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Two isostructural heterometallic ZrMOFs (denoted as ZrMOF-Co/Ni) were obtained by stepwise sysnthesis approach. Single-crystal X-ray structural analyses indicate that two ZrMOFs are both built from trinuclear zirconocene-based metallo-pyridine buliding blocks, featuring 2D infinite chain structure. Furthermore, the magnetic studies reveal that ZrMOF-Co shows antiferromagnetic performance, while ZrMOF-Ni feature ferromagnetic behavior.

The properties of SBS modified bitumen waterproof membrane (SMBM) will deteriorate under the action of heat. In this paper, SBS modified bitumen (SMB) and SMBM were aged at 80 °C for different times (0,10,20,30,40 days). The low temperature flexibility, softening point, viscosity and mass changes ratio of SMB and mechanical properties of SMBM before and after aging were tested, the microstructure and chemical structure of SMB were investigated by fluorescence microscope (FM) and Fourier transform infrared spectroscopy (FTIR). The results show that the low temperature flexibility, softening point and viscosity of SMB decrease significantly at the initial stage of heat aging (10 days), especially the influence of heat aging on the low temperature flexibility and viscosity of SMB is more obvious, and their properties degradation rate slowdown in the later stage of aging. The mass changes ratio of SMB first decreases and then increases with aging time. FM shows that the network crosslinking structure of SMB is destroyed gradually with the extension of aging time. The network crosslinking structure disappears after 40 days of heat aging. FTIR shows that carbonyl and sulfoxide compounds are increasing after aging, more carbonyl compounds than sulfoxide compounds are formed after aging for 10 days, and the degradation rate of SBS decreases. The maximum tension of SMBM first increases and then decreases, the elongation at maximum tension decreases with aging time.

Based on the reason that SBS modified bitumen (SMB) with sulfur stabilizer is easy to degrade during aging, a novel non-sulfur stabilizer, P-benzoquinone oxime (GMF), was used to modify SMB. The effects of GMF and sulfur stabilizer on the thermal storage stability, low-temperature performance and aging resistance of SMB were investigated. The results indicate that GMF is more beneficial to improve the thermal storage stability, the low temperature flexibility and softening point of SMB than that of sulfur. And GMF can restrain the degradation of the low temperature flexibility of SMB after thermal aging as compared with sulfur. Fourier transform infrared spectroscopy indicates that the aging growth index of GMF/SBS modified bitumen is 33.5% lower than that of sulfur/SBS modified bitumen after aging. Fluorescence microscope proves that the addition of GMF can prevent the destruction of cross-linking network structure of SBS in bitumen during aging process, which also demonstrates that GMF can improve the aging resistance of SMB. Therefore, GMF can be more suitable as a stabilizer for SMB.

The nervous system of the silkworm is vital for the development of organisms. It achieves and maintains normal life activities by regulating the function of the organs and all kinds of physiological processes in the silkworm. BmApontic (BmApt), as an important bZIP transcription factor, is required for the formation of pigmentation in the silkworm. However, the function of BmApt in the development of the nervous system of the silkworm remains unclear. Here, we showed that amino acid sequence of BmApt was evolutionarily conserved in its Myb/SANT motif and basic DNA binding domain. BmApt was expressed in the nervous system at the embryonic stage. Knockdown of Bmapt by RNA interference resulted in abnormal development of axons. Moreover, the expression of BmnetrinA, BmnetrinB and Bmfrazzled was decreased in the Bmapt knockdown embryos. These results demonstrate that BmApt controls neurodevelopment by activating the expression of Bmnetrin and Bmfrazzled.

Based on the ABAQUS / Explicit finite element method, the forming force changing trend of deep drawing test for 6A16 aluminum alloy plate after pre-aging and storage at room temperature for one month was simulated under friction coefficient ranging from 0 to 0.22. The lubricants selected for the tests were mechanical oil, butter and dry film lubricant, and the friction coefficient of these lubricants were 0.05, 0.10 and 0.15, respectively. Microstructural evolution of 6A16 aluminum alloy plate during drawing forming was investigated by OM, SEM and EBSD. The results showed that, with the increase of friction coefficient, the stress, strain and deformation degree in deformation zone increased, while the grain size in deformation zone decreased. Thus, the hardness of the cup-typed component increased with the increase of friction coefficient. Butter-lubricated cups had the highest tensile strength and yield strength after paint-bake cycle. The combination of simulation results and microstructure analysis of 6A16 aluminum alloy plate after drawing forming indicates that the appropriate lubricant is butter.

