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This study aimed to investigate the efficacy of piezosurgery (PI) in promoting immediate clotting after flapless extraction in patients undergoing dual antiplatelet therapy (DAPT).In this randomized controlled trial, 80 DAPT patients were equally divided into the PI and turbine handpiece (TH) groups. Accordingly, flapless extraction of a single tooth using PI or TH was performed on each patient, and the immediate clotting status was evaluated. The results of the preoperative hematological examinations, surgery-related variables and postoperative complications were recorded for analysis.Both groups presented with low platelet aggregation and similar coagulation functions. The PI group exhibited a higher proportion of patients with normal intra-alveolar clotting (≤30 min) (70% vs. 40%, P = 0.007) and fewer intraoperative complications (25% vs. 47.5%, P = 0.036) than that in the TH group. Logistic regression analysis indicated that the applied instrument was an independent risk factor for prolonged immediate bleeding (odds ratio = 3.10, 95% confidence interval: 1.20-8.00, P = 0.019). Intergroup differences were insignificant in terms of the other surgery-related variables and postoperative complications, except for the longer surgical duration in the PI group.The application of PI may contribute to better immediate clotting in DAPT patients after flapless extraction compared with the use of TH.

Background: The incidence of oral squamous cell carcinoma (OSCC) is increasing, with an estimated 369,000 new patients each year worldwide. Surgery is the primary treatment modality for early-stage OSCC, but there is scant evidence to prove the value of elective neck dissection (END) for relatively small early-stage OSCC. This study aimed to identify factors predicting survival for patients with clinical stage T1N0M0 (cT1N0M0) OSCC and whether up-front END improved survival. Patients and Methods: Patients with cT1N0M0 OSCC who underwent tumor resection with or without END were identified and extracted from the SEER database. Kaplan-Meier survival analysis was used to assess overall survival and disease-specific survival. Prognostic factors were determined using Cox regression analysis. Results: A total of 5,752 patients with cT1N0M0 OSCC were extracted, of whom 2,194 (38.1%) underwent tumor resection surgery with concurrent END and 3,558 (61.9%) underwent only tumor resection. In a multivariate Cox analysis, a relatively advanced age (>62 years) and relatively high pathologic grade were the significant negative predictors, but married status (hazard ratio, 0.709; P=.006) and undergoing END (hazard ratio, 0.708; PConclusions: Patients with cT1N0M0 OSCC gain significant overall and disease-specific survival benefit from END.

Background:Impaction of mandibular third molars (M3) is one of the most common diseases. Extraction of M3 usually exacerbates osseous defects at the distal aspect of the adjacent second molar (M2). BonMaker® ATB has been cited as a novel autogenous bone grafting material. The aim of this pilot study was to introduce a novel method for repairing the distal osseous defects of M2 after the surgical removal of M3 with autogenous tooth graft powder (ATGP).Method:A total of five patients were enrolled in this prospective split-mouth observational clinical pilot study. Third molars were extracted unilaterally from patients with proximal alveolar bone loss ≥5 mm of M3. The ATGP was prepared chairside and randomly implanted in one of the M3 extraction sockets, and the other side was treated with a blank and considered the control site. Patients were followed up at six months.ResultsThe five patients included three males and two females. Their ages ranged from 25 to 30 years, with a median of 27 years. Primary wound healing without complications was achieved in all the patients. There was a greater tendency for swelling of the cheeks and trismus to occur at the experimental site on the third postoperative day. Compared with the control site, the experimental site exhibited progressive bone filling and ossification in the sixth postoperative month. Moreover, the probing pocket depth of the experimental site was lower than that of the control site.ConclusionThe results of this study demonstrate that ATGP effectively and economically repairs distal osseous defects of M2. Further study is required to validate the effectiveness with a larger study population.

