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Coal seam water injection is widely used for coal seam gas control, and the key to its effectiveness in controlling gas lies in the wetting effect of water on coal body. However, the gas in coal seriously interferes with the wetting effect of water on coal. This paper uses a self-developed coal and water contact angle testing equipment under gas atmosphere and a self-developed water’s surface tension testing software under gas atmosphere to study the wetting parameters of coal and water interface under gas atmosphere, elucidating the wetting characteristics of coal and water interface under gas atmosphere and revealing its influencing mechanism. The results show that the surface tension of water, surface energy of coal, and adhesion work gradually decrease with the increase of gas pressure in a gas atmosphere. However, the coal and water contact angle and coal and water interface energy gradually increase with the increase of gas pressure, which implies a decrease in the wetting effect of water on coal. A molecular structure model of anthracite coal has been established based on the industrial analysis, elemental analysis, and micro spectral analysis of coal. The molecular formula of coal can be described by C99H54N2O3S. The bridge carbon ratio of the coal molecular model is 0.61, which is consistent with the bridge carbon ratio in the 13C-NMR spectrum. In the micro wetting system of coal water under gas atmosphere, with the increase of gas pressure, the adsorption degree of water molecules weakens, the degree of gas displacement in coal decreases, the diffusion coefficient of methane molecules decreases, the dispersion degree of water molecules increases, the aggregation degree of water molecules weakens, and the diffusion coefficient of water molecules increases. The research results lay a theoretical foundation for revealing the mechanism of wetting coal containing gas by coal seam water injection.

To investigate the long-term stability of deep rocks, a three-dimensional (3D) time-dependent model that accounts for excavation-induced damage and complex stress state is developed. This model comprises three main components: a 3D viscoplastic isotropic constitutive relation that considers excavation damage and complex stress state, a quantitative relationship between critical irreversible deformation and complex stress state, and evolution characteristics of strength parameters. The proposed model is implemented in a self-developed numerical code, i.e. CASRock. The reliability of the model is validated through experiments. It is indicated that the time-dependent fracturing potential index (ξTFPI) at a given time during the attenuation creep stage shows a negative correlation with the extent of excavation-induced damage. The time-dependent fracturing process of rock demonstrates a distinct interval effect of the intermediate principal stress, thereby highlighting the 3D stress-dependent characteristic of the model. Finally, the influence of excavation-induced damage and intermediate principal stress on the time-dependent fracturing characteristics of the surrounding rocks around the tunnel is discussed.

The Moon, as the closest celestial body to the Earth, plays a pivotal role in the progression of deep space exploration, and the establishment of research outposts on its surface represents a crucial step in this mission. Lunar lava tubes are special underground caves formed by volcanic eruptions and are considered as ideal natural shelters and scientific laboratories for lunar base construction. This paper begins with an in-depth overview of the geological origins, exploration history, and distribution locations of lunar lava tubes. Subsequently, it delves into the presentation of four distinctive advantages and typical concepts for constructing bases within lava tubes, summarizing the ground-based attempts made thus far in lunar lava tube base construction. Field studies conducted on a lava tube in Hainan revealed rock compositions similar to those found during the Apollo missions and clear lava tube structures, making it a promising analog site. Lastly, the challenges and opportunities encountered in the field of geotechnical engineering regarding the establishment of lunar lava tube bases are discussed, encompassing cave exploration technologies, in-situ testing methods, geomechanical properties under lunar extreme environments, base design and structural stability assessment, excavation and reinforcement techniques, and simulated Earth-based lava tube base.

Stress measurement plays a crucial role in geomechanics and rock engineering, especially for the design and construction of large-scale rock projects. This paper presents a novel method, based on the traditional stress relief approach, for indirectly measuring rock stress using optical techniques. The proposed method allows for the acquisition of full-field strain evolution on the borehole's inner wall before and after disturbance, facilitating the determination of three-dimensional (3D) stress information at multiple points within a single borehole. The study focuses on presenting the method's theoretical framework, laboratory validation results, and equipment design conception. The theoretical framework comprises three key components: the optical imaging method of the borehole wall, the digital image correlation (DIC) method, and the stress calculation procedure. Laboratory validation tests investigate strain field distribution on the borehole wall under varying stress conditions, with stress results derived from DIC strain data. Remarkably, the optical method demonstrates better measurement accuracy during the unloading stage compared to conventional strain gauge methods. At relatively high stress levels, the optical method demonstrates a relative error of less than 7% and an absolute error within 0.5 MPa. Furthermore, a comparative analysis between the optical method and the conventional contact resistance strain gauge method highlights the optical method's enhanced accuracy and stability, particularly during the unloading stage. The proposed optical stress measurement device represents a pioneering effort in the application of DIC technology to rock engineering, highlighting its potential to advance stress measurement techniques in the field.

The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutation, can disrupt epigenetics, transcriptional regulation, and tumor microenvironment interactions, leading to cancer development. Targeting these kinase mutations with small molecule drugs or antibodies has shown clinical benefits. For example, erdafitinib is approved for treating locally advanced or metastatic urothelial cancer patients with FGFR2/FGFR3 mutations, and pemigatinib is approved for treating cholangiocarcinoma with FGFR2 fusion/rearrangement. Effective screening of FGFR variant patients is crucial for the clinical application of FGFR inhibitors. Various detection methods, such as polymerase chain reaction, next-generation sequencing, fluorescence in situ hybridization, and immunohistochemistry, are available, and their selection should be based on diagnostic and treatment decision-making needs. Our developed expert consensus aims to standardize the diagnosis and treatment process for FGFR gene mutations and facilitate the practical application of FGFR inhibitors in clinical practice.

High mountain valleys are characterized by the development of intricate ground stress fields due to geological processes such as tectonic stress, river erosion, and rock weathering. These processes introduce considerable stability concerns in the surrounding rock formations for underground engineering projects in these regions, highlighting the imperative need for rigorous stability assessments during the design phase to ensure construction safety. This paper introduces an innovative approach for the pre-evaluation of the stability of surrounding rocks in underground caverns situated within high mountain valleys. The methodology comprises several pivotal steps. Initially, we conduct inverse calculations of the ground stress field in complex geological terrains, combining field monitoring and numerical simulations. Subsequently, we ascertain stress-strength ratios of the surrounding rocks using various rock strength criteria. To assess the stability characteristics of the surrounding rocks in the 1# spillway cave within our project area, we employ numerical simulations to compute stress-strength ratios based on different rock strength criteria. Furthermore, we undertake a comparative analysis, utilizing data from the 5# Underground Laboratory (Lab 5) of Jinping II Hydropower Station, aligning the chosen rock strength criterion with the damage characteristics of Lab 5′s surrounding rocks. This analysis serves as the cornerstone for evaluating other mechanical responses of the surrounding rocks, thereby validating the pre-evaluation methodology. Our pre-evaluation method takes into account the intricate geological evolution processes specific to high mountain valleys. It also considers the influence of the initial geostress field within the geological range of underground caverns. This comprehensive approach provides a robust foundation for the analysis and assessment of the stability of surrounding rocks, especially in high mountain valley areas, during the design phase of underground engineering projects. The insights derived from this analysis hold substantial practical significance for the effective guidance of such projects.

