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Purpose: To observe retinal sensitivity (RS) and microvasculature changes in preoperative and postoperative idiopathic macular epiretinal membrane (iERM) with optical coherence tomography (OCT) classification by microperimetry (MP) and optical coherence tomography angiography (OCTA). Methods: In this retrospective study, 53 eyes of 53 patients affected with iERM were enrolled and 35 iERM eyes underwent pars plana vitrectomy associated with internal limiting membrane peeling. All iERM eyes were evaluated and graded by OCT. According to the thickness of the fovea relative to the surrounding macula from OCT radial line scans, we classified iERM into 3 grades. MP was used to measure RS of macular within 20° centered on the fovea and fixation stability (FS). OCTA was used to measure the superficial and deep capillary plexus (DCP) layers using 6 mm × 6 mm scans. Measurements were taken at the baseline visit and 3-month postoperation. Evaluated factors included: best corrected visual acuity, RS, FS, vessel density. Results: Eyes with iERM had worse RS than control eyes (p < 0.0001), especially in higher grade iERM eyes. And higher grade iERM eyes had a marked increase foveal vessel density (FVD) (p < 0.0001) in superficial capillary plexus (SCP) and DCP, and a significant decrease parafoveal vessel density (Para VD) in DCP. After surgery, there was no difference in RS and FS than preoperation (p > 0.05), whether in grade 1 or 2 iERM eyes. However, in OCTA analyses, grade 1 iERM eyes had less whole vessel density (WVD) and perifoveal vessel density (Peri VD) in SCP, than preoperation (p < 0.05). And grade 1 iERM eyes had higher Para VD and Peri VD in DCP (p < 0.05), than preoperative OCTA results. Grade 2 iERM eyes had less WVD, FVD, and Peri VD in SCP, than preoperation (p < 0.05). After surgery, in grade 2 iERM eyes, there was a positive correlation between whole retinal sensitivity and WVD (p < 0.05) in SCP. And there were positive correlations between Para RS and Para VD (p < 0.05), Peri RS and Peri VD (p < 0.05) in SCP. Conclusions: Classification helps to reveal different changes in iERM eyes. Higher grade iERM eyes had worse RS and microvasculature changes. MP and OCTA play an important role in assessing iERM and help surgical decisions for patients with iERM.

We investigate the phased evolution and variation of the South Asian monsoon and resulting weathering intensity and physical erosion in the Himalaya–Karakoram Mountains since late Pliocene time (c.3.4 Ma) using a comprehensive approach. Neodymium and strontium isotopic compositions and single-grain zircon U–Pb age spectra reveal the sources of the deposits in the east Arabian Sea, and show a combination of sources from the Himalaya and the Karakoram–Kohistan–Ladakh Mountains, with sediments from the Indian Peninsula such as the Deccan Traps or Craton. We interpret shifts in the sediment sources to have been forced by sea-level changes that correlate with South Asian monsoon rainfall variation since late Pliocene time. We collected 908 samples from the International Ocean Discovery Program Hole U1456A, which was drilled in the east Arabian Sea. Time series of hematite content and grain size of the sediments were examined downcore. We found South Asian monsoon precipitation and weathering intensity experienced three phases from late Pliocene time. Lower monsoon precipitation, with a lower variability and strong weathering intensity, occurred during 3.4–2.4 Ma; an increased and more variable South Asian monsoon rainfall, along with strengthened but fluctuating weathering intensity, occurred at 1.8–1.1 Ma; and a reduced rainfall with lower South Asian monsoon precipitation variability and moderate weathering intensity marked the period 1.1–0.1 Ma. Maximum entropy spectral analysis and wavelet transform show that there were orbital-dominated cycles of periodsc.100 andc.41 ka in these proxy-based time series. We propose that the monsoon, sea level, global temperature and insolation together forced the weathering and erosion in SW Asia.

Traffic loads have an important impact on long-term performance of buried urban pipelines due to generation of cyclic stress and fatigue damage. As a key task for pipeline fatigue assessment, the investigation of traffic-induced pipe stress and fatigue load spectrums is always a big challenge. Focusing on the metal pipelines buried under urban intersection, an integrated framework is proposed for fatigue assessment of the pipelines under traffic loads using video monitoring data acquired by the widespread surveillance cameras in cities. The computer vision algorithms and a quarter vehicle model are first employed to identify traffic loads. Analytical pipe-soil models are then developed to calculate pipeline stress and establish the traffic-induced fatigue load spectrums of buried pipelines, based on which the Monte-Carlo simulations are finally conducted to evaluate cumulative fatigue damage and fatigue reliability. A case study on a DN500 steel pipeline buried under an urban intersection demonstrates and validates the fatigue assessment procedure. The results can provide a basis for decision support regarding maintenance and replacement of urban pipelines.

