9 results on '"Zheng-Hang Yu"'
Search Results
2. Cross-cultural adaptation and construct validity of the Chinese Version of Visual Vertigo Analogue Scale by using structural equation modeling.
- Author
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Li, Xiao-Xiao, Yu, Hai-Yun, Li, Jing-Jing, Liu, Xiao-Long, Zheng, Hang-Yu, Li, Yan-Fei, Li, Qi, and Liu, Si-Yuan
- Subjects
STRUCTURAL equation modeling ,VISUAL analog scale ,TEST validity ,CHINESE language ,VISUAL training ,CONFIRMATORY factor analysis ,VARIANCES - Abstract
BACKGROUND: Visual vertigo (VV) is a disease characterized by various visual signal-induced discomforts, including dizziness, unsteady balance, activity avoiding, and so forth. Distinguishing it from other kinds of dizziness is important because it needs the combination of visual training and vestibular rehabilitation together. However, there is no appropriate tool to diagnose VV in China, thus we would like to introduce an effective tool to China. OBJECTIVE: The aim of this study was to establish the reliability and validity of the Chinese version of visual vertigo analogue scale (VVAS-CH) and to achieve its cross-cultural adaptation in order to promote its further usage in China. METHODS: A total of 1681 patients complaining of vertigo or dizziness were enrolled and they were asked to complete the VVAS-CH. The cross-cultural adaptation, reliability and construct validity of the VVAS-CH were determined. RESULTS: Split-half reliability was 0.939, showing a good reliability. Factor analysis identified only one common factor for the nine items that explained 64.83% of the total variance. Most fit indices reached acceptable levels, proving the good fit of the VVAS-CH model. CONCLUSIONS: The VVAS-CH validated in this study can be used as an effective tool for diagnosing and evaluating VV in patients whose native language is Chinese. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Conductive Hydrogel for a Photothermal-Responsive Stretchable Artificial Nerve and Coalescing with a Damaged Peripheral Nerve
- Author
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Bo Shi, Chang-Chun Wang, Benlong Shi, Yong Qiu, Dun Liu, Jia-Hao Liu, Zezhang Zhu, Jia-Min Gan, Zheng-Hang Yu, Mei Dong, Xiao-Quan Shen, Di Zhao, and Qun-Dong Shen
- Subjects
Bioelectronics ,Materials science ,General Engineering ,General Physics and Astronomy ,02 engineering and technology ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,In vivo ,Peripheral nerve ,Peripheral nerve injury ,Self-healing hydrogels ,General Materials Science ,Implant ,0210 nano-technology ,Artificial tissue ,Biomedical engineering - Abstract
Modern development of flexible electronics has made use of bioelectronic materials as artificial tissue in vivo. As hydrogels are more similar to nerve tissue, functional hydrogels have become a promising candidate for bioelectronics. Meanwhile, interfacing functional hydrogels and living tissues is at the forefront of bioelectronics. The peripheral nerve injury often leads to paralysis, chronic pain, neurologic disorders, and even disability, because it has affected the bioelectrical signal transmission between the brain and the rest of body. Here, a kind of light-stimuli-responsive and stretchable conducting polymer hydrogel (CPH) is developed to explore artificial nerve. The conductivity of CPH can be enhanced when illuminated by near-infrared light, which can promote the conduction of the bioelectrical signal. When CPH is mechanically elongated, it still has high durability of conductivity and, thus, can accommodate unexpected strain of nerve tissues in motion. Thereby, CPH can better serve as an implant of the serious peripheral nerve injury in vivo, especially in the case that the length of the missing nerve exceeds 10 mm.
- Published
- 2020
4. Folate-Modified Photoelectric Responsive Polymer Microarray as Bionic Artificial Retina to Restore Visual Function
- Author
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Zheng-Hang Yu, Huai-Jin Guan, Fude Feng, Jia-Hao Liu, Mei Dong, Qun-Dong Shen, Xi Liu, Weijian Chen, Qiuyu Xia, Cheng Sun, and Yi-Nuo Yang
- Subjects
Bionics ,Nerve stimulation ,Retina ,Materials science ,genetic structures ,Polymers ,Prostheses and Implants ,Thiophenes ,Responsive polymer ,eye diseases ,Rats ,medicine.anatomical_structure ,Folic Acid ,Folic acid ,Visual function ,medicine ,Optic nerve ,Animals ,General Materials Science ,sense organs ,Neuron ,Biomedical engineering ,Visual phototransduction - Abstract
A high-optical-resolution artificial retina system that accurately communicates with the optic nerve is the main challenge in the modern biological science and bionic field. Here, we developed a bionic artificial retina possessing phototransduction "cells" with measurements even smaller than that of the neural cells. Using the technique of micrometer processing, we constructed a pyramid-shape periodic microarray of a photoreceptor. Each "sensing cell" took advantage of polythiophene derivative/fullerene derivative (PCBM) as a photoelectric converter. Because folic acid played an essential role in eye growth, we particularly modified the polythiophene derivatives with folic acid tags. Therefore, the artificial retina could enlarge the contact area and even recognize the nerve cells to improve the consequence of nerve stimulation. We implanted the artificial retina into blinded rats' eyes. Electrophysiological analysis revealed its recovery of photosensitive function 3 months after surgery. Our work provides an innovative idea for fabricating a high-resolution bionic artificial retina system. It shows great potential in artificial intelligence and biomedicine.
