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Abstract Background Definitive concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced, inoperable non-small cell lung cancer (NSCLC). Previous studies have mainly focused on examining local failure and recurrence patterns after surgery and the principles of lymph node metastasis (LNM) in surgical candidates with NSCLC. However, these studies were just only able to guide postoperative radiotherapy (PORT) and the patterns of LNM in patients with resected NSCLC was inadequate to represent that in locally advanced inoperable NSCLC patients for guiding target volume delineation of CCRT. In this study, we aimed to analyze the metastasis regularities and establish the correlations between different lymph node levels in NSCLC patients without any intervention using positron emission tomography/computed tomography (PET/CT) images. Methods Overall, 358 patients with N1–N3 NSCLC admitted in our hospital between 2018 and 2022 were retrospectively analyzed. The diagnosis of metastatic lymph nodes was reviewed and determined using the European Organization for Research and Treatment of Cancer standard and the standardized value of the PET/CT examination. Univariate and multivariate analysis were performed to investigate the correlations between the different levels were evaluated by using of the chi-square test and logistic regression model. Results The lymph nodes with the highest metastasis rates in patients with left lung cancer were in order as follows: 10L, 4L, 5, 4R, and 7; while in those with right lung cancer they were 10R, 4R, 7, 2R, and 1R. Notably, we found left lung patients were more likely to have contralateral hilar, mediastinal and supraclavicular lymph nodes involved, and the right lung group exhibited a higher propensity for ipsilateral mediastinum and supraclavicular lymph node invasion. Furthermore, correlation analysis revealed there were significant correlative patterns in the LNM across different levels. Conclusions This study elucidated the patterns of primary LNM in patients with NSCLC who had not undergone surgery (without any treatment interventions) and the correlations between lymph node levels. These findings were expected to provide useful reference for target volume delineation in definitive concurrent chemoradiotherapy in locally advanced NSCLC patients.

Abstract Silicon interposers embedded with ultra-deep through-silicon vias (TSVs) are in great demand for the heterogeneous integration and packaging of opto-electronic chiplets and microelectromechanical systems (MEMS) devices. Considering the cost-effective and reliable manufacturing of ultra-deep TSVs, the formation of continuous barrier and seed layers remains a crucial challenge to solve. Herein, we present a novel dual catalysis-based electroless plating (ELP) technique by tailoring polyimide (PI) liner surfaces to fabricate dense combined Ni barrier/seed layers in ultra-deep TSVs. In additional to the conventional acid catalysis procedure, a prior catalytic step in an alkaline environment is proposed to hydrolyze the PI surface into a polyamide acid (PAA) interfacial layer, resulting in additional catalysts and the formation of a dense Ni layer that can function as both a barrier layer and a seed layer, particularly at the bottom of the deep TSV. TSVs with depths larger than 500 μm and no voids are successfully fabricated in this study. The fabrication process involves low costs and temperatures. For a fabricated 530-μm-deep TSV with a diameter of 70 μm, the measured depletion capacitance and leakage current are approximately 1.3 pF and 1.7 pA at 20 V, respectively, indicating good electrical properties. The proposed fabrication strategy can provide a cost-effective and feasible solution to the challenge of manufacturing ultra-deep TSVs for modern 3D heterogeneous integration and packaging applications.

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Purpose: This retrospective study aims to assess the efficacy of the combined application of electromagnetic navigation (EMN) and porcine fibrin sealant (PFS) in the microwave ablation (MWA) treatment of lung tumors. Material and methods: In our department from January 2022 to August 2023, 73 patients underwent MWA under standard computed tomography (CT) guidance (CT group) or CT guidance with additional application of EMN and PFS (CT-EMN-PFS group), respectively. The basic data of patients were recorded and analyzed using the Student's t-test and Chi-square test between the two groups, and single factor and multi-factors binary logistic regression analyses were conducted to determine the risk factors of pneumothorax; meanwhile the incidence of complications, the number of CT scans and dose length product (DLP) were calculated and compared between the two guidance modes. Results: Forty-seven patients underwent standard CT-guided MWA, meanwhile the remaining 26 patients underwent CT-guided MWA with combined application of EMN and PFS. The patients with lesions close to the bronchi or interlobar fissures, and underlying emphysema had a higher risk of pneumothorax, the corresponding odds ratio (OR) was 23.290 (p = 0.004), 33.300 (p = 0.019), and 8.007 (p = 0.012), respectively; the combined use of EMN and PFS could reduce the incidence of pneumothorax, with an OR of 0.094 (95 % confidence interval [CI]: 0.015–0.602, p = 0.013). The incidence rates of pneumothorax, pneumorrhagia and pleural effusion were 59.57 %, 61.70 %, and 19.15 % respectively in the CT group, and 30.77 %, 50.00 % and 7.69 % respectively in the CT-EMN-PFS group. The incidence rate of pneumothorax in the CT-EMN-PFS group was significantly lower than that in the CT group (p = 0.017). The median number of CT scans was 9 in the CT group and 5 in the CT-EMN-PFS group, respectively, meanwhile the median DLP was 1060.69 mGy*cm in the CT group and 600.04 mGy*cm in the CT-EMN-PFS group, respectively, which indicated there was a statistical difference in the amount of radiation exposure between the two groups (p

As to the roadbed projects in coastal areas, capillary water rise can produce roadbed diseases and affect the safety and durability of road operation. It is important to study the capillary water rise height. The article regards capillary water rise as a kind of unsaturated soil seepage phenomenon, and introduces fractal dimension to unsaturated soil permeability coefficient modification. A capillary water rise height model based on fractal theory is proposed to obtain the capillary water rise height curve with time. Then a vertical tube method capillary water rise height test was conducted on a mainline roadbed soil sample in Nantong, with the control test of changes in the dry density of the soil sample and the fractal dimension of the initial particle size distribution. The results show that: the capillary water rise presents a rapid increase at the beginning, and then slowly increases, and finally stabilizes. The larger the fractal dimension of the particle size distribution of soil sample, the greater the capillary water rise height; the smaller the dry density of the soil sample, that is, the greater the porosity, the greater the capillary water rise height. In the capillary water rise height model, the capillary water rise height is related to the sample porosity, saturated permeability coefficient, capillary water rise height corresponding to the inlet value, fractal dimension, etc. In the theoretical model, the variation of fractal dimension only changes the capillary water height corresponding to the inlet value, not the saturated permeability coefficient; while the dry density change, i.e., the porosity change, only leads to the saturated permeability coefficient change, does not affect the intake value corresponding to the height of capillary water, the results from theoretical model are consistent with those from the test, verifying the effectiveness of the theoretical model. This study provides theoretical guidance for the prevention and control of road-base capillary water disease.

