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The hydrothermal performance of the microchannel heat sinks with different pin fins (PF-MCHS) is studied experimentally and numerically. Five pin fins, namely rectangular pin fin (RPF), backward triangular pin fin (BTPF), forward triangular pin fin (FTPF), diamond pin fin (DPF) and ellipsoidal pin fin (EPR) are integrated in the microchannel for enhancing heat transfer. The results show that the PF-MCHSs possess 51.8–94.8 % higher average Nusselt number than the conventional microchannel (CMC) without pin fins, which indicates that these pin fins all can cause significant heat enhancement in the microchannels. Among all finned microchannels, the MC- RPF and MC-BTPF can offer the larger Nusselt number than the other microchannels. In addition to the improved thermal performance, the pin fins also result in the larger apparent friction factor. Furthermore, taking the MC-RPF and MC-BTPF as examples, three non-dimensional parameters α = P/L, β = wp/hc and γ = lp/hc are proposed for optimizing the global characteristics of microchannels. The rise of Nussle number and apparent friction factor is often accompanied by a decrease in α, or an increase in β and γ.

PurposeNon-puerperal mastitis (NPM) accounts for approximately 4-5% of all benign breast lesions. Ultrasound is the preferred method for screening breast diseases; however, similarities in imaging results can make it challenging to distinguish NPM from invasive ductal carcinoma (IDC). Our objective was to identify convenient and objective hematological markers to distinguish NPM from IDC.MethodsWe recruited 89 patients with NPM, 88 with IDC, and 86 with fibroadenoma (FA), and compared their laboratory data at the time of admission. LASSO regression, univariate logistic regression, and multivariate logistic regression were used to screen the parameters for construction of diagnostic models. Receiver operating characteristic curves, calibration curves, and decision curves were constructed to evaluate the accuracy of this model.ResultsWe found significant differences in routine laboratory data between patients with NPM and IDC, and these indicators were candidate biomarkers for distinguishing between the two diseases. Additionally, we evaluated the ability of some classic hematological markers reported in previous studies to differentiate between NPM and IDC, and the results showed that these indicators are not ideal biomarkers. Furthermore, through rigorous LASSO and logistic regression, we selected age, white blood cell count, and thrombin time to construct a differential diagnostic model that exhibited a high level of discrimination, with an area under the curve of 0.912 in the training set and with 0.851 in the validation set. Furthermore, using the same selection method, we constructed a differential diagnostic model for NPM and FA, which also demonstrated good performance with an area under the curve of 0.862 in the training set and with 0.854 in the validation set. Both of these two models achieved AUCs higher than the AUCs of models built using machine learning methods such as random forest, decision tree, and SVM in both the training and validation sets.ConclusionCertain laboratory parameters on admission differed significantly between the NPM and IDC groups, and the constructed model was designated as a differential diagnostic marker. Our analysis showed that it has acceptable efficiency in distinguishing NPM from IDC and may be employed as an auxiliary diagnostic tool.

IntroductionIn the soda-saline grasslands of the Songnen Plain, Jilin Province, China, the prohibition of grazing has led to significant changes in plant communities and soil properties. However, the intricate interplay between soil physical and chemical attributes, the soil microbial community, and their combined influence on soil humus composition remains poorly understood.MethodsOur study aimed to evaluate the impact of natural vegetation restoration on soil properties, microbial community diversity, and composition in the soda-saline soil region of the Songnen Plain. We conducted assessments of soil physical and chemical properties, analyzed community diversity, and composition at a soil depth range of 0–20 cm. The study covered soils with dominant soda-saline vegetation species, including Suaeda glauca Bunge, Puccinellia chinampoensis Ohwi, Chloris virgata Swarta, Phragmites australis (Clay.), Leymus chinensis (Trin.), and Tzvelev. We compared these vegetated soils to bare land devoid of any plants.ResultsWe found that soil organic content (SOC) in vegetation restoration areas was higher than in bare land, with SOC content varying between 3.64 and 11.15 g/kg in different vegetated areas. Notably, soil pH emerged as a pivotal factor, explaining 11.4% and 12.2% of the variance in soil bacteria and fungi, respectively. There were correlations between SOC content and the relative abundance of specific microbial groups, with Acidobacteria and Mortierella showing a positive correlation, while Actinobacteria, Gemmatimonadetes, and Ascomycota exhibited significant negative correlations with SOC.DiscussionThe disparities in SOC composition and content among the soda-saline vegetation types were primarily attributed to variations in pH. Consequently, reducing soil pH is identified as a critical step in the process of vegetation restoration in soda-saline land. Prohibiting grazing has the potential to increase soda-saline SOC content and enhance microbial diversity, with Leymus chinensis and Phragmites australis showing particularly promising results in terms of higher SOC carbon content and microbial diversity.