Abstract Lenvatinib, a multitarget kinase inhibitor, has been proven to be effective in the treatment of advanced hepatocellular carcinoma. It has been previously demonstrated that tumour associated macrophages (TAMs) in tumour tissues can promote HCC growth, invasion and metastasis. Furthermore, lenvatinib has certain immunomodulatory effects on the treatment of HCC. However, the role of lenvatinib in macrophage polarization during HCC treatment has not been fully explored. In this study, we used a variety of experimental methods both in vitro and in vivo to investigate the effect of lenvatinib on TAMs during HCC progression. This study is the first to show that lenvatinib can alter macrophage polarization in both humans and mice. Moreover, macrophages treated with lenvatinib in vitro displayed enhanced classically activated macrophages (M1) activity and suppressed liver cancer cell proliferation, invasion, and migration. Furthermore, during the progression of M1 macrophage polarization induced by lenvatinib, STAT-1 was the main target transcription factor, and inhibiting STAT-1 activity reversed the effect of lenvatinib. Overall, the present study provides a theoretical basis for the immunomodulatory function of lenvatinib in the treatment of HCC.

The steep Martian terrain features numerous notches and alcoves that could potentially be adapted as temporary shelters. By sealing their entrances and modifying the interior space, these alcoves can be transformed into habitable structures. Given their prolonged exposure to Martian temperature fluctuations, it is crucial to understand the mechanical properties of alcove rocks to design appropriate shelter parameters. This study investigates the mechanical behavior of basalt specimens subjected to Martian cryogenic freeze-thaw (F-T) cycles (−143∼35 °C) and subsequent uniaxial cyclic loading tests. The test results indicate that the longitudinal wave velocity, peak stress, and elastic modulus of basalt specimens degrade to varying degrees with an increasing number of F-T cycles. At higher stress levels, the ratio of dissipated energy density to elastic energy density in basalt specimens subjected to different F-T treatments converges to approximately 0.25. During the uniaxial cyclic loading tests, both cumulative acoustic emission (AE) counts and average maximum principal strains of the specimens increase stepwise. For specimens after F-T treatment, the spectral-domain characteristics can be classified into three frequency bands, with the middle and high frequencies predominating. The application of the Gaussian Mixture Model (GMM) clustering algorithm enhances the analysis of AE results, facilitating the identification of tensile and shear cracks. As the number of F-T cycles increases, the percentage of shear cracks in basalt specimens decreases from 76.5% (0 cycle) to 53.5% (7 cycles).

Background: Neoadjuvant (NE), adjuvant (AD), and perioperative (PE) immunotherapies have gained validation in early-stage non-small cell lung cancer (NSCLC) trials. However, a comprehensive assessment of their comparative efficacy and safety is lacking. Objectives: To compare the efficacy and safety of NE, AD, and PE immunotherapies in early-stage NSCLC. Design: A systematic review and network meta-analysis using a Bayesian framework. Data sources and methods: We searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) of immune checkpoint inhibitors plus chemotherapy (CT) for early-stage NSCLC. Hazard ratios (HRs) and odds ratios (ORs) for binary endpoints with 95% confidence intervals (CIs) were calculated. Results: We included 10 RCTs involving 5569 NSCLC patients, categorized as NE, PE, or AD immunotherapy. Indirect comparisons highlighted differences in efficacy between PE and AD immunotherapy, specifically in event-free survival (EFS)/disease-free survival (DFS) (HR = 0.72, 95% CI: 0.53–0.96). NE/PE immunotherapies improved pathologic complete response (pCR) (OR = 7.56, 95% CI: 5.24–10.92), major pathologic response (MPR) (OR = 5.46, 95% CI: 3.97–7.51), and EFS (HR = 0.58, 95% CI: 0.52–0.65), while AD immunotherapy enhanced DFS (HR = 0.78, 95% CI: 0.69–0.90). Overall survival (OS) benefits were seen only with PE immunotherapy (HR = 0.66, 95% CI: 0.55–0.81). PE treatment improved EFS across various subgroups (PD-L1

The change of external environmental pressure is one of the main factors affecting the gas desorption pattern of coal samples. In order to study the difference of gas desorption under atmospheric pressure and step-down pressure, we conducted the experiments of atmospheric pressure desorption and step-down pressure desorption on coal samples under different adsorption equilibrium pressures by using the self-developed gas-bearing coal desorption system, to compare and analyze their desorption characteristics and summarize the applicability of different empirical formulas to the desorption data. The results show that: the gas desorption volume in both desorption environments shows a “rapid rise - slowing down - stabilizing” with time; in the process of step-down desorption, the gas desorption volume in the same desorption time increases as the desorption pressure decreases, and the desorption takes longer time to reach the equilibrium state. In the process of stepwise desorption, the amount of gas desorbed in the same desorption time increases with the decrease of desorption pressure, and the time required for desorption to reach the equilibrium state becomes longer, and the accumulated gas desorption volume at different adsorption equilibrium pressures is negatively correlated with the desorption pressure.