- Published
- 2020
5. Effect of La0.67Sr0.33 MnO3 Insertion Layer on the Ferroelectric and Resistive Switching Behaviors of PbZr0.52Ti0.48O3/Nb:SrTiO3 Heterostructures
- Author
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Dong, Jing Yi, primary, Bai, Yu, additional, Zheng, Hang Yu, additional, Huang, He Yang, additional, Lin, Jun Liang, additional, Zhang, Fan, additional, Wang, Chao, additional, and Wang, Zhan Jie, additional
- Published
- 2020
- Full Text
- View/download PDF
6. Light‐Induced ROS Generation and 2‐DG‐Activated Endoplasmic Reticulum Stress by Antitumor Nanosystems: An Effective Combination Therapy by Regulating the Tumor Microenvironment
- Author
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Xuanzhong Xiao, Zheng-Hang Yu, Mei Dong, Jiacheng Zhao, Jia-Hao Liu, Zhi-Gui Su, Qun-Dong Shen, and Chenggen Qian
- Subjects
Light ,medicine.medical_treatment ,Antineoplastic Agents ,Apoptosis ,Photodynamic therapy ,02 engineering and technology ,Deoxyglucose ,010402 general chemistry ,01 natural sciences ,Biomaterials ,Necrosis ,Phagocytosis ,Combination cancer therapy ,Tumor Microenvironment ,medicine ,Humans ,General Materials Science ,Tumor microenvironment ,Photosensitizing Agents ,Endoplasmic reticulum ,Cancer ,General Chemistry ,Endoplasmic Reticulum Stress ,021001 nanoscience & nanotechnology ,medicine.disease ,Combined Modality Therapy ,0104 chemical sciences ,Kinetics ,Nanomedicine ,Photochemotherapy ,Cancer cell ,MCF-7 Cells ,Unfolded protein response ,Cancer research ,Reactive Oxygen Species ,0210 nano-technology ,Intracellular ,Biotechnology - Abstract
A multimodal cancer therapeutic nanoplatform is reported. It demonstrates a promising approach to synergistically regulating the tumor microenvironment. The combination of intracellular reactive oxygen species (ROS) generated by irradiation of photosensitizer and endoplasmic reticulum (ER) stress induced by 2-deoxy-glucose (2-DG) has a profound effect on necrotic or apoptotic cell death. Especially, targeting metabolic pathway by 2-DG is a promising strategy to promote the effect of photodynamic therapy and chemotherapy. The nanoplatform can readily release its cargoes inside cancer cells and combines the advantages of ROS-sensitive releasing chemotherapeutic drugs, upregulating apoptosis pathways under ER stress, light-induced generation of cytotoxic ROS, achieving tumor accumulation, and in vivo fluorescence imaging capability. This work highlights the importance of considering multiple intracellular stresses as design parameters for nanoscale functional materials in cell biology, immune response, as well as medical treatments of cancer, Alzheimer's disease, etc.
- Published
- 2019
7. Effect of La0.67Sr0.33 MnO3 Insertion Layer on the Ferroelectric and Resistive Switching Behaviors of PbZr0.52Ti0.48O3/Nb:SrTiO3 Heterostructures.
- Author
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Dong, Jing Yi, Bai, Yu, Zheng, Hang Yu, Huang, He Yang, Lin, Jun Liang, Zhang, Fan, Wang, Chao, and Wang, Zhan Jie
- Subjects
HETEROSTRUCTURES ,LEAD titanate ,FERROELECTRICITY ,BARIUM titanate ,HYSTERESIS loop ,INTERFACE structures ,ENERGY bands - Abstract
Recently, ferroelectric resistive switching (RS) effect in the ferroelectric/semiconductor heterostructures has been widely studied and the RS performance has been greatly improved. However, the relationships between ferroelectric and RS behaviors as well as interface structure of ferroelectric/semiconductor heterostructures need to be further studied. Herein, a La 0. 6 7 Sr 0. 3 3 MnO
3 (LSMO) layer with the thickness of 7 nm is inserted into PbZr 0. 5 2 Ti 0. 4 8 O3 /Nb:SrTiO3 (PZT/NSTO) heterostructures, and its effects on the ferroelectric and RS behaviors are investigated. The PZT/NSTO heterostructures show significantly asymmetric ferroelectric loops, and the RS ratio in which can reach to three orders of magnitude. However, by inserting the LSMO layer, the ferroelectric loops became relatively symmetric, but the RS effect almost disappeared. It can be considered that the LSMO layer affects the interfacial energy band structure of the PZT/NSTO heterostructures, which makes ferroelectric polarization lose its effect on the modulation of the depletion layer width. Therefore, the existence of the adjustable depletion layer is very important for the RS effect of ferroelectric/semiconductor heterostructures. An ultrathin La0.67 Sr0.33 MnO3 (LSMO) layer with the thickness of 7 nm was inserted into PbZr0.52 Ti0.48 O3 /Nb:SrTiO3 (PZT/NSTO) heterostructures. In the PZT/NSTO heterostructures, the ON/OFF ratio reached three orders of magnitude and the P-E hysteresis loops presented obvious asymmetry. However, in the PZT/LSMO/NSTO heterostructures, the P-E hysteresis loops became relatively symmetrical while the resistive switching effect almost disappeared. The role of LSMO insertion can be considered as changing the interfacial energy band structures of the PZT/NSTO heterostructures. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
8. Cross-cultural adaptation and construct validity of the Chinese Version of Visual Vertigo Analogue Scale by using structural equation modeling.