Abstract Background Glioblastoma multiforme (GBM) is a fatal malignant primary brain tumor in adults. The therapeutic efficacy of chemotherapeutic drugs is limited due to the blood-brain barrier (BBB), poor drug targeting, and short biological half-lives. Multifunctional biomimetic nanodrugs have great potential to overcome these limitations of chemotherapeutic drugs. Methods We synthesized and characterized a biomimetic nanodrug CMS/PEG-DOX-M. The CMS/PEG-DOX-M effectively and rapidly released DOX in U87 MG cells. Cell proliferation and apoptosis assays were examined by the MTT and TUNEL assays. The penetration of nanodrugs through the BBB and anti-tumor efficacy were investigated in the orthotopic glioblastoma xenograft models. Results We showed that CMS/PEG-DOX-M inhibited cell proliferation of U87 MG cells and effectively induced cell apoptosis of U87 MG cells. Intracranial antitumor experiments showed that free DOX hardly penetrated the BBB, but CMS/PEG-DOX-M effectively reached the orthotopic intracranial tumor through the BBB and significantly inhibited tumor growth. Immunofluorescence staining of orthotopic tumor tissue sections confirmed that nanodrugs promoted apoptosis of tumor cells. This study developed a multimodal nanodrug treatment system with the enhanced abilities of tumor-targeting, BBB penetration, and cancer-specific accumulation of chemotherapeutic drugs by combining chemotherapy and photothermal therapy. It can be used as a flexible and effective GBM treatment system and it may also be used for the treatment of other central nervous systems (CNS) tumors and extracranial tumors.

Four typical halophytic communities found in saline-sodic soil, including Phragmites australis, Suaeda glauca, Leymus chinensis, and Puccinellia parl, were investigated in this study. A comparison was made among the electrical conductivity (EC) value, pH value, soil organic carbon (SOC), and soil enzyme activity across various soil depths. The findings of this study indicate that the EC and pH levels of the soil at the 0–40 cm depth vary among the four communities, with Suaeda glauca having the highest values, followed by Puccinellia parl, Phragmites australis, and Leymus chinensis. The highest value of SOC among the four communities was observed in the Leymus chinensis community (0.85–0.94 g/kg), followed by the Phragmites australis community (0.50–0.77 g/kg), and the lowest levels were observed in the Puccinellia parl community (0.37–0.78 g/kg). As the soil depth increases, there is a decline in the amount of SOC. With an increase in soil depth, the content of SOC in the soil decreased, and the content of total nitrogen (TN) and the activity of six enzymes in the soil of each community increased. Furthermore, at the soil layer of 0–20 cm, the TN content in the soils was negatively correlated with pH and EC (p < 0.01), and so was the total phosphorus (TP). Additionally, the TP content is considerably positively connected with alkaline phosphatase (ALP) activity, whereas the TN content is significantly positively correlated with Soil Urease (S-UE) activity. Within the soil depth of 20–40 cm, the levels of TN, TP, and SOC exhibit a negative association with pH and EC. However, this link is weaker compared to that observed in the surface soil. A strong inverse correlation (p < 0.05) exists between the TP concentration and the ALP activity. The objective of this study was to investigate the use of halophytes in various saline-sodic soils for diverse avenues of restoration, and to establish a database on the role and efficacy of plant roots in enhancing saline-sodic soil.

Background. Chronic subdural hematoma is a common disease in neurosurgery, but organized chronic subdural hematoma is rarely seen clinically. This article reports a case of misdiagnosis of organized chronic subdural hematoma as acute epidural hematoma. Through literature review, the causes of misdiagnosis and the treatment methods of organized chronic subdural hematoma are discussed. Case Description. A 70-year-old male patient was admitted to the hospital due to headache and dizziness after head trauma. Emergency head CT reported “left frontotemporal parietal epidural hematoma.” Because the head CT showed that the hematoma occupying effect was obvious, an emergency “intracranial hematoma evacuation” was performed. After opening the skull during the operation, no epidural hematoma was seen. Upon incision of the dura mater, the outer membrane of organized chronic subdural hematoma was found. When the outer membrane was cut open, a large amount of reddish-brown silt-like materials was found in the capsule cavity. The inner membrane was not forcibly removed. Postoperative head CT showed that the organized chronic subdural hematoma was basically cleared. Conclusion. The early symptoms of organized chronic subdural hematoma are atypical, with insidious onset and easy misdiagnosis. By carefully inquiring about the medical history and carefully reading the head CT, such misdiagnosis can be avoided. Craniotomy is currently an important treatment option for organized chronic subdural hematoma.