Objective: MiR-203 has been shown to participate in multiple malignancies, but the role of miR-203 in hepatoblastoma (HB) remains unclear. The aim of our study was to investigate the effects of miR-203 in HB. Methods: A total of 15 pairs of HB tissues and para-tumour normal tissues were collected for the experiments. RT-qPCR and Western blotting were performed to detect the expression of CRNDE, miR-203, and VEGFA at the mRNA and/or protein levels, respectively. A dual luciferase assay verified the target relationship between miR-203 and the 3′UTR of VEGFA as well as miR-203 and CRNDE. In addition, MTT, wound healing, and tube formation assays were performed to assess the effects of miR-203, VEGFA, and CRNDE on cell proliferation, migration, and angiogenesis, respectively. Results: Our data revealed that miR-203 expression was decreased in HB tissues, while long non-coding RNA (lncRNA) CRNDE expression was increased. The dysregulation of miR-203 and CRNDE was closely related to tumour size and stage. Moreover, overexpression of miR-203 inhibited angiogenesis. A dual luciferase assay verified that VEGFA is a direct target of miR-203 and that CRNDE binds to miR-203. Furthermore, our results showed that miR-203 suppressed cell viability, migration, and angiogenesis by regulating VEGFA expression. Additionally, it was confirmed that CRNDE promoted angiogenesis by negatively regulating miR-203 expression. Conclusion: lncRNA CRNDE targets the miR-203/VEGFA axis and promotes angiogenesis in HB. These results provide insight into the underlying mechanisms of HB and indicate that CRNDE and miR-203 might be potential targets for HB therapy.

The South China tigers (Panthera tigris amoyensis) are extinct in the wild, but viable populations remain in breeding centers and zoos after 60 years of effective conservation efforts. At present, however, the existing genetic variation of these tigers remains unknown. In this study, we assembled a high-quality chromosome-level genome using long-read sequences and re-sequenced 29 high-depth genomes of the South China tigers. We identified two significantly differentiated genomic ancestries in the extant populations, which also harbored some rare genetic variants introgressed from other subspecies, suggesting limited but essential genetic diversity to sustain the South China tigers. The unique pattern of dual ancestry and the genomic resources generated in our study pay the way for a genomics-informed conservation, following the real-time monitoring and controlled exchange of all reproductive South China tigers.

There are two distinct phases in the evolution of drift wave envelope in the presence of zonal flow. A long-lived standing wave phase, which we call the Caviton, and a short-lived traveling wave phase (in radial direction) we call the Instanton. Several abrupt phenomena observed in tokamaks, such as intermittent excitation of geodesic acoustic mode (GAM) shown in this paper, could be attributed to the sudden and fast radial motion of Instanton. The composite drift wave — zonal flow system evolves at the two well-separate scales: the micro-scale and the meso-scale. The eigenmode equation of the model defines the zero-order (micro-scale) variation; it is solved by making use of the two-dimensional (2D) weakly asymmetric ballooning theory (WABT), a theory suitable for modes localized to rational surface like drift waves, and then refined by shifted inverse power method, an iterative finite difference method. The next order is the equation of electron drift wave (EDW) envelope (containing group velocity of EDW) which is modulated by the zonal flow generated by Reynolds stress of EDW. This equation is coupled to the zonal flow equation, and numerically solved in spatiotemporal representation; the results are displayed in self-explanatory graphs. One observes a strong correlation between the Caviton-Instanton transition and the zero-crossing of radial group velocity of EDW. The calculation brings out the defining characteristics of the Instanton: it begins as a linear traveling wave right after the transition. Then, it evolves to a nonlinear stage with increasing frequency all the way to 20 kHz. The modulation to Reynolds stress in zonal flow equation brought in by the nonlinear Instanton will cause resonant excitation to GAM. The intermittency is shown due to the random phase mixing between multiple central rational surfaces in the reaction region.

Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities. The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes. Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange. MSC-derived exosomes (MSC-Exos) have potential for cell-free therapy for diseases of, for instance, the kidney, liver, heart, nervous system, and musculoskeletal system. Hence, MSC-Exos are an alternative to MSC-based therapy for regenerative medicine. We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.

This study focuses on the tourism industry and tries to explore the relationship between diversification and performance of tourism enterprises. By collecting and analyzing the data of 144 tourism companies (28 A-share enterprises and 116 New Third Board tourism enterprises), this paper studies the moderating role of executive team experience in the relationship between diversification strategy and performance. Finally, the following conclusions are drawn: 1. The diversification of A-share tourism enterprises is beneficial to the improvement of enterprise performance; there is no significant performance difference between diversification strategy and non-diversification strategy of New Third Board tourism enterprises, and there is no significant relationship between diversification degree and performance. 2. Regardless of A shares or tourism enterprises, related diversification, unrelated diversification, professional type has no significant differences in the performance of enterprise. 3. The average tenure of the executive team is inconsistent in the performance of tourism enterprises with different sizes and degrees of diversification, and the average age of the executive team is inconsistent in the performance of tourism enterprises with different sizes.

Based on the ABAQUS/explicit finite element method, the deep drawing of 6A16 alloy pre-aged and then storaged at room temperature for 1 week with various blank-holder forces (10, 14, 18 kN) was studied. The distribution and variation of stress and strain in deformation zones were investigated to drive the forming property and process of the alloy. Besides, the simulation result was verified combined with the deep drawing experiments. The results show that the stress and strain of the deformation zone have an incremental trend with the blank-holder force increasing while the deformation degree and grain size within a certain deformation zone have an obvious increase and an enlargement, respectively. After the deep drawing, the hardness of products also increases with the enhancement of blank-holder force. The blank-holder force of 18 kN is certified as the preferential one by the analysis of microstructure and simulation results.

To gain insight into the response of mulberry to phytoplasma-infection, the expression profiles of mRNAs and proteins in mulberry phloem sap were examined. A total of 955 unigenes and 136 proteins were found to be differentially expressed between the healthy and infected phloem sap. These differentially expressed mRNAs and proteins are involved in signaling, hormone metabolism, stress responses, etc. Interestingly, we found that both the mRNA and protein levels of the major latex protein-like 329 (MuMLPL329) gene were increased in the infected phloem saps. Expression of the MuMLPL329 gene was induced by pathogen inoculation and was responsive to jasmonic acid. Ectopic expression of MuMLPL329 in Arabidopsis enhances transgenic plant resistance to Botrytis cinerea, Pseudomonas syringae pv tomato DC3000 (Pst. DC3000) and phytoplasma. Further analysis revealed that MuMLPL329 can enhance the expression of some defense genes and might be involved in altering flavonoid content resulting in increased resistance of plants to pathogen infection. Finally, the roles of the differentially expressed mRNAs and proteins and the potential molecular mechanisms of their changes were discussed. It was likely that the phytoplasma-responsive mRNAs and proteins in the phloem saps were involved in multiple pathways of mulberry responses to phytoplasma-infection, and their changes may be partially responsible for some symptoms in the phytoplasma infected plants.

In this paper, the aging behavior of high dosage styrene–butadienestyrene (SBS) modified bitumen (HSMB) for waterproof materials and low dosage SBS modified bitumen (LSMB) for pavement were investigated. The effects of heat as well as ultraviolet-heat synergism on properties and chemical structure of HSMB and LSMB were evaluated by physical properties, fluorescence microscope (FM) and Fourier transform infrared spectroscopy (FTIR). The results showed that the change of softening point and low temperature flexibility of HSMB was much less than that of LSMB after heat aging, which indicated that the aging resistance of HSMB was better than that of LSMB. The physical properties changes of HSMB and LSMB after UV-heat synergism aging were much serious than that of HSMB and LSMB after heat aging. FM indicated that HSMB showed the network structure, and its structure was only partially destroyed after heat aging and completely destroyed after UV-heat synergism aging, while LSMB presented the sea-island structure, and the sea-island structure almost disappeared after aging. FTIR also showed that the change of carbonyl index ( I C = O ), sulfoxide index ( I S = O ) and butadiene double bonds index ( I C = C ) of HSMB was smaller than that of LSMB after aging. The aging kinetic models of HSMB and LSMB were established by viscosity, the aging kinetic models showed that HSMB had lower aging reaction rate and larger activation energy than LSMB under the same aging condition, which meant that HSMB had better aging resistance.