Abstract Serial casting as one of the applications to treat early-onset scoliosis has been reported efficiently to improve deformity, but no report has focused on the efficacy of braces in the treatment of congenital early-onset scoliosis and comparison with progressive idiopathic early-onset scoliosis. Patients with progressive EOS treated with braces in our institution with a minimum of 4 years follow-up were reviewed. Two groups according to the etiological diagnosis were analyzed and compared: the congenital scoliosis (CS) group and idiopathic scoliosis (IS) group. The success cases and the failure cases were also compared. 27 patients with an average main Cobb angle of 38.19° (20–55) underwent initial bracing at an average age of 55.7 months (24–108), the average follow-up time was 76.19 months (49–117). In IS group the main Cobb angle was corrected to 18.69 ± 12.06° (48.61%) following the first bracing; the final Cobb angle was 23.08 ± 22.15°(38.76%) after brace removal. In CS group the main Cobb angle was corrected to 33.93 ± 10.31°(17.1%) following the first bracing and 37.93 ± 14.74°(3.53%) after brace removal. Both coronal chest width and T1-T12 height increased dramatically from pre-bracing to the last follow-up. Patients diagnosed as IS tended to have a better result in main Cobb angle correction than that of CS (P = 0.049). By the time of last follow-up, 8 patients had undergone surgery, and the operation time was postponed by 68.88 ± 26.43 months. For patients with progressive early-onset scoliosis, bracing is an efficient nonsurgical alternative to casting, and some of them can be cured; if not, eventual surgical intervention can be delayed for a period of time without restrictions on the thoracic cavity.

Abstract Background Esophageal cancer (EC), a common and fatal disease, includes two histological subtypes; esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (ECA). To aid policymakers in the allocation of resources for the prevention and treatment of EC, updated data on EC deaths and disability‐adjusted life years (DALYs) attributable to high body mass index (BMI) are necessary. The objective of this study was to identify trends in EC associated with high BMI between 1990 and 2019 using 2019 Global Burden of Disease data. Methods In this observational population‐based study, epidemiological data on the association between high BMI and EC were obtained from GBD 2019. The age‐standardized mortality rate (ASMRs) and disability‐adjusted life year rate (ASDRs) attributable to high BMI‐related EC were stratified by year, age, country, and sociodemographic index (SDI). The estimated annual percentage change (EAPC) was calculated to evaluate the temporal trends of the ASMRs and ASDRs between 1990 and 2019. Results In 2019, the proportion of EC deaths and DALYs attributed to high BMI was 18.1% and 18.9%, respectively, resulting in 89 904 (95% confidence interval [CI]: 27 879–171 255) deaths and 2 202 314 (95% CI: 681 901–4 173 080) DALYs. High BMI‐related deaths and DALYs showed a strong upward trend, increasing by more than two‐fold since 1990. East Asia and Western Europe showed the highest risk of EC mortality and DALYs attributable to high BMI; China and the USA bear the greatest burden. The ASMR and ASDR increased in five SDI regions. Conclusions The incidence of EC is increasing, particularly in developing nations, which may be attributed to the prevalence of high BMI. To mitigate the impact of high BMI on the incidence of EC, it is important to increase awareness of its deleterious effects, which may alleviate the burden of this disease.

BackgroundGlobally, diet low in milk is the third greatest risk factor for colorectal cancer (CRC). However, there has been a lack of detailed worldwide analysis of the burden and trends of CRC attributable to diet low in milk.ObjectiveWe aim to assess the spatiotemporal trends of CRC-related mortality and disability-adjusted life-years (DALYs) attributable to diet low in milk at the global, regional, and national levels from 1990 to 2019.MethodsData of mortality, DALYs, age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of CRC attributable to diet low in milk were extracted from the Global Burden of Disease (GBD) 2019 study. The burden of CRC attributable to diet low in milk was estimated using the ASMR and ASDR, while accounting for sex, age, country, and socio-demographic index (SDI). From 1990 to 2019, the estimated annual percentage change (EAPC) was calculated to clarify the temporal trends in the ASMR and ASDR attributable to diet low in milk.ResultsIn 2019, there were 166,456 (95% UI = 107,221–226,027) deaths and 3,799,297 (95% UI = 2,457,768–5,124,453) DALYs attributable to diet low in milk, accounting for 15.3 and 15.6% of CRC-related deaths and DALYs in 2019. CRC-related deaths and DALYs attributed to diet low in milk increased by 130.5 and 115.4%, from 1990 to 2019. The burden of CRC attributable to diet low in milk varied notably among regions and nations. High-middle SDI regions had the highest ASDR and ASMR of CRC linked to diet low in milk, while there was a slight downward trend high SDI regions. Among geographical regions, East Asia had the highest number of CRC-related deaths and DALYs attributable to diet low in milk. Notably, the burden of CRC was highest in males and the elderly. With coefficients of −0.36 and −0.36, the EAPC in ASMR and ASDR was significantly inversely correlated with the Human Development Index in 2019.ConclusionGlobally, the number of CRC deaths attributable to diet low in milk has continued to increase over the last 30 years. Therefore, government and authorities should conduct education campaigns to encourage individuals to increase daily milk intake.

The non-overshooting conditions measured by the state/output 2-norm of discrete-time switched linear systems(DTSLS) are investigated in this paper. A sufficient and necessary condition for state non-overshooting of discrete-time linear time invariant(LTI) systems is firstly derived, and the non-overshooting region, which is a pair of zero-symmetrical cones, is defined and analyzed. Adopting the idea of dividing the state space into distinct non-overshooting regions, some state non-overshooting conditions for DTSLS are addressed. The output non-overshooting problem, which is more complex, is solved in a similar way, and several output non-overshooting conditions are established. Finally, an illustrative example is given to verify the proposed conditions.

With the rapid advancement of satellite remote sensing technology, many scientists and organizations, including NASA, ESA, NAOC, and Roscosmos, observe and study significant changes in the geomagnetic field, which has greatly promoted research on the geomagnetic field and made it an important research direction in Earth system science. In traditional geomagnetic field research, tesseroid cells face degradation issues in high-latitude regions and accuracy limitations. To overcome these limitations, this paper introduces the Discrete Global Grid System (DGGS) to construct a geophysical model, achieving seamless global coverage through multi-level grid subdivision, significantly enhancing the processing capability of multi-source and multi-temporal spatial data. Addressing the challenges of the lack of analytical solutions and clear integration limits for DGGS cells, a method for constructing shape functions of arbitrary isoparametric elements is proposed based on the principle of isoparametric transformation, and the shape functions of isoparametric DGGS cells are successfully derived. In magnetic vector forwarding, considering the potential error amplification caused by Poisson’s formula, the DGGS grid is divided into six regular triangular sub-units. The triangular superconvergent point technique is adopted, and the positions of integration points and their weight coefficients are accurately determined according to symmetry rules, thereby significantly improving the calculation accuracy without increasing the computational complexity. Finally, through the forward modeling algorithm based on tiny tesseroid cells, this study comprehensively compares and analyzes the computational accuracy of the DGGS-based magnetic vector forwarding algorithm, verifying the effectiveness and superiority of the proposed method and providing new theoretical support and technical means for geophysical research.

Abstract A self‐confined solid‐state dewetting mechanism is reported that can fundamentally reduce the use of sophisticated nanofabrication techniques, enabling efficient wafer‐scale patterning of non‐closely packed (ncp) gold nanoparticle arrays. When combined with a soft lithography process, this approach can address the reproducibility challenges associated with colloidal crystal self‐assembly, allowing for the batch fabrication of ncp gold arrays with consistent ordering and even optical properties. The resulting dewetted ncp gold nanoparticle arrays exhibit strong surface lattice resonance properties when excited in inhomogeneous environments under normal white‐light incidence. With these SLR properties, the sensitive plasmonic sensing of molecular interactions is achieved using a simple transmission setup. This study will advance the development of miniaturized and portable devices.

