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Transition metal carbides/nitrides (MXenes) are emerging two-dimensional (2D) materials that have been widely investigated in recent years.

Background Observational studies have suggested that intake of nuts is associated with lower risk of cardiometabolic diseases, whereas refined grain consumption has been linked to higher risk. Little is known about whether substituting white rice, a refined grain, with nuts may confer benefit among adults at high risk of cardiometabolic diseases. Objectives We aimed to evaluate isocaloric substitution of peanuts for white rice bars as snacks on changes in fasting glucose, lipid profile, body weight, as well as changes in metabolic syndrome (MetS) status among participants with MetS or at risk of MetS. Methods This parallel-arm randomized controlled trial included 224 participants either with MetS (according to the International Diabetes Federation criteria for Chinese adults, n = 163) or at risk of MetS (central obesity plus 1 additional MetS risk factor, n = 61). Participants were randomly assigned to either the peanut arm (56 g/d as snacks, n = 113) or the control arm (isocaloric white rice bars, n = 111) for 12 wk. Results A total of 209 participants (93.3%) completed the 12-wk intervention with a compliance rate > 85% among all participants. No between-group differences were found for improvements in fasting glucose, HDL cholesterol, waist circumference, and body weight. Participants in the peanut group had a significantly higher MetS reversion rate (no longer meeting MetS criteria after the 12-wk trial) than those in the control group (RR: 2.33; 95% CI: 1.10, 4.89; P = 0.026). Conclusions Including peanuts as a snack in the habitual diet in place of a refined-grain snack did not significantly change glycemic or lipid parameters, but improved overall MetS risk without promoting weight gain among Chinese adults at high risk of cardiometabolic diseases. Further larger-scale trials are needed to confirm these findings and elucidate underlying biological mechanisms.This trial was registered at clinicaltrials.gov as NCT03194152.

The efficient separation of emulsified oily wastewater is urgently needed and remains a worldwide challenge. However, the preparation of underwater superoleophobic materials still suffer from complicated process control, special equipment and expensive reagents, which further restricts the large-scale application of such materials. Herein, one-step constructing of underwater superoleophobic beds is introduced for highly efficient gravity-directed separation of various oil-in-water emulsions. Importantly, this study simplifies the fabrication process of underwater superoleophobic materials. It's worth noting that the strategy can achieve the effective separation of a range of oil-in-water emulsions by only requires simple accumulation of hydrophilic materials. More importantly, the underwater superoleophobic sandwich-structured beds still maintain the separation efficiency more than 99.2% after 10 cycles. In addition, this strategy is suitable for a variety of hydrophilic materials, which provides new perspectives for fabrication of novel oil-water emulsion-separating materials. One-step constructing of underwater superoleophobic bed was used for high efficiency separation of oil-in-water emulsions.

Here, a novel combined heterotrophic and bio-electrochemical hydrogen autotrophic (CHBHA) system was developed to remove perchlorate under low chemical dosages and energy consumption. The perchlorate removal performance at various hydraulic retention times (HRTs) and acetate dosages was investigated. For influent containing 10 ± 0.10 mg/L perchlorate, the optimal removal efficiency by the CHBHA system was 98.96 ± 1.62 %, 92.99 ± 2.99 %, 97.85 ± 0.41 %, and 98.24 ± 1.56 % at different operating stages. Perchlorate was mainly removed in the heterotrophic part (H-part) at a sufficient HRT (6 h) and acetate dosage (14.75 mg/L). At other stages, perchlorate was synergistically removed by the H-part and electrochemical hydrogen autotrophic part (E-part). Since the H-part removed some perchlorate, the E-part's applied current decreased, thus reducing energy costs. The maximum current efficiency of CHBHA system was 22.09 %. Compared with the single E-part system, the combined system used 65 % less energy. Perchlorate was converted into active chlorine in the E-part, which improved the effluent quality. The bacterial community structures of the two parts were significantly different. Comamonas, Dechloromonas, Acinetobacter, and Chryseobacterium were enriched in the H-part, and the dominant genera in the E-part were Thauera, Azonexus, Hydrogenophaga, and Tissierella.

Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore effects of lifestyle on the associations in a Chinese population. The study included 1877 community-dwelling Chinese individuals aged 50–70 years (751 men and 1126 women), free of diabetes at baseline and followed for 6 years. A total of 160 GPL species were quantified in plasma at baseline by using high-throughput targeted lipidomics. Log-Poisson regression was used to assess the associations between GPLs and incidence of diabetes. Over the 6 years of follow-up, 499 participants (26.6%) developed diabetes. After multivariable adjustment, eight GPLs were positively associated with incident diabetes (RRper SD 1.13–1.25; all false-discovery rate [FDR]-corrected p