AIM: To analyse macular microvascular alterations in myopic choroidal neovascularization (mCNV) and the efficiency of anti-vascular endothelial growth factor (anti-VEGF) therapy for mCNV by optical coherence tomography angiography (OCTA). METHODS: A total of 123 patients were included in this retrospective study, divided into mCNV group, high myopia (HM) group, and normal group at the Affiliated Eye Hospital of Wenzhou Medical University from January 2017 to January 2019. Superficial vessel density, deep capillary density, foveal avascular zone (FAZ) area, A-circularity index (AI) and vessel density around the 300 μm width of the FAZ region density (FD) and the area of choroidal neovascularization (CNV) lesion (only for mCNV group) were measured on 3×3 mm2 OCTA images. FAZ area was corrected for axial length. Central macular thickness (CMT) was measured on OCT in mCNV group. Compared the parameters on OCTA of 3 groups and pre-anti-VEGF and post-anti-VEGF at 1, 2, 3, and 6mo follow-up in mCNV group. RESULTS: There were significant differences among 3 groups in superficial vessel density, deep capillary density and FD (P

We investigated the microscopic mineral characteristics of modern eolian dust particulates and the trace-element compositions of the siliciclastic fractions of these samples, collected from the Philippine Sea in 2014 and 2015, and conducted an air mass backwards trajectory analysis of dust particulates in the spring and winter of 2015, to better constrain the provenances and transport dynamics of dust delivered to this region. The microscopic minerals show obvious signatures of dust deposition and physical abrasion, indicating long-distance wind transport from the Asian deserts. The trace-element compositions (Zr–Th–Sc) display a binary mixture of eolian materials derived from the eastern Asian deserts and the central Asian deserts, which is similar to the result of the Sr–Nd isotopic compositions of modern sediment trap sediments collected on the Benham Rise in 2015. We demonstrate that modern dust sediments in the Philippine Sea primarily originate from the Ordos Desert (generally > 80%), while the contributions of the Taklimakan Desert and the Badain Jaran Desert are small. Eolian dust particulates raised from source regions are predominantly transported to the Philippine Sea by the East Asian winter monsoon, but not by the westerlies. In addition, our results indicate that increased precipitation in the source regions can result in relatively low dust fluxes in the Philippine Sea, and there is a period of 6–7 days for eolian dust originating from source areas to be delivered to the Philippine Sea.

Multiproxy records from Core MD06-3054 in the western Philippine Sea and published results from the nearby Core MD06-3052, which are both located at the northern margin of the Western Pacific Warm Pool (WPWP), provide precise reconstructions and evidence for the potential controls on continental erosion and weathering intensities in Luzon. These data also constrain sediment source-to-sink processes in the sea since 27 ka at the millennial scale. We demonstrate that the siliciclastic fraction is derived from Luzon volcanic rocks and eolian dust from mainland Asia. Stronger physical erosion and chemical weathering generally occurred during the last glaciation, Heinrich Event 1, the Younger Dryas, and the period from 10.3 to 11.3 ka. In contrast, the Bolling-Allerod was characterized by weaker physical erosion and chemical weathering. During the last glaciation, Heinrich Event 1, and the Younger Dryas, the lower sea level led to enhanced erosion and weathering of the exposed shelf sediments. In contrast, the weaker physical erosion and chemical weathering that occurred during the Bolling-Allerod and the Holocene, except after 2.1 ka, are closely correlated with the higher sea level. The stronger physical erosion and chemical weathering at 10.3–11.3 ka may be derived from the reworking of older sediments during the time of a strengthening summer monsoon. Furthermore, enhanced human activity since 2.1 ka has become the dominant control on erosion in Luzon. Rapid weathering changes in the WPWP during the last deglaciation highlight the high variability in local controls at low latitudes during these periods and the potential influence of controls at high latitudes.

Clay mineral assemblages at International Ocean Discovery Program Expedition 355 Site U1456 drilled in the eastern Arabian Sea have been investigated to reveal the sediment provenances and reconstruct the erosion/weathering patterns in the western Himalaya and Indian subcontinent, thus constraining the evolution of the Indian summer monsoon and its forcing mechanism since 1.2 Ma. The clay mineral assemblages at Site U1456 mainly comprise smectite (with an average value of 59%) and illite (with an average value of 33%), with chlorite (with an average value of 5%) and kaolinite (with an average value of 3%) as minor constituents. In terms of sediment provenance, our results indicate that illite and chlorite are predominantly derived from the Indus River, which originates from the western Himalaya and Karakoram, while smectite is primarily sourced from the Narmada River and Tapti River in the Deccan Traps, with a non-negligible contribution from the Indus River in some cases. Variations in smectite/(illite + chlorite) ratio are ultimately controlled by the Indian summer monsoon, which is characterized by approximate glacial/interglacial cyclicity, showing higher values (i.e., enhanced chemical weathering) during interglacial periods. In addition, a major shift in smectite/(illite + chlorite) ratio at 0.9 Ma is correlated to the Mid-Pleistocene Transition (∼1.2–0.9 Ma). Both the Marine Isotope Stage 13 event (533–478 ka) and the Mid-Brunhes Event (∼430 ka) are also recorded in the clay mineral proxies. Based on the spectral analysis, smectite/(illite + chlorite) ratio displays a transition from nonprimary periodicity (29-kyr) to strong eccentricity (100-kyr) and precession (22-kyr) periodicities at approximately 0.9 Ma, which corresponds to the Mid-Pleistocene Transition. Our study indicates that the variability of the Indian summer monsoon at orbital timescales is controlled by high-latitude (i.e., ice volume) and low-latitude (i.e., summer insolation) processes.