The impact of the wetland ecosystem on arid and semi-arid areas is much higher than that in humid areas. It plays a more significant role in regulating climate, conserving water sources, purifying water bodies, and protecting biodiversity. The West Liao River Basin is located in a moderately temperate, semi-arid, and continental monsoon climatesensitive area, with a fragile ecological environment. Climate warming and drought have gradually caused dry-flow of some river sections in the basin, reduction in the water area, shrinking of wetlands, degradation of vegetation ecological function, and decline of biodiversity. Ultimately, the effect of ecological barriers is significantly weakened. The research of the temporal and spatial evolution of landscape patterns and their relationship with human activities in arid and semi-arid regions is of great significance for the protection and restoration of wetland resources. Based on Landsat remote sensing images in 1985 and 2015, the temporal and spatial evolution of landscape patterns in four key wetland areas in the West Liao River Basin was studied by 3S technology and landscape ecology indexes. Results show that during the 30a years, the wetland resources area in the West Liao River Basin is drastically reduced. Wetland resources of the four study areas, the Dalinor, the Saihanwula, the Hongshan Reservoir, and the West Liao River Estuary, were decreased by 13.80%, 31.06%, 61.10%, and 66.03%, respectively. The reduced wetland resources in the Dalinor and the Saihanwula were mainly converted into grassland, while those of the Hongshan Reservoir and the West Liao River Estuary were mostly converted into farmland. The diversity and evenness indexes of landscape in the Hongshan Reservoir and the West Liao River Estuary are gradually decreasing. The diversity and evenness indexes of the Dalinor and the Saihanwula are not significantly changed but are slightly disturbed by human activities. Changes in the landscape pattern index highlight the decrease in the water area, the increase in the area of dry and paddy fields, and the improvement of sandy land. All these further reflect that insufficient water resources supplementation and increasing human disturbance have a profound impact on the landscape pattern, which has also become the main driving force for the evolution of the landscape pattern in the West Liao River Basin.

The Global Energy Interconnection is an important strategic approach used to achieve efficient worldwide energy allocation. The idea of developing integrated power, information, and transportation networks provides increased power interconnection functionality and meaning, helps condense forces, and accelerates the integration of global infrastructure. Correspondingly, it is envisaged that it will become the trend of industrial technological development in the future. In consideration of the current trend of integrated development, this study evaluates a possible plan of coordinated development of fiber-optic and power networks in the Pan-Arctic region. Firstly, the backbone network architecture of Global Energy Interconnection is introduced and the importance of the Arctic energy backbone network is confirmed. The energy consumption and developmental trend of global data centers are then analyzed. Subsequently, the global network traffic is predicted and analyzed by means of a polynomial regression model. Finally, in combination with the current construction of fiber-optic networks in the Pan-Arctic region, the advantages of the integration of the fiber-optic and power networks in this region are clarified in justification of the decision for the development of a Global Energy Interconnection scheme. Keywords: Energy Interconnection, Data center, Network traffic, Integrated development of energy and information networks, Global Energy Interconnection

The agricultural productivity of farmland in Northeast China’s Liaohe Plain is restricted by the salinity and sodicity of the soils, which have additionally low organic matter content. In order to improve saline–sodic soils, organic amendments are frequently applied. Our objective was to clarify how different organic amendments affect the diversity and composition of soil microbes, as well as how these factors are related to crop yield. In 2020–2021, we conducted an experiment with different organic amendments. The treatments included the application of crop residue incorporation (SR), lignite humic acid (LHA; 6 ton/ha), or cow manure (FM; 30 ton/ha), and a control (CK). The results show that, compared with CK, the content of SOM in soil treated with organic amendments increased by 5.3–7.4 g/kg; the available potassium (AK) of the LHA treatment was significantly higher than that of the FM and SR treatments by 32.17 and 42.79 mg/kg, respectively; and the available phosphorus (AP) of the LHA treatment was significantly higher than that of the SR treatment by 7.19 mg/kg. The pH and EC1:5 values of the LHA treatment were significantly lower than those of CK by 1.36 units and 0.2 mS/cm, respectively. The application of organic amendments and changes in environmental conditions also significantly affected community structure and increased soil microbial richness and diversity. SR treatment increased the abundance of Acidobacteria. Further FAPROTAX (Functional Annotation of Prokaryotic Taxa) analysis showed that organic amendments can increase the abundance of microbes involved in the carbon and nitrogen cycle processes, such as aerobic_ammonia_oxidation, aerobic_chemoheterotrophy, nitrification, etc., which increases the kernel number per row and increases crop yield. LHA can increase the microbial abundance of the nitrogen cycle and reduce soil carbon mineralization, while also increasing soil nutrients and crop yield. This study provides a comprehensive understanding of the application of organic amendments in saline–sodic cultivated land.