Conservation laws and the associated hydrodynamic modes have important consequences on the growth of higher Rényi entropies in isolated quantum systems. It has been shown in various random unitary circuits and Hamiltonian systems that the dynamics of the Rényi entropies in the presence of a U(1) symmetry obey $S^{(n\geq 2)}(t) \propto t^{1/z}$, where $z$ is identified as the dynamical exponent characterizing transport of the conserved charges. Here, however, we demonstrate that this simple identification may not hold in certain quantum systems with kinetic constraints. In particular, we study two types of U(1)-symmetric quantum automaton circuits with XNOR and Fredkin constraints, respectively. We find numerically that while spin transport in both models is subdiffusive, the second Rényi entropy grows diffusively in the XNOR model, and superdiffusively in the Fredkin model. For systems with XNOR constraint, this distinction arises since the spin correlation function can be attributed to an emergent tracer dynamics of tagged particles, whereas the Rényi entropies are constrained by collective transport of the particles. Our results suggest that care must be taken when relating transport and entanglement entropy dynamics in generic quantum systems with conservation laws., 6 pages, 7 figures

Quantum many-body scar states are special eigenstates of nonintegrable models with distinctive entanglement features that give rise to infinitely long-lived coherent dynamics under quantum quenches from certain initial states. We elaborate on a construction of quantum many-body scar states in which they emerge from Einstein-Podolsky-Rosen (EPR) states in systems with two layers, wherein the two layers are maximally entangled. We apply this construction to spin systems as well as systems of itinerant fermions and bosons and demonstrate how symmetries can be harnessed to enhance its versatility. We show that several well-known examples of quantum many-body scars, including the tower of states in the spin-1 XY model and the $\eta$-pairing states in the Fermi-Hubbard model, can be understood within this formalism. We also demonstrate how an {\it infinite} tower of many-body scar states can emerge in bilayer Bose-Hubbard models with charge conservation., Comment: 19 pages, 8 figures

We show that a class of $\mathcal{PT}$ symmetric non-Hermitian Hamiltonians realizing the Yang-Lee edge singularity exhibits an entanglement transition in the long-time steady state evolved under the Hamiltonian. Such a transition is induced by a level crossing triggered by the critical point associated with the Yang-Lee singularity and hence is first-order in nature. At the transition, the entanglement entropy of the steady state jumps discontinuously from a volume-law to an area-law scaling. We exemplify this mechanism using a one-dimensional transverse field Ising model with additional imaginary fields, as well as the spin-1 Blume-Capel model and the three-state Potts model. We further make a connection to the forced-measurement induced entanglement transition in a Floquet non-unitary circuit subject to continuous measurements followed by post-selections. Our results demonstrate a new mechanism for entanglement transitions in non-Hermitian systems harboring a critical point., Updated to published version

A path for experimentally building realistic models of quantum spin liquids is laid out: The construction is based on superconducting wire arrays and could lead to topological qubits.

Malignant myoepithelioma of the head and neck (HNMM) is a rare malignancy, and its characteristics and survival rates have not been well-defined. This study aimed to define the epidemiology of HNMM and identify the prognostic factors associated with the disease. Data on all patients diagnosed with HNMM between 1991 and 2016 were gathered from the Surveillance Epidemiology and End Results (SEER) database. The demographics, clinicopathological characteristics, treatment, and prognoses of the patients were described. Cox regression analysis was used to identify the prognostic factors, and the prognostic nomograms for overall survival (OS) and disease-specific survival (DSS) were constructed. A total of 333 cases of HNMM were identified. The average age at diagnosis was 60.6 years, and 50.1% of the patients were men. After diagnosis, 46.2% of patients underwent surgery alone, 43.5% of patients underwent surgery and radiotherapy, and 3.6% of patients received only radiotherapy. Survival analysis showed that the 5-year OS and DSS for all HNMM patients were 69.7 and 82.1%, respectively. In the multivariate analysis model, the undifferentiated pathological grade (P

Quantum many-body scars (QMBS) constitute a new quantum dynamical regime in which rare "scarred" eigenstates mediate weak ergodicity breaking. One open question is to understand the most general setting in which these states arise. In this work, we develop a generic construction that embeds a new class of QMBS, rainbow scars, into the spectrum of an arbitrary Hamiltonian. Unlike other examples of QMBS, rainbow scars display extensive bipartite entanglement entropy while retaining a simple entanglement structure. Specifically, the entanglement scaling is volume-law for a random bipartition, while scaling for a fine-tuned bipartition is sub-extensive. When internal symmetries are present, the construction leads to multiple, and even towers of rainbow scars revealed through distinctive non-thermal dynamics. Remarkably, certain symmetries can lead rainbow scars to arise in translation-invariant models. To this end, we provide an experimental road map for realizing rainbow scar states in a Rydberg-atom quantum simulator, leading to coherent oscillations distinct from the strictly sub-volume-law QMBS previously realized in the same system., 5+5 pages, 4+4 figures