Long marine sequences deposited in the Arabian Sea are suitable to study the orbital sensitivity of sediment dynamics from a source-to-sink perspective. The clay mineralogy and Sr Nd isotopic compositions have been analyzed for the detrital fraction of sediments from IODP Site U1457 located in the Laxmi basin, eastern Arabian Sea to constrain the sediment sources and reconstruct a high-resolution record of sediment export to the Indus deep-sea fan over the past 600 kyr. The 87Sr/86Sr ratio (varying from 0.7154 to 0.7255) and eNd (varying from −12.9 to −9.5) imply a mixing of sediments derived from not only the Indus River but also the rivers draining the Deccan Traps. The variations in the smectite/(illite + chlorite) ratio combined with Sr Nd isotopes permit the reconstruction of past changes in the relative proportions of sediments derived from the Indus River (mainly illite, chlorite and kaolinite) and the Deccan Traps (smectite). The wavelet and cross-spectral analyses further reveal that sediment transport to the eastern Arabian Sea since 600 kyr is mainly dominated by sea-level variations in the eccentricity (100-kyr) band, while the Indian summer monsoon might contribute moderately to the precession (23-kyr) band. The eNd and turbidite frequency indicate that more turbidite events are associated with Indus River-sourced sediments at IODP Site U1457 during sea-level lowstands, which might reflect a reconnection of deep-sea channels to the Indus River mouth and/or reworking of previously deposited Indus River sediments located northward.

AIM: To compare the safety and efficacy of conbercept intravitreal injection and half-dose photodynamic therapy (PDT) in treating chronic central serous chorioretinopathy (CSC). METHODS: This study was retrospective. Thirty-seven patients (37 eyes) with chronic CSC received conbercept injections while 57 patients (57 eyes) were treated with half-dose PDT. All subjects were followed in 6mo. Outcome measures included change in best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and resolution of subretinal fluid (SRF). RESULTS: There was no adverse event observed in either treatment group. At the 6-month follow-up, 26 eyes (70.3%) in the conbercept group and 54 eyes (94.7%) in the half-dose PDT group (P0.05). The SFCT also improved in all subjects (P

PURPOSE To evaluate pre- and postoperative microvasculature features in eyes with different idiopathic macular epiretinal membrane (iERM) classifications using optical coherence tomography angiography (OCTA). METHODS In this retrospective study, 100 eyes with iERM were enrolled; 62 eyes underwent pars plana vitrectomy (PPV). All iERM eyes were evaluated and graded using optical coherence tomography (OCT). According to the thickness of the fovea relative to the surrounding macula from OCT radial line scans, we classified iERM into three grades. Optical coherence tomography angiography (OCTA) was used to measure the foveal avascular zone (FAZ)-related parameters and the superficial and deep capillary plexus layers using 3 × 3 mm scans. Measurements were taken at baseline and 3 months postoperatively. Best corrected visual acuity (BCVA), vessel density (VD), FAZ area, FAZ perimeter (PERIM), acircularity index (AI), and foveal vessel density (FD) were evaluated. RESULTS Idiopathic macular epiretinal membrane (iERM) eyes with a higher grade had a lower FAZ area and perimeter (p

A 1108.6 m long core was recovered at Site U1457 located on the Indus Fan in the Laxmi Basin of the eastern Arabian Sea during IODP Expedition 355. Shipboard examinations defined five lithologic units (I to V) of the lower Paleocene to Holocene sedimentary sequence. In this study, δ13C values of sedimentary organic matter (SOM) confirm the differentiation of the lithologic units and further divide units III and IV into two subunits (1 and 2). Based on the underlying assumption that the SOM is decided primarily by a mixture of marine and terrestrial origins, δ13CSOM values at Site U1457 provide information on the terrestrial catchment conditions since late Miocene time. Low δ13CSOM values from late Miocene to late Pleistocene times are similar (c. −22.0 ‰) for the most part, reflecting a consistent contribution of terrestrial organic matter from the catchment areas characterized by dominant C3 land plants. Significantly lower δ13CSOM values (c. −24.0 ‰) in Unit III-2 (∼8 to ∼7 Ma) might be due to a greater input of C3 terrestrial organic matter. The increase in δ13CSOM values at ∼7 Ma and the appearance of high δ13CSOM values (c. −18.0 ‰) within Unit III-1 (∼7 to ∼2 Ma) indicate that C4 biomass overwhelmed the terrestrial catchment environment as a result of enhanced terrestrial aridity in the Himalayan foreland. The three-end-member simple mixing model, estimating the relative contributions of SOM from terrestrial C3 and C4 plants and marine phytoplankton, supports our interpretation of the distribution of C3 and C4 land plants in the terrestrial catchment environment.