Abstract The common human coronaviruses (HCoVs) HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 which are members of the coronavirus family are long co-existed with humans and widely distributed globally. Common HCoVs usually cause mild, self-limited upper respiratory tract infections (URTI), and also associated with lower respiratory tract infections (LRTI), especially in children. However, there are little multicentre studies have been conducted in children of several different areas in China, and the epidemic potential of common HCoVs remains unclear. Understanding of the common HCoVs is valuable for clinical and public health. Herein, we retrospectively analysed the medical records of children with acute lower respiratory tract infection admitted to 9 hospitals from different regions in China from 2014 to 2019. Of the 124 patients who tested positive for coronaviruses, OC43 was the predominant type, accounting for 36.3% (45/124) of the detections. Children aged ≤ 6 months and 12–23 months had the highest detection rate of common HCoVs, and the detection rate gradually declined after 2 years old. These four HCoVs could be detected all year round. Among the areas of our study, the overall positive rate was higher in southern China, especially in Guangzhou (29/124, 23.4%). Moreover, common HCoV-positive patients were codetected with 9 other common respiratory pathogens. 229E (11/13, 84.6%) was the most frequently associated with codetection, with EV/RhV was the most frequently codetected virus. Cough (113/124, 91.1%) and fever (73/124, 58.9%) were the most common symptoms of common HCoVs infection.

Abstract Aim To evaluate a teaching experience in evidence‐based nursing learning through case‐based learning (CBL) and flipped learning (FL). Design Embedded mixed methods study. Methods In the first phase, a questionnaire on utility, satisfaction and perceived competency development is used to collect quantitative data, and the open question instrument is used to collect qualitative data. After the first phase, an in‐depth semi‐structured interview is used. Results Five themes are identified: the enhancement of learning content, knowledge integration and transfer, the development of teamwork competency, the didactic support of FL and the difficulties and challenges faced by students. Regarding utility, ‘combine theory and practice’ and ‘select the best evidence from what is found in the search’ have the highest values. The most developed skills are communication and critical thinking ability. Finally, most participants are satisfied. Conclusions The combination of CBL and FL is an innovative strategy for learning evidence‐based nursing courses. No Patient or Public Contribution.

Abstract Background During the COVID-19 epidemic, the prevalence of neck pain among college students has increased due to the shift from offline to online learning and increasing academic and employment pressures. Therefore, this systematic review aimed to identify the personal, occupational, and psychological factors associated with the development of neck pain to promote the development of preventive strategies and early intervention treatment. Methods Seven electronic databases were searched from inception to December 2022 for cross-sectional studies, cohort studies, case­­-­control studies, and randomized controlled trials (RCTs) on neck pain. The quality of the selected studies were assessed by American Agency for Healthcare Research and Quality (AHRQ) or the Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the effects of the included risk factors on neck pain. Results Thirty studies were included, including 18,395 participants. And a total of 33 potentially associated risk factors were identified. Ultimately, 11 risk factors were included in the meta-analysis after assessing, and all results were statistically significant (P

Abstract Purpose The aim of this study was to evaluate the feasibility and efficacy of simultaneous resection of synchronous advanced esophageal and gastric cancers. Methods We retrospectively analyzed the clinical data of 16 patients who underwent resection of synchronous advanced esophageal squamous cell carcinoma (ESCC) and gastric adenocarcinoma from January 2009 to Dec 2021. Subtotal esophagectomy and total gastrectomy were performed using the Ivor-Lewis or McKeown approach. Reconstruction was performed using a pedicled jejunal graft or colon interposition. Perioperative and postoperative data of all patients were analyzed. Results There were no in-hospital mortalities following surgery, but 9 patients (56.3%) suffered major perioperative complications. Comparison of the groups that received reconstruction using the jejunum and the colon indicated similar incidences of perioperative complications, overall survival, and disease-free survival. Cox regression analysis indicated that lymph node metastasis of both cancers was independent risk factor for overall survival. Conclusion The existence of synchronous tumors of the esophagus and stomach is not unusual, the radical surgical treatment could be carried out whenever possible.

Abstract Aim This study aims to develop and validate a clinical nutrition risk screening tool to predict nutrition risk in home for the patients with gastric cancer after surgery at home so that high‐risk patients can be targeted for preventive nutrition care. Design The development of self‐screening tool for nutrition risk in patients with gastric cancer after gastrectomy (SNRSGC) through literature review, expert panel ratings and cognitive interview; the validation of SNRSGC is evaluated through prospective research on participants. Methods This research is divided into four parts: Step 1, Identification of a potential referred nutritional risk screening; Step 2, Item generation and scoring are selected through literature review methods to screen sensitive indicators which can reflect the nutritional characteristics of patients after gastric cancer surgery, establish the frame and update according to the latest guidelines; Step 3, Item reduction is determined by the rating of SNRSGC items by an expert panel and cognitive interview; Step 4, During the validation stage, we conducted research design based on the Consensus‐based Standards for the selection of health Measurement Instruments checklist to evaluate the validity, reliability, interpretability and acceptability of SNRSGC. Results SNRSGC is the first screening tool specifically to predict nutrition risk for stay‐at‐home postoperative patients with gastric cancer, which can help patients at home detect nutritional risks at home in time and guide patients to seek medical treatment as soon as possible to improve their nutritional status.

Background. Psoriasis, a systemic disorder mediated by the immune system, can appear on the skin, joints, or both. Individuals with cutaneous psoriasis (PsC) have an elevated risk of developing psoriatic arthritis (PsA) during their lifetime. Despite this known association, the cellular and molecular mechanisms underlying this progression remain unclear. Methods. We performed high-dimensional, in-depth immunophenotyping of peripheral blood mononuclear cells (PBMCs) in patients with PsA and psoriasis vulgaris (PsV) by mass cytometry. Blood samples were collected before and after therapy for a longitudinal study. Then three sets of comparisons were made here: active PsA vs. active PsV, untreated PsV vs. treated PsV, and untreated PsA vs. treated PsA. Results. Marked differences were observed in multiple lymphocyte subsets of PsA related to PsV, with expansion of CD4+ T cells, CD16− NK cells, and B cells. Notably, two critical markers, CD28 and CD127, specifically differentiated PsA from PsV. The expression levels of CD28 and CD127 on both Naïve T cells (TN) and central memory CD4+ T cells (TCM) were considerably higher in PsA than PsV. Meanwhile, after treatment, patients with PsV had higher levels of CD28hi CD127hi CD4+ TCM cells, CD28hi CD127hi CD4+ TN cells, and CD16− NK cells. Conclusion. In the circulation of PsA patients, the TN and CD4+ TCM are characterized with more abundant CD28 and CD127, which effectively distinguished PsA from PsV. This may indicate that individuals undergoing PsV could be stratified at high risk of developing PsA based on the circulating levels of CD28 and CD127 on specific cell subsets.