Abstract Interactions of tumor cells with immune cells in the tumor microenvironment play an important role during malignancy progression. We previously identified that GAS5 inhibited tumor development by suppressing proliferation of tumor cells in non-small cell lung cancer (NSCLC). Herein, we discovered a tumor-suppressing role for tumor cell-derived GAS5 in regulating tumor microenvironment. GAS5 positively coordinated with the infiltration of macrophages and T cells in NSCLC clinically, and overexpression of GAS5 promoted macrophages and T cells recruitment both in vitro and in vivo. Mechanistically, GAS5 stabilized p53 by directly binding to MYBBP1A and facilitating MYBBP1A-p53 interaction, and enhanced p53-mediated transcription of IRF1, which activated type I interferon signaling and increased the production of downstream CXCL10 and CCL5. We also found that activation of type I interferon signaling was associated with better immunotherapy efficacy in NSCLC. Furthermore, the stability of GAS5 was regulated by NAT10, the key enzyme responsible for N4-acetylcytidine (ac4C) modification, which bound to GAS5 and mediated its ac4C modification. Collectively, tumor cell-derived GAS5 could activate type I interferon signaling via the MYBBP1A-p53/IRF1 axis, promoting immune cell infiltration and potentially correlating with immunotherapy efficacy, which suppressed NSCLC progression. Our results suggested GAS5 as a promising predictive marker and potential therapeutic target for combination therapy in NSCLC. A schematic diagram demonstrating the regulatory effect of GAS5 on immune cell infiltration by activating type I interferon signaling via MYBBP1A-p53/IRF1 axis in non-small cell lung cancer. IFN, interferon.

The inclined layered rock tunnel engineering in the alpine canyon area subject to tectonic stress will be influenced by high lateral stress. Currently, there are scarce reports on the impact of the lateral pressure coefficient on the stability of inclined layered rock tunnels. Hence, the mechanical response of the inclined layered tunnel model was investigated based on the 3D-printed model test, supplemented by acoustic emission (AE) and digital image correlation (DIC) monitoring methods under three cases of lateral pressure coefficients of 1.2, 1.5 and 1.8. The results reveal that for the tunnel model with a 60° bedding inclination, the bearing capacity is negatively correlated with the lateral pressure coefficient. The normal deformation of the bedding of the tunnel model is prominent, exhibiting significant asymmetric deformation characteristics. When the lateral pressure coefficient k increases from 1.2 to 1.5, the failure of the tunnel model changes from shear-slip failure along the layer to bedding cracking and buckling failure of the sidewall. The test results have enlightenment significance for the stability evaluation of inclined layered surrounding rock tunnels in the alpine canyon area.

When the drilling core method is used to determine the coalbed gas content, the cutting heat generated by the core bit cutting coal will increase the core tube temperature, and the excessively high core tube temperature will have an heating effect on the coal core, which will accelerate the coal core gas desorption rate and increase the gas loss amount. The generation of cutting heat of core bit and the measurement of core tube temperature are the basis for grasping the gas desorption law of coal core and projecting the amount of gas loss. Firstly, the self-developed core tube temperature measurement device was used to conduct on-site core temperature measurement experiments at different cutting speeds. Then, the cutting temperature of core bit was solved by establishing thermodynamic model for cutting coal and heat transfer model of cutting edge. Finally, based on the thermal conductivity characteristics of the core tube, the core tube temperature at different cutting speeds was simulated, and the simulated temperature was compared with the on-site measured temperature to verify the reliability of the model. The results show that when coring in primary structural coal, the temperature change trend of core tube wall temperature measurement point at different cutting speeds is basically consistent, the temperature measurement point at the front end of the core tube mainly goes through a relatively stable period in the drilling process, a sharp rising period in the cutting process, a slow rise and cooling period in the withdrawal process. However, the temperature measurement point at the back end of the core tube wall mainly goes through a relatively stable phase and a slowly increasing phase. The temperature rise of the core bit and the core tube wall are significantly positively correlated with the cutting speed. When coring in hard coal seam and the core depth is not large, the cutting heat generated by the core bit and the coal body is the dominant factor for the temperature rise of the core tube. The core tube wall temperature calculated using the model matches well with the field measured temperature, and the error is small, which fully shows that the coring thermodynamic model is feasible. This study provides a basis for further research on the dynamic distribution characteristic of coal core temperature during coring, which is of profound significance to calculate the gas loss and coalbed gas content.

The fusion genes NRG1 and NRG2, members of the epidermal growth factor (EGF) receptor family, have emerged as key drivers in cancer. Upon fusion, NRG1 retains its EGF-like active domain, binds to the ERBB ligand family, and triggers intracellular signaling cascades, promoting uncontrolled cell proliferation. The incidence of NRG1 gene fusion varies across cancer types, with lung cancer being the most prevalent at 0.19 to 0.27%. CD74 and SLC3A2 are the most frequently observed fusion partners. RNA-based next-generation sequencing is the primary method for detecting NRG1 and NRG2 gene fusions, whereas pERBB3 immunohistochemistry can serve as a rapid prescreening tool for identifying NRG1-positive patients. Currently, there are no approved targeted drugs for NRG1 and NRG2. Common treatment approaches involve pan-ERBB inhibitors, small molecule inhibitors targeting ERBB2 or ERBB3, and monoclonal antibodies. Given the current landscape of NRG1 and NRG2 in solid tumors, a consensus among diagnostic and treatment experts is proposed, and clinical trials hold promise for benefiting more patients with NRG1 and NRG2 gene fusion solid tumors.

Abstract Currently, the heat generated during coal core tube sampling causes rapid gas desorption, leading to substantial measurement errors in laboratory gas content assessments. Reducing these errors requires studying frictional heat from core tube friction against the hole wall and coal core temperature rise. Combining the independently developed device to simulate the thermal effect of coring and the COMSOL finite element analysis software, the intensity of the frictional heat source during the core tube sampling and drilling process was analyzed under different coring depth and rotational speed conditions. The research results show that: At constant speed, frictional heat intensifies as the core depth increases. However, the rate of temperature rise decreases with increasing core depth; when the coring depth is constant, the frictional heat is proportional to the rotational speed. For example, at a depth of 140 m and a rotational speed of 120 r/min, the intensity of frictional heat generated by drilling is 2.21 ∗ 10E6J. Similarly, at 180 r/min, the strength is 2.28 ∗ 10E6J, and at 240 r/min, the strength reaches 3.65 ∗ 10E6J; Under certain conditions, core tube wall temperature will not rise indefinitely but will stabilize to a certain value.