We explore a class of random tensor network models with "stabilizer" local tensors which we name Random Stabilizer Tensor Networks (RSTNs). For RSTNs defined on a two-dimensional square lattice, we perform extensive numerical studies of entanglement phase transitions between volume-law and area-law entangled phases of the one-dimensional boundary states. These transitions occur when either (a) the bond dimension $D$ of the constituent tensors is varied, or (b) the tensor network is subject to random breaking of bulk bonds, implemented by forced measurements. In the absence of broken bonds, we find that the RSTN supports a volume-law entangled boundary state with bond dimension $D\geq3$ where $D$ is a prime number, and an area-law entangled boundary state for $D=2$. Upon breaking bonds at random in the bulk with probability $p$, there exists a critical measurement rate $p_c$ for each $D\geq 3$ above which the boundary state becomes area-law entangled. To explore the conformal invariance at these entanglement transitions for different prime $D$, we consider tensor networks on a finite rectangular geometry with a variety of boundary conditions, and extract universal operator scaling dimensions via extensive numerical calculations of the entanglement entropy, mutual information and mutual negativity at their respective critical points. Our results at large $D$ approach known universal data of percolation conformal field theory, while showing clear discrepancies at smaller $D$, suggesting a distinct entanglement transition universality class for each prime $D$. We further study universal entanglement properties in the volume-law phase and demonstrate quantitative agreement with the recently proposed description in terms of a directed polymer in a random environment., Comment: Updated to published version

We study a generalization of the two-dimensional transverse-field Ising model, combining both ferromagnetic and antiferromagnetic two-body interactions, that hosts exact global and local ${\mathbb{Z}}_{2}$ gauge symmetries. Using exact diagonalization and stochastic series expansion quantum Monte Carlo methods, we confirm the existence of the topological phase in line with previous theoretical predictions. Our simulation results show that the transition between the confined topological phase and the deconfined paramagnetic phase is of first order, in contrast to the conventional ${\mathbb{Z}}_{2}$ lattice gauge model in which the transition maps onto that of the standard Ising model and is continuous. We further generalize the model by replacing the transverse field on the gauge spins with a ferromagnetic $XX$ interaction while keeping the local gauge symmetry intact. We find that the ${\mathbb{Z}}_{2}$ topological phase remains stable, while the paramagnetic phase is replaced by a ferromagnetic phase. The topological-ferromagnetic quantum phase transition is also of first order. For both models, we discuss the low-energy spinon and vison excitations of the topological phase and their avoided level crossings associated with the first-order quantum phase transitions.

We develop a general theory for two-dimensional (2D) anomalous Floquet higher-order topological superconductors (AFHOTSC), which are dynamical Majorana-carrying phases of matter with no static counterpart. Despite the triviality of its bulk Floquet bands, an AFHOTSC generically features the simultaneous presence of corner-localized Majorana modes at both zero and $\pi/T$ quasi-energies, a phenomenon beyond the scope of any static topological band theory. We show that the key to AFHOTSC is its unavoidable singular behavior in the phase spectrum of the bulk time-evolution operator. By mapping such evolution-phase singularities to the stroboscopic boundary signatures, we classify all 2D AFHOTSCs that are protected by a rotation group symmetry in symmetry class D. We further extract a higher-order topological index for unambiguously predicting the presence of Floquet corner Majorana modes, which we confirm numerically. Our theory serves as a milestone towards a dynamical topological theory for Floquet superconducting systems., Comment: 6 pages, 4 figures

Controllable Rydberg atom arrays have provided new insights into fundamental properties of quantum matter both in and out of equilibrium. In this work, we study the effect of experimentally relevant positional disorder on Rydberg atoms trapped in a 2D square lattice under antiblockade (facilitation) conditions. We show that the facilitation conditions lead the connectivity graph of a particular subspace of the full Hilbert space to form a 2D Lieb lattice, which features a singular flat band. Remarkably, we find three distinct regimes as the disorder strength is varied: a critical regime, a delocalized but nonergodic regime, and a regime with a disorder-induced flat band. The critical regime's existence depends crucially upon the singular flat band in our model, and is absent in any 1D array or ladder system. We propose to use quench dynamics to probe the three different regimes experimentally.