Background RAD51 is a central protein involved in homologous recombination, which has been linked to cancer development and progression. systemic inflammatory indicator markers such as neutrophil-to-lymphocyte ratio and lymphocyte-to-monocyte ratio have also been implicated in cancer. However, the relationship between Rad51 and these inflammatory markers in esophageal cancer patients undergoing esophagectomy is not yet understood. Methods We retrospectively observed 320 esophageal cancer patients who underwent esophagectomy. We collected clinical characteristics, postoperative complications, and survival analysis data and analyzed the relationship between Rad51 expression, inflammatory markers, and prognosis. Results We found significant linear relationships among the inflammatory markers. There were also close relationships between Rad51 expression and neutrophil-to-lymphocyte ratio or C-reactive protein. Patients with low lymphocyte percentage were more likely to have low Rad51 expression ( P = .026), high C-reactive protein ( P = .007), and high neutrophil-to-lymphocyte ratio ( P = .006). Low lymphocyte-to-monocyte ratio was associated with poor overall survival and was an independent prognostic factor (HR = 2.214; 95% confidence interval: 1.044-4.695, P = .038). In patients without lymph node metastases, low albumin (HR= 0.131; 95% confidence interval: 0.025-0.687, P = .016), high neutrophil-to-lymphocyte ratio (HR = 0.002; 95% confidence interval: 0.000-0.221, P = .009), and high Rad51 expression (HR = 14.394; 95% confidence interval: 2.217-97.402, P = .006) were associated with poor overall survival. Conclusions Our study found a close correlation between elevated Rad51 expression and inflammatory markers. High Rad51 expression, high neutrophil-to-lymphocyte ratio, and low lymphocyte-to-monocyte ratio are associated with lower survival rates. The combined assessment of Rad51 and inflammatory markers can be useful for preoperative assessment and prognostic evaluation in esophageal squamous cell carcinoma patients.

AbstractGlocalization, adapting global practices to local contexts, has become increasingly important in scientific research. However, the impact of global and local collaboration networks on glocalization remains underexplored. In this study, we conduct a bibliometric analysis to examine publications in the field of glocalization recorded in the Scopus database from 1993–2023. Using data from 12,046 publications, we identify key themes, publication trends, and methodological designs related to glocalization and collaboration networks. We then develop a theoretical model incorporating these factors to better understand the relationship between global and local collaboration networks and glocalization. This unprecedented study suggests that global and local collaboration networks are important in promoting glocalization in scientific research. We discuss the implications of our findings for future research and practitioners seeking to promote glocalization in their scientific endeavors.

Abstract Aim This study aimed to evaluate the effect of abdominal massage (AM) on feeding intolerance (FI) in patients receiving enteral nutrition (EN). Design A systematic review and meta‐analysis. Methods We searched seven electronic databases to September 2021. STATA and RevMan were used to analyse the data. Results Eleven studies were included. The results revealed that AM could significantly reduce gastric residual volume and abdominal circumference difference, and reduce the incidence of gastric retention, vomiting, abdominal distention (all p

As the second-generation high-temperature superconducting conductors, rare earth–barium–copper–oxide (REBCO) coated conductor (CC) tapes have good potential as high-field and high-energy superconductors. In superconducting applications, several joints are required for conjugating comparatively short REBCO CC tapes. Soldering lap joints are the simplest and most commonly applied REBCO CC joints. In addition to joint resistance, the mechanical behavior and electromechanical properties are also crucial for superconducting applications. In this paper, the electromechanical properties and mechanical behaviors of soldering lap joints at 77 K under a self-field were studied. The mechanical behavior was addressed by using a full three-dimensional multilayer elastic–plastic finite element model (FEM) with REBCO CC tape main layers and solder connecting layers. Then, the electromechanical properties were analyzed by using Gao’s strain-Ic degradation general model on the basis of the FEM results. Both the mechanical behavior and electromechanical properties were verified by experimental results. The effects of soldering lap conditions including lap length, soldering thickness and lap style on the electromechanical properties and mechanical behaviors were discussed. The results indicate that shorter overlap lengths and a thinner solder can reduce the premature degradation of Ic due to stress concentrations nearby the joint edges; moreover, the irreversible critical strain is significantly higher in the back-to-back joint approach compared to the widely used face-to-face joint approach.

Physically unclonable functions (PUFs) are crucial for enhancing cybersecurity by providing unique, intrinsic identifiers for electronic devices, thus ensuring their authenticity and preventing unauthorized cloning. The SRAM-PUF, characterized by its simple structure and ease of implementation in various scenarios, has gained widespread usage. The soft-decision Reed–Muller (RM) code, an error correction code, is commonly employed in these designs. This paper introduces the design of an RM code soft-decision attack algorithm to reveal its potential security risks. To address this problem, we propose a soft-decision SRAM-PUF structure based on the elliptic curve digital signature algorithm (ECDSA). To improve the processing speed of the proposed secure SRAM-PUF, we propose a custom ECDSA scheme. Further, we also propose a universal architecture for the critical operations in ECDSA, elliptic curve scalar multiplication (ECSM), and elliptic curve double scalar multiplication (ECDSM) based on the differential addition chain (DAC). For ECSMs, iterations can be performed directly; for ECDSMs, a two-dimensional DAC is constructed through precomputation, followed by iterations. Moreover, due to the high similarity of ECSM and ECDSM data paths, this universal architecture saves hardware resources. Our design is implemented on a field-programmable gate array (FPGA) and an application-specific integrated circuit (ASIC) using a Xilinx Virtex-7 and an TSMC 40 nm process. Compared to existing research, our design exhibits a lower bit error rate (2.7×10−10) and better area–time performance (3902 slices, 6.615 μs ECDSM latency).

IntroductionEndophytic microorganisms are bacteria or fungi that inhabit plant internal tissues contributing to various biological processes of plants. Some endophytic microbes can promote plant growth, which are known as plant growth-promoting endophytes (PGPEs). There has been an increasing interest in isolation and identification of PGPEs for sustainable production of crops. This study was undertaken to isolate PGPEs from roots of a halophytic species Sesuvium portulacastrum L. and elucidate potential mechanisms underlying the plant growth promoting effect.MethodsSurface-disinfected seeds of S. portulacastrum were germinated on an in vitro culture medium, and roots of some germinated seedlings were contaminated by bacteria and fungi. From the contamination, an endophytic fungus called BF-F (a fungal strain isolated from bacterial and fungal contamination) was isolated and identified. The genome of BF-F strain was sequenced, its genome structure and function were analyzed using various bioinformatics software. Additionally, the effect of BF-F on plant growth promotion were investigated by gene cluster analyses.ResultsBased on the sequence homology (99%) and phylogenetic analysis, BF-F is likely a new Cladosporium angulosum strain or possibly a new Cladosporium species that is most homologous to C. angulosum. The BF-F significantly promoted the growth of dicot S. portulacastrum and Arabidopsis as well as monocot rice. Whole genome analysis revealed that the BF-F genome has 29,444,740 bp in size with 6,426 annotated genes, including gene clusters associated with the tryptophan synthesis and metabolism pathway, sterol synthesis pathway, and nitrogen metabolism pathway. BF-F produced indole-3-acetic acid (IAA) and also induced the expression of plant N uptake related genes.DiscussionOur results suggest that BF-F is a novel strain of Cladosporium and has potential to be a microbial fertilizer for sustainable production of crop plants. The resulting genomic information will facilitate further investigation of its genetic evolution and its function, particularly mechanisms underlying plant growth promotion.

Optically levitated oscillators in high vacuum have excellent environmental isolation and low mass compared with conventional solid-state sensors, which makes them suitable for ultrasensitive force detection. The force resolution usually scales with the measurement bandwidth, which represents the ultimate detection capability of the system under ideal conditions if sufficient time is provided for measurement. However, considering the stability of a real system, a method based on the Allan variance is more reliable to evaluate the actual force detection performance. In this study, a levitated optomechanical system with a force detection sensitivity of 6.33 ± 1.62 zN/Hz1/2 was demonstrated. And for the first time, the Allan variance was introduced to evaluate the system stability due to the force sensitivity fluctuations. The force detection resolution of 166.40 ± 55.48 yN was reached at the optimal measurement time of 2751 s. The system demonstrated in this work has the best force detection performance in both sensitivity and resolution that have been reported so far for optically levitated particles. The reported high-sensitivity force detection system is an excellent candidate for the exploration of new physics such as fifth force searching, high-frequency gravitational waves detection, dark matter research and so on.