International audience; Changes in terrigenous organic matter (OM) input, productivity and the associated bottom-water redox conditions, together with forcing mechanisms and global carbon cycle implications of such variations, on the western margin of the Western Pacific Warm Pool (WPWP) during the Quaternary remain controversial. In this study, we reconstructed the hydrological dynamics, terrigenous OM input, productivity, and deep-sea redox conditions using one core from the continental slope of the Philippine Sea. The new data were integrated with published proxies from the same core and two additional cores from the abyssal Philippine Sea. The results exhibited noticeable variations in the abovementioned indicators, in correspondence to changes in the supply of terrigenous material. The continental slope deposition featured signals of strong physical erosion and chemical weathering of unconsolidated sediments on the exposed continental shelf during the Quaternary sea-level lowstands, which significantly contributed to increased terrigenous OM input and productivity and, in turn, decreased bottom-water oxygenation and atmospheric CO2 concentrations. In the abyssal Philippine Sea, increased Asian dust-driven OM input and productivity also acted as a sink of atmospheric CO2 during sea-level lowstands. Analysis of the data suggested that the enhanced terrigenous OM input and biological pump and thus the decreased dissolved oxygen level of the bottom water on the western margin of the WPWP played important roles in modifying the global carbon cycle during sea-level lowstands. In contrast, the influence of hydrological dynamics on terrigenous OM input, productivity, and redox conditions therein during the Quaternary was limited.

We present a new set of clay mineral and grain-size data for the siliciclastic sediment fraction from International Ocean Discovery Program (IODP) Site U1456 located in the eastern Arabian Sea to reconstruct the variabilities in the continental erosion and weathering intensity in the western Himalaya, elucidate the sediment source-to-sink processes and discuss the potential controls underlying these changes since 3.7 Ma. The clay minerals mainly consist of smectite (0–90%, average 44%) and illite (3–90%, average 44%), with chlorite (1–26%, average 7%) and kaolinite (0–19%, average 5%) as minor components. The compositional variations in the clay minerals at IODP Site U1456 suggest four phases of sediment provenance: the Indus River (phase 1, 3.7–3.2 Ma), the Indus River and Deccan Traps (phase 2, 3.2–2.6 Ma), the Indus River (phase 3, 2.6–1.2 Ma) and the Indus River and Deccan Traps (phase 4, 1.2–0 Ma). These provenance changes since 3.7 Ma can be correlated with variations in the Indian summer monsoon intensity. The siliciclastic sediments in the eastern Arabian Sea were mainly derived from the Indus River when the Indian summer monsoon was generally weak. In contrast, when the Indian summer monsoon intensified, the siliciclastic sediment supply from the Deccan Traps increased. In particular, this study shows that the smectite/(illite+chlorite) ratio is a sensitive tool for reconstructing the history of the variation in the Indian summer monsoon intensity over the continents surrounding the Arabian Sea since 3.7 Ma.

We present a new high-resolution multiproxy data set of mass accumulation rates, Sr-Nd isotopes, as well as major and trace elements for the siliciclastic sediment fraction from International Marine Global Change Study Core MD06-3052, located on the continental slope of the western Philippine Sea. We integrate our new data with published grain sizes and sea surface temperatures from the same core, as well as with Equatorial Pacific sea level, and East Asian summer monsoon precipitation, in order to constrain at high-resolution changes in physical erosion and chemical weathering intensities on Luzon, and sediment source-to-sink processes. We assess the potential significance of chemical weathering of arc silicates in regulating global atmospheric CO2 since 156 kyr BP. Sr-Nd isotopes show that the siliciclastic sediments were dominantly sourced from volcanic rocks exposed on Luzon (~ 68–100%), with a lesser contribution from Asian dust (~ 0–32%). Different indices indicate that stronger physical erosion and chemical weathering occurred during Marine Isotope Stage (MIS) 6 (130–156 kyr BP), as well as in the latter stage of MIS 3 and MIS 2 (14–40 kyr BP). The large sea-level lowstands and associated significant exposure of continental shelf in the western Philippine Sea during these two cold periods should favor physical erosion and chemical weathering of unconsolidated sediments on the exposed shelf. Furthermore, we notice the relatively good coherence between chemical weathering intensities on Luzon and global atmospheric CO2 concentrations over these cold intervals. We suggest that strengthening of chemical weathering of silicates on Luzon and other tropical arcs (within 20° of the Equator) during the Quaternary glacial sea-level lowstands may significantly contribute to the lowering of atmospheric CO2 concentrations during ice ages. We estimate that a significant fraction, up to ~ 16% (i.e., ~ 8 ppmv), of all atmospheric CO2 ultimately sequestered by silicate weathering may be processed through an area corresponding to only ~ 1% of the exorheic drainage area worldwide.

