppressants were given; however, symptoms were not relieved even after treatment. Echocardiography suggested a mass in left atrium, which was surgically removed and pathologically confirmed to be atrial myxoma. Clinical symptoms completely relieved after operation. In conclusion, atrial myxoma with bloodstream metastasis sometimes presented with similar clinical symptoms of Takayasu arteritis and may lead to misdiagnosis of these two diseases. Usually, accepted diagnosis criteria are not enough in distinguishing these diseases. Echocardiography should be considered in these patients.