This paper proposes a CMOS fully integrated 860-GHz terahertz (THz) sensor. The sensor integrates a single-NMOS THz detector, a low-noise chopper instrumentation amplifier and a high-resolution ΔΣ-ADC. The detector consists of a novel on-chip grounded patch antenna and a source-feeding NMOS field-effect transistor (FET) of the minimum size. A microstrip transmission line is designed to improve the power transfer efficiency between the antenna and the NMOS transistor. A notch filter is proposed to improve detector performance. To enable the theoretical analysis of the operation of the THz detector and the formulation of design guidelines, we propose a THz-FET device model in which a source-coupled FET for THz detection is modeled as a dc voltage source with a resistor. The model indicates that an FET with the minimum physical dimensions for a given CMOS process can produce the maximum output signal. The sensor is implemented in a 180-nm standard CMOS process. The detector achieves a voltage responsivity of 3.3 kV/W and an NEP of 106 pW/Hz1/2 at 860 GHz. The sensor noise and the readout circuit noise are 10.81 and 2.03 μ Vrms, respectively. The sensor obtains clear raster-scanning transmission images under continuous THz illumination.

// Li Peng 1, 2, 3 , Xiao-Qing Yuan 4, 5 , Chao-Yang Zhang 1, 2, 3 , Fei Ye 6 , Hui-Fang Zhou 7 , Wen-Ling Li 1, 2, 3 , Zhao-Yang Liu 1, 2, 3 , Ya-Qin Zhang 1, 2, 3 , Xi Pan 1, 2, 3, 8 , Guan-Cheng Li 1, 2, 3 1 Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410078, P.R. China 2 Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, P.R. China 3 Cancer Research Institute, Central South University, Changsha 410078, P.R. China 4 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China 5 Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P.R. China 6 Department of Cardiology, the Third Xiangya Hospital, Central South University, Changsha 410100, P.R. China 7 Department of Physiology, Changsha Health Vocational College, Changsha 410100, P.R. China 8 Department of Oncology, the third Xiangya Hospital, Central South University, Changsha 410013, P.R. China Correspondence to: Guan-Cheng Li, email: ligc61@csu.edu.cn Xiao-Qing Yuan, email: yuanxq@csu.edu.cn Keywords: transforming growth factor beta 1, hepatocellular carcinoma, prognosis, overall survival, meta-analysis Received: December 28, 2016 Accepted: March 04, 2017 Published: March 13, 2017 ABSTRACT Transforming growth factor beta (TGF-β) promotes the pathogenesis of hepatocellular carcinoma (HCC). We evaluated the associations between TGF-β1 expression and clinicopathological parameters in HCC patients from The Cancer Genome Atlas (TCGA), as well as the prognostic power of TGF-β1 expression. Eligible studies were retrieved from several databases, and effects (hazard ratios (HRs) with 95% confidence intervals (CIs)) for overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS), metastasis-free survival (MFS), and progression-free survival (PFS) were pooled to assess the prognostic ability of TGF-β1 expression in HCC patients. Twelve qualified articles and our TCGA data comprising 2,021 HCC patients were incorporated. In the TCGA analysis, HCC patients with higher TGF-β1 expression presented a shorter OS than those with lower TGF-β1 expression (HR = 1.42, p < 0.05). In the meta-analysis, univariate analyses showed that HCC patients with higher TGF-β1 expression had a shorter OS (pooling HR = 1.71, p < 0.01) and DFS/RFS/MFS/PFS (pooling HR = 1.60, p < 0.01) than those with lower TGF-β1 expression. In conclusion, our results suggested that high TGF-β1 expression promotes a poor prognosis in HCC patients.