Abstract Background RET fusions are rare oncogenic drivers in non-small cell lung cancer (NSCLC). While activating RET rearrangements are found in NSCLC patients harboring epidermal growth factor receptor (EGFR) genetic alterations at resistance to EGFR inhibitors, the extent to which co-occurring genomic alterations exist and how they might affect prognosis or therapy response is poorly understood. Methods Targeted next-generation sequencing (NGS) was used to assess 380 baseline patients with primary RET fusions and 71 EGFR-mutated NSCLC patients who acquired RET fusions after developing resistance to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Results Primary RET fusions were more likely associated with females and younger age, with KIF5B being the predominant fusion partner. In baseline patients, both SMAD4 (5.3% vs. 0.0%, P = 0.044) and MYC copy-number gain variants (6.9% vs. 0.0%, P = 0.009) were more frequently co-mutated with KIF5B-RET than CCDC6-RET. By contrast, CDKN2A (11.3% vs. 2.4%, P = 0.003) mutations were significantly enriched in CCDC6-RET-rearranged baseline patients. A significant increase in the proportion of CCDC6-RET was observed in acquired RET-rearranged patients (47.3% vs. 22.5%, P

Complementary Metal Oxide Semiconductor (CMOS) and Micro-Electro-Mechanical System (MEMS) devices play significant roles in emerging research fields such as artificial intelligence (AI) [...]

Global climate change, dominated by climate warming, is seriously affecting the balance of global ecosystems, but the risk of species extinction is particularly high in low-altitude mountain areas. To clarify the response of the endemic and critically endangered species Ilex nanchuanensis to climate change, this study used the MaxEnt model to simulate and predict the potential habitat of I. nanchuanensis during the Last Interglacial, Last Glacial Maximum, the current period, and two future periods (the 2050 s and 2070 s). The results showed that the hottest monthly minimum temperature is the most important climatic factor affecting the geographical distribution of I. nanchuanensis. Furthermore, I. nanchuanensis will be at risk of population shrinkage and extinction in the future, with the center of mass moving further northwest as concentrations of greenhouse gases increase, especially in the 2070 s, when its geographical distribution shrinks the most under the RCP6 scenario. Therefore, to actively respond to the impacts of climate change, protected areas should be established around the geographical distribution centers of species, and core, buffer, and experimental areas should be scientifically and rationally delineated for the conservation and cultivation of germplasm resources.

Branching fractions (BFs) of Sm ii for 71 lines from 12 excited levels ranging from 31,638.79 to 35,463.91 cm ^−1 were determined for the first time based on the Fourier transform spectra available from the National Solar Observatory database. New transition probabilities and oscillator strengths for these lines were derived by combining the determined BFs with reliable lifetimes measured using a time-resolved laser-induced fluorescence technique. Furthermore, BFs for 38 lines from five levels included in earlier studies were also determined for comparisons. The new results reported in this work will be useful in many fields, especially for astrophysics.

In past years, optical lattices have been demonstrated as an excellent platform for making, understanding, and controlling quantum matters at nonlinear and fundamental quantum levels. Shrinking experimental observations include matter-wave gap solitons created in ultracold quantum degenerate gases, such as Bose–Einstein condensates with repulsive interaction. In this paper, we theoretically and numerically study the formation of one-dimensional gap soliton molecules and clusters in ultracold coherent atom ensembles under electromagnetically induced transparency conditions and trapped by an optical lattice. In numerics, both linear stability analysis and direct perturbed simulations are combined to identify the stability and instability of the localized gap modes, stressing the wide stability region within the first finite gap. The results predicted here may be confirmed in ultracold atom experiments, providing detailed insight into the higher-order localized gap modes of ultracold bosonic atoms under the quantum coherent effect called electromagnetically induced transparency.

The LGS1 (Large grain size 1) gene, also known as GS2/GL2/OsGRF4, is involved in regulating grain size and quality in rice, but the mechanism governing grain size has not been elucidated. We performed transcriptomic, proteomic, and phosphoproteomic analyses of young rice panicles in Samba (a wild-type cultivar with extra-small grain) and NIL-LGS1 (a nearly isogenic line of LGS1 with large grain in the Samba genetic background) at three developmental stages (4–6) to identify internal dynamic functional networks determining grain size that are mediated by LGS1. Differentially expressed proteins formed seven highly functionally correlated clusters. The concordant regulation of multiple functional clusters may be key features of the development of grain length in rice. In stage 5, 16 and 24 phosphorylated proteins were significantly up-regulated and down-regulated, and dynamic phosphorylation events may play accessory roles in determining rice grain size by participating in protein–protein interaction networks. Transcriptomic analysis in stage 5 showed that differentially expressed alternative splicing events and dynamic gene regulatory networks based on 39 transcription factors and their highly correlated target genes might contribute to rice grain development. Integrative multilevel omics analysis suggested that the regulatory network at the transcriptional and posttranscriptional levels could be directly manifested at the translational level, and this analysis also suggested a regulatory mechanism, regulation of protein translation levels, in the biological process that extends from transcript to protein to the development of grain. Functional analysis suggested that biological processes including MAPK signaling, calcium signaling, cell proliferation, cell wall, energy metabolism, hormone pathway, and ubiquitin-proteasome pathway might be involved in LGS1-mediated regulation of grain length. Thus, LGS1-mediated regulation of grain size is affected by dynamic transcriptional, posttranscriptional, translational and posttranslational changes.

A humanoid robot is an advanced representation of robot techniques. It can move like a human and possesses the ability to use human tools. Sensing and intelligent control technologies have increased the intelligence of humanoid robots. However, the dexterity of a humanoid robot is still far from that of a human. Herein, a bending sensor is introduced to detect human motion, which can thus be digitized to enable a humanoid robot to learn to be more dexterous. This bending sensor is fabricated of carbon fiber with a cascade structure, resulting in excellent characteristics, including a quantitative detection capability, high gauge factor, low hysteresis, long‐term durability, and high‐frequency response. Thus, the bending sensor can recognize both the large‐scale motion of joint bending and subtle motion of muscle contraction. Fourteen bending sensors corresponding to the 14 knuckles of the human hand can accurately recognize and digitize hand gestures. These multichannel sensors are combined with nine additional bending sensors to comprehensively digitize the grasping process of the upper limb and recognize the grasping of objects with different sizes and weights. These successful applications demonstrate that the bending sensor can open a path toward learning human behavior for a humanoid robot.