Clifford circuits are insufficient for universal quantum computation or creating $t$-designs with $t\ge 4$. While the entanglement entropy is not a telltale of this insufficiency, the entanglement spectrum is: the entanglement levels are Poisson-distributed for circuits restricted to the Clifford gate-set, while the levels follow Wigner-Dyson statistics when universal gates are used. In this paper we show, using finite-size scaling analysis of different measures of level spacing statistics, that in the thermodynamic limit, inserting a single T $(\pi/8)$ gate in the middle of a random Clifford circuit is sufficient to alter the entanglement spectrum from a Poisson to a Wigner-Dyson distribution., Comment: 14 pages, 8 figures; Submission to SciPost

We explore thermalization and quantum dynamics in a one-dimensional disordered SU(2)-symmetric Floquet model, where a many-body localized phase is prohibited by the non-abelian symmetry. Despite the absence of localization, we find an extended nonergodic regime at strong disorder where the system exhibits nonthermal behaviors. In the strong disorder regime, the level spacing statistics exhibit neither a Wigner-Dyson nor a Poisson distribution, and the spectral form factor does not show a linear-in-time growth at early times characteristic of random matrix theory. The average entanglement entropy of the Floquet eigenstates is subthermal, although violating an area-law scaling with system sizes. We further compute the expectation value of local observables and find strong deviations from the eigenstate thermalization hypothesis. The infinite temperature spin autocorrelation function decays at long times as $t^{-\beta}$ with $\beta < 0.5$, indicating subdiffusive transport at strong disorders., Comment: updated to accepted version

Background Treatment of clinical N0 neck tumours is controversial in early-stage oral squamous cell carcinoma (OSCC), possibly because T1N0M0 and T2N0M0 merge together at early stages. The purposes of this study were to compare survival outcomes only for T2N0M0 cases based upon treatment elective neck dissection versus neck observation. Methods T2N0M0 OSCC cases were identified in the Surveillance, Epidemiology, and End Results database of the United States National Cancer Institute between 2004 and 2015. Survival curves for different variable values were generated using Kaplan-Meier estimates and compared using the log-rank test. Variables that achieved significance at P Results A total of 2857 patients were selected, and 2313 cases were available for disease specific survival (DSS). The 5-year and 10-year overall survival (OS) were 66.7 and 46% for patients receiving elective neck dissection (END), respectively, and 56.4 and 37.2% for patients with neck observation (P < 0.0001). The 5-year and 10-year DSS were 73.6 and 64% for the END group, respectively, versus 64.5 and 54.5% for the neck observation group (P < 0.0001). More importantly, performing END was independently associated with favourable DSS and OS for patients with T2N0M0 OSCC [hazard ratio (HR) = 0.769, P = 0.0069 for DSS; HR = 0.829, P = 0.0031 for OS, neck observation group as reference] according to multivariate survival analysis. Conclusion END is recommended for T2N0M0 OSCC cases and it is associated with improved DSS and OS.

BACKGROUND: The purpose of this study was to elucidate the clinicopathological characteristics of patients with lymphoepithelial carcinoma of salivary gland (LEC-SG) and determine the factors associated with survival. METHODS: A total of 179 LEC-SG patients from the Surveillance, Epidemiology, and End Results (SEER) database between 1975 to 2016 were included. The clinicopathological characteristics and overall survival of LEC-SG patients were described, and the features affecting prognosis were further determined using Kaplan-Meier Curves and Cox survival analysis. RESULTS: The median overall survival of LEC-SG patients was 206 months, and the 1-, 5-, 10- and 20-year survival rates were 91.0%, 80.2%, 66.4%, and 37.6%, respectively. The prognoses were significantly associated with age, ethnicity, marital status, tumor invasion, as well as lymph node metastases [P60 years) and lymph node metastases were independently associated with poor survival (P

Background Malignant tumours of the temporomandibular joint (MTTMJ) are extremely rare. Studies describing its unique epidemiology, clinicopathological features, treatment and prognosis comprehensively are limited. To address these issues, current investigation was performed. Methods A retrospective research was carried out by using population-based data from the Surveillance, Epidemiology, and End Results database (1973–2016). Results Data for a total of 734 patients, including 376 men and 358 women, was found. The median age was 47 years. The 5-year and 10-year disease specific survival (DSS) rates were 69.2 and 63.6%, respectively. Significant differences in DSS were found according to age, race, tumour type, AJCC/TNM stage, surgery, radiotherapy, chemotherapy and different treatment modalities (P 44 years and AJCC stage III and IV were associated with poor DSS. Conclusion MTTMJ was mostly found in white people with a median age of 47 years without any sex predominance. Patient’s age and AJCC stage was independent predictor of DSS.