Sedimentary evidence for enhanced volcanic eruption during the glacial/interglacial transition in the volcanically active mid-ocean ridges is still lacking. Here, we present the sedimentary records of enhanced deglacial volcanic activity in a well-dated sediment core from the middle part of Central Indian Ridge (CIR), which can provide clue for comprehensively understanding of the temporal relation of increase in submarine volcanism relative to glacial/interglacial transition. Notably, the 35-kyr sediment core used in this study contains continuous, discernible pyroclastic deposit layers (0.5–5 cm thick), which are composed mainly of angular and curved fluidal shards with vesicles, possibly suggesting volatile-rich ridge eruptions. High-resolution elemental profiles of the core provide definite records of at least 17 volcanic eruptions during the past 35 kyr. Interestingly, volcanism was sparse during the Last Glacial Maximum (LGM), but increased significantly during the last deglaciation after ~18 kyr BP. The last deglaciation-associated volcanic eruptions in the CIR may be linked to decompression melting during the LGM sea-level lowstand, reaffirming an influence of sea level variability on global ocean ridge magmatism. Combining the previous results, furthermore, simultaneous strengthening of submarine and subaerial volcanic eruptions during the last deglaciation could have accelerated the rise of atmospheric CO2, with the ensuing warming constituting positive feedback upon deglaciation. Highlights • A succession of pyroclastic records in a well-dated sediment core from the CIR was identified. • The morphologies of the pyroclasts are consistent with volatile-rich submarine eruption. • Deglaciation-associated enhanced volcanism seems robust in the mid-ocean ridges. • Tentative support for a link between ridge volcanism and climate change is provided.

To assess the environmental impacts of offshore wind farming and sea sand mining, coastal areas are zoned on the basis of their natural oceanographic characteristics. Textural and geochemical properties of South Korean coastal sediments, including mean grain size (Mz), CaCO3 and organic-matter contents, and metal concentrations (Al, K, Ba, rare earth elements, Zr, etc.), were analyzed and categorized in this case study, practically applying common sediment properties for rational zoning of the South Korean coastal environment. Three characteristic zones are scientifically classified in the study area, although four groups of sediment sampling stations were statistically clustered based on their major sediment properties. Zone 1, in the northwestern part of the Korean west coast, is characterized as covered with coarse-grained sediments containing low concentrations of the measured elements under a macro-tidal regime (6.5–9 m), while Zone 3 is characterized by fine-grained sediments with high elemental concentrations under a micro-tidal regime (>3.5 m). Silty Zone 2 sediments appear to be a mixture of sandy Zone 1 and muddy Zone 3 sediments under a meso-tidal regime. The difference in tidal forces among the zones is proposed as a primary constraint of overall sediment textural and geochemical characteristics, while sediment provenance provides subsequent control. Sediment contamination with anthropogenic pollutants is unperceivable in this case study. However, the K and Li concentrations in coarse-grained feldspar and fine-grained illite, respectively, are likely not limited by the tidal flow regime.

The late Quaternary paleoceanography and paleoenvironment of the South China Sea (SCS) have been well reconstructed over the last decade. In contrast, the provenance of the terrigenous sediments that have accumulated in the northwestern continental shelf mud area remains enigmatic. This study investigated the provenance of these sediments and the paleoenvironmental changes archived in Core X2 via the analysis of geochemical elements, grain size, and accelerator mass spectrometry (AMS) 14 C ages. Based on the upper continental crust (UCC)-normalized REE patterns and REE fractionation parameters, southwestern and western Taiwanese rivers and the Pearl River were identified as the main sources of the fine-grained sediment deposited in the northwestern shelf mud area off Hainan Island. This finding further confirms the long-distance transport (> 1000 km) of fine-grained sediment from Taiwanese rivers to the northern SCS shelf and slope. Obvious changes in the grain size and Chemical Index of Alteration (CIA) record occurred at approximately 4.0 cal kyr BP and were likely caused by increased Hainan Island inputs due to sea level changes.

High-resolution sea surface temperature records based on long-chain unsaturated alkenones ( U 37 K ′ -SST) in the south Yellow Sea (YS) during the period of 3500–1300 cal. yr BP were reconstructed in sediment core Z8 from the Shandong mud wedge. The SST records show broad variations between 14.3 and 16.9 °C (15.6 °C on the average), with a high SST phase at 3500-2750 cal. yr BP, a low and intense fluctuating SST period at 2500-2000 cal. yr BP and a sharp cooling period at 1750-1300 cal. yr BP. Superimposed on this trend, five cooling periods occurred in 3360–3250 cal. yr BP, 3150–3050 cal. yr BP, 2750–2650 cal. yr BP, 2350–2150 cal. yr BP, and 1750-1300 cal. yr BP. Variation pattern of the SST records is similar to the fluctuations of the Kuroshio Current (KC), indicating a close relationship between the Yellow Sea Warm Current (YSWC) and the KC. The general U 37 K ′ -SST curve fluctuates with the local air temperature variations. The intensity of the East Asia Winter Monsoon (EAWM) could be a key factor affected the prevailing relationship between the cold coastal current and the warm YSWC, and dominated the SST variation in core site Z8 during 3500–1300 cal. yr BP. Furthermore, our temperature records, within age uncertainty, coincides with the changes of the solar irradiance changes, suggesting a possible link between solar forcing and climate variability.