Abstract Background The normal metabolism of transitory starch in leaves plays an important role in ensuring photosynthesis, delaying senescence and maintaining high yield in crops. OsCKI1 (casein kinase I1) plays crucial regulatory roles in multiple important physiological processes, including root development, hormonal signaling and low temperature-treatment adaptive growth in rice; however, its potential role in regulating temporary starch metabolism or premature leaf senescence remains unclear. To reveal the molecular regulatory mechanism of OsCKI1 in rice leaves, physiological, transcriptomic and proteomic analyses of leaves of osckI1 allele mutant lses1 (leaf starch excess and senescence 1) and its wild-type varieties (WT) were performed. Results Phenotypic identification and physiological measurements showed that the lses1 mutant exhibited starch excess in the leaves and an obvious leaf tip withering phenotype as well as high ROS and MDA contents, low chlorophyll content and protective enzyme activities compared to WT. The correlation analyses between protein and mRNA abundance are weak or limited. However, the changes of several important genes related to carbohydrate metabolism and apoptosis at the mRNA and protein levels were consistent. The protein-protein interaction (PPI) network might play accessory roles in promoting premature senescence of lses1 leaves. Comprehensive transcriptomic and proteomic analysis indicated that multiple key genes/proteins related to starch and sugar metabolism, apoptosis and ABA signaling exhibited significant differential expression. Abnormal increase in temporary starch was highly correlated with the expression of starch biosynthesis-related genes, which might be the main factor that causes premature leaf senescence and changes in multiple metabolic levels in leaves of lses1. In addition, four proteins associated with ABA accumulation and signaling, and three CKI potential target proteins related to starch biosynthesis were up-regulated in the lses1 mutant, suggesting that LSES1 may affect temporary starch accumulation and premature leaf senescence through phosphorylation crosstalk ABA signaling and starch anabolic pathways. Conclusion The current study established the high correlation between the changes in physiological characteristics and mRNA and protein expression profiles in lses1 leaves, and emphasized the positive effect of excessive starch on accelerating premature leaf senescence. The expression patterns of genes/proteins related to starch biosynthesis and ABA signaling were analyzed via transcriptomes and proteomes, which provided a novel direction and research basis for the subsequent exploration of the regulation mechanism of temporary starch and apoptosis via LSES1/OsCKI1 in rice.

In this paper, an adaptive and robust Kalman filter algorithm based on the maximum correntropy criterion (MCC) is proposed to solve the problem of integrated navigation accuracy reduction, which is caused by the non-Gaussian noise and time-varying noise of GPS measurement in complex environment. Firstly, the Grubbs criterion was used to remove outliers, which are contained in the GPS measurement. Then, a fixed-length sliding window was used to estimate the decay factor adaptively. Based on the fixed-length sliding window method, the time-varying noises, which are considered in integrated navigation system, are addressed. Moreover, a MCC method is used to suppress the non-Gaussian noises, which are generated with external corruption. Finally, the method, which is proposed in this paper, is verified by the designed simulation and field tests. The results show that the influence of the non-Gaussian noise and time-varying noise of the GPS measurement is detected and isolated by the proposed algorithm, effectively. The navigation accuracy and stability are improved.

Ecological fire prevention forest belts can effectively alleviate the spread of forest fires and reduce the harm caused by forest fires. Exploring the distribution and changes in suitable growth areas for fire-resistant forest species under the effects of climate change can provide effective references for the introduction of ecological fire prevention and tree species preservation in the region. This study is based on the distribution data of six typical ecological fire prevention forest species in the subtropical regions of China. The maximum entropy model (MaxEnt), optimized by the ENMeval data package, was used to analyze the potential relationship between the ecological environment variables and fire prevention forest species. The potential distribution of certain tree species in the historical period and in future periods is simulated. In addition, the area changes, migration trends, and stable areas of tree species under climate change are also discussed. The research results indicated the following: (1) The AUC values of the optimized model are all higher than 0.9, indicating the optimal prediction results. (2) The climate variables that have the greatest impact on the suitable habitat of Schima superba were the annual mean temperature, precipitation of the driest month, and mean diurnal range. Quercus glauca was mainly influenced by the minimum temperature of the coldest month and the precipitation of the warmest quarter. Castanopsis eyrei was mainly influenced by the precipitation of the driest month and the annual precipitation. The distribution of suitable growth areas for Symplocos sumuntia is mainly influenced by the precipitation of the driest month. The distribution of Camellia oleifera was influenced by the minimum temperature of the coldest month. The potential habitat distribution of Photinia serratifolia was greatly influenced by annual precipitation. (3) Until 2090, the expansion degree of the suitable growth area will be Symplocos sumuntia (51.05%) > Schima superba (19.41%) > Camellia oleifera (10.14%) > Quercus glauca (6.80%) > Castanopsis eyrei (2.34%) > Photinia serratifolia (−6.97%). (4) The centroid of Schima superba will migrate northward. Quercus glauca will migrate northeast. The suitable areas for the migration of Symplocos sumuntia and Castanopsis eyrei will move in a northwest direction, with repeated changes in alum migration, as well as with the largest migration span for Castanopsis eyrei. In addition, Camellia oleifera will move southwest. The centroid of Photinia serratifolia will migrate to the southeast. (5) The six fire-resistant tree species in this study were noted to have excellent stability in Guizhou, Hunan, Jiangxi, Fujian, Guangdong, and Guangxi. This conclusion can provide an effective reference for the introduction of ecological fire prevention tree species and the protection of tree species under climate change in subtropical forest-fire-prone areas in China.

Metal surface quality control is significant in the production line of metal products. Detecting metal surface defects is challenging due to the various types and morphological patterns. Recent advances have witnessed deep learning-based automated optical inspection systems as a promising solution. This paper presents an enhanced YOLOv4 model for metal surface defect detection (MSDD). Specifically, we integrate three boosting components into the original YOLOv4, including 1) a self-dependent attentive fusion (SAF) block, placed within the model neck, to enhance inter-path and cross-layer feature fusion, 2) a component randomized Mosaic augmentation (CRMA) scheme to strategically discourage an over-transformed image to participate in training, and 3) a perturbation agnostic (PA) label smoothing method to keep the model from making over-confident predictions and thus act as a means of regularization. The proposed method has been validated on a self-developed MSDD dataset. It is shown that each boosting component can lead to an impressive mAP gain, and the final model outperforms the baselines, namely, Faster R-CNN, YOLOv4, YOLOv5, and YOLOX, by 7.85%, 6.51%, 3.76%, and 3.57%, respectively.

Peripheral vascular disease caused by brucellosis is rarely seen around the world; thus, it is easily ignored by patients and doctors, leading to a lack of corresponding screening and delayed comprehensive treatment. Currently, there is no standard or guideline for diagnosing and treating peripheral arterial disease caused by brucellosis. From June 2021 to December 2022, four cases of abdominal aortic pseudoaneurysm caused by brucellosis disease were treated with endovascular aneurysm repair This study reported treatment results as follows and reviewed the incidence, treatment, and prognosis of abdominal aortic pseudoaneurysm caused by brucellosis.

Abstract Purpose Hemivertebra is one of the common pathogenesis of congenital scoliosis. The timing of operation is undefined. Our study compared the surgical outcomes in children under age 10 years with scoliosis due to single nonincarcerated thoracolumbar hemivertebra according to the age at surgery. Methods From January 2009 to August 2017, we retrospectively investigated 34 consecutive cases of congenital scoliosis treated by posterior hemivertebra resection and fusion with pedicle screw fixation. All cases were divided into two groups according to the age at surgery and followed-up for at least 2 years, group 1 (≤ 5 years old), and group 2 (5 to 10 years old). Results The mean Cobb angle of the main curve was improved from 48.58° to 15.53° (68.05%) in group 1, and from 43.73° to 11.33° (75.43%) in group 2. The segmental curve was improved from 44.16° to 11.53° (74.64%) in group 1, and the segmental curve was consistent with the main curve in group 2. The mean segmental kyphosis was improved from 27.50° to 8.42° (67.40%) in group 1, and from 29.00° to 5.00° (84.73%) in group 2. Five patients developed distal adding-on, and four patients were found proximal junctional kyphosis during the follow-up. Conclusion Not all the deformities caused by single nonincarcerated thoracolumbar hemivertebra would progress greatly with the spinal growth. No significant statistical differences were found in the coronal and sagittal correction rate between the two groups. A limited delayed surgery after 5 years but before 10 years of age with close follow-up can achieve satisfied results.