Abstract Four kinds of cryptomelane-type octahedral molecular sieve (OMS)-2-X (the X represents the molar ratio of KMnO4/MnAc2) were prepared as catalytic materials for ozone decomposition through a one-step hydrothermal reaction of KMnO4 and MnAc2, by changing their molar ratios. These samples were characterized by N2 adsorption–desorption, X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), temperature programmed reduction by H2 (H2-TPR) and X-ray photoelectron spectroscopy (XPS). Among them, the OMS-2-0.7 sample showed the best O3 conversion of 92% under high relative humidity (RH) of 90% and gas hourly space velocity of 585,000 h−1. This was accordingly thought as a possible way for purifying ozone-containing waste gases under high RH atmospheres. The efficiency of ozone decomposition of the prepared OMS-2-X sample was found to be related to specific surface area, particle size, surface oxygen vacancies, and Mn3+ cation amounts. The one-step hydrothermal synthesis was shown to be a simple method to prepare the considerably active OMS-2 solids for ozone decomposition.

Background Saline-sodic soils are widely distributed in arid and semi-arid regions around the world. High levels of salt and sodium inhibit the growth and development of crops. However, there has been limited reports on both osmotic potential in soil solutions (OPss) and characteristics of Na+ and K+ absorption in rice in saline-sodic soils under various amendments application. Methods A field experiment was conducted between 2009 and 2017 to analyze the influence of amendments addition to saline-sodic soils on rice growth and yield. Rice was grown in the soil with no amendment (CK), with desulfurization gypsum (DG), with sandy soil (SS), with farmyard manure (FM) and with the mixture of above amendments (M). The osmotic potential in soil solution, selective absorption of K+ over Na+ (SA), selective transport of K+ over Na+ (ST), the distribution of K+ and Na+and yield components in rice plants were investigated. Results The results indicated that amendments application have positive effects on rice yield. The M treatment was the best among the tested amendments with the highest rice grain yield. M treatment increased the OPss values significantly to relieve the inhibition of the water uptake by plants. Additionally, the M treatment significantly enhanced K+ concentration and impeded Na+ accumulation in shoots. SA values were reduced while ST values were increased for all amendments. In conclusion, a mixture of desulfurization gypsum, sandy soil and farmyard manure was the best treatment for the improvement of rice growth and yield in the Songnen Plain, northeast China.

Background/Aims: New strategies are required to combat neuronal ischemia-reperfusion injuries. K6PC-5 is a novel sphingosine kinase 1 (SphK1) activator whose potential activity in neuronal cells has not yet been tested. Methods: Cell survival and necrosis were assessed with a Cell Counting Kit-8 assay and lactate dehydrogenase release assay, respectively. Mitochondrial depolarization was tested by a JC-1 dye assay. Expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) signaling components were examined by quantitative real-timePCR and western blotting. Results: K6PC-5 protected SH-SY5Y neuronal cells and primary murine hippocampal neurons from oxygen glucose deprivation/re-oxygenation (OGDR). K6PC-5 activated SphK1, and SphK1 knockdown by targeted short hairpin RNA (shRNA) almost completely abolished K6PC-5-induced neuronal cell protection. Further work showed that K6PC-5 inhibited OGDR-induced programmed necrosis in neuronal cells. Importantly, K6PC-5 activated Nrf2 signaling, which is downstream of SphK1. Silencing of Nrf2 by targeted shRNA almost completely nullified K6PC-5-mediated neuronal cell protection against OGDR. Conclusion: K6PC-5 activates SphK1-Nrf2 signaling to protect neuronal cells from OGDR. K6PC-5 might be a promising neuroprotective strategy for ischemia-reperfusion injuries.

