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1. [Features of absorption of cortisol by peripheral blood cells in patients with bronchial asthma].

Author

Trofimov VI, Mineev VN, Zhikkharev SS, and Karpov OI

Subjects
Erythrocytes physiology, Humans, Lymphocytes physiology, Asthma blood, Epinephrine physiology, Erythrocytes metabolism, Hydrocortisone blood, Lymphocytes metabolism
Abstract

Hydrocortisone absorption by lymphocytes and red blood cells was reduced in patients with bronchial asthma (BA). Adrenaline produced the stimulatory effect on hydrocortisone absorption by lymphocytes and red blood cells in practically normal subjects and in BA patients in whom that effect was decreased. In patients with the steroid-dependent clinico-pathogenetic pattern of BA, hydrocortisone absorption by lymphocytes was reduced to a considerable degree. It is stressed that cellular mechanisms of glucocorticoid insufficiency are implicated in the BA pathogenesis.

Published
1989

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