The evolution of the Kuroshio Current (KC) in the Okinawa Trough (OT) has long been of paleoceanographic interest and has been the focus of many investigations because of its large impacts on both the ocean environment and the climate in East Asia. Here, we present a new high-resolution mercury (Hg) record from the OT sediments that provides robust evidence for the glacial-interglacial variabilities of KC inflow. The Hg levels are anomalously high in the Holocene deposits, which feature a large and abrupt Hg increase at ~9.6 ka and a significant drop at 4.5–3.2 ka. Our observations show that most Hg was derived from seafloor hydrothermal plumes via active lateral transportation. Thus, the generally high Hg levels since ~9.6 ka are associated with enhanced basin-wide deep-water circulation triggered by the KC inflow. This driving mechanism for the deposition and widespread of Hg is also evidenced by an abrupt drop in Hg levels during the late Holocene neoglacial cold period (~5–3 ka) when the KC inflow was temporarily interrupted and deep-water circulation was consequently weak or even absent in the OT. The changes in sedimentary Hg appear to be synchronous with those in other geochemical proxies that suggest that bottom water conditions switched from anoxic to oxic due to increased upwelling from the bottom in tandem with the strengthening KC and reduced freshwater effect since ~9.6 ka. This study shows that the hydrothermal Hg is a sensitive and independent tool for the reconstruction of palaeo-dynamics of KC in the OT.

Background: To analyze the efficiency of anti-vascular endothelial growth factor (anti-VEGF) therapy for myopic choroidal neovascularization (CNV) by optical coherence tomography angiography (OCTA) and to determine the reduction ratio of CNV lesions after anti-VEGF therapy. Methods: A total of 41 patients (41 eyes) with myopic CNV who were treated with anti-VEGF were included in the study. The best corrected visual acuity (BCVA), superficial vessel density, deep vessel density, the area of foveal avascular zone (FAZ), central macular thickness (CMT) and the area and the flow area of CNV lesion at baseline and at the follow-up after 1, 2, 3 and 6 months were measured. Results: After treatment, BCVA improved (F=6.848, P

Discriminating sediment sources quantitatively of several unique shelf-mud deposits in the Yellow Sea has received considerable attention, because they are active sedimentary depocenters that can elucidate the river sediment dispersal patterns and the depositional systems of the sea. Here, we propose a new sediment source proxy model of rare earth elements (REEs) that reflects innate characteristics of their fractionation distribution patterns and provides a reasonable and practical estimation for quantifying sediment source apportionments in the Yellow Sea. REEs of riverine and shelf-mud sediments were granulometrically and chemically partitioned, and the unique characteristics of their fractionation patterns were recorded and numerically indexed. We found distinct differences in the REE fractionation pattern index of riverine sediments, possibly due to the different source rock compositions. Notably, the acid-leached phase of the clay fraction may be a better material for quantitative evaluation of river contributions in the Yellow Sea. Using the REE-source index model presented here, proportional contributions of Chinese river sediments to the central and southeastern Yellow Sea mud deposits were estimated to be 55–80% and 10–40%, respectively, with higher percentage in the leached fraction. Our results elucidate the disagreement between mud budget and river discharge, particularly in Korean coastal mud deposits, as well as the source interpretation of the Yellow Sea shelf-mud deposits, which have been debated since the 1980s.

Clay mineralogical analysis and scanning electron microscope (SEM) analysis were performed on deep-sea sediments cored on the Benham Rise (core MD06-3050) in order to reconstruct long-term evolution of East Asian Summer Monsoon (EASM) rainfall in the period since 2.36 Ma. Clay mineralogical variations are due to changes in the ratios of smectite, which derive from weathering of volcanic rocks in Luzon Island during intervals of intensive monsoon rainfall, and illite- and chlorite-rich dusts, which are transported from East Asia by winds associated with the East Asian Winter Monsoon (EAWM). Since Luzon is the main source of smectite to the Benham Rise, long-term consistent variations in the smectite/(illite + chlorite) ratio in core MD06-3050 as well as ODP site 1146 in the Northern South China Sea suggest that minor contributions of eolian dust played a role in the variability of this mineralogical ratio and indicate strengthening EASM precipitation in SE Asia during time intervals from 2360 to 1900 kyr, 1200 to 600 kyr, and after 200 kyr. The EASM rainfall record displays a 30 kyr periodicity suggesting the influence of El Nino–Southern Oscillation (ENSO). These intervals of rainfall intensification on Luzon Island are coeval with a reduction in precipitation over central China and an increase in zonal SST gradient in the equatorial Pacific Ocean, implying a reinforcement of La Nina-like conditions. In contrast, periods of reduced rainfall on Luzon Island are associated with higher precipitation in central China and a weakening zonal SST gradient in the equatorial Pacific Ocean, thereby suggesting the development of dominant El Nino-like conditions. Our study, therefore, highlights for the first time a long-term temporal and spatial co-evolution of monsoonal precipitation in East Asia and of the tropical Pacific ENSO system over the past 2.36 Ma.

