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Your search keyword '"Zheng, Junpeng"' showing total 20 results
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20 results on '"Zheng, Junpeng"'

14. Dihydronaphthyl-based [60]fullerene bisadducts for efficient and stable polymer solar cells

Author

Meng, Xiangyue, primary, Zhang, Wenqing, additional, Tan, Zhan'ao, additional, Du, Chun, additional, Li, Cuihong, additional, Bo, Zhishan, additional, Li, Yongfang, additional, Yang, Xiulin, additional, Zhen, Mingming, additional, Jiang, Feng, additional, Zheng, Junpeng, additional, Wang, Taishan, additional, Jiang, Li, additional, Shu, Chunying, additional, and Wang, Chunru, additional

Published
2012
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19. Multifunctional nanoprobe for MRI/optical dual-modality imaging and radical scavenging.

Author

Zhen M, Zheng J, Wang Y, Shu C, Gao F, Zou J, Pyykkö I, and Wang C

Subjects
Animals, Blood-Brain Barrier chemistry, Blood-Brain Barrier metabolism, Contrast Media pharmacokinetics, Coordination Complexes chemistry, Free Radical Scavengers chemistry, Free Radical Scavengers metabolism, Fullerenes chemistry, Gadolinium chemistry, Humans, Liver diagnostic imaging, Magnetic Resonance Imaging, Mice, Radiography, Rats, Reactive Oxygen Species chemistry, Tissue Distribution, Contrast Media chemistry, Nanostructures chemistry
Abstract

The development of novel nanomaterials for the diagnosis and/or treatment of human diseases has become an important issue. In this work, a multifunctional theranostic agent was designed by covalently binding hydroxyl- and amino-bearing C60 derivatives (C60 O∼10 (OH)∼16 (NH2 )∼6 (NO2 )∼6 ⋅24 H2 O) with gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) to yield C60 O∼10 (OH)∼16 (NH2 )∼6 (NO2 )∼6 ⋅24 H2 O/(Gd-DTPA)3 (DF1 Gd3 ). The obtained DF1 Gd3 shows more than fourfold contrast improvement over commercial Gd-DTPA along with multiwavelength fluorescent emission for dual-modality diagnosis. An inner-ear magnetic resonance imaging (MRI) study was designed as a model of biological barriers, including the blood/brain barrier (BBB) for DF1 Gd3 to investigate its in vivo behavior. This revealed that the fabricated contrast agent dramatically increases the local contrast but can not cross the middle ear/inner ear barrier and endolymph/perilymph barrier in the inner ear, and thus it is also BBB-prohibited in normal individuals. In vivo biodistribution studies suggested that 1) DF1 Gd3 could circulate in vessels for a relatively long time and is mainly eliminated through liver and kidney, 2) DF1 Gd3 may potentially function as a liver-specific MRI contrast agent. Interestingly, DF1 Gd3 also shows an excellent quenching effect on hydroxyl radicals, as revealed by the DMPO spin trap/ESR method. The combination of enhanced MRI/FL imaging and local treatment of lesions is unique to DF1 Gd3 and potentiates the medical paradigm of "detect and treat/prevent" in combating human diseases related to reactive oxygen., (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2013
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20. Enhanced photodynamic efficiency of an aptamer-guided fullerene photosensitizer toward tumor cells.

Author

Liu Q, Xu L, Zhang X, Li N, Zheng J, Guan M, Fang X, Wang C, and Shu C

Subjects
Cell Line, Tumor, Cell Survival drug effects, Humans, Light, Lung Neoplasms drug therapy, Photochemotherapy, Photosensitizing Agents therapeutic use, Photosensitizing Agents toxicity, Reactive Oxygen Species metabolism, Aptamers, Nucleotide chemistry, Fullerenes chemistry, Photosensitizing Agents chemistry
Abstract

Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT., (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2013
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