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5 results on '"Zheng-Yun Jin"'

1. Gastrodia elata Blume extract improves high-fat diet-induced type 2 diabetes by regulating gut microbiota and bile acid profile

Author

Danqi Wang, Jun-Xia Wang, Chunri Yan, Yize Liu, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Zheng-Yun Jin, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, and Lin-Hu Quan

Subjects
Gastrodia elata Blume, type 2 diabetes, insulin resistance, gut microbiota, bile acid, Microbiology, QR1-502
Abstract

In this study, we aimed to characterize the anti-type 2 diabetes (T2D) effects of Gastrodia elata Blume extract (GEBE) and determine whether these are mediated through modification of the gut microbiota and bile acids. Mice were fed a high-fat diet (HFD), with or without GEBE, and we found that GEBE significantly ameliorated the HFD-induced hyperglycemia, insulin resistance, and inflammation by upregulating glucose transporter 4 (GLUT4) and inhibiting the toll-like receptor 4-nuclear factor kappa-B signaling pathway in white adipose tissue (WAT). In addition, we found that GEBE increased the abundance of Faecalibaculum and Lactobacillus, and altered the serum bile acid concentrations, with a significant increase in deoxycholic acid. The administration of combined antibiotics to mice to eliminate their intestinal microbiota caused a loss of the protective effects of GEBE. Taken together, these findings suggest that GEBE ameliorates T2D by increasing GLUT4 expression in WAT, remodeling the gut microbiota, and modifying serum bile acid concentrations.

Published
2022
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2. Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition

Author

Yize Liu, Zheng-Yun Jin, Jun-Xia Wang, Danqi Wang, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, and Lin-Hu Quan

Subjects
General Medicine, Food Science
Abstract

Ginsenoside Rg1 activates brown adipose tissue by modulating intestinal microbial and bile acid components to fight obesity in HFD-induced mice.

Published
2023

3. Effects of myostatin gene knockout on porcine extraocular muscles

Author

Si-Tong Lv, Kai Gao, Hak Myong Choe, Zheng-Yun Jin, Shuang-Yan Chang, Biao-Hu Quan, and Xi-Jun Yin

Subjects
Animal Science and Zoology, Bioengineering, Biotechnology
Abstract

Myostatin (MSTN), a negative regulator of skeletal muscle mass, is not well known in extraocular muscles (EOMs). EOMs are specialized skeletal muscles. Hence, in this study, the effect of MSTN on the superior rectus (SR) and superior oblique (SO) of 2-month-old MSTN knockout (MSTN

Published
2022

4. Positive growth of smooth muscle in uterine horns of myostatin homozygous mutant gilt

Author

Xin-Yue Liu, Hak Myong Choe, Zhou-Yan Li, Zheng-Yun Jin, Shuang-Yan Chang, Jin-Dan Kang, Xi-jun Yin, and Biao-Hu Quan

Subjects
General Veterinary, Swine, Sus scrofa, Uterus, Animals, Female, Muscle, Smooth, Myostatin, Muscle, Skeletal
Abstract

Current studies on myostatin (MSTN), a well-known negative regulator of skeletal muscle, studies mainly focus on the its effects on skeletal muscle.However, its effects on smooth muscle are less studied, especially in the uterine horns. To identify the role of MSTN in uterine horn smooth muscle, this study used 6-8-month-old homozygous MSTN mutant (MSTN

Published
2022

5. miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy

Author

Shuang-Yan Chang, Sheng-Zhong Han, Hak-Myong Choe, Kai Gao, Zheng-Yun Jin, Xin-Yue Liu, Liu-Hui Yang, Si-Tong Lv, Xi-Jun Yin, Lin-Hu Quan, and Jin-Dan Kang

Subjects
Swine, Muscle Fibers, Skeletal, Cell Differentiation, Cell Biology, Muscle Development, Biochemistry, MicroRNAs, Quality of Life, Animals, Atrophy, Muscle, Skeletal, 3' Untranslated Regions, Cell Proliferation, GRB2 Adaptor Protein
Abstract

Loss of muscle mass can lead to diseases such as sarcopenia, diabetes, and obesity, which can worsen the quality of life and increase the incidence of disease. Therefore, understanding the mechanism underlying skeletal muscle differentiation is vital to prevent muscle diseases. We previously found that microRNA-320 (miR-320) is highly expressed in the lean muscle-type pigs, but its regulatory role in myogenesis remains unclear. The bioinformatics prediction indicated that miR-320 could bind to the 3 'untranslated region of growth factor receptor-bound protein-2 (Grb2). We hypothesized that miR-320 targets Grb2 to regulate myoblasts differentiation. To verify this, we transfected miR-320 mimic and inhibitor into C2C12 myoblasts to assess the role of miR-320 during myoblasts differentiation. We used real-time qPCR, luciferase reporter assays, and western blotting to confirm that miR-320 directly targets Grb2 to promote myoblasts differentiation. Moreover, by using a dexamethasone-induced atrophic model of myotubes, we discovered that miR-320 promotes the repair of damaged myotubes. Our findings expand understanding of miRNAs and genes related to regulating skeletal muscle differentiation, and provide insight into underlying therapeutic strategies for muscle diseases.

Published
2022

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