Abstract The rearranged during transfection (RET) gene is one of the receptor tyrosine kinases and cell‐surface molecules responsible for transmitting signals that regulate cell growth and differentiation. In non‐small cell lung cancer (NSCLC), RET fusion is a rare driver gene alteration associated with a poor prognosis. Fortunately, two selective RET inhibitors (sRETi), namely pralsetinib and selpercatinib, have been approved for treating RET fusion NSCLC due to their remarkable efficacy and safety profiles. These inhibitors have shown the ability to overcome resistance to multikinase inhibitors (MKIs). Furthermore, ongoing clinical trials are investigating several second‐generation sRETis that are specifically designed to target solvent front mutations, which pose a challenge for first‐generation sRETis. The effective screening of patients is the first crucial step in the clinical application of RET‐targeted therapy. Currently, four methods are widely used for detecting gene rearrangements: next‐generation sequencing (NGS), reverse transcription‐polymerase chain reaction (RT‐PCR), fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC). Each of these methods has its advantages and limitations. To streamline the clinical workflow and improve diagnostic and treatment strategies for RET fusion NSCLC, our expert group has reached a consensus. Our objective is to maximize the clinical benefit for patients and promote standardized approaches to RET fusion screening and therapy.

Abstract Malignant pleural mesothelioma (MPM) is a malignant tumor originating from the pleura, and its incidence has been increasing in recent years. Due to the insidious onset and strong local invasiveness of MPM, most patients are diagnosed in the late stage and early screening and treatment for high‐risk populations are crucial. The treatment of MPM mainly includes surgery, chemotherapy, and radiotherapy. Immunotherapy and electric field therapy have also been applied, leading to further improvements in patient survival. The Mesothelioma Group of the Yangtze River Delta Lung Cancer Cooperation Group (East China LUng caNcer Group, ECLUNG; Youth Committee) developed a national consensus on the clinical diagnosis and treatment of MPM based on existing clinical research evidence and the opinions of national experts. This consensus aims to promote the homogenization and standardization of MPM diagnosis and treatment in China, covering epidemiology, diagnosis, treatment, and follow‐up.

Poor sealing of gas extraction boreholes is one key to restrict gas extraction efficiency. In this paper, a novel borehole sealed quality detection device for the gas extraction of a coal mine is developed based on the theory of air leakage. By comparing the amount of gas extracted at different test points, it is possible to determine whether there is air leakage around the borehole, and the specific leakage position and leakage amount. Moreover, this device has the advantages of simple operation and a short test period. Based on the above analysis, a corresponding air leakage disposal method was proposed to handle the leaky boreholes. Field tests showed that the air–gas mixture flow in the test borehole was reduced by a factor of approximately 1.55 and the concentration of pure seam gas was increased approximately six times after the disposal of the air leaks. The combination of the leakage disposal method and the leakage detection device can accurately seal the borehole at the position of the leak, thus effectively ensuring the effectiveness of gas extraction from the borehole. The findings have important implications for improving the efficiency of gas extraction in coal mining operations.

PurposeTo investigate the effects of various intervention approaches on cancer-related fatigue (CRF) in patients with breast cancer.MethodComputer searches were conducted on PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), and Wanfang databases from their establishment to June 2023. Selection was made using inclusion and exclusion criteria, and 77 articles were included to compare the effects of 12 interventions on patients with breast cancer.ResultsSeventy-seven studies with 12 various interventions were examined. The network findings indicated that cognitive behavioral therapy (CBT) (SMD, -1.56; 95%CI, -3.08~-0.04), Chinese traditional exercises (CTE) (SMD, -0.85; 95%CI, -1.34~-0.36), aerobic exercise (AE) (SMD, -0.77; 95%CI, -1.09~-0.45), multimodal exercise (ME) (SMD, -0.75; 95%CI, -1.26~-0.25), music interventions (MI) (SMD, -0.74; 95%CI, -1.45~-0.03), and yoga (YG) (SMD, -0.44; 95%CI, -0.83 to -0.06) can reduce CRF more than the control group (CG). For relaxation exercises (RE) (MD, -6.69; 95%CI, -9.81~-3.57), MI (MD, -5.45; 95%CI, -7.98~-2.92), AE (MD, -4.34; 95%CI, -5.90~-2.78), ME (MD, -3.47; 95%CI, -4.95~-1.99), YG (MD, -2.07; 95%CI, -3.56~-0.57), and mindfulness training (MD, -1.68; 95%CI, -2.91~-0.46), PSQI improvement was superior to CG. In addition, for CTE (MD, 11.39; 95%CI, 4.11-18.66), YG (MD, 11.28; 95%CI, 1.63-20.93), and AE (MD, 9.34; 95%CI, 0.26~18.42), Functional Assessment of Cancer Therapy-Breast improvement was superior to CG.ConclusionCognitive behavioral therapy (CBT) is the most effective measure for alleviating CRF in patients with breast cancer and Relaxation exercises (RE) is the most effective measure for improving sleep quality. In addition, Chinese traditional exercises (CTE) is the best measure for enhancing quality of life. Additional randomized controlled trials (RCTs) are expected to further investigate the efficacy and mechanisms of these interventions.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023471574.

Transboundary forests in the Himalayas are one of the world’s biodiversity hotspots, but exploring the patterns and influencing factors related to forest disturbance-recovery is still limited. In this study, we used a random forests model, a LandTrendr temporal segmentation algorithm and geographical detector to investigate the spatial and temporal evolution characteristics of forest disturbance and recovery and their influencing factors in the central Himalayas from 1995 to 2018. The results showed that forest disturbance was dominant (∼2.94 × 104 km2) and greater than recovery (∼0.56 × 104 km2). Both disturbance and recovery showed a significant decreasing trend (p

Abstract Thymic epithelial tumors (TETs) are a relatively rare type of thoracic tumor, accounting for less than 1% of all tumors. The incidence of TETs is about 3.93/10000 in China, slightly higher than that of European and American countries. For resectable TETs, complete surgical resection is recommended. Radiotherapy or chemotherapy may be used as postoperative adjuvant treatment. Treatment for advanced, unresectable TETs consist mainly of radiotherapy and chemotherapy, but there is a lack of standard first‐ and second‐line treatment regimens. Recently, targeted therapies and immune checkpoint inhibitors have shown promising outcomes in TETs. Based on the currently available clinical evidences and the opinions of the national experts, the Thymic Oncology Group of Yangtze River Delta Lung Cancer Cooperation Group (East China LUng caNcer Group, ECLUNG; Youth Committee) established this Chinese expert consensus on the clinical diagnosis and treatment of TETs, covering the epidemiology, diagnosis, treatment, prognosis and follow‐up of TETs.

