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To evaluate the efficacy and safety of recanalizing hyaluronic acid-occluded retinal central artery by intra-arterially infusing hyaluronidase. Between December 2015 and December 2016, 30 patients with monocular blindness due to the injection of hyaluronic acid in facial tissue underwent ophthalmic artery recanalization. The outcome of the intra-arterial treatment was retrospectively reviewed. The fundus was examined 24 hours after the treatment to observe revisualization of the retinal arteries. The success rate of intra-arterial recanalization of the ophthalmic artery, procedure-related complications, visual acuity recovery, eyeball and eyelid movement restoration was followed up for up to 3 months. The success rate of ophthalmic arterial catheterization was 100%. No interventional procedure-related adverse events were found. Twenty-six patients presented ptosis and 23 patients presented ocular motility disorders. The ptosis disappeared and 18 patients had normal eye movement after the intra-arterial therapy. Five of the 30 patients had visual improvement and four patients with complete vision loss gained some light perception. After the intra-arterial thrombolysis, digital subtraction angiographic imaging revealed enlarged and numerous branches of the ophthalmic artery and a clearer ring around the eye. Intra-arterial infusion of hyaluronidase and mechanical recanalization is an effective and safe approach for recovering the visual acuity in the patients with monocular blindness caused by the migration of hyaluronic acid injected in the facial tissues. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Recent works have shown that interval bound propagation (IBP) can be used to train verifiably robust neural networks. Reseachers observe an intriguing phenomenon on these IBP trained networks: CROWN, a bounding method based on tight linear relaxation, often gives very loose bounds on these networks. We also observe that most neurons become dead during the IBP training process, which could hurt the representation capability of the network. In this paper, we study the relationship between IBP and CROWN, and prove that CROWN is always tighter than IBP when choosing appropriate bounding lines. We further propose a relaxed version of CROWN, linear bound propagation (LBP), that can be used to verify large networks to obtain lower verified errors than IBP. We also design a new activation function, parameterized ramp function (ParamRamp), which has more diversity of neuron status than ReLU. We conduct extensive experiments on MNIST, CIFAR-10 and Tiny-ImageNet with ParamRamp activation and achieve state-of-the-art verified robustness. Code and the appendix are available at https://github.com/ZhaoyangLyu/VerifiablyRobustNN., Comment: Accepted to CVPR 2021 (Oral)

Temperature plays a key role in phenology and growth of dominant tree species and hence in the structure and function of coniferous forests in cold temperate zones. We used a dendrochronological method to determine the critical temperatures of Pinus sylvestris var. mongolica (Mongolian pine) radial growth and the xylem growing season. Results showed that Mongolian pine radial growth is sensitive to daily mean temperatures of 4.0–5.5 °C in early spring, 14.0 °C in summer and 2.0–2.5 °C in autumn. A temperature of 4 °C might be the initial temperature required for sap flow, photosynthesis and tree germination in this area in early spring, and 5.5 °C is the most critical temperature for earlywood onset growth. The advance and extension of temperature 14.0 °C in summer can exacerbate water stress for trees and inhibit earlywood growth under the condition of insufficient precipitation. In autumn, 2.0–2.5 °C may be the minimum temperature for the xylem growth. These critical temperatures are important in predicting the changes in the phenology of cambial activity and the growth of conifers in cold temperate regions under a scenario of a warming climate. We defined the mean xylem growing season of pines in this region as 151 days from early May to early October. With the increase in temperatures during 1972–2015, the start date of the xylem growing season advanced by 0.24 days/year, the duration of the xylem growing season increased by 0.27 days/year and the basal area increment of Mongolian pine increased significantly (P

The stability and balance of forest ecosystems have been seriously affected by climate change. Herein, we use dendrochronological methods to investigate the radial growth and climate response of pioneer tree species in the southern margin of cold temperate coniferous forest based on Populus davidiana growing on the Greater Hinggan Mountains in northeastern China. Correlations of P. davidiana growth with temperature and precipitation in a year (October–September) were rhythmically opposed: while temperatures in previous October–June (winter and spring) and in May–September (growing season) respectively inhibited and promoted radial growth on P. davidiana (p < 0.01), precipitation in the same periods respectively promoted and inhibited of growth (p < 0.01). High temperature or less rain/snow in winter and early spring, and low temperature or excess rainfall in summer, are inconducive to P. davidiana growth and vice versa (p < 0.01). In addition, in March–April, when air temperature was above 0 °C and ground temperature below 0 °C, physiological drought caused significant growth inhibition in P. davidiana (p < 0.05). In general, temperatures play a driving and controlling role in the synergistic effect of temperature and precipitation on P. davidiana growth. Under current conditions of available water supply, changes of temperature, especially warming, are beneficial to the growth of P. davidiana in the study area. The current climate conditions promote the growth of P. davidiana, the pioneer species, compared with the growth inhibition of Larix gmelinii, the dominant species. Thus, the structure and function of boreal forest might be changed under global warming by irreversible alterations in the growth and composition of coniferous and broadleaf tree species in the forest.