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Evidence indicates that combinations of anti‐EGFR antibodies and KRAS p.G12C (c.34G>T) inhibitors can be an effective treatment strategy for advanced colorectal cancer. We hypothesized that KRAS c.34G>T (p.G12C)‐mutated colorectal carcinoma might be a distinct tumor subtype. We utilized a prospective cohort incident tumor biobank (including 1347 colorectal carcinomas) and detected KRAS c.34G>T (p.G12C) mutation in 43 cases (3.2%) and other KRAS mutations (in codon 12, 13, 61, or 146) in 467 cases (35%). The CpG island methylator phenotype (CIMP)‐low prevalence was similarly higher in KRAS c.34G>T mutants (52%) and other KRAS mutants (49%) than in KRAS‐wild‐type tumors (31%). KRAS c.34G>T mutants showed higher CIMP‐high prevalence (14%) and lower CIMP‐negative prevalence (33%) compared with other KRAS mutants (6% and 45%, respectively; p = 0.0036). Similar to other KRAS mutants, KRAS c.34G>T‐mutated tumors were associated with cecal location, non‐microsatellite instability (MSI)‐high status, BRAF wild type, and PIK3CA mutation when compared with KRAS‐wild‐type tumors. Compared with BRAF‐mutated tumors, KRAS c.34G>T mutants showed more frequent LINE‐1 hypomethylation, a biomarker for early‐onset colorectal carcinoma. KRAS c.34G>T mutants were not associated with other features, including the tumor tissue abundance of Fusobacterium nucleatum (F. animalis), pks+Escherichia coli, Bifidobacterium, or (enterotoxigenic) Bacteroides fragilis. Among 1122 BRAF‐wild‐type colorectal carcinomas, compared with KRAS‐wild‐type tumors, multivariable‐adjusted colorectal cancer‐specific mortality hazard ratios (95% confidence interval) were 1.82 (1.05–3.17) in KRAS c.34G>T (p.G12C)‐mutated tumors (p = 0.035) and 1.57 (1.22–2.02) in other KRAS‐mutated tumors (p = 0.0004). Our study provides novel evidence for clinical and tumor characteristics of KRAS c.34G>T (p.G12C)‐mutated colorectal carcinoma. [ABSTRACT FROM AUTHOR]

The fascinating search for ultraefficient and high‐powered supercapacitors has stimulated continuous exploration of diverse energy storage materials like transition metal hydroxides with core–shell structure. Thus in this paper, a novel core–shell hybrid electrode material of nickel hydroxide (Ni(OH)2) supported on copper hydroxide nanorod arrays (Cu(OH)2 NAs), which is constructed on copper foam as the substrate by an in situ chemical oxidation reaction accompanied by chemical bath deposition, is reported. As a result, it is found that the pre‐fabricated Cu(OH)2@Ni(OH)2 electrode has a remarkable areal capacitance of 9.27 F cm−2 and good cycling performance (retains 92.38% after 6000 cycles) compared to its counterpart Cu(OH)2 nanorods (88.57%). Additionally, the Cu(OH)2@Ni(OH)2 material, as a positive electrode, can also be used to assemble a hybrid supercapacitor (HSC) while activated carbon is chosen as the negative electrode. As a result, the constructed HSC device with the desired working voltage of 0–1.5 V can light up the light‐emitting diode indicator, proving the potential practicability of the pre‐fabricated HSC device. [ABSTRACT FROM AUTHOR]

In this work, MgCo 2 O 4 @NiMn layered double hydroxide (LDH) core-shell structured nanocomposites on Ni foam (NF) are synthesized by facile hydrothermal and calcination methods. MgCo 2 O 4 /NF is synthesized first via a hydrothermal reaction and annealing treatment, and then utilized to prepare MgCo 2 O 4 @NiMn-LDH/NF core-shell structured nanocomposites via the second hydrothermal process. It is found that the MgCo 2 O 4 @NiMn-LDH/NF nanocomposite prepared from 6 h hydrothermal reaction (MC@NM-LDH-2) exhibits an excellent specific capacitance of 3757.2 F g -1 (at 1 A g -1 ). Moreover, a high capacitance retention (86.9% after 6000 cycles) and a low internal resistance (Rs) (0.565 Ω) can be achieved. Furthermore, an all-solid-state asymmetric supercapacitor (ASC) is assembled using MgCo 2 O 4 @NiMn-LDH/NF-2 as positive electrode and activated carbon (AC) as negative electrode. The as-fabricated MgCo 2 O 4 @NiMn-LDH/NF-2//AC ASC shows a high energy density of 62.33 Wh kg -1 at 750 W kg -1 . Meanwhile, the MgCo 2 O 4 @NiMn-LDH/NF-2//AC ASC device possesses an outstanding cycling stability of 93.7% retention of the initial capacitance after 6000 cycles and three ASC devices connected in series can light up a LED bulb for 15 min. Our results manifest that these core-shell structure MgCo 2 O 4 @NiMn-LDH nanocomposites could envision huge potential application in energy storage devices., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Inc. All rights reserved.)