Based on fracture mechanics theory and wing crack model, a three-dimensional strength criterion for hard rock was developed in detail in this paper. Although the basic expression is derived from initiation and propagation of a single crack, it can be extended to microcrack cluster so as to reflect the macroscopic failure characteristic. Besides, it can be derived as Hoek–Brown criterion when the intermediate principal stress σ2 is equal to the minimum principal stress σ3 (Zuo et al., 2015). In addition, the opening direction of the microcrack cluster decreases with the increase of the intermediate principal stress coefficient, which could be described by an empirical function and verified by 10 kinds of hard rocks. Rock strength is influenced by the coupled effect of stress level and the opening direction of the microcrack clusters related to the stress level. As the effects of these two factors on the strength are opposite, the intermediate principal stress effect is induced.

Objectives: Several randomized controlled trials (RCTs) indicated that first-line programmed cell death protein-1/death-ligand 1 inhibitors plus chemotherapy (PD-1/PD-L1 + chemo) led to survival benefits in extensive-stage small-cell lung cancer (ES-SCLC) compared with platinum-based chemotherapy. This study aims to identify the optimal PD-1/PD-L1 + chemo combination strategy. Methods: We included RCTs comparing PD-1/ PD-L1 + chemo versus chemo alone in ES-SCLC. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR), and grade ⩾3 treatment-related adverse events were considered. Odds ratios (ORs), hazard ratios (HRs), and their 95% confidence intervals (CIs) were extracted. Results: Six RCTs with 2600 patients were analyzed in this Bayesian network meta-analysis. Results showed that adding PD-1/PD-L1 inhibitors to chemotherapy led to significant benefits in OS (HR = 0.72, 95% CI: 0.66–0.79), PFS (HR = 0.69, 95% CI: 0.63–0.75), and ORR (OR = 1.32, 95% CI: 1.12–1.56), and no differences in toxicity were found (OR = 1.09, 95% CI: 0.92–1.30). Serplulimab plus chemotherapy was found to provide the best OS (HR = 0.63, 95% CI: 0.49–0.82), the best PFS (HR = 0.47, 95% CI: 0.38–0.59), and the best ORR (OR = 1.7, 95% CI: 1.15–2.53). Moreover, although there were no difference between PD-L1 + chemo and PD-1 + chemo regarding OS (HR = 0.99, 95% CI: 0.91–1.08) and ORR (OR = 1.27, 95% CI: 0.91–1.78), PD-1 + chemo showed a significant benefit in PFS (HR = 0.82, 95% CI: 0.68–0.98) compared with PD-L1 + chemo. Conclusions: Serplulimab plus chemotherapy seems to be superior first-line immunotherapy combination for patients with ES-SCLC. PD-1 + chemo seems to outperform PD-L1 + chemo in PFS.

Abstract Human epidermal growth factor receptor 2 (HER2) possesses tyrosine kinase activity and participates in cell growth, differentiation and migration, and survival. Its alterations, mainly including mutations, amplifications, and overexpression are associated with poor prognosis and are one of the major drivers in non–small cell lung cancer (NSCLC). Several clinical trials had been investigating on the treatments of HER2‐altered NSCLC, including conventional chemotherapy, programmed death 1 (PD‐1) inhibitors, tyrosine kinase inhibitors (TKIs) and antibody‐drug conjugates (ADCs), however, the results were either disappointing or encouraging, but inconsistent. Trastuzumab deruxtecan (T‐DXd) was recently approved by the Food and Drug Administration as the first targeted agent for treating HER2‐mutant NSCLC. Effective screening of patients is the key to the clinical application of HER2‐targeted agents such as TKIs and ADCs. Various testing methods are nowadays available, including polymerase chain reaction (PCR), next‐generation sequencing (NGS), fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), etc. Each method has its pros and cons and should be reasonably assigned to appropriate patients for diagnosis and guiding treatment decisions. To help standardize the clinical workflow, our expert group reached a consensus on the clinical management of HER2‐altered NSCLC, focusing on the diagnosis and treatment strategies.

Abstract Background Currently, immunotherapy is widely used in the treatment of various stages of non-small cell lung cancer. According to clinical experience and results of previous studies, immunotherapy as neoadjuvant therapy seems to exhibit better efficacy against early resectable non-small cell lung cancer as compared to advanced lung cancer, which is often defined as unresectable non-small cell lung cancer. However, this observation has not been established in clinical studies. This systematic review aimed to evaluate the efficacy of immunotherapy in early and late lung cancer, wherein objective response rate (ORR) and disease control rate (DCR) were used as evaluation indexes. The present study also evaluated the safety of immunotherapy in early and late lung cancer, wherein the rate of treatment-related adverse reactions (TRAEs) was used as an indicator. Methods Electronica databases, including PubMed, Cochrane Library, Embase, and other databases, were searched to identify relevant studies. Besides this, all the available reviews, abstracts, and meeting reports from the main international lung cancer meetings were searched manually. ORR, DCR, and TRAEs were extracted as the primary outcomes. Results A total of 52 randomized controlled trials involving 13,660 patients were shortlisted. It was observed that immunotherapy alone significantly improved DCR in early lung cancer in comparison to advanced lung cancer. Importantly, the improvement in ORR was not to the same extent as reported in the case of advanced lung cancer. The combination of immunotherapy with other therapies, especially immunochemotherapy, significantly improved ORR and DCR in early lung cancer. In terms of safety, immunotherapy either alone or in combination with other therapies exhibited a better safety profile in early lung cancer than in advanced lung cancer. Conclusions Altogether, the benefits of immunotherapy in early lung cancer appeared to be better than those observed in advanced lung cancer, especially with the regard to the regimen of immunotherapy in combination with chemotherapy. In terms of safety, both immunotherapy alone and its combination with chemotherapy were found to be safer in early lung cancer as compared to advanced lung cancer.

Abstract Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first “tumor agnostic” drugs approved for pan‐cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second‐generation drugs designed to overcome first‐generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription‐polymerase chain reaction, and (DNA and/or RNA‐based) next‐generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first‐ and second‐generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors.

Novel methodologies for introducing sulfoxonium groups into organic molecules are desirable. Here the authors report the synthesis of an iodonium-sulfoxonium ylide reagent that enables the preparation of sulfoxonium-containing cyclic structures upon reaction with alkenes, alkynes, nitriles or allenes.