Background To investigate the clinicopathological characteristics of head and neck small cell carcinoma (H&NSmCC) and identify prognostic factors on the basis of the Surveillance, Epidemiology and End Results (SEER) database. Methods Total of 789 primary cases from 1973 to 2016 were included. Univariate and multivariate analyses were performed to identify independent prognostic indicators. An H&NSmCC-specific nomogram was constructed and compared with the AJCC staging system by calculating the time-dependent area under the curve (AUC) of the receiver operating characteristic (ROC) curves. Results The incidence of H&NSmCC peaked during the period of 50 to 70 years old, and the most frequent location was the salivary gland. The 5-year disease specific survival (DSS) was 27%. In the multivariate survival analysis, AJCC III + IV stage [HR = 2.5, P = 0.03, I + II stage as Ref], positive N stage [HR = 1.67, P = 0.05, negative N stage as Ref], positive M stage [HR = 4.12, P = 0.000, negative M stage as Ref] and without chemotherapy [HR = 0.56, P = 0.023, received chemotherapy as Ref] were independently associated with DSS. The H&NSmCC-specific nomogram was built based on the independent prognostic indicators. The nomogram demonstrated better predictive capacity than the AJCC staging system for 5-year DSS [(AUC: 0.75 vs 0.634; Harrell’s C-index (95% CI): 0.7(0.66–0.74) vs 0.59(0.55–0.62), P Conclusion N stage, M stage, AJCC stage and chemotherapy were independent prognostic indicators included in the prognostic nomogram model, which can better predict the survival of H&NSmCC than the AJCC staging system.

We use Nielsen's geometric approach to quantify the circuit complexity in a one-dimensional Kitaev chain across a topological phase transition. We find that the circuit complexities of both the ground states and non-equilibrium steady states of the Kitaev model exhibit non-analytical behaviors at the critical points, and thus can be used to detect both {\it equilibrium} and {\it dynamical} topological phase transitions. Moreover, we show that the locality property of the real-space optimal Hamiltonian connecting two different ground states depends crucially on whether the two states belong to the same or different phases. This provides a concrete example of classifying different gapped phases using Nielsen's circuit complexity. We further generalize our results to a Kitaev chain with long-range pairing, and discuss generalizations to higher dimensions. Our result opens up a new avenue for using circuit complexity as a novel tool to understand quantum many-body systems., 4.5+5 pages, 4+3 figures

We introduce the notion of combinatorial gauge symmetry -- a local transformation that includes single spin rotations plus permutations of spins (or swaps of their quantum states) -- that preserve the commutation and anti-commutation relations among the spins. We show that Hamiltonians with simple two-body interactions contain this symmetry if the coupling matrix is a Hadamard matrix, with the combinatorial gauge symmetry being associated to the automorphism of these matrices with respect to monomial transformations. Armed with this symmetry, we address the physical problem of how to build quantum spin liquids with physically accessible interactions. In addition to its intrinsic physical significance, the problem is also tied to that of how to build topological qubits., Comment: Updated to published version

We extend the notion of fragile topology to periodically-driven systems. We demonstrate driving-induced fragile topology in two different models, namely, the Floquet honeycomb model and the Floquet $\pi$-flux square-lattice model. In both cases, we discover a rich phase diagram that includes Floquet fragile topological phases protected by crystalline rotation or mirror symmetries, Floquet Chern insulators, and trivial atomic phases, with distinct boundary features. Remarkably, the transitions between different phases can be feasibly achieved by simply tuning the driving amplitudes, which is a unique feature of driving-enabled topological phenomena. Moreover, corner-localized fractional charges are identified as a ``smoking-gun'' signal of fragile topology in our systems. Our work paves the way for studying and realizing fragile topology in Floquet systems., Comment: 16 pages, 7 figures