Metasurfaces have recently gained increasing attention and shown great potential in replacing bulk optics with ultracompact flat metadevices, owing to their unprecedented capabilities of molding optical fields with surface‐confined configurations and exceedingly low losses. However, most existing metasurfaces are typically passive and feature well‐defined responses determined by material compositions and configurations, which severely limit the functionalities in intelligent and adaptive nanophotonics. Therefore, it is highly desired to realize active metasurfaces with dynamic modulation postfabrication. Herein, a highly efficient tunable metawaveplate at the telecom wavelength of 1.55 μm by structuring the phase‐change alloy Sb2Se3 is designed, which can switch from a half‐waveplate to a quarter‐waveplate once Sb2Se3 transits from the amorphous to the crystalline state. Capitalizing on the designed Sb2Se3 meta‐atom and the Pancharatnam–Berry phase, two switchable meta‐devices capable of actively shaping the wavefronts of the transmitted waves are proposed, including tunable beam steering and metalens with tailored focal intensity. The presented tunable metasurfaces can open new avenues for adaptive photonics with advanced functionalities.

Abstract Van der Waals (vdW) heterostructures provide a unique opportunity to develop various electronic and optoelectronic devices with specific functions by designing novel device structures, especially for bioinspired neuromorphic optoelectronic devices, which require the integration of nonvolatile memory and excellent optical responses. Here, we demonstrate a programmable optoelectronic synaptic floating‐gate transistor based on multilayer graphene/h‐BN/MoS2 vdW heterostructures, where both plasticity emulation and modulation were successfully realized in a single device. The dynamic tunneling process of photogenerated carriers through the as‐fabricated vdW heterostructures contributed to a large memory ratio (105) between program and erase states. Our device can work as a functional or silent synapse by applying a program/erase voltage spike as a modulatory signal to determine the response to light stimulation, leading to a programmable operation in optoelectronic synaptic transistors. Moreover, an ultra‐low energy consumption per light spike event (~2.5 fJ) was obtained in the program state owing to a suppressed noise current by program operation in our floating‐gate transistor. This study proposes a feasible strategy to improve the functions of optoelectronic synaptic devices with ultra‐low energy consumption based on vdW heterostructures designed for highly efficient artificial neural networks.

Activation of c-MET receptor tyrosine kinase involves hepatocyte growth factor (HGF) and glycosaminoglycans, but the molecular mechanism is still under debate. Here, the authors present cryoEM structures of c-MET bound to two HGF splice variants and heparin, revealing the structural basis for c-MET activation.

Abstract Polygonatum odoratum (Mill.) Druce (Asparagaceae, Asparagales) is a widely cultivated medicinal herb in China. However, this useful herb is understudied despite being known as a medicinal resource with top grade medical and edible properties since long. In this study, P. odoratum and four cultivars were investigated. The variations in morphological characteristics and vegetative phases of each cultivar were observed. For genetic aspect, the plastid genome of P. odoratum varies in length from 154,569 bp to 155,491 bp, containing a large single‐copy region of 83,486–84,459 bp, a small single‐copy region of 18,292–18,471 bp, and two inverted repeats of 26,302–26,370 bp. A total of 131 genes were predicted, including 85 protein‐coding, 38 tRNA, and eight rRNA genes. Genome comparisons revealed a slight variation in the sequence across the five accessions, but two highly variable regions (trnC‐petN and rpl32‐trnL) were detected when comparing the four different cultivars. For the RAD‐seq markers, a total of 33.64 Gb of clean data, with an average value of 1.08 Gb per sample, were analyzed for the presence of single nucleotide polymorphisms (SNPs). Well‐resolved phylogenies of the P. odoratum cultivars are constructed; the nonmonophyletic relationship in the plastome‐based phylogenetic trees, yet monophyletic form in the RAD‐based linkage map suggested possibility of hybrid cultivar for P. odoratum “Dazhu” (GDDZ), which was further supported by morphological observations. Quality assessment based on the standards of the Chinese Pharmacopoeia on Polygonati Odorati Rhizoma (POR) on the four cultivars used in this study recorded that PORs from P. odoratum “Zhongzhu” (GDZZ) met the minimum criteria for the acceptance as raw material for medicinal drug production. This study has provided insights on the morphological variations, genetic background, and medicinal qualities of P. odoratum cultivars that could be explored for future genetic improvement as well as breeding programs of P. odoratum for POR production.

Abstract To analyse the cause of the atmospheric PM2.5 pollution that occurred during the COVID-19 lockdown in Nanning, Guangxi, China, a single particulate aerosol mass spectrometer, aethalometer, and particulate Lidar coupled with monitoring near-surface gaseous pollutants, meteorological conditions, remote fire spot sensing by satellite and backward trajectory models were utilized during 18–24 February 2020. Three haze stages were identified: the pre-pollution period (PPP), pollution accumulation period (PAP) and pollution dissipation period (PDP). The dominant source of PM2.5 in the PPP was biomass burning (BB) (40.4%), followed by secondary inorganic sources (28.1%) and motor vehicle exhaust (11.7%). The PAP was characterized by a large abundance of secondary inorganic sources, which contributed 56.1% of the total PM2.5 concentration, followed by BB (17.4%). The absorption Ångström exponent (2.2) in the PPP was higher than that in the other two periods. Analysis of fire spots monitored by remote satellite sensing indicated that open BB in regions around Nanning City could be one of the main factors. A planetary boundary layer-relative humidity-secondary particle matter-particulate matter positive feedback mechanism was employed to elucidate the atmospheric processes in this study. This study highlights the importance of understanding the role of BB, secondary inorganic sources and meteorology in air pollution formation and calls for policies for emission control strategies.

Static experiments and dynamic displacement experiments were conducted to quantitatively determine the amount of precipitate generated by the CO2-formation water reaction at different temperatures, pressures, and scaling ion concentrations during CO2 flooding in the Chang 8 block of Changqing Oilfield, the influence of precipitate on the physical properties of reservoirs was investigated, and the corresponding mathematical characterization model was established. The mathematical characterization equation was used to correct the numerical simulation model of E300 module in Eclipse software. The distribution pattern of inorganic salt precipitates during continuous CO2 flooding in Chang 8 block was simulated, and the influence of inorganic salt precipitates on oil recovery was predicted. The inorganic salt precipitate generated during CO2-formation water reaction was mainly CaCO3, and the pressure difference and scaling ion concentration were proportional to the amount of precipitate generated, while the temperature was inversely proportional to the amount of precipitate. The rate of core porosity change before and after CO2 flooding was positively correlated with temperature and flooding pressure difference. The core porosity increase in the CO2-formation water-core reaction experiment was always lower than that of CO2-distilled water-core reaction experiment because of precipitation. The area around the production wells had the most precipitates generated with the injection of CO2. The oil field became poor in development because of the widely distributed precipitate and the recovery decreased to 33.45% from 37.64% after 20-year-CO2 flooding when considering of precipitation.

