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204 results on '"Zhong, Zibiao"'

10. Biosafe, rapid, and ultrahigh‐capacity endotoxin purification in blood by a sustainable and recyclable MOF‐functionalized chitin microsphere adsorbent.

Author

Liu, Anxiong, Chen, Lu, Qi, Luhe, Huang, Jing, Zou, Yongkang, Hu, Zhiwen, Yu, Le, Zhong, Zibiao, Ye, Qifa, and Chen, Chaoji

Subjects
CHITIN, WASTE recycling, ADSORPTION capacity, ENDOTOXINS, HEMOPERFUSION
Abstract

Sepsis is responsible for approximately 5.3 million deaths globally each year. Here, we constructed hierarchical chitin microspheres loaded with MOF‐919 (Ch/metal–organic frameworks [MOFs]) for the rapid and efficient removal of lipopolysaccharide (LPS) in complex blood environments. Furthermore, abundant active sites on MOF‐919(Sc) also enable a record‐high adsorption capacity of 9.56 mg/g in biomass‐based adsorbents due to the coordination interactions between endotoxin and MOF‐919(Sc). The LPS level of sepsis rabbits was less than 2 EU/mL (clearance rate >95%) after 90‐min hemoperfusion, showing no adverse effect on the rabbit organs. Additionally, compared to the commonly used LPS scrubber Toraymyxin (polymethyl methacrylate), the chitin adsorbent is significantly more cost‐effective and environmentally friendly. The preparation strategy for hierarchical porous microspheres offers notable advantages in designability, recyclability, and renewability, providing a new approach to sepsis treatment and promising prospects for the biomedical application of sustainable biomass materials. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Corrigendum to “Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose-sodium alginate composite sponges for accelerated wound healing” [International Journal of Biological Macromolecules volume 191 (2021) 27–39/10.1016/IJBIOMAC-D-21-05321]

Author

Xie, Hongxia, primary, Xia, Haoyang, additional, Huang, Lin, additional, Zhong, Zibiao, additional, Ye, Qifa, additional, Zhang, Lina, additional, and Lu, Ang, additional

Published
2023
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20. Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection.

Author

Mu, Lanxin, Qi, Luhe, Long, Haitao, Huang, Jing, Zhong, Zibiao, Shi, Xiaowen, Chen, Chaoji, and Ye, Qifa

Subjects
HEPATOCELLULAR carcinoma, DISEASE relapse, CANCER relapse, LIVER cancer, HEMOSTASIS
Abstract

Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor cells in the bloodstream. To address this issue, a novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, which has the potential to ablate microlesions and improve the immune microenvironment simultaneously. Specifically, the integrated strategy is realized based on the fibrous chitosan/polydopamine sponge (CPDS), which is constructed from shearing‐flow‐induced oriented hybrid chitosan fibers and subsequent self‐assembly of polydopamine. The CPDS demonstrates high elasticity, excellent water absorption, and photothermal conversion performance. The results confirm the efficient hemostatic properties of the fibrous CPDS in various bleeding models. Notably, in subcutaneous and orthotopic postoperative recurrence and metastasis models of hepatocellular carcinoma, the fibrous CPDS significantly inhibits local tumor recurrence and distant metastasis. Moreover, the combination with lenvatinib can substantially enhance the antitumor effect. This comprehensive treatment strategy offers new insights into hepatectomy of liver cancer, representing a promising approach for clinical management. [ABSTRACT FROM AUTHOR]

Published
2024
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31. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4

Author

Wang, Chun, Chen, Zhihang, Yi, Yun, Ding, Yang, Xu, Fei, Kang, Hui, Lin, Kun, Shu, Xiawen, Zhong, Zibiao, Zhang, Zhonglin, Liu, Jing, Xu, Zhong, Liu, Lan, He, Xingxing, Chang, Ying, and Zhao, Qiu