Introduction. Chondrocyte apoptosis is considered one of the pathogenic factors of osteoarthritis (OA), but its importance in the pathogenesis of OA remains unclear. Recent research adds progress to the knowledge that the mitochondrial signaling pathway mediates chondrocyte apoptosis in OA. Method. Rat chondrocyte exposed to H2O2 was used as the experimental oxidative stress model. Chondrocyte viability was tested by cell counting kit-8 (CCK-8) assay. Cell apoptosis and ROS were tested by flow cytometry. Contents of malondialdehyde (MDA), catalase (CAT), caspase-3, caspase-9, cytochrome C, superoxide dismutase (SOD)-2, and adenosine triphosphate (ATP) were evaluated by biochemical detection. The expressions of related genes and proteins were assessed by quantitative polymerase chain reaction (qPCR) and western blot. Results. H2O2 provokes oxidative stress and decreases the viability of chondrocyte, which leads to the release of cytochrome C and inhibition of SOD-2 activity. The damage of mitochondrion disturbs the energy metabolism of chondrocyte and eventually induces chondrocyte apoptosis through the mitochondrial pathway. Furthermore, pretreated with anglicasinensis polysaccharide (ASP) or caspase inhibitors increase the expression of Bcl-2 and Bcl-xL but do not work for the expression of Bax and Bad. Conclusion. Oxidative stress induces chondrocyte apoptosis through caspase-dependent and caspase-independent mitochondrial pathways. ASP protects chondrocyte from H2O2-induced oxidative stress and subsequent cell injury through its antioxidant effect by inhibiting the caspase pathway.

Mouse incisors are capable of continuously growing due to the renewal of dental epithelium stem cells and mesenchymal stem cells residing at the proximal ends. The transcription factor Sox9 plays important roles in maintaining the stem cells of hair follicles, retinal progenitor cells and neural crest stem cells. Whether Sox9 is involved during mouse incisor development is not reported yet. In this study, we examined the expression pattern of Sox9 during mouse incisor development by in situ hybridization and immunohistochemistry. Sox9 mRNA and protein showed similar expression pattern from embryonic day (E) 13.5 to postnatal (PN) day 10. At E13.5 and E14.5, Sox9 was strongly expressed in the dental epithelium. At E16.5, Sox9 started to be detected in the mesenchymal cells within the dental pulp, especially the dental pulp cells that adjacent to the labial cervical loop. Similarly with E14.5, Sox9 was strongly detected in the labial cervical loop, including the basal epithelium, the stellate reticulum and the outer enamel epithelium from E16.5 to PN10. The mesenchyme adjacent to the labial cervical loop also showed strong signal of Sox9. The spatiotemporal expression of Sox9 suggested its possible involvement during mouse incisor development.

This study investigated voriconazole (VRC) unbound plasma concentration and its relationship with adverse drug reactions (ADRs) in patients with malignant hematologic disease. Plasma samples were collected from patients or spiked in vitro. A time-saving rapid equilibrium dialysis assay was used for the separation of unbound and bound VRC, following a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis method for drug concentration detection. Liver function and treatment details were collected from the electronic medical records of patients. Protein concentration was determined according to instructions. VRC plasma protein binding rate (PPB) in patient is significantly higher [69.5 ± 6.2%] than that in in-vitro samples, influenced by total drug concentration (Ct), plasma protein concentration, and protein type. The α1-acid glycogen (AAG) has the highest affinity with VRC. Relationship between total PPB of VRC with PPB of individual protein is not a simple addition, but a compressive combination. Unbound drug concentration (Cu) of VRC shows significant relationships with Ct, protein concentration, AST level, metabolism type of CYP2C19 and co-administration of high PPB medicines. Unbound plasma concentration of VRC shows a more sensitive relationship with ADRs than Ct.

We study one-dimensional spin-1/2 models in which strict confinement of Ising domain walls leads to the fragmentation of Hilbert space into exponentially many disconnected subspaces. Whereas most previous works emphasize dipole moment conservation as an essential ingredient for such fragmentation, we instead require two commuting U(1) conserved quantities associated with the total domain-wall number and the total magnetization. The latter arises naturally from the confinement of domain walls. Remarkably, while some connected components of the Hilbert space thermalize, others are integrable by Bethe ansatz. We further demonstrate how this Hilbert-space fragmentation pattern arises perturbatively in the confining limit of $\mathbb{Z}_2$ gauge theory coupled to fermionic matter, leading to a hierarchy of time scales for motion of the fermions. This model can be realized experimentally in two complementary settings., Comment: Updated to published version