Ligularia virgaurea is the most widely functional native herbage in the alpine meadow pastures of the Qinghai-Tibet Plateau (QTP) and has multiple pharmacological and biological activities. The effect of L. virgaurea as a dietary component on the digestion and metabolism of sheep was evaluated by conducting feeding trials in metabolic cages. Thirty-two Tibetan yearling rams (29 ± 1.56 kg BW) were randomly allotted to four groups included in a completely randomised design with eight animals per treatment. Sheep were fed a basal diet (freshly native pasture) without the addition of L. virgaurea (control) or with the addition of L. virgaurea (100, 200, or 300 mg/kg BW per day) for 45 days. Addition of L. virgaurea to the diet of Tibetan sheep was found to influence the average daily gain (quadratic [Q], P 0.05; Q, P 0.05; Q, P ≤ 0.001) were also affected by the dietary inclusion of L. virgaurea. Effects of L. virgaurea feeding were also witnessed on methane energy (CH4-E) (L, P = 0.029), gross energy (GE) (Q, P = 0.013), digestible energy (DE) (Q, P = 0.015), and metabolisable energy (ME) intake (Q, P = 0.015). Energy utilisation efficiency expressed as a proportion of GE intake (DE/GE intake, ME/GE intake, ME/DE intake, FE/GE intake, and CH4-E/GE intake) manifested quadratic changes (P

Marsh wetlands present a rich variety of ecosystem goods and services, including important carbon sinks, of great significance to changes in the global environment. However, seasonal responses of marsh wetlands remain understudied and poorly understood. Therefore, this study adapted the Landsat-based Detection of Trends in Disturbance and Recovery (LandTrendr) model using field and Landsat data during 1990–2017 to identify the seasonal and spatial variations in marsh wetlands in the headwaters of the Brahmaputra, Ganges, and Indus Rivers (HBGIR) and analyze the drivers of their spatiotemporal changes. The spatiotemporal change in the marsh wetlands was divided into the three stages of expansion (1990–1998), retreat (1998–2004), and stability (2004–2017). The marsh wetland area showed an increasing trend before 1998 and a stable and slightly increasing trend after 2004. The expansion area of the marsh wetlands was located in the reserves of Shiquanhe and Manasarovar and their surrounding areas. The marsh wetlands were subjected to the largest expansion in summer (114.45 km2), followed by spring (80.45 km2). The expansion of the marsh wetlands in summer was mainly driven by snow depth and temperature, with the strongest interaction factor of 0.6 between them. However, the retreat of the marsh wetlands was driven by the expansion of construction and cultivated lands in the HBGIR. Finally, the LandTrendr model modified in this study was useful for improving the change-detection accuracy of the marsh wetlands. This study provides an important theoretical basis for wetland protection and management for the Tibetan Plateau.

Copper (Cu) pollution is one of environmental problems that adversely affects the growth and development of plants. However, knowledge of lignin metabolism associated with Cu-induced phytotoxicity mechanism is insufficient. The objective of this study was to reveal the mechanisms underlying Cu-induced phytotoxicity by evaluating changes in the photosynthetic characteristics and lignin metabolism in the seedlings of wheat cultivar ‘Longchun 30′. Treatment with varying concentrations of Cu clearly retarded seedling growth, as demonstrated by a reduction in the growth parameters. Cu exposure reduced the photosynthetic pigment content, gas exchange parameters, and chlorophyll fluorescence parameters, including the maximum photosynthetic efficiency, potential efficiency of photosystem II (PS II), photochemical efficiency of PS II in light, photochemical quenching, actual photochemical efficiency, quantum yield of PS II electron transport, and electron transport rate, but notably increased the nonphotochemical quenching and quantum yield of regulatory energy dissipation. Additionally, a significant increase was observed in the amount of cell wall lignin in wheat leaves and roots under Cu exposure. This increase was positively associated with the up-regulation of enzymes related to lignin synthesis, such as phenylalanine ammonia-lyase, 4-coumarate:CoA ligase, cinnamyl alcohol dehydrogenase, laccase, cell wall bound (CW-bound) guaiacol peroxidase, and CW-bound conifer alcohol peroxidase, and TaPAL, Ta4CL, TaCAD, and TaLAC expression. Correlation analysis revealed that lignin levels in the cell wall were negatively correlated with the growth of wheat leaves and roots. Taken together, Cu exposure inhibited photosynthesis in wheat seedlings, resulting from a reduction in photosynthetic pigment content, light energy conversion, and photosynthetic electron transport in the leaves of Cu-stressed seedlings, and the Cu-inhibitory effect on seedling growth was related to the inhibition of photosynthesis and an increase in cell wall lignification.

Laser cladding is a new technology for fabricating coatings with good properties, such as wear resistance, lubrication, and corrosion resistance. Usually, parts of 45 steel are used as a shaft under conditions of high-speed rotation or friction and wear, and they have a short service life and sometimes cause accidents. In order to avoid serious accidents, a cladding coating made from a Ni-based alloy with ceramic particles was fabricated via laser technology on a substrate of 45 steel in this research. The microstructure and properties were investigated via SEM, EDS, XRD, and a wear and friction tester. The results show that there was an obvious boundary between the cladding coating and the substrate. The main phases were γ(Fe, Ni), WC, TiC, Cr2Ti, and Cr23C6. In the middle of cladding coating, the microstructure was composed of dendrite and cellular crystals, while the microstructure was composed of equiaxial crystals in the bonding region. Inside the cellular crystal, the main phase was γ~(Fe, Ni), which occasionally also showed the appearance of some white particles inside the cellular crystal. Compared with the cellular crystal, the boundary had less of the Fe and Ni elements and more of the Cr and W elements. The amount of C element around the dendrite crystal was more than that around the boundary of cellular crystal due to the long formation time of dendrite. The white particles around the boundary were carbides, such as WC and Cr23C6 phases. Meanwhile, the segregation of the Si element also appeared around the boundaries of the crystal. The maximum microhardness was 772.4 HV0.5, which was about 3.9 times as much as the substrate’s microhardness. The friction coefficients of the 45 steel substrate and Ni-based alloy coating were usually around 0.3 and 0.1, respectively. The Ni-based coating had a smaller coefficient and more stable fluctuations. The wear volume of the cladding coating (0.16 mm3) was less than that of the substrate (1.1 mm3), which was about 14.5% of the wear volume of 45 steel substrate. The main reason was the existence of reinforced phases, such as γ~(Fe, Ni), Cr23C6, and Cr2Ti. The added small WC and TiC particles also enhanced the wear resistance further. The main wear mechanism of the cladding coating was changed to be adhesive wear due to the ceramic particles, which was helpful in improving the service life of 45 steel.