Context Few lipidomic studies have specifically investigated the association of circulating glycerolipids and type 2 diabetes (T2D) risk, especially among Asian populations. It remains unknown whether or to what degree fatty liver could explain the associations between glycerolipids and T2D. Objective We aimed to assess associations between plasma glycerolipids and incident T2D and to explore a potential role of liver fat accumulation in the associations. Methods This was a prospective cohort study with 6 years of follow-up. The study population included 1781 Chinese participants aged 50 to 70 years. The main outcome measure was incident T2D. Results At the 6-year resurvey, 463 participants had developed T2D. At the false discovery rate (FDR) of 5%, 43 of 104 glycerolipids were significantly associated with incident T2D risk after multivariate adjustment for conventional risk factors. After further controlling for glycated hemoglobin (HbA1c), 9 of the 43 glycerolipids remained significant, including 2 diacylglycerols (DAGs) (16:1/20:4, 18:2/20:5) and 7 triacylglycerols (TAGs) (46:1, 48:0, 48:1, 50:0, 50:1, 50:2, and 52:2), with relative risks (RRs) (95% CIs) ranging from 1.16 (1.05-1.27) to 1.23 (1.11-1.36) per SD increment of glycerolipids. However, additional adjustment for fatty liver index largely attenuated these findings (RR [95% CI] 0.88 [0.81 to 0.95] to 1.10 [1.01 to 1.21]). Mediation analyses suggested that the fatty liver index explained 12% to 28% of the glycerolipids-T2D associations (all P < 0.01). Conclusion Higher plasma levels of DAGs and TAGs were associated with increased incident T2D risk in this Chinese population, which might be partially explained by liver fat accumulation.

Background: Different processing approaches could usually alter contents of different nutritional ingredients for wheat grains which benefits human health. The present study is aimed to assess the dietary fiber and other nutritional ingredients of purple wheat (Jizi439) bran via proper processing and to analyze its benefits to prevent diseases and enhance health so as to prove the dietary fiber powder made from purple wheat （Jizi439）to be an effective health food. Methods: Approach I Pulverizing: Purple wheat bran was put into blade pulverizer to get the pulverized bran into particles with a 60-meshdiameter. Puffing: The pulverized bran was sprayed with pure water to moisten the bran, making its moisture reach 22%. The moistened bran was put into twin-screw bulking machine under a temperature of 135 ℃ , and puffed at 400 r/min, to get puffed pellets. Milling: The puffed bran pellets were put into wall mill under 32℃ and 6 – 7 MPa and at 350 r/min to get dietary fiber powder (DFP) in particles with a 130-mesh diameter. Approach II: Except for the processing parameters, the procedure of Approach II was the same as Approach I. Results: The significant increase of nutritional elements contents in dietary fiber powder have been found when it is processed via different approaches. Different processing treatment and processing parameters bring forth different effects on the nutritional elements which are released from purple wheat bran. It is indicated that the contents of SDF produced via Approach I is greatly higher than that of the SDF produced via Approach II ( p ≤0.01), which suggests that Approach I is much effective for processing purple wheat bran for producing solvable dietary fiber Conclusions: Purple wheat bran is a high-effective health food, but only it is properly processed. Different processing has different impacts on the active substances of the purple wheat bran powder related to health function. In this study, only Approach I helps to increase the health nutritional ingredients which bring forth positive effects on the enhancement of health function, while Approach II fail to improve the function on health enhancement. Keywords: Dietary fiber powder, Purple wheat bran; Health food; Disease prevention

OBJECTIVE Little is known about how metabolic perturbations are linked to hyperuricemia in the general population. Therefore we aimed to examine metabolomics profiles in relation to uric acid change and incident hyperuricemia. METHODS This study included 1,621 community-dwelling Chinese participants ages 50-70 years without hyperuricemia at baseline, with a mean duration of follow-up of 6 years. A total of 56 metabolites (22 amino acids and 34 acylcarnitines) at baseline were quantified by gas or liquid chromatography coupled to mass spectrometry. Annual change in uric acid was calculated, and incident hyperuricemia was defined as plasma uric acid >420 μmoles/liter in men and >360 μmoles/liter in women. RESULTS The mean ± SD annual change in uric acid was 9.6 ± 12.1 μmoles/liter and the incidence of hyperuricemia was 23.1% (375 of 1,621). After adjustment for conventional risk factors, 9 metabolites (cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines C14:1OH, C18, C18:2, C20, and C20:4) were significantly associated with uric acid change (Bonferroni corrected P < 0.05) and with incident hyperuricemia (relative risks ranged from 1.14 to 1.21 per SD increment of metabolites; P < 0.05). A network analysis showed significant associations between the module containing long-chain acylcarnitines and incident hyperuricemia. Moreover, levels of these 9 metabolites were specifically correlated with intake of foods, including red and processed meat or soy products. CONCLUSION Plasma cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines are positively associated with incident hyperuricemia. The levels of these metabolites may be partially driven by intakes of meat and soy products that are associated with hyperuricemia.

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