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Benign prostatic hyperplasia is the most common benign disease that causes urination dysfunction in middle-aged and elderly men, and is also the main cause of lower urinary tract symptoms. Transurethral plasmakinetic resection of prostate has been widely used in clinical practice for its good efficacy and safety. In order to further standardize the clinical application of this surgery, the National Health Commission published the initial Clinical Pathway Interpretation of Transurethral Plasmakinetic Resection of Prostate for Benign Prostatic Hyperplasia in 2019. In view of the limited content of this clinical pathway, using it as a blueprint, we have interpreted it and applied the ideas and methods of evidence-based medicine, aiming to provide a more detailed evidence supplement to help medical staff and managers better understand, grasp and correctly use this clinical pathway.

Bladder cancer is the tenth most frequently diagnosed cancer in the world, and is more common among men. Transurethral resection of bladder tumor is not only an important diagnostic method for bladder tumors, but also a major treatment for non-muscle invasive bladder cancer. Com-pared with traditional unipolar electrotomy, plasma bipolar electrotomy has the advantages of good surgical results and fewer complications, and its clinical application is becoming more and more exten-sive. In order to standardize the diagnosis and treatment of common diseases, the National Health Commission continues to issue relevant clinical pathways; however, the content of a clinical pathway is limited, and its interpretation can help it be better disseminated and used. This interpretation is based on the latest "clinical pathway for transurethral plasma resection of bladder tumor (2019 edition)". It uses the method of evidence-based medicine to make a detailed and necessary supplementary descrip-tion of the pathway, and gives a detailed interpretation of the drug delivery scheme involved, so as to provide reference for medical staff and managers to better understand, grasp and correctly use it.

High-resolution planetary remote sensing imagery provides detailed information for geomorphological and topographic analyses. However, acquiring such imagery is constrained by limited deep-space communication bandwidth and challenging imaging environments. Conventional super-resolution methods typically employ separate models for different scales, treating them as independent tasks. This approach limits deployment and real-time applications in planetary remote sensing. Moreover, capturing global context is crucial in planetary remote sensing images due to their contextual similarities. To address these limitations, we propose Discrete Cosine Transform (DCT)–Global Super Resolution Neural Operator (DG-SRNO), a global context-aware arbitrary-scale super-resolution model. DG-SRNO achieves super-resolution at any scale using a single framework by learning the mapping between low-resolution (LR) and high-resolution (HR) function spaces. We mathematically prove the global receptive field of DG-SRNO. To evaluate DG-SRNO's performance in planetary remote sensing tasks, we introduce the Ceres 800 dataset, a planetary remote sensing super-resolution dataset. Extensive quantitative and qualitative experiments demonstrate DG-SRNO's impressive reconstruction capabilities. [ABSTRACT FROM AUTHOR]

Gate-level circuit partitioning is an important development trend for improving the efficiency of simulation in EDA software. In this paper, a gate-level circuit partitioning algorithm, based on clustering and an improved genetic algorithm, is proposed for the gate-level simulation task. First, a clustering algorithm based on betweenness centrality is proposed to quickly identify clusters in the original circuit and achieve the circuit coarse. Next, a constraint-based genetic algorithm is proposed which provides absolute and probabilistic genetic strategies for clustered circuits and other circuits, respectively. This new genetic strategy guarantees the integrity of clusters and is effective for realizing the fine partitioning of gate-level circuits. The experimental results using 12 ISCAS ‘89 and ISCAS ‘85 benchmark circuits show that the proposed algorithm is 5% better than Metis, 80% better than KL, and 61% better than traditional genetic algorithms for finding the minimum number of connections between subsets.

The present study was performed to investigate the effect of 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one (BHP) on the induction of apoptosis and cell cycle arrest in T24 human bladder carcinoma cells. An MTT assay was used to investigate the inhibition of cell proliferation. Flow cytometry was used to observe alterations in the cell cycle, generation of reactive oxygen species (ROS), alterations in mitochondrial membrane potential (MMP) and induction of apoptosis in the T24 cells following BHP treatment. Western blot analysis was performed for the determination of expression levels of apoptotic proteins, and 4,6-diamidino-2-phenylindole dihydrochloride staining was used to observe apoptosis and DNA damage. The results demonstrated that treatment of the bladder cancer cells with BHP enhanced the activation of caspases and increased the production of ROS. It also caused damage to DNA, reduced MMP, and increased the secretion of endonuclease G and apoptosis-inducing factor from the mitochondria. The expression levels of cyclin E and cell division cycle 25C were reduced, whereas the expression levels of p21 and phosphorylated p53 were increased in the BHP-treated cells. In addition, treatment with BHP caused cell cycle arrest at the G0/G1 phase, increased the expression levels of B cell lymphoma-2 (Bcl-2)-associated X protein and poly(ADP-ribose) polymerase, decreased the expression of Bcl-2 and ultimately induced apoptosis of the T24 cells. Thus, BHP inhibited the proliferation of bladder cancer cells by inducing cell apoptosis through the mitochondrial pathway. [ABSTRACT FROM AUTHOR]

This study investigated the removal of hexavalent chromium (Cr(VI)) in aqueous solutions using pomelo peel (PP) and FeCl3-modified pomelo peel (FPP) as novel biomass adsorbents. Batch adsorption experiments were performed to evaluate the effects of pH, time, temperature, initial concentration, and adsorbent dose on Cr(VI) removal by PP and FPP. The results show that the maximum adsorption capacity of Cr(VI) was 21.55 mg/g for FPP and 0.57 mg/g for PP at a pH of 2.0 and a temperature of 40°C. The surface shape, microstructure, and chemical composition of FPP were analyzed with scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and energy dispersive spectroscopy (EDS), and compared with those of PP. The results show that the adsorption performance of FPP was much better than that of PP, indicating that FPP can be an alternative high-efficiency adsorbent for Cr(VI) removal.