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538 results on '"Zhau, Haiyen E."'

3. Cultured circulating tumor cells and their derived xenografts for personalized oncology.

Author

Wang, Ruoxiang, Chu, Gina CY, Mrdenovic, Stefan, Annamalai, Alagappan A, Hendifar, Andrew E, Nissen, Nicholas N, Tomlinson, James S, Lewis, Michael, Palanisamy, Nallasivam, Tseng, Hsian-Rong, Posadas, Edwin M, Freeman, Michael R, Pandol, Stephen J, Zhau, Haiyen E, and Chung, Leland WK

Subjects
Cancer metastasis, Circulating tumor cell, Peripheral blood, ex vivo culture
Abstract

Recent cancer research has demonstrated the existence of circulating tumor cells (CTCs) in cancer patient's blood. Once identified, CTC biomarkers will be invaluable tools for clinical diagnosis, prognosis and treatment. In this review, we propose ex vivo culture as a rational strategy for large scale amplification of the limited numbers of CTCs from a patient sample, to derive enough CTCs for accurate and reproducible characterization of the biophysical, biochemical, gene expressional and behavioral properties of the harvested cells. Because of tumor cell heterogeneity, it is important to amplify all the CTCs in a blood sample for a comprehensive understanding of their role in cancer metastasis. By analyzing critical steps and technical issues in ex vivo CTC culture, we developed a cost-effective and reproducible protocol directly culturing whole peripheral blood mononuclear cells, relying on an assumed survival advantage in CTCs and CTC-like cells over the normal cells to amplify this specified cluster of cancer cells.

Published
2016

5. Figures S1-S5 from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc

Author

Lin, Tzu-Ping, primary, Li, Jingjing, primary, Li, Qinlong, primary, Li, Xiangyan, primary, Liu, Chunyan, primary, Zeng, Ni, primary, Huang, Jen-Ming, primary, Chu, Gina Chia-Yi, primary, Lin, Chi-Hung, primary, Zhau, Haiyen E., primary, Chung, Leland W.K., primary, Wu, Boyang Jason, primary, and Shih, Jean C., primary

Published
2023
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10. Supplementary Figure 5 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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11. Supplementary figure 1 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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12. Supplementary Figure 4 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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13. Data from Near IR Heptamethine Cyanine Dye–Mediated Cancer Imaging

Author

Yang, Xiaojian, primary, Shi, Chunmeng, primary, Tong, Rong, primary, Qian, Weiping, primary, Zhau, Haiyen E., primary, Wang, Ruoxiang, primary, Zhu, Guodong, primary, Cheng, Jianjun, primary, Yang, Vincent W., primary, Cheng, Tianmin, primary, Henary, Maged, primary, Strekowski, Lucjan, primary, and Chung, Leland W.K., primary

Published
2023
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14. Supplementary Materials and Methods from miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

Author

Gururajan, Murali, primary, Josson, Sajni, primary, Chu, Gina Chia-Yi, primary, Lu, Chia-Lun, primary, Lu, Yi-Tsung, primary, Haga, Christopher L., primary, Zhau, Haiyen E., primary, Liu, Chunyan, primary, Lichterman, Jake, primary, Duan, Peng, primary, Posadas, Edwin M., primary, and Chung, Leland W.K., primary

Published
2023
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15. Supplementary Figure 2 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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16. Data from miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

Author

Gururajan, Murali, primary, Josson, Sajni, primary, Chu, Gina Chia-Yi, primary, Lu, Chia-Lun, primary, Lu, Yi-Tsung, primary, Haga, Christopher L., primary, Zhau, Haiyen E., primary, Liu, Chunyan, primary, Lichterman, Jake, primary, Duan, Peng, primary, Posadas, Edwin M., primary, and Chung, Leland W.K., primary

Published
2023
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17. Supplementary Figure 6 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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18. Supplementary Table S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer

Author

Josson, Sajni, primary, Gururajan, Murali, primary, Hu, Peizhen, primary, Shao, Chen, primary, Chu, Gina Chia-Yi, primary, Zhau, Haiyen E., primary, Liu, Chunyan, primary, Lao, Kaiqin, primary, Lu, Chia-Lun, primary, Lu, Yi-Tsung, primary, Lichterman, Jake, primary, Nandana, Srinivas, primary, Li, Quanlin, primary, Rogatko, Andre, primary, Berel, Dror, primary, Posadas, Edwin M., primary, Fazli, Ladan, primary, Sareen, Dhruv, primary, and Chung, Leland W.K., primary

Published
2023
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19. Data from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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20. Supplementary Figure S3 from miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer

Author

Josson, Sajni, primary, Gururajan, Murali, primary, Hu, Peizhen, primary, Shao, Chen, primary, Chu, Gina Chia-Yi, primary, Zhau, Haiyen E., primary, Liu, Chunyan, primary, Lao, Kaiqin, primary, Lu, Chia-Lun, primary, Lu, Yi-Tsung, primary, Lichterman, Jake, primary, Nandana, Srinivas, primary, Li, Quanlin, primary, Rogatko, Andre, primary, Berel, Dror, primary, Posadas, Edwin M., primary, Fazli, Ladan, primary, Sareen, Dhruv, primary, and Chung, Leland W.K., primary

Published
2023
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21. Supplementary Table 1 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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22. Supplementary Fig S1 from miR-154* and miR-379 in the DLK1-DIO3 MicroRNA Mega-Cluster Regulate Epithelial to Mesenchymal Transition and Bone Metastasis of Prostate Cancer

Author

Gururajan, Murali, primary, Josson, Sajni, primary, Chu, Gina Chia-Yi, primary, Lu, Chia-Lun, primary, Lu, Yi-Tsung, primary, Haga, Christopher L., primary, Zhau, Haiyen E., primary, Liu, Chunyan, primary, Lichterman, Jake, primary, Duan, Peng, primary, Posadas, Edwin M., primary, and Chung, Leland W.K., primary

Published
2023
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23. Supplementary Materials and Methods from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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25. Suplplementary Figure Legend from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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27. Supplementary Figure 3 from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis

Author

Nandana, Srinivas, primary, Tripathi, Manisha, primary, Duan, Peng, primary, Chu, Chia-Yi, primary, Mishra, Rajeev, primary, Liu, Chunyan, primary, Jin, Renjie, primary, Yamashita, Hironobu, primary, Zayzafoon, Majd, primary, Bhowmick, Neil A., primary, Zhau, Haiyen E., primary, Matusik, Robert J., primary, and Chung, Leland W.K., primary

Published
2023
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28. Data from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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34. Supplementary Legends 1-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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36. Supplementary Data 6-9 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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38. Supplementary Data 1-5 from Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis

Author

Sung, Shian-Ying, primary, Hsieh, Chia-Ling, primary, Law, Andrew, primary, Zhau, Haiyen E., primary, Pathak, Sen, primary, Multani, Asha S., primary, Lim, Sharon, primary, Coleman, Ilsa M., primary, Wu, Li-Chin, primary, Figg, William D., primary, Dahut, William L., primary, Nelson, Peter, primary, Lee, Jae K., primary, Amin, Mahul B., primary, Lyles, Robert, primary, Johnstone, Peter A.J., primary, Marshall, Fray F., primary, and Chung, Leland W.K., primary

Published
2023
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46. A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models.

Author

Mrdenovic, Stefan, Wang, Yanping, Yin, Lijuan, Chu, Gina Chia-Yi, Ou, Yan, Lewis, Michael S., Heffer, Marija, Posadas, Edwin M., Zhau, Haiyen E., Chung, Leland W. K., Edderkaoui, Mouad, Pandol, Stephen J., Wang, Ruoxiang, and Zhang, Yi

Subjects
RENAL cancer, DRUG toxicity, RENAL cell carcinoma, NEPHROTOXICOLOGY, CANCER treatment, CELL death, MTOR inhibitors
Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted cancer therapy may thwart the resistance to produce a substantial effect. Methods: We tested whether the resistance can be circumvented by subcellular targeted cancer therapy with DZ-CIS, which is a chemical conjugate of the tumor-cell specific heptamethine carbocyanine dye (HMCD) with cisplatin (CIS), a chemotherapeutic drug with limited use in ccRCC treatment because of frequent renal toxicity. Results: DZ-CIS displayed cytocidal effects on Caki-1, 786-O, ACHN, and SN12C human ccRCC cell lines and mouse Renca cells in a dose-dependent manner and inhibited ACHN and Renca tumor formation in experimental mouse models. Noticeably, in tumor-bearing mice, repeated DZ-CIS use did not cause renal toxicity, in contrast to the CIS-treated control animals. In ccRCC tumors, DZ-CIS treatment inhibited proliferation markers but induced cell death marker levels. In addition, DZ-CIS at half maximal inhibitory concentration (IC50) sensitized Caki-1 cells to small-molecule mTOR inhibitors. Mechanistically, DZ-CIS selectively accumulated in ccRCC cells' subcellular organelles, where it damages the structure and function of mitochondria, leading to cytochrome C release, caspase activation, and apoptotic cancer cell death. Conclusions: Results from this study strongly suggest DZ-CIS be tested as a safe and effective subcellular targeted cancer therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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