// Li Peng 1, 2 , Xiao-Qing Yuan 3, 4, * , Zhao-Yang Liu 1, 2 , Wen-Ling Li 1, 2 , Chao-Yang Zhang 1, 2 , Ya-Qin Zhang 1, 2 , Xi Pan 5 , Jun Chen 1, 2 , Yue-Hui Li 1, 2 , Guan-Cheng Li 1, 2, * 1 Key Laboratory of Carcinogenesis of the Chinese Ministry of Health and the Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, P.R. China 2 Cancer Research Institute, Central South University, Changsha 410078, P.R. China 3 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China 4 Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P.R. China 5 Department of Oncology, The third Xiangya Hospital, Central South University, Changsha 410013, P.R. China * These authors have contributed equally to this work Correspondence to: Guan-Cheng Li, email: ligc61@csu.edu.cn or libsun@163.com Keywords: H19, prognosis, female cancers, TCGA, meta-analysis Received: June 30, 2016 Accepted: November 14, 2016 Published: December 01, 2016 ABSTRACT Upregulation of lncRNA H19 expression is associated with an unfavorable prognosis in some cancers. However, the prognostic value of H19 in female-specific cancers has remained uncharacterized. In this study, the prognostic power of high H19 expression in female cancer patients from the TCGA datasets was analyzed using Kaplan-Meier survival curves and Cox’s proportional hazard modeling. In addition, in a meta-analysis of non-female cancer patients from TCGA datasets and 12 independent studies, hazard ratios (HRs) with 95% confidence interval (CI) for overall survival (OS) and disease-free survival (DFS)/relapse-free survival (RFS)/metastasis-free survival (MFS)/progression-free survival (PFS) were pooled to assess the prognostic value of high H19 expression. Kaplan-Meier analysis revealed that patients with uterine corpus cancer and higher H19 expression had a shorter OS (HR=2.710, p

In recent years, organic-inorganic hybrid metal halides have emerged as a highly promising class of semiconducting light emitting diodes (LEDs) due to their fascinating photoluminescence properties. Here, by specifically selecting different organic cations as templates, a series of new hybrid cuprous halides have been solvothermally prepared, namely [Me-Py]CuI2 (1), [(Me)2-DABCO]Cu2I4 (2), [Me-MePy]Cu2I3 (3), and [H2DABCO]Cu3X5 (X = I (4) and Br (5)). These hybrid cuprous halides feature one-dimensional (1D) [CuI2]-, [Cu2I3]- and [Cu3X5]2- (X = Br, I) chains surrounded and charge-balanced by organic cations. Under UV photoexcitation, these hybrid cuprous halides exhibit strong tunable photoluminescence from cyan (480 nm) to red (675 nm) emissions with large Stokes shifts (345 nm). The intrinsic nature of PL emissions is also investigated based on temperature-dependent PL emission, lifetime, photoluminescence quantum efficiencies, etc.

Two Zr-based metal-organic cages (Zr-MOCs) were synthesized under solvothermal conditions. Directed by the solvent system, two Zr-MOCs that built from the same trinuclear zirconocene unit and 2,6-naphthalenedicarboxylic ligand (2,6-H2NDC) exhibit different geometry configurations. Zr-MOC-1 presents a tetrahedral cage structure, while Zr-MOC-2 features a capsule-like cage skeleton. The adsorption performances of Zr-MOCs for organic dyes from aqueous solution were first reported, which indicates that two Zr-MOCs show good adsorption behaviors for anionic and cationic dyes.

FoxA transcription factors play vital roles in regulating the expression of organ-specific genes. BmSGF1, the sole FoxA family member in Bombyx mori, is required for development of the silk gland. However, the function of BmSGF1 in development of the nervous system in the silkworm remains unknown. Here, we show that the amino acids sequence of BmSGF1 is evolutionarily conserved in its middle region from Trichoplax adhaerens to human and diverged from the homologues in most other species in its N-terminal region. BmSGF1 expresses in the nervous system at the embryonic stage. Knockdown of Bmsgf1 by RNA interference (RNAi) results in abnormal development of axons. Therefore, our results demonstrate that BmSGF1 is an indispensable regulator for neurodevelopment.

