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Abstract Photon management strategies are crucial to improve the efficiency of perovskite thin film (PTF) solar cell. In this work, a nano-cone (NC) based 2D photonic nanostructure is designed and simulated aiming at achieve superior light trapping performance by introducing strong light scattering and interferences within perovskite active layer. Compared to the planar PTF solar cell, the NC nanostructured device with 45 degrees half apex angle obtains highest short-circuit current density, which improved over 20% from 15.00 mA/cm2 to 18.09 mA/cm2. This work offers an alternative design towards effective light trapping performance using 2D photonic nanostructure for PTF solar cell and could potentially be adopted as the nano-structuring strategy for the future perovskite solar cell industry.

Abstract Ceramic matrix composites (CMCs) play an important role in various load-bearing applications. However, fabricating CMCs with both high toughness and stiffness, which are normally mutually exclusive properties, is challenging. Here, we develop an SiOC composite film reinforced with nanoscale tungsten-based particles with a structure and property gradient by integrating hybrid nanoparticle inkjet printing and selective laser sintering. Mechanical results of the resulting SiOC-WOx films exhibit a stiffness-toughness co-enhancement, including a 2-fold improvement in hardness and modulus, and a 3.8-fold better fracture toughness than the matrix material. Moreover, the films exhibit interfacial bonding strengths of up to 86.6 MPa and operate stably at 1050 °C. This performance is attributed to a gradient in the metal-to-ceramic composition and uniformly dispersed self-assembled nanoscale reinforcing particles. This nanoparticle laser sintering method could be used to prepare other materials with structure and property gradients.

PurposeTo establish various radiomics models based on conventional CT scan images and enhanced CT images, explore their value in the classification of pheochromocytoma (PHEO) and lipid-poor adrenal adenoma (LPA) and screen the most parsimonious and efficient modelMethodsThe clinical and imaging data of 332 patients (352 lesions) with PHEO or LPA confirmed by surgical pathology in the Affiliated Hospital of Qingdao University were retrospectively analyzed. The region of interest (ROI) on conventional and enhanced CT images was delineated using ITK-SNAP software. Different radiomics signatures were constructed from the radiomics features extracted from conventional and enhanced CT images, and a radiomics score (Rad score) was calculated. A clinical model was established using demographic features and CT findings, while radiomics nomograms were established using multiple logistic regression analysis.The predictive efficiency of different models was evaluated using the area under curve (AUC) and receiver operating characteristic (ROC) curve. The Delong test was used to evaluate whether there were statistical differences in predictive efficiency between different models.ResultsThe radiomics signature based on conventional CT images showed AUCs of 0.97 (training cohort, 95% CI: 0.95∼1.00) and 0.97 (validation cohort, 95% CI: 0.92∼1.00). The AUCs of the nomogram model based on conventional scan CT images and enhanced CT images in the training cohort and the validation cohort were 0.97 (95% CI: 0.95∼1.00) and 0.97 (95% CI: 0.94~1.00) and 0.98 (95% CI: 0.97∼1.00) and 0.97 (95% CI: 0.94∼1.00), respectively. The prediction efficiency of models based on enhanced CT images was slightly higher than that of models based on conventional CT images, but these differences were statistically insignificant(P>0.05).ConclusionsCT-based radiomics signatures and radiomics nomograms can be used to predict and identify PHEO and LPA. The model established based on conventional CT images has great identification and prediction efficiency, and it can also enable patients to avoid harm from radiation and contrast agents caused by the need for further enhancement scanning in traditional image examinations.

This paper introduces a new device concept and outlines the fabrication process of a bipolar junction transistor based on an IGZO/NiO/PbSe nanoband array heterostructure. We performed comprehensive electrical property testing and characterization analysis on the device to thoroughly assess the device's performance. The heterojunction structure efficiently amplifies the opto-electric responsivity and enhances the transmission efficiency of photogenerated carriers. Significantly, the phototransistor demonstrates a high photoresponsivity of 4000 A/W under an incident light power of 1 μW/cm2 and a wavelength of 850 nm. Hence, a solution detection system integrated with a bipolar phototransistor is designed. Through the analysis of the output signals, the system accurately determines the identity of the solute present in the solution.