In the process of working face mining, the permeability of the coal seam and the crack evolution characteristics of overlying strata are very important for efficient gas drainage. In this study, the distribution characteristics of the stress field and crack field in the working face and their relations are analyzed mainly by 3DEC numerical simulation. Furthermore, combined with the on-site measurement of coal seam stress, gas pressure, and gas seepage in front of the working face and the gas seepage in overlying strata before and after mining, the coupling effect of stress field and gas field and the law of gas migration and distribution in the working face are deeply explored. The results show that the changing trend of gas seepage and gas pressure is controlled by the stress change of the working face, and with the increase of stress, gas pressure and gas seepage also increase. The peak position of gas pressure is the farthest from the coal wall, about 22.5~25 m, followed by the peak of stress and gas seepage. When the permeability of coal and rock mass increases, the gas seepage increases and the gas pressure decreases. The coal seam stress and gas seepage in the working face and gas seepage in the overlying strata fracture zone along the tailgate side are generally greater than those on the headgate side, but the gas pressure is the opposite. Mining cracks and strata separation provide a good channel and space for gas migration and accumulation. Along the strike and tendency of the working face, gas is mainly concentrated in the overlying strata crack space above the separation zone and the roof and overlying strata crack space on the side of the tailgate, respectively. Based on this, the directional borehole gas drainage technology and borehole layout scheme in the fractured zone are put forward, which effectively reduce the gas concentration in the working face by 30~36%.

Abstract Organic single crystals with low defect density are key functional materials for next‐generation electronics. Classical crystallization commonly results in a high density of molecular steps, which are defects that can trap charge carriers and reduce the mobility of organic semiconductors. Herein, a novel nonclassical crystallization mechanism involving nucleation, fusion, and growth is designed. The introduction of the fusion stage changes the crystal growth mode from three‐dimensional island growth to two‐dimensional layer‐by‐layer growth and leads to large‐area two‐dimensional molecular crystals with almost no molecular steps. Therefore, the average mobility is observed to improve from 1.26 to 2.07 cm2 V−1 s−1. The nonclassical crystallization mechanism paves the way for atomically flat single crystals to probe the intrinsic optoelectronic properties of organic semiconductors.

Abstract Mechanoluminescence, a smart luminescence phenomenon in which light energy is directly produced by a mechanical force, has recently received significant attention because of its important applications in fields such as visible strain sensing and structural health monitoring. Up to present, hundreds of inorganic and organic mechanoluminescent smart materials have been discovered and studied. Among them, strontium‐aluminate‐based materials are an important class of inorganic mechanoluminescent materials for fundamental research and practical applications attributed to their extremely low force/pressure threshold of mechanoluminescence, efficient photoluminescence, persistent afterglow, and a relatively low synthesis cost. This paper presents a systematic and comprehensive review of strontium‐aluminate‐based luminescent materials’ mechanoluminescence phenomena, mechanisms, material synthesis techniques, and related applications. Besides of summarizing the early and the latest research on this material system, an outlook is provided on its environmental, energy issue and future applications in smart wearable devices, advanced energy‐saving lighting and displays.

Grasping the spatial correlation structure of transportation carbon emission efficiency (TCEE) and its influencing factors is significant for promoting high-quality and coordinated development of the transportation industry and the relevant region. Based on the ideal point cross-efficiency (IPCE) model, the social network analysis method was employed herein to explore the spatial correlation network structure of China’s provincial TCEE and its influencing factors. The results obtained showed the following outcomes. (1) During the study period, China’s provincial TCEE formed a complex and multithreaded network association relationship, but its network association structure was still relatively loose and presented the hierarchical gradient characteristics of dense in the east and sparse in the west. (2) The correlation of China’s TCEE formed a block segmentation based on the regional boundaries, and its factional structure was relatively obvious. The eastern region was closely connected with the central region, and generally connected with the western and northeastern regions. The central region was mainly connected with the eastern and western regions, and relatively less connected with the northeastern region. Besides, the northeastern region was weakly connected with the western region. (3) Shanghai, Beijing, Zhejiang, Guangdong, Jiangsu, Tianjin, and other developed provinces were in the core leading position in the TCEE network, which significantly impacted the spatial correlation of TCEE. However, Heilongjiang, Jilin, Xinjiang, Qinghai, and other remote provinces in the northeast and northwest were at the absolute edge of the network, which weakly impacted the spatial correlation of TCEE. (4) Provincial distance, economic development-level difference, transportation intensity difference, and transportation structure difference had significant negative impacts on the spatial correlation network of China’s provincial TCEE. In contrast, the energy-saving technology level difference had a significant positive impact on it. The regression coefficients of transportation energy structure and environmental regulation differences were positive but insignificant; their response mechanism and effects need to be improved and enhanced.

Dung decomposition is a key process affecting the cycling of carbon (C), nitrogen (N) and phosphorus (P). However, dung decomposition and nutrients (i.e., C, N and P) cycling in relation to stocking rate are still poorly understood in the alpine meadow. In this study, we carried out a 720-days field experiment to explore the differences in composition, mass, decomposition and nutrient cycling between sheep dung collected from grazing grassland with a high stocking rate (HSRD) and a low stocking rate (LSRD). Our results demonstrate that the dung mass, and C, N and P return were significantly higher for HSRD, whereas the C and N content were significantly greater in LSRD. The time required to achieve 75 % C, N and P loss from HSRD was longer (859.06 to 2664.7 days) than that (806.6 to 2123.7 days) from LSRD. However, after 720 days of decomposition, the release rates of DM (dry matter), C and N from LSRD were lower than that from HSRD; as a result, the leaching and residual mass respectively accounted for 2.03 % and 31.95 % of the original C content in LSRD, which were lower than that in HSRD (2.45 and 36.48 %, respectively); N released into the atmosphere (37.13 %) from LSRD was greater than that (32.08 %) from HSRD. Our findings suggest that stocking rate may change dung quantity, composition and decomposition rate, affecting biogeochemical cycling processes in grassland ecosystems.