The sediment grain-size effect (GSE), a fundamental factor relevant to the interpretation of elemental concentrations and isotopic compositions, has been normalized using conservative elements such as aluminum (Al), cesium (Cs), and lithium (Li) (C-(Al,C- Cs,C- Li)), which serve as proxies for the natural metal controlling variables of grain size, mineralogy, and organic matter. However, a secondary GSE reportedly remains even after compensation by the Al-normalization procedure, particularly for the concentrations of transition metals (C-T.M). This secondary effect also occurred in the C-(Li,C- Cs)/C-Al ratios of the Korean coastal sediments examined in this study. The primary and secondary GSEs on Cs and Li concentrations can be explained by the quartz-dilution effect and the Cs- and Li-incorporation effect of phyllosilicate minerals, respectively, based on a model involving three component end-members: a Cs and Li-free sand-dominated sediment component consisting mostly of quartz and feldspar, a Cs- and Li bearing silt-dominated component of mica, and a Cs- and Li-enriched clay-dominated component of illite. Although the primary and secondary GSEs on the concentrations of transition metals (particularly Cu and Ni) in coastal sediments might be normalized by dividing the metal concentrations by the square of the Al concentration (C-T.M/(C-Al)(2)), the GSEs can also be normalized by dividing the concentrations by the exact Cs (or Li) concentration (C-T.M/C-Cs). (C) 2016 Elsevier Ltd. All rights reserved.

Sediment provenance in the Yellow Sea and northern East China Seas (YECSs) has long been a subject of interest, but its quantification is still inconclusive. Here, we present an improved Al Mg regression analysis by refining its methodological approach to strengthen quantification of sediment source-to-sink transports in the YECSs, with focus on its forcing mechanisms during the Holocene. Our quantitative source estimates clearly depict a considerable supply of the Chinese river (CR) sediments (~50%) to the southwestern Korean coastal region, and the Korean river (KR) sediments (30–40%) to the Central Yellow Sea Mud deposit, which accounts for a good balance between the sediment supply and budget of the shelf deposit. Of particular note is an abrupt decline in the CR contributions around 124°E, which indicates that the CR sediments do not directly reach the eastern part of the Yellow Sea blocked by a strong physical boundary. Further, the observed variations in proportions between Huanghe-, Changjiang- and Korean river-derived sediments over the last 15 kyr – notably an abrupt increase of CR contribution since ~7 ka, followed by a sudden drop at ~3–4 ka – exhibit a good correspondence with other mineralogical proxy records. These temporal provenance changes witnessed robust palaeoenvironmental signals which fit to major climatic and oceanographic events linked with sea-level, intensity of the Kuroshio Current inflow and the East Asian monsoon. This study improves understanding of what pathways and sinks exist within the YECS basin, and how rates of sediment supply from adjacent rivers have changed over time.

International audience; El Niño/Southern Oscillation (ENSO) activity and the Pacific Walker Circulation are controlled by the zonal sea surface temperature (SST) gradient between the western and Eastern Equatorial Pacific (EEP) and the corresponding barometric difference. Variations in the zonal SST gradient since the early Pleistocene have primarily been triggered by changes in the SST in the Eastern Equatorial Pacific. However, the response of the ENSO‐like long‐term state to the cooling of the EEP and its coupling role with tropical Pacific climate changes are still not well established. Here we present a high‐resolution grain‐size record spanning the last 2.36 Myr, obtained from marine core sediment located in the West Philippine Sea in order to decipher the tropical pacific climate changes and reveal its controlling mechanism. By combining our data with other long‐term climatic records from the Equatorial Pacific, we demonstrate that the cooling of SST and enhanced upwelling in the EEP resulted in the development of the Walker Circulation and increased monsoon precipitation in Luzon from 2.2 to 1.6 Myr, from 1.2 to 0.8 Myr, and since 0.2 Myr ago. The progressive cooling of the high‐latitudes in the Quaternary may be responsible for our observation here. A newly identified 100 kyr dominant period between 2.2 and 1.6 Myr in the ENSO‐like modulated Pacific climate records indicates that the ENSO‐like system may play a key role in facilitating or responding to the global climate changes.