The imperative for energy conservation and environmental protection has led to the development of innovative aircraft designs. This study explored a novel thrust control configuration for blended-wing-body (BWB) aircraft with distributed electric boundary-layer ingestion (BLI) propulsors, addressing the issues of sagging and altitude loss during landing. The research focused on a small-scale BWB demonstrator equipped with six BLI fans, each with a 90 mm diameter. Various thrust control configurations were evaluated to achieve significant thrust reduction while maintaining lift, including dual-layer sleeve, separate flap-type, single-stage linkage flap-type, and dual-stage linkage flap-type configurations. The separate flap-type configuration was tested through ground experiments. Control experiments were conducted under three different experimental conditions as follows: deflection of the upper cascades only, deflection of the lower cascades only, and symmetrical deflection of both cascades. For each condition, the deflection angles tested were 0°, 10°, 20°, 30°, 40°, 50°, and 60°. The thrust reductions observed for these three conditions were 0%, 37.5%, and 27.5% of the maximum thrust, respectively, without additional changes in the pitch moment. A combined thrust adjustment method maintaining a zero pitch moment demonstrated a linear thrust reduction to 20% of its initial value. The experiment concluded that the novel thrust control configuration effectively adjusted thrust without altering the BLI fans’ rotation speed, solving the coupled lift–thrust problem and enhancing BWB landing stability.

ABSTRACTObjective: Hydroxytyrosol (HT) is a polyphenol with a wide range of biological activities. Excessive drinking can lead to oxidative stress and inflammation in the liver, which usually develop into alcohol liver disease (ALD). At present, there is no specific drug to treat ALD. In this paper, the protection effect of HT on ALD and the underline mechanism were studied.Methods: HepG2 cells were exposed to ethanol in vitro and C57BL/6J mice were fed with a Lieber-DeCarli ethanol liquid diet in vivo.Results: triglyceride (TG) level in serum and the expression of fatty acid synthase (FASN) were reduced significantly by the treatment with HT The acetaldehyde dehydrogenase (ALDH) activity was increased, the serum level of malondialdehyde (MDA) was decreased, catalase (CAT) and glutathione (GSH) were increased, suggesting that HT may reduce its oxidative damage to the body by promoting alcohol metabolism. Furthermore, according to the mRNA levels of tnf-α, il-6 and il-1β, HT inhibited ethanol-induced inflammation significantly. The anti-inflammatory mechanism of HT may be related to suppress the STAT3/iNOS pathway.Dissussion: Our study showed that HT could ameliorate ethanol-induced hepatic steatosis, oxidative stress and inflammation and provide a new candidate for the prevention and treatment of ALD.

Abstract The conjugate heat transfer of a turbine blade is influenced by several factors. To analyze the influence of each factor, the published one-dimensional conjugate heat transfer model was improved through theoretical analysis in this study. An overall cooling effectiveness equation containing three dimensionless parameters (adiabatic film cooling effectiveness η, Biot number on the mainstream side Bi g , and ratio between the heat transfer coefficients of the external and internal walls h g /h i ) was obtained. The sensitivity of the overall cooling effectiveness ϕ to these three parameters was obtained through a multi-parameter sensitivity analysis. The results showed that increasing η could improve ϕ the most effectively. The interactions between the dimensionless parameters were analyzed by developing sensitivity charts. The results showed that increasing η from 0.4 to 0.5 could reduce the sensitivity of ϕ to the other two parameters by approximately 15%, whereas increasing Bi g had little effect on the sensitivity of ϕ to each dimensionless parameter. Increasing h g /h i could improve the sensitivity to η. The above conclusions could also be applied to the plate film hole and plate impingement effusion structures. The effects of different internal cooling structures and film hole structures on the three dimensionless parameters were studied by performing numerical simulations, which verified the accuracy of the one-dimensional conjugate heat transfer model in this study. The results showed that the internal cooling structures had little effect on the distribution of η and Bi g . The heat transfer coefficient on the coolant side could be effectively improved by installing film holes. The film hole structures mainly affected ϕ by influencing the distribution of η.

The power consumption and the opto-electric noise of organic photo-detectors are the challenges for large-scale detecting and imaging applications to surpass. This article presents a new device concept of organic heterojunction PIN channel for photo-transistor. The presence of the channel's heterostructure enables rectifying capability and effective control of defect density, which leads to low power consumption (0.12 to 7.5 nW) and low dynamic noise (4.5 × 1013 Jones detectivity). Significantly, through adopting the highly efficient Perovskite Quantum Dots as intrinsic sensing core, the device exhibits high responsivity up to 7190 A/W. As we demonstrate a large-scale 10 × 20 imaging array with integrated photo-transistor, the output signals are read-out and rebuilt by I-V converting amplifier with analog-to-digital circuit and numerical computation method to visualize the functionality of the system.