Abstract

Reprogramming of lipid metabolism during hepatocarcinogenesis is not well elucidated. Here, we aimed to explore pivotal RNA-binding motif proteins (RBMs) in lipid metabolism and their therapeutic potential in hepatocellular carcinoma (HCC). Through bioinformatic analysis, we identified RBM45 as a critical gene of interest among differentially expressed RBMs in HCC, with significant prognostic relevance. RBM45 influenced the malignant biological phenotype and lipid metabolism of HCC cells. Mechanically, RBM45 promotes de novo lipogenesis in HCC by directly targeting two key enzymes involved in long-chain fatty acid synthesis, ACSL1 and ACSL4. RBM45 also targets Rictor, which has been demonstrated to modulate lipid metabolism profoundly. RBM45 also aided lipid degradation through activating a key fatty acid β oxidation enzyme, CPT1A. Thus, RBM45 boosted lipid synthesis and decomposition, indicating an enhanced utility of lipid fuels in HCC. Clinically, body mass index was positively correlated with RBM45 in human HCCs. The combination of a PI3K/AKT/mTOR pathway inhibitor in vitro or Sorafenib in orthotopic liver cancer mouse models with shRBM45 has a more significant therapeutic effect on liver cancer than the drug alone. In summary, our findings highlight the versatile roles of RBM45 in lipid metabolism reprogramming and its therapeutic potential in HCC.

Published
2023
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33. Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

Author

Cao, Qin, Liu, Zhongzhong, Xiong, Yan, Zhong, Zibiao, and Ye, Qifa

Subjects
Article Subject, lipids (amino acids, peptides, and proteins)
Abstract

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC.

Published
2020
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37. Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy

Author

Liu, Zhongzhong, primary, Ye, Shaojun, additional, Zhong, Xiang, additional, Wang, Wei, additional, Lai, Chin‑Hui, additional, Yang, Wang, additional, Yue, Pengpeng, additional, Luo, Jun, additional, Huang, Xiaoying, additional, Zhong, Zibiao, additional, Xiong, Yan, additional, Fan, Xiaoli, additional, Li, Ling, additional, Wang, Yanfeng, additional, and Ye, Qifa, additional

Published
2020
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38. Clinical characteristics and immunosuppressant management of coronavirus disease 2019 in solid organ transplant recipients

Author

Zhong, Zibiao, primary, Zhang, Qiuyan, additional, Xia, Haoyang, additional, Wang, Aiping, additional, Liang, Wenjin, additional, Zhou, Wei, additional, Zhou, Lihua, additional, Liu, Xiao, additional, Rao, Lingzhang, additional, Li, Zhifeng, additional, Peng, Zhiyong, additional, Mo, Pingzheng, additional, Xiong, Yong, additional, Ye, Shaojun, additional, Wang, Yanfeng, additional, and Ye, Qifa, additional

Published
2020
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39. Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion

Author

Lin, Danni, primary, Xiang, Tao, additional, Qiu, Qiangmin, additional, Leung, Junto, additional, Xu, Junjie, additional, Zhou, Wei, additional, Hu, Qianchao, additional, Lan, Jianan, additional, Liu, Zhongzhong, additional, Zhong, Zibiao, additional, Wang, Yanfeng, additional, and Ye, Qifa, additional

Published
2020
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47. Simvastatin ameliorates total liver ischemia/reperfusion injury via KLF2-mediated mechanism in rats

Author

Liu, Zhongzhong, primary, Lai, Chin-hui, additional, Zhang, Xingjian, additional, Luo, Jun, additional, Huang, Xiaoying, additional, Qi, Xiao, additional, Wang, Wei, additional, Zhong, Zibiao, additional, Xiaoli, Fan, additional, Li, Ling, additional, Xiong, Yan, additional, Senninger, Norbert, additional, Wang, Yanfeng, additional, Ye, Qifa, additional, and Ye, Shaojun, additional

Published
2019
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49. Elucidation of molecular pathways responsible for the accelerated wound healing induced by a novel fibrous chitin dressing

Author

Zhong, Zibiao, primary, Huang, Yao, additional, Hu, Qianchao, additional, He, Weiyang, additional, Duan, Bo, additional, Yan, Xiaomin, additional, Yang, Zhenjie, additional, Liang, Wenjin, additional, Liu, Zhongzhong, additional, Peng, Zhonghua, additional, Wang, Yanfeng, additional, Zhang, Lina, additional, and Ye, Qifa, additional

Published
2019
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