- Author
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Li XX, Yu HY, Li JJ, Liu XL, Zheng HY, Li YF, Li Q, and Liu SY
- Subjects
- Humans, Male, Female, Middle Aged, Reproducibility of Results, Adult, China, Aged, Young Adult, Latent Class Analysis, Dizziness diagnosis, Visual Analog Scale, Vertigo diagnosis, Cross-Cultural Comparison
- Abstract
Background: Visual vertigo (VV) is a disease characterized by various visual signal-induced discomforts, including dizziness, unsteady balance, activity avoiding, and so forth. Distinguishing it from other kinds of dizziness is important because it needs the combination of visual training and vestibular rehabilitation together. However, there is no appropriate tool to diagnose VV in China, thus we would like to introduce an effective tool to China., Objective: The aim of this study was to establish the reliability and validity of the Chinese version of visual vertigo analogue scale (VVAS-CH) and to achieve its cross-cultural adaptation in order to promote its further usage in China., Methods: A total of 1681 patients complaining of vertigo or dizziness were enrolled and they were asked to complete the VVAS-CH. The cross-cultural adaptation, reliability and construct validity of the VVAS-CH were determined., Results: Split-half reliability was 0.939, showing a good reliability. Factor analysis identified only one common factor for the nine items that explained 64.83% of the total variance. Most fit indices reached acceptable levels, proving the good fit of the VVAS-CH model., Conclusions: The VVAS-CH validated in this study can be used as an effective tool for diagnosing and evaluating VV in patients whose native language is Chinese.
- Published
- 2024
- Full Text
- View/download PDF
9. The Correlation Between Detection Value of Distortion-Product Otoacoustic Emissions and the Early Prognosis of Sudden Sensorineural Hearing Loss.
- Author
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Liu SY, Shi WY, Zheng HY, Yuan YX, Li JJ, and Li Q
- Subjects
- Audiometry, Pure-Tone, Auditory Threshold, Humans, Otoacoustic Emissions, Spontaneous, Prognosis, Hearing Loss, Sensorineural diagnosis, Hearing Loss, Sudden diagnosis
- Abstract
Background: To explore the correlation between the detection value of distortion-product otoacoustic emissions and the early prognosis of sudden sensorineural hearing loss., Methods: Seventy-eight patients with first-onset sudden sensorineural hearing loss (all frequencies) from April 2018 to July 2019 were included in this study. Distortion-product otoacoustic emissions and pure-tone audiometry tests were performed at days 0, 3, and 6 of admission. Repeated measures analysis of variance was performed to evaluate the changes in the signal-to-noise ratio for different distortion-product otoacoustic emissions frequencies over time and the interaction of grouping factors and time factors., Results: The distortion-product otoacoustic emissions evocation rate in the 4 groups was significantly different starting at day 3 of treatment. It was higher in the cured (35.3%) and obviously effective (20.0%) groups than in the other 2 groups (0%, 0%). At the 6 f2 frequencies of 1105 Hz, 1560 Hz, 2211 Hz, 3125 Hz, 4416 Hz, and 8837 Hz, the signal-to-noise ratio was different among the groups (P < .05) and was notably higher in the cured group. The analysis of the signal-to-noise ratio change before and after treatment at the intermediate f2 frequencies of 1105 Hz, 1560 Hz, and 2211 Hz in all patients indicated a linear correlation between the signal-to-noise ratio change and the pure-tone hearing threshold change, with a correlation coefficient of 0.481., Conclusion: Distortion-product otoacoustic emissions evocation in the early stage (within 3 days of treatment) or the signal-to-noise ratio trend over time at intermediate frequencies may predict the prognosis of sudden sensorineural hearing loss.
- Published
- 2022
- Full Text
- View/download PDF
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