Background: The objective of this study was to explore the effects of 30 kHz ultrasound on the efficacy of paclitaxel in subcutaneous breast tumors in Balb/c mice in vivo. Materials and Methods: 40 Balb/c female mice were divided into 5 groups: model control group, paclitaxel intraperitoneal (ip) group (20 mg/kg, ip, at 3 day intervals for a total of 3 doses (q3d×3)), paclitaxel intratumoral (it) group (20 mg/kg, it, q3d×3), paclitaxel intraperitoneal (20 mg/kg, ip, q3d×3) combined with low-frequency ultrasound (LFU) group, and paclitaxel intratumoral (20 mg/kg, it, q3d×3) combined with LFU group. Ultrasound parameters were 30 kHz, 200 MW intensity, 15 min, q3d×3. The antitumoral effect was determined by examining the tumor weight in subcutaneously inoculated EMT6 breast carcinoma models in Balb/c mice. All subcutaneous tumors were examined using high performance liquid chromatography (HPLC) upon completion of the experiments. Drug concentrations in the subcutaneous tumors were also analyzed using HPLC. Finally, paraffin sections of the subcutaneous tumors were made, and after hematoxylin and eosin staining, the tumor morphology was examined under a light microscope. Results: LFU combined with paclitaxel significantly restrained tumor growth in transplanted subcutaneous EMT6 tumors in Balb/c mice, and this effect correlated with increased local concentrations of paclitaxel in the tumors. Body weight measurement did not reveal significant adverse effects on the Balb/c mice during the study. Conclusion: LFU combined with paclitaxel has a significant synergistic effect in the treatment of breast cancer.

The metastasis-associated lung adenocarcinoma transcript 1(MALAT1), a member of the long non-coding RNA (lncRNA) family, has been reported to be highly enriched in many kinds of cancers and to be a metastasis marker and a prognostic factor. In this study, we found that MALAT1 expression levels were significantly increased in cervical cancer (CC) cells and tissues. The down-regulation of MALAT1 by shRNA in CC cells inhibited the invasion and metastasis in vitro and in vivo. Microarray analysis showed that the knockdown of MALAT1 up-regulated the epithelial markers E-cadherin and ZO-1, and down-regulated the mesenchymal markers β-catenin and Vimentin. This regulation was further confirmed by subsequent observation from RT-PCR, western blot, and immunofluorescence results. Meanwhile, the transcription factor snail, which functions to modulate epithelial-mesenchymal transition (EMT), was also down-regulated at both transcript and protein levels by MALAT1 down-regulation. In addition, we found that MALAT1 expression levels were positively related to HPV infection in cervical epithelial tissues by microarray analysis. Taken together, these results suggest that MALAT1 functions to promote cervical cancer invasion and metastasis via induction of EMT, and it may be a target for the prevention and therapy of cervical cancers.

Cobalt(III) corrole was firstly applied to the hydration of terminal alkynes. The alkyne hydration proceeded in good to excellent yield with 0.03 to 0.3 mol% cobalt corrole catalyst loading. A wide range of substrates were tolerated. Particularly, the reaction can give 90% yield in a gram scale experiment.

Background Spinal cord injury (SCI) is a serious central nervous system disorder caused by trauma that has gradually become a major challenge in clinical medical research. As an important branch of worldwide medical research, traditional Chinese medicine (TCM) is rapidly moving towards a path of reform and innovation. Therefore, this paper systematically reviews research related to existing TCM treatments for SCI, with the aims of identifying deficits and shortcomings within the field, and proposing feasible alternative prospects. Methods All data and conclusions in this paper were obtained from articles published by peers in relevant fields. PubMed, SciFinder, Google Scholar, Web of Science, and CNKI databases were searched for relevant articles. Results regarding TCM for SCI were identified and retrieved, then manually classified and selected for inclusion in this review. Results The literature search identified a total of 652 articles regarding TCM for SCI. Twenty-eight treatments (16 active ingredients, nine herbs, and three compound prescriptions) were selected from these articles; the treatments have been used for the prevention and treatment of SCI. In general, these treatments involved antioxidative, anti-inflammatory, neuroprotective, and/or antiapoptotic effects of TCM compounds. Conclusions This paper showed that TCM treatments can serve as promising auxiliary therapies for functional recovery of patients with SCI. These findings will contribute to the development of diversified treatments for SCI.

