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3 results on '"Zhenni Que"'

1. Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing

Author

Yi Liu, Changlan Xiang, Zhenni Que, Chenglong Li, Wen Wang, Lijuan Yin, Chenyu Chu, and Yin Zhou

Subjects
neutrophil, aging, heterogeneity, COVID-19, wound healing, immune response, Immunologic diseases. Allergy, RC581-607
Abstract

Neutrophils play a critical role in the immune response to infection and tissue injury. However, recent studies have shown that neutrophils are a heterogeneous population with distinct subtypes that differ in their functional properties. Moreover, aging can alter neutrophil function and exacerbate immune dysregulation. In this review, we discuss the concept of neutrophil heterogeneity and how it may be affected by aging. We then examine the implications of neutrophil heterogeneity and aging for COVID-19 pathogenesis and wound healing. Specifically, we summarize the evidence for neutrophil involvement in COVID-19 and the potential mechanisms underlying neutrophil recruitment and activation in this disease. We also review the literature on the role of neutrophils in the wound healing process and how aging and neutrophil heterogeneity may impact wound healing outcomes. Finally, we discuss the potential for neutrophil-targeted therapies to improve clinical outcomes in COVID-19 and wound healing.

Published
2023
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3. Classical Dichotomy of Macrophages and Alternative Activation Models Proposed with Technological Progress

Author

Yuwen Ma, Yali Wei, Dengbo Yao, Mengxi Wang, and Zhenni Que

Subjects
General Immunology and Microbiology, Technological change, Computer science, Implant dentistry, Sequence Analysis, RNA, Gene Expression Profiling, Macrophages, Classical dichotomy, Gene Expression, Functional genes, General Medicine, Review Article, Macrophage Activation, General Biochemistry, Genetics and Molecular Biology, Dental Implantation, Macrophage, Animals, Humans, Medicine, Activation model, Transcriptome, Neuroscience
Abstract

Macrophages are important immune cells that participate in the regulation of inflammation in implant dentistry, and their activation/polarization state is considered to be the basis for their functions. The classic dichotomy activation model is commonly accepted, however, due to the discovery of macrophage heterogeneity and more functional and iconic exploration at different technologies; some studies have discovered the shortcomings of the dichotomy model and have put forward the concept of alternative activation models through the application of advanced technologies such as cytometry by time-of-flight (CyTOF), single-cell RNA-seq (scRNA-seq), and hyperspectral image (HSI). These alternative models have great potential to help macrophages divide phenotypes and functional genes.

Published
2021

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