ABSTRACT Enterobacter cloacae is a troublesome pathogen causing refractory infections of the lower respiratory tract, urethra and abdominal cavity, endocarditis, osteomyelitis, and neonatal septicemia. It is prone to developing resistance to ordinary antibiotics and has brought a serious problem to clinical treatment. An artful synergistic combination of an antibacterial natural product allicin and a newly isolated bacteriophage, named BD523, was constructed herein. This combination significantly lowered effective dosage of allicin and effectually overcame bacterial drug-resistance. We experimentally evidenced that allicin interacts with bacterial DNA in the groove region by inserting itself into the DNA double helix and, subsequently, disrupts the bacterial DNA by cleaving phosphate diester bonds of deoxynucleotides. Further, BD523 destroys the cell wall and membrane of bacteria by synthesizing lyase proteins, including holin and endolysins. Thus, the synergistic effect of the combination benefits from complementary targeting mechanisms of allicin and BD523. They cooperatively act on bacterial DNA, cell wall, and membrane to improve antibacterial efficiency and avoid drug-resistance. IMPORTANCE Bacterial drug-resistance is a serious problem afflicting pharmacologists all over the world. Many strategies have been developed and practiced to overcome it, but almost no one is satisfactory due to the continual change of bacteria. Combinations of antibiotics and bacteriophages are promising because of the cooperation of 2 bacterial killers with distinct mechanisms. The combination of allicin and an Enterobacter cloacae bacteriophage reported herein can significantly improve the effect of allicin against E. cloacae. Its synergistic effect was even superior to the combination of bacteriophage and neomycin, of which the MIC was significantly lower than allicin. It was ascribed to the complementary antibacterial and the possible resistance-proof mechanism of bacteriophage and allicin. This study provided a pragmatic way to conquer the cunning bacterium, and may offer reference for research and development of new bacterial killers.

ObjectiveThis study aimed to compare the dynamics of lower and upper genital tract microbiota in normal term pregnancy, histological chorioamnionitis (HCA), and clinical chorioamnionitis (CCA) patients to provide a reference for the diagnosis and treatment of chorioamnionitis (CAM) patients.MethodsWe prospectively collected vaginal and cervical secretions, as well as placenta tissues, fetal membranes, and amniotic fluid from normal-term pregnant women, HCA and CCA patients. Then, we performed genomic DNA extraction and PCR amplification for all samples. The eligible samples were analyzed by 16S ribosomal RNA (16S rRNA) sequencing. Additionally, all placenta tissues were histopathologically examined, and neonatal pharyngeal swabs and placenta tissues from the HCA and CCA groups were subjected to microbial culture.ResultsA total of 85 term pregnant women were enrolled in this study, including 34 in the normal group (N), 37 in the HCA group, and 14 in the CCA group. A total of 171 qualified samples were analyzed by 16S rRNA sequencing. The results suggested that the cervical microbiota was highly similar to the vaginal microbiota in normal term parturients, with Lactobacillus as the dominant bacterium. Moreover, there was no difference in the alpha and beta diversity of vaginal microbiota between the N, HCA, and CCA groups at the genus level. Besides, no significant differences were detected in cervical microbiome among the three groups. Regarding intrauterine microorganisms, the N and HCA groups had similar microbial composition but were different from the CCA group. No microbe was detected in the placental tissue of normal term parturients, while some microorganisms were found in the intrauterine amniotic fluid and fetal membrane samples. Regardless of cultivation or 16S rRNA sequencing, an extremely low microbial positive rate was detected in HCA and CCA intrauterine samples. Compared to the normal group, Lactobacillus was significantly reduced in the CCA group intrauterine, and Ureaplasma and Enterococcus increased with no statistically significant.ConclusionThe N, HCA and CCA groups had similar composition of vaginal and cervical microflora. Some normal-term pregnant women can harbor non-pathogenic microbiota in the uterine cavity. Sterile inflammation is more frequent than microbial-associated inflammation in term HCA and CCA parturients.

This paper aims at proposing a data-driven Reynolds Averaged Navier–Stokes (RANS) calculation model based on physically constrained deep learning. Using the standard k − ɛ model as the template, part of the source terms in the ɛ equation is replaced by the deep learning model. The simulation results of this new model achieve a high error reduction of 51.7% compared to the standard k − ɛ model. To improve the generality, the accuracy, and the convergence for the undeveloped flow, this paper focuses on optimizing the training process and introducing a data correction method named “coordinate” technology. For the training dataset, the k-field and ɛ-field are automatically corrected by using this technology when the flow state deviates from the theoretical estimation of the standard k − ɛ model. Based on the coordinate technology, a source term of the equation is built by deep learning, and the simulation error is reduced by 6.2% compared to the uncoordinated one. The results confirm that the coordinate technology can effectively adapt to the undeveloped flow where the standard k − ɛ model is not suited and improve the accuracy of the data-driven RANS modeling when dealing with complex flows.