To obtain a better understanding of the source compositions of the river sediments around the Yellow Sea and their relationship with source rocks, elements and strontium-neodymium (Sr-Nd) isotopes of different grain-sizes (silt and clay populations) and chemical (labile and residual phases) fractionations in riverine sediments were studied extensively. These results clearly revealed a systematic compositional disparity between Korean river (KR) and Chinese river (CR) sediments, especially in the residual (detrital) fraction. The geochemical dissimilarity between these might reflect inherited signatures of their source rocks but with minor control from chemical weathering. In particular, the remarkable enrichment of some elements (iron (Fe) and magnesium (Mg)) and the behavior of large ion lithophile elements (e.g., barium (Ba), potassium (K) and Sr) during weathering as well as less-radiogenic Sr isotopic compositions implies that CR sediments might be weathering products of relatively more mafic rocks, with abundant ferromagnesian and plagioclase feldspar minerals, compared with KR sediments derived from silicic granites with relatively higher quartz and potassium feldspar contents. This different petrological rationale is clearly evident in an A-CN-K diagram, which estimated the source rock of CR sediments as granodioritic, a composition that reflects accurately the average composition of weathered continental crust in China. The recognition of such geochemical systematics in two river sediments, especially in grain-size and chemically partitioned data, may contribute to the establishment of provenance tracers for the Yellow Sea and East China Sea sediments with multi-sources as well the dust deposition in the western Pacific. (C) 2015 Elsevier Ltd. All rights reserved.

We present a new high-resolution multiproxy data set of Sr-Nd isotopes, rare earth element, soluble iron, and total organic carbon data from International Marine Global Change Study Core MD06-3047 located in the western Philippine Sea. We integrate our new data with published clay mineralogy, rare earth element chemistry, thermocline depth, and delta C-13 differences between benthic and planktonic foraminifera, in order to quantitatively constrain Asian dust input to the basin. We explore the relationship between Philippine Sea and high-latitude Pacific eolian fluxes, as well as its significance for marine productivity and atmospheric CO2 during the mid-late Quaternary. Three different indices indicate that Asian dust contributes between similar to 15% and similar to 50% to the detrital fraction of the sediments. Eolian dust flux in Core MD06-3047 is similar to that in the polar southern Pacific sediment. Coherent changes for most dust flux maximum/minimum indicate that dust generation in interhemispheric source areas might have a common response to climatic variation over the mid-late Quaternary. Furthermore, we note relatively good coherence between Asian dust input, soluble iron concentration, local marine productivity, and even global atmospheric CO2 concentration over the entire study interval. This suggests that dust-borne iron fertilization of marine phytoplankton might have been a periodic process operating at glacial/interglacial time scales over the past 700 ka. We suggest that strengthening of the biological pump in the Philippine Sea, and elsewhere in the tropical western Pacific during the mid-late Quaternary glacial periods may contribute to the lowering of atmospheric CO2 concentrations during ice ages.

For this study, elemental and Sr-Nd isotopic compositions of AMS C-14 age-dated core sediments from the northern Okinawa Trough were investigated to reconstruct sediment provenance and transport processes over the last 22.3 ka and further to trace the forcing mechanisms behind the provenance changes. The results clearly showed that large compositional variations of these elements and isotopes occur in deposition, suggesting three-phases of changes in sediment source: paleo-Huanghe (Unit 3, 223-14.8 ka), East China Sea shelf-derived (Unit 2, 14.8-7.3 ka), and Taiwan-derived detritus stages (Unit 1

In this study, Holocene changes in the riverine, eolian, and erosional supplies to the eastern part of the central Yellow Sea (YS) and their forcing mechanisms were determined on the basis of multiple mineralogical and geochemical indices of three age-dated piston cores from the central Yellow Sea mud (CYSM) deposition. The core records of the indices, including clay minerals, rare earth element fractionation parameters, and conservative trace elements, revealed abrupt changes in the sediment sources, especially similar to 9.0 and 4.8 ka. The late last deglaciation and early Holocene sediments (Units 3 and 4, similar to 14.1 to similar to 9.0 ka) most likely originated from the paleo-Huanghe and the sea bed erosion, together with some contribution from the paleo-Changjiang Shoal sediments that extended northeastward into the YS. After that period, the dominant sediment source gradually changed to the Changjiang during the middle Holocene (similar to 9.0-4.8 ka, Unit 2), while the supplies from Huanghe and sea bed erosion to the south YS decreased. In the last 4.8 ka (Unit 1), the CYSM largely received Changjiang-derived sediments. Besides, some clay-sized particulates from the Huanghe, sea bed erosion, and Korea rivers might be transported to the CYSM during Unit 1. Possible mechanisms behind such changes in the riverine and erosional sediment sources and contributions include position shifts of river mouths, tidal stress evolutions, shelf sea-level fluctuations, East Asian monsoon climate changes, and the development of the YSWC and coastal circulation systems. (C) 2015 Elsevier Ltd. All rights reserved.