Abstract Background Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective function of OI in hydrogen peroxide (H2O2)-treated neuronal cells. Methods SH-SY5Y neuronal cells and epigenetically de-repressed (by TSA treatment) primary murine neurons were treated with OI and/or H2O2. Nrf2 pathway genes were examined by Western blotting assay and real-time quantitative PCR analysis. Neuronal cell death was tested by the LDH and trypan blue staining assays. Apoptosis was tested by TUNEL and Annexin V assays. Results In SH-SY5Y neuronal cells and primary murine neurons, OI activated Nrf2 signaling, causing Keap1-Nrf2 disassociation, Nrf2 protein stabilization and nuclear translocation, as well as expression of Nrf2-regulated genes (HO1, NQO1 and GCLC) and ninjurin2 (Ninj2). Functional studies showed that OI attenuated H2O2-induced reactive oxygen species (ROS) production, lipid peroxidation and DNA damage as well as neuronal cell death and apoptosis. shRNA-mediated knockdown, or CRISPR/Cas9-induced knockout of Nrf2 almost abolished OI-induced neuroprotection against H2O2. Keap1 is the primary target of OI. Keap1 knockout by CRISPR/Cas9 method mimicked and abolished OI-induced actions in SH-SY5Y cells. Introduction of a Cys151S mutant Keap1 in SH-SY5Y cells reversed OI-induced Nrf2 activation and anti-H2O2 neuroprotection. Conclusions OI activates Keap1-Nrf2 signaling to protect SH-SY5Y cells and epigenetically de-repressed primary neurons from H2O2 in vitro.

Background Forage production in the saline-sodic soil of the western Songnen Plain Northeast China depends on irrigation. Therefore, the water use efficiency (WUE) and soil chemical properties are key factors in the overall forage productivity in this water scarce region. Improving forage yield, WUE, and soil properties under irrigation are very important for food and ecological security in this water-deficient region. Additionally, a suitable irrigation schedule for this region is necessary. Methods A field experiment was conducted between 2015 and 2018 to evaluate the effects of irrigation on artificial grassland productivity and the changes in soil chemical properties as well as to plan a reliable irrigation schedule for the western Songnen Plain. Eight irrigation treatments were designed, which depended on the three growth stages of alfalfa. The shoot height (SH), the chlorophyll content (SPAD), the dry yield (DM), the ratio of stem to leaves (SLR), the WUE, the changes in the chemical properties of the soil, and precipitation and evaporation were investigated. Results The SH, DM, WUE, and SLR were significantly increased by irrigation (P < 0.01). However, the SPAD resulting from irrigation was not significantly higher than the SPAD of CK (no irrigation) (P < 0.05). In addition, the soil chemical properties at the depth of 0–100 cm were significantly decreased by irrigation P (0.05). For example, the soil electrical conductivity, sodium absorption ratio, and total alkalization were reduced 182–345 μS cm−1, 8.95–9.00 (mmolc/L)1/2, and 3.29–4.65 mmolc L−1 by different irrigation treatments, respectively. Finally, considering the highest WUE of I5 (irrigation at branch stage) (2.50 kg m−3), relative high DM of I5 (787.00 g m−2), the precipitation, the evaporation, the water resources, and the changes of the soil’s chemical properties, 236.50 mm of irrigation water was recommended at the branching stage of alfalfa for the western Songnen Plain, Northeast China.

ObjectiveTraumatic brain injury (TBI) occurs commonly in children. Repeat computed tomography (CT) follow up of TBI patients is often scheduled to identify progressive hemorrhagic injury (PHI). However, the utility of repeated CT scans, especially in children with mild TBI [Glasgow Coma Scale (GCS) scores of 13–15], has been debated. The purposes of the present study were to identify clinical predictors of PHI in children with mild TBI and to clarify relevant clinical factors via radiological examination.MethodsFrom 2014 to 2016, we retrospectively enrolled children