The sensitivity and photoelectric noise of UV photodetectors are challenges that need to be overcome in pharmaceutical solute detection applications. This paper presents a new device concept for a CsPbBr3 QDs/ZnO nanowire heterojunction structure for phototransistors. The lattice match of the CsPbBr3 QDs and ZnO nanowire reduces the generation of trap centers and avoids carrier absorption by the composite center, which greatly improves the carrier mobility and high detectivity (8.13 × 1014 Jones). It is worth noting that by using high-efficiency PVK quantum dots as the intrinsic sensing core, the device has a high responsivity (6381 A/W) and responsivity frequency (300 Hz). Thus, a UV detection system for pharmaceutical solute detection is demonstrated, and the type of solute in the chemical solution is estimated by the waveform and the size of the output 2f signals.

Automatic voice pathology detection can provide objective estimation and prevention in the early stages of voice diseases. Glottal flow waveform directly reflects the state of glottal excitation. Extracting acoustic features from glottal source signals may contribute to the detection of pathological voice. To improve the performance of voice pathology detection, this article investigates the contribution of the glottal flow waveform for pathological voice detection by evaluating the classification result using features extracted from raw speech utterances and corresponding glottal flow waveforms. The individual feature sets used are extracted from raw or glottal voice utterances with identical parameter settings, which are openSMILE acoustic features, audio features computed by Moving Picture Experts Group-7 standard and classical glottal source features. In addition, a feature selection method in terms of the wrapper approach is used to combine the single features ranked by using the Fisher discrimination ratio. Voice pathology detection experiments were carried out using Random Forest. The best accuracies of 88.52% for the Saarbrücken Voice database and 100.00% for the Massachusetts Eye and Ear Infirmary database are achieved using the combined feature set extracted from the glottal source signal, with improvement of 0.44-3.13% in the accuracies obtained by using raw speech utterances. Compared to state-of-the-art methods, the proposed method achieves the highest accuracy for the Massachusetts Eye and Ear Infirmary database and an increase of 2.75-17.16% in detection accuracy compared to other conventional pipeline systems for the Saarbrücken Voice databse. The experimental results demonstrate that using glottal flow waveform as source signal can improve the performance of pathological voice detection.

Hydrophobicity has been widely reported for its superior behavior in drag reduction, self-cleaning, and anti-corrosion in many areas. Especially in engineering design, the research of the unique property of the slip flow with complex flow patterns is essential for practical applications. In this paper, the flow characteristics of a superhydrophobic U-shaped microchannel are systematically investigated, as the curved part is a fundamental component in microfluids. A slip model is established based on theoretical and experimental solutions. Various types of U-shaped microchannels, radii of curvature, and contact angles are studied with a wide range of Reynolds numbers from 0 to 300. We propose a velocity distribution to examine the non-uniformity of slip velocity on the cross-section. This imbalance is improved with an increase in the apparent contact angle and flow rate, and a decrease in the radius of curvature. The secondary flow and vortices generated by the centrifugal force are enhanced, and their positions are changed due to the slippery boundary. The results show a considerable drag reduction from 10% to 40% with different contact angles. The variation of curvature does not have a decisive impact on the final performance when the surface wettability maintains a steady state. Our research elucidates the physical principle of the slip model in curved channels, showing extensive applications of hydrophobicity in the design of complex microchips and the optimization strategy of heat transfer systems.

Due to the complexity and non-stationarity of the voice generation system, the nonlinearity of speech signals cannot be accurately quantified. Recently, the recurrence quantification analysis method has been used for voice disorder detection. In this paper, multiscale recurrence quantification measures (MRQMs) are proposed. The signals are reconstructed in the high-dimensional phase space at the equivalent rectangular bandwidth scale. Recurrence plots (RPs) combining the characteristics of human auditory perception are drawn with an appropriate recurrence threshold. Based on the above, the nonlinear dynamic recurrence features of the speech signal are quantized from the recurrence plot of each frequency channel. Furthermore, this paper explores the recurrence quantification thresholds that are most suitable for pathological voices. Our results show that the proposed MRQMs with support vector machine (SVM), random forest (RF), Bayesian network (BN) and Local Weighted Learning (LWL) achieve an average accuracy of 99.45%, outperforming traditional features and other complex measurements. In addition, MRQMs also have the potential for multi-classification of voice disorder, achieving an accuracy of 89.05%. This study demonstrates that MRQMs can characterize the recurrence characteristic of pathological voices and effectively detect voice disorders.