The absence of both the inversion symmetry and out-of-plane mirror symmetry together with spin-orbit coupling (SOC) can induce novel electronic and piezoelectric properties. In this work, the piezoelectric properties along with carrier mobilities of Janus monolayer XTeI (X=Sb and Bi) are studied by density functional theory (DFT). By using generalized gradient approximation (GGA) plus SOC, they are found to be indirect gap semiconductors with the Rashba spin splitting. The piezoelectric tensors of Janus monolayer XTeI (X=Sb and Bi) are reported by using density functional perturbation theory (DFPT). Due to lacking both the inversion symmetry and out-of-plane mirror symmetry for Janus monolayer XTeI (X=Sb and Bi), both in-plane and out-of-plane piezoelectric effects can be observed, and the large piezoelectric coefficients are predicted (e.g. $d_{11}$=12.95 pm/V for SbTeI and $d_{11}$=8.20 pm/V for BiTeI), which are comparable and even higher than ones of many other two-dimensional (2D) materials and other well-known bulk piezoelectric materials, especially for out-of-plane piezoelectric coefficients. With GGA+SOC, the high electron carrier mobilities are obtained, and the electron mobility of BiTeI along armchair direction reaches up to about 1319 $\mathrm{cm^2V^{-1}s^{-1}}$. The carrier mobility shows a rather pronounced anisotropy between electron and hole/armchair and zigzag directions. It is found that tensile strain can improve the piezoelectric coefficients $d_{11}$ of Janus monolayer XTeI (X=Sb and Bi). For example, at 4\% strain, the $d_{11}$ of SbTeI (BiTeI) is up to 20.12 pm/V (11.48 pm/V), compared with unstrained 12.95 pm/V (8.20 pm/V). Our works imply Janus monolayer XTeI (X=Sb and Bi) have potential applications in flexible electronics and piezoelectric devices, and can stimulate further experimental works., 8 pages, 5 figures

In the field of medical imaging research, renal segmentation is an important task which is tedious and error-prone when performed manually. Deep learning methods have been successfully applied to feature learning in medical applications. In this paper, We focused on the high accuracy of the classification task because of its effect on the accuracy of a better segmentation, and a Renal Segmentation Algorithm Combined Low-level Features with Deep Coding Feature from medicine images is proposed. Firstly, we use the advantage of Stacked auto-encoder networks to automatically learn the high-level features that capture the structured information and semantic context in the image. Several low-level features are extracted, which can effectively capture contrast and spatial information in the renal regions, and incorporated to compensate with the learned high-level features at the output of the very last fully connected layer. The concatenated feature vector is further fed into a Least squares SVM detector with Morlwet kernel to obtain classification results. We trained the deep network on medicine data set and experimentally shows that our proposed method has high classification accuracy and can speed up the clinical task to segment the renal.

Liver cancer is a serious threat to public health and has fairly complicated pathogenesis. Therefore, the identification of key genes and pathways is of much importance for clarifying molecular mechanism of hepatocellular carcinoma (HCC) initiation and progression. HCC-associated gene expression dataset was downloaded from Gene Expression Omnibus database. Statistical software R was used for significance analysis of differentially expressed genes (DEGs) between liver cancer samples and normal samples. Gene Ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, based on R software, were applied for the identification of pathways in which DEGs significantly enriched. Cytoscape software was for the construction of protein–protein interaction (PPI) network and module analysis to find the hub genes and key pathways. Finally, weighted correlation network analysis (WGCNA) was conducted to further screen critical gene modules with similar expression pattern and explore their biological significance. Significance analysis identified 1230 DEGs with fold change >2, including 632 significantly down-regulated DEGs and 598 significantly up-regulated DEGs. GO term enrichment analysis suggested that up-regulated DEG significantly enriched in immune response, cell adhesion, cell migration, type I interferon signaling pathway, and cell proliferation, and the down-regulated DEG mainly enriched in response to endoplasmic reticulum stress and endoplasmic reticulum unfolded protein response. KEGG pathway analysis found DEGs significantly enriched in five pathways including complement and coagulation cascades, focal adhesion, ECM–receptor interaction, antigen processing and presentation, and protein processing in endoplasmic reticulum. The top 10 hub genes in HCC were separately GMPS, ACACA, ALB, TGFB1, KRAS, ERBB2, BCL2, EGFR, STAT3, and CD8A, which resulted from PPI network. The top 3 gene interaction modules in PPI network enriched in immune response, organ development, and response to other organism, respectively. WGCNA revealed that the confirmed eight gene modules significantly enriched in monooxygenase and oxidoreductase activity, response to endoplasmic reticulum stress, type I interferon signaling pathway, processing, presentation and binding of peptide antigen, cellular response to cadmium and zinc ion, cell locomotion and differentiation, ribonucleoprotein complex and RNA processing, and immune system process, respectively. In conclusion, we identified some key genes and pathways closely related with HCC initiation and progression by a series of bioinformatics analysis on DEGs. These screened genes and pathways provided for a more detailed molecular mechanism underlying HCC occurrence and progression, holding promise for acting as biomarkers and potential therapeutic targets.

