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9 results on '"Zheng, Gaomin"'

1. FASN-mediated fatty acid biosynthesis remodels immune environment in Clonorchis sinensis infection-related intrahepatic cholangiocarcinoma

Author

Xu, Lixia, Zhang, Ying, Lin, Zhilong, Deng, Xinlang, Ren, Xiaoxue, Huang, Mingle, Li, Shangru, Zhou, Qianying, Fang, Fei, Yang, Qingxia, Zheng, Gaomin, Chen, Zebin, Wu, Zhongdao, Sun, Xi, Lin, Jie, Shen, Jingxian, Guo, Jianping, Li, Xiaoxing, Xue, Tianchen, Tan, Jing, Lin, Xiaoxuan, Tan, Li, Peng, Hong, Shen, Shunli, Peng, Sui, Li, Shaoqiang, Liang, Lijian, Cleary, James M., Lai, Jiaming, Xie, Yubin, and Kuang, Ming

Published
2024
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3. Table S3 from Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis

Author

Liu, Xin, primary, Wang, Xin, primary, Yang, Qingxia, primary, Luo, Li, primary, Liu, Ziqin, primary, Ren, Xiaoxue, primary, Lei, Kai, primary, Li, Shangru, primary, Xie, Zonglin, primary, Zheng, Gaomin, primary, Zhang, Yifan, primary, Hao, Yijie, primary, Zhou, Qianying, primary, Hou, Yingdong, primary, Fang, Fei, primary, Song, Wu, primary, Cui, Ji, primary, Ma, Jinping, primary, Xie, Wenxuan, primary, Shen, Shunli, primary, Tang, Ce, primary, Peng, Sui, primary, Yu, Jun, primary, Kuang, Ming, primary, Song, Xinming, primary, Wang, Fang, primary, and Xu, Lixia, primary

Published
2024
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4. Figure S9 from Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis

Author

Liu, Xin, primary, Wang, Xin, primary, Yang, Qingxia, primary, Luo, Li, primary, Liu, Ziqin, primary, Ren, Xiaoxue, primary, Lei, Kai, primary, Li, Shangru, primary, Xie, Zonglin, primary, Zheng, Gaomin, primary, Zhang, Yifan, primary, Hao, Yijie, primary, Zhou, Qianying, primary, Hou, Yingdong, primary, Fang, Fei, primary, Song, Wu, primary, Cui, Ji, primary, Ma, Jinping, primary, Xie, Wenxuan, primary, Shen, Shunli, primary, Tang, Ce, primary, Peng, Sui, primary, Yu, Jun, primary, Kuang, Ming, primary, Song, Xinming, primary, Wang, Fang, primary, and Xu, Lixia, primary

Published
2024
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5. Data from Th17 Cells Secrete TWEAK to Trigger Epithelial–Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis

Author

Liu, Xin, primary, Wang, Xin, primary, Yang, Qingxia, primary, Luo, Li, primary, Liu, Ziqin, primary, Ren, Xiaoxue, primary, Lei, Kai, primary, Li, Shangru, primary, Xie, Zonglin, primary, Zheng, Gaomin, primary, Zhang, Yifan, primary, Hao, Yijie, primary, Zhou, Qianying, primary, Hou, Yingdong, primary, Fang, Fei, primary, Song, Wu, primary, Cui, Ji, primary, Ma, Jinping, primary, Xie, Wenxuan, primary, Shen, Shunli, primary, Tang, Ce, primary, Peng, Sui, primary, Yu, Jun, primary, Kuang, Ming, primary, Song, Xinming, primary, Wang, Fang, primary, and Xu, Lixia, primary

Published
2024
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8. Genomic Characteristics, Metabolic Signature and Immune Microenvironment of Clonorchis Sinensis-Related Intrahepatic Cholangiocarcinoma

Author

Xu, Lixia, primary, Zhang, Ying, additional, Lin, Zhilong, additional, Deng, Xinlang, additional, Huang, Mingle, additional, Ren, Xiaoxue, additional, Yang, Qingxia, additional, Zheng, Gaomin, additional, Chen, Zebin, additional, Wu, Zhongdao, additional, Sun, Xi, additional, Lin, Jie, additional, Li, Xiaoxing, additional, Shen, Shunli, additional, Li, Shaoqiang, additional, Peng, Baogang, additional, Liang, Lijian, additional, Lai, Jiaming, additional, Xie, Yubin, additional, and Kuang, Ming, additional

Published
2022
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9. Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis.

Author

Liu X, Wang X, Yang Q, Luo L, Liu Z, Ren X, Lei K, Li S, Xie Z, Zheng G, Zhang Y, Hao Y, Zhou Q, Hou Y, Fang F, Song W, Cui J, Ma J, Xie W, Shen S, Tang C, Peng S, Yu J, Kuang M, Song X, Wang F, and Xu L

Subjects
Humans, Animals, Mice, Th17 Cells, Cytokine TWEAK, Epithelial-Mesenchymal Transition genetics, Prognosis, TWEAK Receptor genetics, Cell Line, Tumor, Cell Movement genetics, Tumor Microenvironment, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Liver Neoplasms genetics, Liver Neoplasms secondary
Abstract

Liver metastasis is the leading cause of mortality in patients with colorectal cancer. Given the significance of both epithelial-mesenchymal transition (EMT) of tumor cells and the immune microenvironment in colorectal cancer liver metastasis (CRLM), the interplay between them could hold the key for developing improved treatment options. We employed multiomics analysis of 130 samples from 18 patients with synchronous CRLM integrated with external datasets to comprehensively evaluate the interaction between immune cells and EMT of tumor cells in liver metastasis. Single-cell RNA sequencing analysis revealed distinct distributions of nonmalignant cells between primary tumors from patients with metastatic colorectal cancer (mCRC) and non-metastatic colorectal cancer, showing that Th17 cells were predominantly enriched in the primary lesion of mCRC. TWEAK, a cytokine secreted by Th17 cells, promoted EMT by binding to receptor Fn14 on tumor cells, and the TWEAK-Fn14 interaction enhanced tumor migration and invasion. In mouse models, targeting Fn14 using CRISPR-induced knockout or lipid nanoparticle-encapsulated siRNA alleviated metastasis and prolonged survival. Mice lacking Il17a or Tnfsf12 (encoding TWEAK) exhibited fewer metastases compared with wild-type mice, while cotransfer of Th17 with tumor cells promoted liver metastasis. Higher TWEAK expression was associated with a worse prognosis in patients with colorectal cancer. In addition, CD163L1+ macrophages interacted with Th17 cells, recruiting Th17 via the CCL4-CCR5 axis. Collectively, this study unveils the role of immune cells in the EMT process and identifies TWEAK secreted by Th17 as a driver of CRLM., Significance: TWEAK secreted by Th17 cells promotes EMT by binding to Fn14 on colorectal cancer cells, suggesting that blocking the TWEAK-Fn14 interaction may be a promising therapeutic approach to inhibit liver metastasis., (©2024 American Association for Cancer Research.)

Published
2024
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