A pathological voice detection system is designed to detect pathological characteristics of vocal cords from speech. Such systems are particularly susceptible to domain mismatch where the training and testing data come from the source and target domains, respectively. Due to the difference in speech disease etiology, recording environment, and device, etc., the feature distributions of source and target domain are quite different. Meanwhile, considering the high costs of annotating labels, it is hard to acquire labeled data in the target domain. This paper attempts to formulate cross-domain pathological voice detection as an unsupervised domain adaptation problem. Joint subspace transfer learning (JSTL) aims to find a projection matrix to transform source and target domain data into a common space. The maximum mean discrepancy function is used to measure the divergence across databases. Intra-class and inter-class distance act as regularization to guarantee the maximum separability between different classes. A graph matrix is constructed to help transfer knowledge from the relevant source data to the target data. Three popular pathological voice databases were selected in this paper. For six cross-database experiments, the accuracy of the method proposed increased by up to 15%. For different voice categories, the category of structural voice showed the most significant increase, nearly 20%.

Sulcus vocalis is an indentation parallel to the edge of vocal fold, which may extend into the cover and ligament layer of the vocal fold or deeper. The effects of sulcus vocalis depth d on phonation and the vocal cord vibrations are investigated in this study. The three-dimensional laryngeal models were established for healthy vocal folds (0 mm) and different types of sulcus vocalis with the typical depth of 1 mm, 2 mm, and 3 mm. These models with fluid-structure interaction (FSI) are computed numerically by sequential coupling method, which includes an immersed boundary method (IBM) for modelling the glottal airflow, a finite-element method (FEM) for modelling vocal fold tissue. The results show that a deeper sulcus vocalis in the cover layer decreases the vibrating frequency of vocal folds and expands the prephonatory glottal half-width which increases the phonation threshold pressure. The larger sulcus vocalis depth makes vocal folds difficult to vibrate and phonate. The effects of sulcus vocalis depth suggest that the feature such as phonation threshold pressure could assist in the detection of healthy vocal folds and different types of sulcus vocalis.

Time-resolved particle image velocimetry is used to study internal flow field characteristics in U-shaped channels of square cross section and different structures of the bend section. The Reynolds number based on the hydraulic diameter of the channel is 8888, 13 333, or 17 777. The mean flow and Reynolds stress are considered, and proper orthogonal decomposition (POD) is used to investigate the flow characteristics. A series of important conclusions are drawn from the results. For the main flow, the structure of the bend section has an obvious influence on the flow field characteristics. The size and number of vortices in the corner area are significantly reduced because the increase in the Reynolds number makes the impact of the influx stronger. It can be seen from the clear differences in the Reynolds stress for different bend sections that the fluctuations caused by the mixing of the main flow and the vortices are significantly stronger than those at the boundary. The flow in the bend section is complex, there is a relatively high proportion of turbulent kinetic energy in the low-order modes, and there is an obvious stripe-like structure in the bend section of the channel in which the bend has both inner and outer circular walls, which matches the velocity field from the POD.

The Massachusetts Eye and Ear Infirmary (MEEI) database is an international-standard training database for voice pathology detection (VPD) systems. However, there is a class-imbalanced distribution in normal and pathological voice samples and different types of pathological voice samples in the MEEI database. This study aimed to develop a VPD system that uses the fuzzy clustering synthetic minority oversampling technique algorithm (FC-SMOTE) to automatically detect and classify four types of pathological voices in a multi-class imbalanced database. The proposed FC-SMOTE algorithm processes the initial class-imbalanced dataset. A set of machine learning models was evaluated and validated using the resulting class-balanced dataset as an input. The effectiveness of the VPD system with FC-SMOTE was further verified by an external validation set and another pathological voice database (Saarbruecken Voice Database (SVD)). The experimental results show that, in the multi-classification of pathological voice for the class-imbalanced dataset, the method we propose can significantly improve the diagnostic accuracy. Meanwhile, FC-SMOTE outperforms the traditional imbalanced data oversampling algorithms, and it is preferred for imbalanced voice diagnosis in practical applications.

Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment. Although macrophages are considered to be one of the main target cells for NDV infection in vivo, very little is known about the ability of NDV to infect chicken macrophages, and virulence mechanisms of NDV as well as the polarized activation patterns of macrophages and correlation with viral infection and replication. In the present study, a cell culture model (chicken bone marrow macrophage cell line HD11) and three different virulence and genotypes of NDV (including class II virulent NA-1, class II lentogenic LaSota, and class I lentogenic F55) were used to solve the above underlying questions. Our data indicated that all three NDV strains had similar replication rates during the early stages of infection. Virulent NDV titers were shown to increase compared to the other lentogenic strains, and this growth was associated with a strong upregulation of both pro-inflammatory M1-like markers/cytokines and anti-inflammatory M2-like markers/cytokines in chicken macrophages. Virulent NDV was found to block toll-like receptor (TLR) 7 expression, inducing higher expression of type I interferons in chicken macrophages at the late stage of viral infection. Only virulent NDV replication can be inhibited by pretreatment with TLR7 ligand. Overall, this study demonstrated that virulent NDV activates a M1-/M2-like mixed polarized activation of chicken macrophages by inhibition of TLR7, resulting in enhanced replication compared to lentogenic viruses.

Voice production occurs through vocal cord and vibration coupled to glottal airflow. Vocal cord lesions affect the vocal system and lead to voice disorders. In this paper, a pathological voice source analysis system is designed. This study integrates nonlinear dynamics with an optimized asymmetric two-mass model to explore nonlinear characteristics of vocal cord vibration, and changes in acoustic parameters, such as fundamental frequency, caused by distinct subglottal pressure and varying degrees of vocal cord paralysis are analyzed. Various samples of sustained vowel /a/ of normal and pathological voices were extracted from MEEI (Massachusetts Eye and Ear Infirmary) database. A fitting procedure combining genetic particle swarm optimization and a quasi-Newton method was developed to optimize the biomechanical model parameters and match the targeted voice source. Experimental results validate the applicability of the proposed model to reproduce vocal cord vibration with high accuracy, and show that paralyzed vocal cord increases the model coupling stiffness.

This work designed a new tilt manipulation stage based on the electrowetting-on-dielectric (EWOD) principle as the actuating mechanism and investigated the performance of that stage. The stage was fabricated using a universal MEMS (Micro-Electro-Mechanical System) fabrication method. In the previously demonstrated form of this device, the tilt stage consisted of a top plate that functions as a mirror, a bottom plate that was designed for changing the shape of water droplets, and supporters that were fixed between the top and bottom plate. That device was actuated by a voltage applied to the bottom plate, resulting in a static electric force actuating the shape change in the droplets by moving the top plate in the vertical direction. Previous experimental results indicated that that device can tilt at up to ±1.8°, with a resolution of 7 μm in displacement and 0.05° in angle. By selecting the best combination of the dielectric layer, the tilt angle was maximized. The new device, fabricated using a common and straightforward fabrication method, avoids deflection of the top plate and grounding in the bottom plate. Because of the limit of Teflon and other MEMS materials, this device has a tilt angle in the range of 3.2-3.5° according to the experimental data for friction and the EWOD device limit, which is close to 1.8°. This paper also describe the investigation of the effects of various parameters, e.g., various dielectric materials, thicknesses, and droplet type and volume, on the performance of the stage. The results indicate that the apparent frictions coefficient of the solid-liquid interface may remain constant, i.e., the friction force is proportional to the normal support force and the apparent frictions coefficient.

This study empirically investigates the influences of several parameters on surface morphology and etch rate in a high-aspect-ratio silicon etching process. Two function formulas were obtained, revealing the relationship between the controlled parameters and the etching results. All the experiments were conducted on an inductively coupled plasma system, using a Bosch process. The tested trenches’ width ranged from 15 to 1500 µm and their depth ranged from 50 to 500 µm, which covers nearly all the typical sizes of micromechanical devices in practical applications. The controlled parameters are etching chamber pressure, bias power, and gas flow rate. The parameters of surface morphology include sidewall angle, surface roughness, and sidewall condition. We tested how the controlled parameters can influence the surface morphology and etch rate and formulated assumptions to explain those relationships. Meanwhile, we utilized linear regression to obtain experiential function formulas of the relationships among etch depth, structure width, etching time, and passivation time, with a correlation coefficient higher than 0.99. Using these formulas, 12-µm-wide and 377-µm-deep (aspect ratio 31.4) trenches with sidewall angles of 89° were achieved. Additionally, this experience was applied as a critical structure in a gas turbine structure system.

