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A meta-analysis method was used to investigate the prognostic value of CD8+ tumor-infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC) patients treated with PD-1/PD-L1 inhibitors. A database search of PubMed, Embase, Web of Science and Cochrane Library up until 7 February, 2023. A clinical study on the relationship between CD8+ TILs and PD-1/PD-L1 inhibitors in the therapeutics of NSCLC. RevMan 5.3 and StataMP 17.0 software were used for meta-analysis. The outcome indicators incorporated overall survival (OS), progression-free survival (PFS) and objective response rate (ORR). Nineteen articles with 1488 patients were included. The analysis results showed that high CD8+ TILs were associated with better OS (HR = 0.60, 95% CI: 0.46–0.77; P < 0.0001), PFS (HR = 0.68, 95% CI: 0.53–0.88; P = 0.003) and ORR (OR = 2.26, 95% CI: 1.52–3.36; P < 0.0001) in NSCLC patients treated with PD-1/PD-L1 inhibitors. Subgroup analysis indicated that patients with high CD8+ TILs had good clinical prognostic benefits whether the location of CD8+ TILs was intratumoral or stromal, and compared with East Asian, high CD8+ TILs in Caucasians showed a better prognosis. High CD8+ TILs in peripheral blood did not improve OS (HR = 0.83, 95% CI: 0.69–1.01; P = 0.06) and PFS (HR = 0.93, 95% CI: 0.61–1.14; P = 0.76) in NSCLC patients receiving PD-1/PD-L1 inhibitors. In spite of the location of CD8+ TILs, high densities of CD8+ TILs were predictive of treatment outcomes in NSCLC patients treated with PD-1/PD-L1 inhibitors. However, high CD8+ TILs in peripheral blood had no predictive effect. [ABSTRACT FROM AUTHOR]

Air viscous resistance has an impact on the precision of the air track experimental results. Based on data obtained from experiments and a simplified model of air viscous resistance of air track, an experimental model of measuring and processing air viscous resistance is established and it is verified by experiments in this paper. [ABSTRACT FROM AUTHOR]

X ray diffraction, fourier infrared spectrum and TGA-DSC combined with fourier infrared spectrum were used to study the mineralogical characteristics of the partings and floors of No. 9 coal in the areas of Jincheng in Shanxi Province. There are several important characteristics of ammonium-illite smectite interlayer including the sub-peak on the left of 1. 033 nm(d(001) of ammonium illite) higher than the right sub-peak, the IR absorption peaks from the distortion vibration of Due to image rights restrictions, multiple line equation(s) cannot be graphically displayed. between 1 427.09 and 1 433.34 cm-1 and NH30 generated heated at the temperature of 561 °C. Ammonium-illite smectite interlayer is hydrothermal altered clay minerals, generated from the illitization of illite smectite interlayers when K+ is substituted by Due to image rights restrictions, multiple line equation(s) cannot be graphically displayed. transformed from organic nitrogen in the condition of relatively high mature, and its formation temperature is about 350 °C. [ABSTRACT FROM AUTHOR]

The combined thermo gravimetric-infrared-mass spectrometry (TG-IR-MS) analysis were conducted under the temperature of 30° to 1 100° with a heating rate of 10°/min to monitor the different rank coal's pyrolysis and nitrogen release behavior online.The thermal analysis results show that the various nitrides like HCN and NH3 are released from coals during pyrolyzing.The released products vary with different coalification coals during pyrolysis.Nitrogen is mainly released in the forms of NH3 and HCN in gas coal,1/3 coking coal and coking coal, but NH3 in the high rank coal.The HCN and NH3 come from different types of nitrogen in the coal's internal structure.The HCN may be mainly derived from the edge of five-membered rings pyrrole nitrogen and six-membered rings pyridine nitrogen in coals, the NH3 from the inside quartery nitrogen.The release of NH3 experience two stages:the lower temperature stage at which it is from the elementary pyrolysis of volatile components;and the high temperature stage at which it is from the secondary pyrolysis of volatile components. [ABSTRACT FROM AUTHOR]

Objective: To assess the clinical efficacy of microwave ablation (MWA) in treating tumour patients with postsurgical intrapulmonary oligometastases or oligorecurrence (PIORO)., Study Design: Descriptive study. Place and Duration of the Study: Departments of Thoracic Surgery and Oncology, Jinan Central Hospital and Qilu Hospital, Jinan, China, from January 2014 to June 2023., Methodology: Clinical data of 31 patients with PIORO receiving treatment with MWA were retrospectively analysed. After undergoing MWA, the patients were followed up for computed tomography (CT) examination on the 7th day, 1st month, and every 3 months, respectively. The Kaplan-Meier method was conducted to evaluate the clinical outcomes; overall survival (OS), progression-free survival (PFS), and time to local progression (TTLP)., Results: All patients with PIORO were successfully treated with MWA. The 3-year survival rate of patients was 35.5%. The median OS was 26.0 months, the median PFS was 11.1 months, and the median TTLP was 14.4 months. Patients with oligometastatic or oligorecurrent tumours ≤3 cm in diameter showed better PFS (≤3 cm, 14.261 m vs. >3 cm, 7.786 m; p <0.01) and TTLP (≤3 cm, 19.522 m vs. >3 cm, 12.214 m; p <0.05) than those with tumours >3 cm in diameter. Clinical characteristics of the patients were not significantly correlated with OS., Conclusion: MWA, as a topically therapeutic method, is an effective procedure for tumour patients with PIORO, especially in cases of oligometastatic or oligorecurrent tumours ≤3 cm in diameter., Key Words: Microwave ablation, Thermal ablation, Oligometastases, Oligorecurrence, Progression-free survival, Survival.