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Geotextile tubes have offered a cost-effective and convenient solution for the treatment of dredged slurry in recent years. Despite their benefits, the dewatering process of this method remains cumbersome and time-consuming. The incorporation of flocculants into dredged slurries has been shown to mitigate the clogging of geotextile tubes, thereby enhancing the efficiency of the dewatering process. To quantify the impact of flocculant addition on the dewatering performance, a series of laboratory tests were conducted to investigate the sedimentation behavior of flocculant-treated river-dredged slurries under filtration of woven geotextiles. The impact of different flocculants is evaluated with the sedimentation rates of dredged slurries, specifically nonionic polyacrylamide (NPAM) and cationic polyacrylamide (CPAM). Results demonstrated that both NPAM and CPAM, at an optimal concentration of around 250 mg/L, could substantially increase the settling rates of slurries when filtered through geotextiles. At equivalent flocculant concentration, NPAM outperforms CPAM in accelerating sedimentation rates. It is also evidenced that adding flocculants can significantly augment the particle size and permeability of slurries. After adding flocculants, the water content and dry density of the final sediments exhibit a more uniform distribution in the vertical direction compared to the original slurry. Furthermore, scanning electron microscopy was employed to analyze the micromorphology of the final sediments treated with different NPAM concentrations. The results showed that the slurries exhibited significant void structure under treatment with the optimal concentration of NPAM, demonstrating the flocculants' effectiveness in enhancing the dewatering process of river-dredged slurries when filtered with geotextiles. [ABSTRACT FROM AUTHOR]

Tumor spread is responsible for most deaths related to cancer. Increasing the accuracy of cancer prognosis is critical to reducing the high mortality rates in cancer patients. Here, we report that the electrostatic potential difference (EPD) between tumor and its paratumor tissue is a prognostic marker for tumor spread. This finding is concluded from the patient‐specific EPD values and clinical observation. The electrostatic potential values were measured on tissue cryosections from 51 patients using Kelvin probe force microscopy (KPFM). A total of ~44% (15/34) patients of Vtumor–paratumor > 0 were featured with tumor spread, whereas only ~18% (2/11) patients of Vtumor–paratumor < 0 had tumor spread. Next, we found the increased enrichment of cancer stem cells in paratumors with lower electrostatic potentials using immunofluorescence imaging, which suggested the attribution of tumor spread to the galvanotaxis of cancer stem cells (CSCs) toward lower potential. The findings were finally validated in breast and lung spheroid models composed of differentiated cancer cells and cancer stem cells at the ratio of 1:1 and embedded in Matrigel dopped with negative‐, neutral‐ and positive‐charged polymers and CSCs prefer to spread out of spheroids to lower electrostatic potential sites. This work may inspire the development of diagnostic and prognostic strategies targeting at tissue EPDs and CSCs for tumor therapy. [ABSTRACT FROM AUTHOR]