Background: Current methods of extending the storage time of wild Cordyceps sinensis adversely affect the nutritive and medicinal value of the product. Thus, this study was designed to investigate the effects of heat treatment, a relatively safe storage extension method, on the biological activity of wild C. sinensis. Methods: Samples were heated to 60, 80, or 100°C for 15, 30, or 60 minutes. SOD activity in wild C. sinensis before and after heating was assayed using a standard colorimetric assay. Deoxyribonuclease (DNase) activity was measured using the plasmid-nicking assay. Cordycepin content was analyzed using HPLC. Polysaccharide content was measured using the phenol-sulfuric method. The Student's t-test was used for comparison. Results: After heating at 60, 80, 100°C for 15, 30, 60 minutes, respectively, no significant reduction in DNase activity or polysaccharide dissolution was noted (P > .05). Interestingly, heating at 80°C for 30 minutes led to a significant increase in the SOD activity of C. sinensis (P .05). Conclusions: These results suggested that heat treatment does not adversely affect SOD or DNase activity, polysaccharide content, or cordycepin dissolution. Thus, heat treatment might be a safe processing method to extend the storage time of wild C. sinensis without compromising biological activity.

Purpose: Although traditional craniotomy (TC) surgery has failed to show benefits for the functional outcome of intracerebral hemorrhage (ICH). However, a minimally invasive hematoma removal plan to avoid white matter fiber damage may be a safer and more feasible surgical approach, which may improve the prognosis of ICH. We conducted a historical cohort study on the use of multimodal image fusion-assisted neuroendoscopic surgery (MINS) for the treatment of ICH, and compared its safety and effectiveness with traditional methods. Methods: This is a historical cohort study involving 241 patients with cerebral hemorrhage. Divided into MINS group and TC group based on surgical methods. Multimodal images (CT skull, CT angiography, and white matter fiber of MRI diffusion-tensor imaging) were fused into 3 dimensional images for preoperative planning and intraoperative guidance of endoscopic hematoma removal in the MINS group. Clinical features, operative efficiency, perioperative complications, and prognoses between 2 groups were compared. Normally distributed data were analyzed using t-test of 2 independent samples, Non-normally distributed data were compared using the Kruskal-Wallis test. Meanwhile categorical data were analyzed via the Chi-square test or Fisher’s exact test. All statistical tests were two-sided, and p < 0.05 was considered statistically significant. Results: A total of 42 patients with ICH were enrolled, who underwent TC surgery or MINS. Patients who underwent MINS had shorter operative time (p

In this study, two-dimensional heat transfer distribution on the leading surface and trailing surface in a rotating smooth channel with typical boundary condition of four surface heating was investigated experimentally for the first time. The Reynolds number, based on channel hydraulic diameter (80 mm) and the bulk mean velocity, ranges from 15,000 to 30,000, and the highest rotation number is 0.359 with the Reynolds number of 15,000. The mean density ratio is about 0.11 in this work. The obtained result showed that rotation has an important effect on the heat transfer distribution along the span-wise direction. On the leading side, rotation-induced secondary flow makes the Nu / Nu 0 at the edge area of the wall surface ( Z / D = 0 and Z / D = 1) is higher than that on the middle area ( Z / D = 0.5). On the trailing surface, the trend of Nu / Nu 0 ratio along the span-wise direction is reversed. Along the stream-wise direction, the Nu / Nu s ratio increases with the rotation number monotonously on the trailing side. However, on the leading side, with the increase in rotation number, the Nu / Nu s does not decrease monotonously along the stream-wise direction, there is a slight enhancement along the stream-wise direction. The secondary flow induced by rotation enhances Nu ¯ / N u s ratio up to 1.35 on the trailing side and weakens the Nu ¯ / N u s ratio close to 0.75 on the leading side with the Re = 15,000, and Ro = 0.359. More details of two-dimensional distribution of temperature and Nu on the leading and trailing side are shown in this work.

Avian paramyxovirus serotype 4 (APMV-4) is found sporadically in wild birds worldwide, and it is an economically important poultry pathogen. Despite the existence of several published strains, very little is known about the distribution, host species, and transmission of APMV-4 strains. To better understand the relationships among these factors, we conducted an APMV-4 surveillance of wild birds and domestic poultry in six provinces of China suspected of being intercontinental flyways and sites of interspecies transmission. APMV-4 surveillance was conducted in 9,160 wild birds representing seven species, and 1,461 domestic poultry in live bird markets (LMBs) from December 2013 to June 2016. The rate of APMV-4 isolation was 0.10% (11/10,621), and viruses were isolated from swan geese, bean geese, cormorants, mallards, and chickens. Sequencing and phylogenetic analyses of the 11 isolated viruses indicated that all the isolates belonging to genotype I were epidemiologically connected with wild bird-origin viruses from the Ukraine and Italy. Moreover, chicken-origin APMV-4 strains isolated from the LBMs were highly similar to wild bird-origin viruses from nearby lakes with free-living wild birds. In additional, a hemagglutination-negative APMV-4 virus was identified. These findings, together with recent APMV-4 studies, suggest potential virus interspecies transmission between wild birds and domestic poultry, and reveal possible epidemiological intercontinental connections between APMV-4 transmission by wild birds.