A CMOS terahertz (THz) detector implemented in a 180-nm standard CMOS process is proposed, and room-temperature detection of 0.94-THz radiation is demonstrated. The detector consists of an integrated on-chip patch antenna and a source-feeding NMOS transistor as the rectifying element. To improve the power transfer efficiency between the patch antenna and NMOS transistor, a novel short-stub matching network is proposed. An open quarter-wavelength microstrip transmission line connecting gate is proposed to eliminate the influence of the bonding wire and pad on the antenna-transistor impedance matching. Illuminated by a 0.94-THz BWO source, the measured voltage responsivity ($R_{\rm v}$) and noise equivalent power (NEP) of the detector are 31 V/W and 1.1 nW/Hz$^{1/2}$, respectively.

Zinc oxide (ZnO) films are deposited on hydrogen (H+)-implanted Si and bare Si substrates respectively by Metal-organic Chemical Vapor Deposition (MOCVD). The properties of the films are investigated with Scanning electron microscopy (SEM), X-ray diffraction (XRD), Atom Force Microscopy (AFM), Raman spectra and Photoluminescence (PL) detections, from which we find that compared with bare Si substrate, H+-implanted Si can act as a compliant substrate (CS) and effectively improve the crystal quality, decrease the inner stress arisen from the misfit between substrate and epitaxial layer, perfect the film surface smooth degree and optimize the optical quality. At the end, the CS working mechanism is discussed.

This paper aimed at that titanium alloy grinding is easy to appear surface burn, crack, then carry out the titanium alloy TC4 abrasive belt grinding experiment, focus on the effect of grinding parameters on the titanium alloy TC4 surface integrity (surface roughness, microstructure and surface residual stress) . The results of the study show that the use of zircon corundum belt and cutting speed velocity range from 18 to 26 meter per second, the surface integrity of titanium alloy TC4 is better.

Today, in order to enrich economic and scientific research value, sensor network and its data management system have been widely used in ocean observing and in real-time continuous data collecting. In this article, the risks associated with modeling, assessing, managing, and communicating of observing systems are taken into consideration, a cyberinfrastructure architecture is designed to ensure the global observation networks real-time, integrated network research and mass data analysis, with its base station communications, satellites and cables to transfer data, using distributed computing platform for real-time analysis of mass data of worldwide sensors to obtain the new progress of research topic and provide disaster warning. This is important to allow researchers study collaboratively with other researchers as if in their laboratories, also cause the public to further contact with sea world, and widen the public education road.

In recent years, a great deal of effort has been made to create terahertz (THz) devices with metamaterials (MM). Among these devices, perfect absorbers and modulators are highly desired in THz system such as communication, remote sensing, imaging, and astronomy. MM absorbers have a variety of potential applications including thermal emitters, detector, stealth technology, phase imaging. High-speed modulators, which allow actively control the spatial transmission (reflection) of an incident THz wave, is the key components of an advanced communication system. In this presentation, we firstly introduce the basic structure and work principle of MM devices, and then we report our recent progress in the design, fabrication and and measurement of the quite a few new MM devices. And as a close to this presentation, we demonstrate the application of our devices in Terahertz communication system.