1. ANTI-QUORUM SENSING AND ANTIBIOTIC ENHANCEMENT OF ALLYLPYROCATECHOL AND METHYL GALLATE
- Author
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Chen Wai Wong, Yong Kiat Teo, Eric Wei Chiang Chan, Zhi Juin Loong, V. S. Anggraeni, Joash Ban Lee Tan, and Carine S. S. Lim
- Subjects
Piper ,biology ,Pseudomonas aeruginosa ,Anacardium ,General Engineering ,medicine.disease_cause ,biology.organism_classification ,chemistry.chemical_compound ,Quorum sensing ,chemistry ,Staphylococcus aureus ,Streptomycin ,medicine ,Food science ,Methyl gallate ,Chromobacterium violaceum ,medicine.drug - Abstract
In this study, the antibiotic enhancement and quorum sensing (QS) inhibition of allylpyrocatechol (APC) and methyl gallate (MG) isolated from leaves of Piper betle (betel) and leaf shoots of Anacardium occidentale (cashew), respectively, were compared. When applied with streptomycin and tested against Staphylococcus aureus and Pseudomonas aeruginosa, the effect of APC was additive while that of MG was synergistic. In terms of QS inhibition against Chromobacterium violaceum, both compounds were equally effective with violacein inhibition observed at concentrations of 60 μg/mL. We successfully increased the purity of APC in the methanol betel leaf extract from 13.2% to 31.5% w/w through solvent partitioning. This study is the first to document the anti-QS activity of APC, which is comparable to that of MG.
- Published
- 2021
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