High-precision, low-temperature-sensitive microelectromechanical system (MEMS) capacitive accelerometers are widely used in aerospace, automotive, and navigation systems. An analytical study of the temperature drift of bias (TDB) and temperature drift of scale factor (TDSF) for an asymmetric comb capacitive accelerometer is presented in this paper. A five-layer model is established for the equivalent expansion ratio in the TDB and TDSF formulas, and the results calculated by the weighted average of thickness and elasticity modulus method are closest to the results of the numerical simulation. The analytical formulas of TDB and TDSF for an asymmetric structure are obtained. For an asymmetric structure, TDB is only related to thermal deformation and fabrication error. Additionally, half of the fixed electrode distance is not included in the expressions of Δ d and Δ D for asymmetric structures, thus resulting in the TDSF of the asymmetric structure being smaller compared to a symmetric structure with the same structural parameters. The TDSF of the symmetric structure is [−200.2 ppm/°C, −261.6 ppm/°C], while the results of the asymmetric structure are [−11.004 ppm/°C, −72.404 ppm/°C] under the same set of parameters. The parameters of the optimal asymmetric structure are obtained for fabrication guidance using numerical methods. In the experiment, the TDSF and TDB of the packaged structure and the non-packaged structure are compared, and a significant effect of the package on the signal output is found. The TDB is reduced from 3000 to 60 μg/°C, while the TDSF is reduced from 3000 to 140 ppm/°C.

In this study, three dimensional numerical simulations of fluid and heat transfer on the transonic vane have been performed using v2-f turbulence model. The objective of this paper is to evaluate the v2-f model’s ability to predict the heat transfer characters on the 3D showerhead film cooled vane. Exit Mach number of Mex=0.76, corresponding to exit Reynolds number based on vane chord of 1.1×106, is tested with an inlet free stream turbulence intensity (Tu) of 16% and integral length scale normalized by vane pitch (Λx/P) of 0.23. For the showerhead film cooling simulations, a new three simulations technique is discussed to calculate the recovery temperature, adiabatic wall temperature, and surface Nusselt number. CFD predictions show an overall good agreement with experimental results.

In this study, the filling process of high aspect ratio through-silicon-vias (TSVs) under dense conditions using the electroplating method was efficiently achieved and optimized. Pulsed power was used as the experimental power source and the electroplating solution was prepared with various additive concentrations. Designed control variable experiments were conducted to determine the optimized method. In the control variable experiments, the relationship of multiple experimental variables, including current density (0.25–2 A/dm2), additive concentration (0.5–2 mL/L), and different shapes of TSVs (circle, oral, and square), were systematically analyzed. Considering the electroplating speed and quality, the influence of different factors on experimental results and the optimized parameters were determined. The results showed that increasing current density improved the electroplating speed but decreased the quality. Additives worked well, whereas their concentrations were controlled within a suitable range. The TSV shape also influenced the electroplating result. When the current density was 1.5 A/dm2 and the additive concentration was 1 mL/L, the TSV filling was relatively better. With the optimized parameters, 500-μm-deep TSVs with a high aspect ratio of 10:1 were fully filled in 20 h, and the via density reached 70/mm2. Finally, optimized parameters were adopted, and the electroplating of 1000-μm-deep TSVs with a diameter of 100 μm was completed in 45 h, which is the deepest and smallest through which a three-dimensional inductor has ever been successfully fabricated.

Owing to its extremely low light absorption, black silicon has been widely investigated and reported in recent years, and simultaneously applied to various disciplines. Black silicon is, in general, fabricated on flat surfaces based on the silicon substrate. However, with three normal fabrication methods—plasma dry etching, metal-assisted wet etching, and femtosecond laser pulse etching—black silicon cannot perform easily due to its lowest absorption and thus some studies remained in the laboratory stage. This paper puts forward a novel secondary nanostructured black silicon, which uses the dry-wet hybrid fabrication method to achieve secondary nanostructures. In consideration of the influence of the structure’s size, this paper fabricated different sizes of secondary nanostructured black silicon and compared their absorptions with each other. A total of 0.5% reflectance and 98% absorption efficiency of the pit sample were achieved with a diameter of 117.1 μm and a depth of 72.6 μm. In addition, the variation tendency of the absorption efficiency is not solely monotone increasing or monotone decreasing, but firstly increasing and then decreasing. By using a statistical image processing method, nanostructures with diameters between 20 and 30 nm are the majority and nanostructures with a diameter between 10 and 40 nm account for 81% of the diameters.