Abstract Persistent mechanoluminescence (ML) with long lifetime is highly required to break the limits of the transient emitting behavior under mechanics stimuli. However, the existing materials with persistent ML are completely trap‐controlled, and a pre‐irradiation is required, which severely hinders the practical applications. In this work, a novel type of ML, self‐charging persistent ML, is created by compositing the Sr3Al2O5Cl2:Dy3+ (SAOCD) powders into flexible polydimethylsiloxane (PDMS) matrix. With no need for any pre‐irradiation, the as‐fabricated SAOCD/PDMS elastomer could exhibit intense and persistent ML under mechanics stimuli directly, which greatly facilitates its applications in mechanics lighting, displaying, imaging, and visualization. By investigating the matrix effects as well as the thermoluminescence, cathodoluminescence, and triboelectricity properties, the interfacial triboelectrification‐induced electron bombardment processes are demonstrated to be responsible for the self‐charged energy in SAOCD under mechanics stimuli. Based on the unique self‐charging processes, the SAOCD/PDMS further exhibits mechanics storage and visualized reading activities, which brings novel ideas and approaches to deal with the mechanics‐related problems in the fields of mechanical engineering, bioengineering, and artificial intelligence.

Deep underground engineering encounters substantial layered hard rock formations, and the engineering triaxial stress path involves an increase in maximum principal stress, constant intermediate principal stress, and a decrease in minimum principal stress. However, previous research has focused on rock layer angles under conventional triaxial stress conditions, disregarding the influence of foliation strike angles in engineering triaxial stress scenarios. This study experimentally investigates the effects of foliation strike angles on layered hard rock under an engineering triaxial stress path. To account for the brittleness of layered hard rock, we propose a specific small sample-processing method tailored to the foliation strike angle. True triaxial loading tests are conducted on steep, thin slate samples with two different loading orientations, accompanied by acoustic emission monitoring. Results indicate that the strength under a traditional true triaxial compression condition is similar for specimens with 90° and 0° strike angles. Stress–strain curves show that larger deformations occur perpendicular to bedding planes, while surface fractures propagate exclusively along the bedding planes. Mechanical responses differ significantly between specimens subjected to the engineering triaxial stress path at 0° and 90° strike angles compared to conventional true triaxial loading tests, with a lower bearing capacity and differentiated intermediate and minimum principal strains in the 0° case. Conversely, the 90° case exhibits a higher bearing capacity, consistent deformation, and more acoustic emission events. Numerical simulations comparing plastic zone sizes during actual underground excavation support these conclusions. These findings highlight the effects of foliation strike angles, favoring the 90° strike-angle configuration for excavation activities and providing enhanced stability in the surrounding rock mass.

Snow cover plays a critical role in global energy and water cycles. Snow cover on the Tibetan Plateau (TP) provides vital water sources in western China and Himalayan regions, in addition to its weather and climate significance. The massive high mountain topography of the TP is the main condition for the presence and persistence of snow cover on the plateau at the mid-low latitudes of the Northern Hemisphere (NH). However, how the mountain topography controls snow-cover distribution on the TP remains largely unclear, and the relationship is not well quantified. Here, the spatial distribution and the topographic controls of snow cover on the TP are examined based on snow cover frequency (SCF) derived from MODIS snow cover product (MOD10A2 v005) and digital elevation model (DEM) data. The results show that snow cover on the TP is spatially unevenly distributed, and that it is characterized by rich snow and high SCF on the interior and the surrounding high mountain ranges, with less snow and low SCF in inland basins and river valleys. Snow cover on the TP presents elevation dependence: the higher the altitude, the higher the SCF, the longer the snow cover duration, and the more stable the intra-annual variation. The annual mean SCF below 3000 m above sea level (m a.s.l) is less than 4%, and it reaches 77% above 6000 m a.s.l. The intra-annual snow cover variation below 4000 m a.s.l features a unimodal distribution, while above 4000 m a.s.l it presents a bimodal distribution. The mean minimum SCF below 6000 m a.s.l occurs in summer, while above 6000 m a.s.l it occurs in winter. Due to differences in solar radiation and moisture condition caused by the mountain slope and aspect, the mean SCF generally increases with mountain slopes, and it is the highest on the north-facing aspect and the lowest on the south-facing aspect.

Many major river systems in Asia, such as the Yangtze, Yarlung Zangbo, Indus, Ganges and Salween originate in the Tibetan mountains and snow cover in Tibet provides substantial water resources for these rivers, in addition to its weather-related and climatic significance. The high mountain terrain of Tibet is the main condition that snow cover exists and persists at mid–low altitudes. However, the relationships between snow cover and topographic factors of the plateau have not been fully addressed. In this study, the overall spatial distribution of snow cover and the impacts of topography (elevation, aspect and slope) on snow cover distribution in Tibet were analyzed based on the MODIS snow cover product and digital elevation model (DEM) using GIS spatial analysis techniques. The results showed that (1) snow cover in Tibet is spatially very uneven and is characterized by rich snow and high SCF (snow cover frequency) on Nyainqentanglha mountain and the surrounding high mountains, with less snow and a low SCF in the southern Tibetan valley and central part of northern Tibet. (2) Snow cover in Tibet has a strong elevation dependence and a higher SCF corresponds well with high mountain ranges. The mean SCF below 2000 m above sea level (m a.s.l) was less than 4%, while above 6000 m a.s.l, it reached 75%. (3) Intra-annual snow cover distribution below 4000 m a.s.l was characterized by unimodal patterns, while above 4000 m a.s.l, it was characterized by bimodal patterns. The lowest SCF below 6000 m a.s.l occurred in summer, while above 6000 m it occurred in winter. (4) The mountain slope and aspect affect snow cover distribution through changing radiation and energy balances in the mountain regions. The mean SCF generally increased with mountain slopes, with the highest on the north-facing aspect and the lowest on the south-facing aspect.

Reports indicate that high-cost, insecurity, and difficulty in complex environments hinder the traditional urban road inundation monitoring approach. This work proposed an automatic monitoring method for experimental urban road inundation based on the YOLOv2 deep learning framework. The proposed method is an affordable, secure, with high accuracy rates in urban road inundation evaluation. The automatic detection of experimental urban road inundation was carried out under both dry and wet conditions on roads in the study area with a scale of a few m2. The validation average accuracy rate of the model was high with 90.1% inundation detection, while its training average accuracy rate was 96.1%. This indicated that the model has effective performance with high detection accuracy and recognition ability. Besides, the inundated water area of the experimental inundation region and the real road inundation region in the images was computed, showing that the relative errors of the measured area and the computed area were less than 20%. The results indicated that the proposed method can provide reliable inundation area evaluation. Therefore, our findings provide an effective guide in the management of urban floods and urban flood-warning, as well as systematic validation data for hydrologic and hydrodynamic models. HIGHLIGHTS First experimental urban road inundation automatic detection study using YOLOv2.; Proposed an inundation area computation method based on a deep learning technique.; Good performance on an experimental urban road inundation detection was tested.;