Abstract Flexible sensors in wearable electronics have become increasingly multifunctional due to the development of materials synthesis and structure design. In particular, structural design can not only add capabilities to sensors fabricated from existing available and normal materials, but also offer opportunities for the fabrication of sensors with certain desired functions. Here, we designed a series of fiber-junction structure models, in which two fibers were simply hooked to each other to form a junction on a flexible printed circuit, for fabrication of directional bending sensors. The value and direction of bending angle are related to the change in electronic signal by a theoretical expression, allowing us to employ a simple and practicable method to use available conductive fiber materials to fabricate high-sensitivity, high-resolution and directional bending sensors. In addition, these models are generally applicable, which have broad combination with different conductive fiber, and corresponding bending sensors all possess capability of directional identification. Furthermore, the capability of identifying directional bending was demonstrated by human motion monitoring such as joint bending and muscle contraction.

In the original article [...]

Corona Virus Disease 2019 (COVID-19) pandemic has become a global challenge faced by people all over the world. Social distancing has been proved to be an effective practice to reduce the spread of COVID-19. Against this backdrop, we propose that the surveillance robots can not only monitor but also promote social distancing. Robots can be flexibly deployed and they can take precautionary actions to remind people of practicing social distancing. In this paper, we introduce a fully autonomous surveillance robot based on a quadruped platform that can promote social distancing in complex urban environments. Specifically, to achieve autonomy, we mount multiple cameras and a three dimensional light detection and ranging sensor (3D LiDAR) on the legged robot. The robot then uses an onboard real-time social distancing detection system to track nearby pedestrian groups. Next, the robot uses a crowd-aware navigation algorithm to move freely in highly dynamic scenarios. The robot finally uses a crowd-aware routing algorithm to effectively promote social distancing by using human-friendly verbal cues to send suggestions to over-crowded pedestrians. We demonstrate and validate that our robot can be operated autonomously by conducting several experiments in various urban scenarios.

The virtual anatomy laboratory was jointly established by the Jilin Province Department of Public Security, Public Security Bureau of Changchun, Jilin University and Neusoft Medical Systems Co., Ltd. on December 30, 2019. Details of the laboratory construction, virtual autopsy process, case analysis, research and development, establishment of standards, application in teaching, and other aspects of the center are summarized in this paper. In addition, we expound the prospective and practical significance of the virtual anatomy laboratory. Based on computed tomography and magnetic resonance detection methods, the prospective applications of virtual anatomy in forensic identification are explored through the analyses of two real-life cases. Using information from traditional anatomy as the gold standard, this study expanded on and explored the application technology and scenarios of virtual anatomy in imaging, clinical diagnosis, and equipment manufacturing, among other fields. The four cooperating units have their strengths and will yield valuable scientific research results and social benefits.

This paper presents a wideband dB-linear variable-gain amplifier (VGA) with a DC-offset cancellation network in a 90-nm CMOS technology for high-speed applications. The VGA consists of a four-stage Cherry-Hooper amplifier, which is based on a feedback resistor and negative Miller capacitance to obtain wide bandwidth without inductors in the main circuit. A unique method for this structure to generate pseudo-exponential function is analyzed in detail. Therefore, an accurate dB-linear characteristic is realized in this VGA without any exponential generator circuits. The linear control voltage is applied directly to the gate of the transistor and this simple control method exhibits good robustness to process and temperature variation. Measurement results show that the voltage gain varies from −28 dB to 27 dB continuously with more than 4.3 GHz bandwidth and a dB-linear range of 32 dB with less than ±0.6 dB gain error. Without the output buffer, it consumes 8.5 mW from a 1.2V supply and occupies a small die area of only 0.04 mm2.

Microseismic data shows that some unconventional reservoirs comprise well-developed natural fractures and complex hydraulic fracture networks. It is neither practical nor advantageous to simulate a huge number of natural and hydraulic fractures with numerical models. Given that the conventional dual-porosity models are not applicable to the highly discrete natural fractures, the paper develops a semianalytical well testing model for horizontal wells with hydraulic fracture networks and randomly-distributed discretely natural fractures.The proposed model has the capability to analyze the pressure behaviors by considering complex fracture networks and isolated natural fractures rapidly and efficiently. The model includes diffusivity equations in three domains: (1) matrix, (2) discretely natural fractures, and (3) hydraulic fracture networks. The pressure transient solution of these diffusivity equations is obtained by using Laplace transforms and superposition principle. We verify the presented model by performing a case study with a numerical simulator for complex natural fractures.It is found that there are some interesting flow behaviors for fracture-network horizontal well with discretely natural fractures like bilinear flow, “V-shape” caused by fluid supply, pseudo boundary-dominated flow, impact of natural fractures, etc. The pseudo boundary-dominated flow provides us the information about how large the area covered by hydraulic fracture networks. The impact of natural fracture shows the parameters of natural fractures. This work provides a good understanding of transient pressure behaviors in unconventional reservoirs and guidelines for the producer optimize field development and well economics.

The objective of this study was to evaluate the effects of isopropyl ester of 2-hydroxy-4-(methylthio)-butyrate acid (HMBi) on ruminal and cecal fermentation, microbial composition, nutrient digestibility, plasma biochemical parameters, and growth performance in finishing beef cattle. The experiment was conducted for 120 days by a complete randomized block design. Sixty 24-month-old Angus steers (723.9 ± 11.6 kg) were randomly assigned to one of the flowing three treatments: basal diet (the concentrate: 7.6 kg/head·d−1, the rice straw: ad libitum) supplemented with 0 g/d MetaSmart® (H0), a basal diet supplemented with 15 g/d of MetaSmart® (H15), and a basal diet supplemented with 30 g/d of MetaSmart® (H30). Results showed that the average daily gain (ADG) increased linearly (P = 0.004) and the feed conversion ratio (FCR) decreased linearly (P < 0.01) with the increasing HMBi supplementation. Blood urea nitrogen (BUN) concentration significantly decreased in the H30 group (P < 0.05) compared with H0 or H15. The ruminal pH value tended to increase linearly (P = 0.086) on day 56 with the increased HMBi supplementation. The concentrations of ammonia–nitrogen (NH3-N), propionate, isobutyrate, butyrate, isovalerate, valerate, and total volatile fatty acid (VFA) were linearly decreased in the cecum (P < 0.05). The results of Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) showed that the abundance of most pathways with a significant difference was higher in the rumen and lower in the cecum in the H30 group compared to the H0 group, and those pathways were mainly related to the metabolism of amino acids, carbohydrates, and lipids. Correlation analysis showed that ADG was positively associated with the ratio of firmicutes/bacteroidetes both in the rumen and cecum. Additionally, the abundance of Lachnospiraceae, Saccharofermentans, Lachnospiraceae_XPB1014_group, and Ruminococcus_1 was positively correlated with ADG and negatively correlated with FCR and BUN in the rumen. In the cecum, ADG was positively correlated with the abundances of Peptostreptococcaceae, Romboutsia, Ruminococcaceae_UCG-013, and Paeniclostridium, and negatively correlated with the abundances of Bacteroidaceae and Bacteroides. Overall, these results indicated that dietary supplementation of HMBi can improve the growth performance and the feed efficiency of finishing beef cattle by potentially changing bacterial community and fermentation patterns of rumen and cecum.