Proton pump inhibitors (PPIs) are a group of gastric acid suppressing drugs, that are strong and long-lasting inhibitors of the proton pump (referred to as acid pump antagonists). They work by irreversibly blocking the H+/K+ ATPase. PPIs are used to treat peptic ulcer disease, gastroesophageal reflux disease, nonsteroidal anti-inflammatory drug-induced gastrointestinal lesions, and Zollinger-Ellison syndrome. The structure of PPIs are similar, they all have a similar core with a sulphur atom chiral center combined with different substituent groups. In relation to the sulphur atom chiral center, the pharmacodynamics, pharmacokinetics are diverse between the racemates and their stereoisomers, which are mainly observed in the following aspects. In regards to pharmacodynamics, the main features of the similarities and differences involve the duration of drug action and the ability to control nocturnal gastric acid secretion. In regards to pharmacokinetic and metabolic pathways, the similarities and differences are measured by the pharmacokinetic and metabolic parameters. These parameters including time to maximal plasma concentration (Tmax), maximal plasma concentration (Cmax), area under the plasma concentration curve (AUC), bioavailability (F) and elimination half-life (t1/2). Compare to the racemates, the stereoisomer (the R-one or the S-one) exhibited less individual differences and better efficiency in acid secretion control. Nowadays, the main reason for PPI development is not so much in relation to the therapeutic effects of these drugs, but is more in the realm of providing longer duration, faster time of onset and better nocturnal gastric acid secretion control. Structure improvement and development of stereoisomer drugs are the two directions for the new generation PPIs. Esomeprazole, dexlansoprazole, ilaprazole and revaprazan, have recently been developed on these principles. However, due to debates on the necessity and superiority of these new drugs, more validation studies are needed.

Background: P53 has been reported to be involved with tumorigenesis and has also been implicated as a significant biomarker in oral squamous cell carcinoma(OSCC). However, the diagnostic value of p53 antibodies remains controversial; hence, we comprehensively and quantitatively assessed the potential in the present systematic review. Materials and Methods : A comprehensive search was performed using PubMed and Embase, up to October 31, 2014, without language restriction. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and symmetric summary receiver operating characteristic (SROC) curves. Results: Of 150 studies initially identified, 7 eligible regarding serum p53 antibodies met the inclusion criteria. Some 85.7% (6/7) were of relatively high quality (QUADAS score≥7). The summary estimates for quantitative analysis of serum p53 antibody in the diagnosis of squamous cell carcinoma were: PLR 2.06 [95% confidence interval (CI) : 1.35-3.15], NLR 0.85 (95%CI: 0.80- 0.90) and DOR 2.47 (95%CI: 1.49- 4.12). Conclusions: This meta-analysis suggests that the use of s-p53-antibodies has potential diagnostic value with relatively high sensitivity and specificity for OSCC particularly with serum specimens for discrimination of OSCCs from healthy controls. However, its discrimination power is not perfect because of low sensitivity. Keywords: OSCC - diagnosis - P53 antibodies - serum biomarker - meta-analysis

In this paper, three ways of technological English teaching for automation specialty are studied, which consist of specialized English course, bilingual course and embedding bilingual teaching. By the detailed comparison and analysis of their respective adaptable properties, some possible suggestions on how to select the more appropriate teaching ways are provided for different students who major in the automation specialty but have specific needs of their own. A case study is then demonstrated for the teaching-way selections for the technological English learning in the automation specialty from Tianjin University of Technology and Education. As a result, this study may supply with a new idea of technological English teaching for educators in the automation specialty.

We develop a tensor network technique that can solve universal reversible classical computational problems, formulated as vertex models on a square lattice [Nat. Commun. 8, 15303 (2017)]. By encoding the truth table of each vertex constraint in a tensor, the total number of solutions compatible with partial inputs/outputs at the boundary can be represented as the full contraction of a tensor network. We introduce an iterative compression-decimation (ICD) scheme that performs this contraction efficiently. The ICD algorithm first propagates local constraints to longer ranges via repeated contraction-decomposition sweeps over all lattice bonds, thus achieving compression on a given length scale. It then decimates the lattice via coarse-graining tensor contractions. Repeated iterations of these two steps gradually collapse the tensor network and ultimately yield the exact tensor trace for large systems, without the need for manual control of tensor dimensions. Our protocol allows us to obtain the exact number of solutions for computations where a naive enumeration would take astronomically long times., Updated version with more careful discussions on the distribution of bond dimensions over random instances, as well as distinguishing between average versus typical behavior. 13.5 pages, 13 figures