Over three million hectares of salt-affected soils characterized with high salinity and sodicity caused serious land degradation in Songnen Plain, northeast China. Soil salinity–sodicity heterogeneous distribution under microtopography is usually influenced by several environmental factors. The side direction movement of soil water driven by water from depression is the key factor that aggravates the soil salinization under microtopography in dry condition. In this study, the differences in surface soil salinity–sodicity (0–10 cm) between dry year and wet year were compared, and the relationship between soil salinity–sodicity and environment factors such as ground elevation, surface ponding time, surface ponding depth, and soil moisture at four soil layers (0–10, 10–30, 30–60, and 60–100 cm) were analyzed using redundancy analysis (RDA) and simple correlation analysis (Pearson analysis) for two different hydrological years. Analyzed soil salinity–sodicity parameters include soluble ions (Na+, K+, Ca2+, Mg2+, CO32−, HCO3−, Cl− and SO42−), salt content (SC), electrical conductivity (EC), sodium adsorption ratio (SAR), and pH. Results showed that values of SAR, Cl−, and SO42− were significantly higher in dry year than in wet year, while Ca2+, Mg2+, K+, and HCO3− showed the opposite results. Values of Na+, CO32−, and EC were significantly higher at higher ground elevation gradient (20–40 cm) in dry year than wet year. Redundancy analysis indicated that spatial distributions and variations of salinity and sodicity in surface soil layer were related with environmental factors of ponding depth, ponding time and ground elevation in wet year, and they were related with ground elevation, ponding depth, ponding time, and soil moisture at 30–60 and 60–100 cm soil layer in dry year. Ponding depth and ground elevation rank first and second as the influential factors of the spatial distribution and variation of soil salinity–sodicity in wet year. However in dry year, primary and secondary influential factors are ground elevation and soil moisture at 60–100 cm soil layer.

In Guangdong province, many hot springs were exploited and developed into popular places for tourist. In addition, hotels have been set up near hot spring sites to attract people, including local citizens, to spend their spare time inside these so-called “spring hotels”. In our study, indoor air quality was investigated in four hot spring hotels in Guangdong province, China. Measured indoor pollutants included CO2, CO, PM10, PM2.5 and Volatile Organic Compounds (VOCs). As the result show, high concentrations of carbon dioxide might be attributed to poor ventilation; and the variations of indoor PM10, PM2.5 concentrations were related to occupants’ activities. Alpha-pinene and toluene were the most common VOC species in the hot spring hotels other than monocyclic aromatic hydrocarbons like Benzene, Toluene, Ethylbenzene and Xylenes (BTEX), which were at medium levels among the reported indoor pollutants. High cancer risk of benzene in the newly decorated rooms should be seriously taken into consideration in the future. Indoor to Outdoor air concentration ratios (I/O) for CO2 and VOCs were higher than 1, indicating their strong indoor sources. Negative correlations were found between indoor CO2 and all the other compounds, and VOCs were shown to be significantly correlated (p < 0.01) to each other, including aromatic hydrocarbons and mono-terpenes. For indoor and outdoor air compounds, correlation coefficients among all compounds did not show a significant correlation, which indicated that these pollutants had different sources. Principal components analysis by SPSS showed that indoor materials, inhabitants’ activities and respiration, cleaning products and outdoor sources were the main sources of indoor detected pollutants in hot spring hotels.

Purpose: To investigate the effect of phentolamine adjuvant therapy on hemodynamics and cardiac function in patients with sepsis-induced myocardial injury. Methods: A total of 96 patients with sepsis-induced myocardial injury between January 2019 and October 2023 admitted in Hangzhou Fuchun Traditional Chinese Orthopedic Hospital, Hangzhou, Zhejiang, China were randomly and equally assigned to control and study groups. The control group received routine treatment while the study group received phentolamine 5 mg/h for 24 h in addition to routine treatment. Blood lactate levels before and after treatment were compared. Intrathoracic blood volume index (ITBVI), systemic vascular resistance index (SVRI), heart rate (HR), mean arterial pressure (MAP), cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP), as well as cardiac index (CI), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD), were also evaluated before and after treatment. Furthermore, 28-day survival rates and intensive care unit (ICU) stay time were compared. Results: The study group showed significantly lower blood lactate levels at 12, 48, and 72 h after treatment compared to control group (p < 0.05). The study group showed significantly higher levels of MAP, ITBVI, SVRI, CI, and LVEF; and significantly lower levels of HR, LVESD, LVEDD, cTnI, and NTproBNP after 7 days than the control group (p < 0.05). No deaths occurred within 7 days after treatment in either group. However, the study group exhibited significantly lower ICU stay time and 28-day mortality than the control group (p < 0.05). Conclusions: Phentolamine adjuvant therapy significantly improves hemodynamics, enhances cardiac function, mitigates myocardial injury, and restores blood lactate levels in patients with sepsis-induced myocardial injury. Longer follow-up would be necessary to evaluate long-term effect and potential complications of phentolamine-adjuvant therapy. [ABSTRACT FROM AUTHOR]