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263 results on '"Zhao Qingyan"'

2. Variation and disparity in awareness of atrial fibrillation in China: A national cross-sectional study

Author

Shi, Shaobo, Zhao, Qingyan, Wu, Gang, Yan, Hong, Yu, Bin, Zheng, Qiangsun, Li, Yigang, Zheng, Liangrong, Yuan, Yiqiang, Zhong, Jingquan, Xu, Jian, Wu, Yanqing, Xu, Jing, Chen, Lin, Li, Shufeng, Jiang, Jian, Wang, Jingfeng, Fan, Jie, Chen, Minglong, Tang, Baopeng, Li, Wei, Wu, Qiang, Shi, Bei, Zhou, Shenghua, Zhao, Xingsheng, Yin, Yuehui, Zhang, Zheng, Zhong, Guoqiang, Han, Xuebin, Liu, Fan, Wu, Ming, Gao, Lianjun, Yang, Bo, Tang, Yanhong, Huang, He, and Huang, Congxin

Published
2024
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5. Prevalence and risk of atrial fibrillation in China: A national cross-sectional epidemiological study

Author

Shi, Shaobo, Tang, Yanhong, Zhao, Qingyan, Yan, Hong, Yu, Bin, Zheng, Qiangsun, Li, Yigang, Zheng, Liangrong, Yuan, Yiqiang, Zhong, Jingquan, Xu, Jian, Wu, Yanqing, Xu, Jing, Chen, Lin, Li, Shufeng, Jiang, Jian, Wang, Jingfeng, Fan, Jie, Chen, Minglong, Tang, Baopeng, Li, Wei, Wu, Qiang, Shi, Bei, Zhou, Shenghua, Zhao, Xingsheng, Yin, Yuehui, Zhang, Zheng, Zhong, Guoqiang, Han, Xuebin, Liu, Fan, Wu, Ming, Gao, Lianjun, Yang, Bo, Huang, He, and Huang, Congxin

Published
2022
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6. Modeling and simulation of fire evacuation considering guiding factors: a case study of Shenyang subway interchange station.

Author

Liu, Jiaxi, Zhang, Rui, Yan, Weidong, Zhao, Qingyan, and Guo, Chunbing

Subjects
BUILDING information modeling, SUBWAY stations, VIRTUAL reality, SIMULATION software, CELLULAR automata, VIRTUAL reality software
Abstract

In case of fire, effective evacuation guidance can reduce evacuees' hesitation time and improve evacuation efficiency. In this paper, an improved model of fire evacuation (guided fire cellular automata, GF-CA) is provided. First, the parameters of the improved model are quantified and analyzed to determine the parameter calculation method and variation law. Second, a typical subway interchange station in Shenyang is used as an example for evacuation simulation. Then, a lightweight building information modeling (BIM) is constructed and applied to the example combining the evacuation simulation software of Pathfinder and virtual reality technology for personnel evacuation simulation. Three types of simulation scenarios are examined, including simulation without guiding factors, simulation with guiding factors based on the improved model, and simulation based on the virtual reality experiment with guiding factors. The results show that the evacuation efficiency is increased by 75.63% after effective guidelines through personnel diversion and reasonable exit allocation, noting that the path results of the model are highly similar to those of the virtual reality experiment, which has good validity and rationality. Meanwhile, we analyze the guiding scheme and propose that we should pay attention to the position of the sign and the configuration of the conductor, and flexibly use the composite scheme, which provides effective technical support for improving evacuation safety and evacuation efficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Effects of Inflammatory Cell Death Caused by Catheter Ablation on Atrial Fibrillation

Author

Liu,Dishiwen, Li,Yajia, Zhao,Qingyan, Liu,Dishiwen, Li,Yajia, and Zhao,Qingyan

Abstract

Dishiwen Liu,1– 3,* Yajia Li,1– 3,* Qingyan Zhao1– 3 1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 2Cardiovascular Research Institute, Wuhan University, Wuhan, 430060, People’s Republic of China; 3Hubei Key Laboratory of Cardiology, Wuhan, 430060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qingyan Zhao, Department of Cardiology & Cardiovascular Research Institute Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, Hubei, 430060, People’s Republic of China, Tel +86- 027 88041911, Fax +86- 027 88042292, Email ruyan71@163.comAbstract: Atrial fibrillation (AF) poses a serious healthcare burden on society due to its high morbidity and the resulting serious complications such as thrombosis and heart failure. The principle of catheter ablation is to achieve electrical isolation by linear destruction of cardiac tissue, which makes AF a curable disease. Currently, catheter ablation does not have a high long-term success rate. The current academic consensus is that inflammation and fibrosis are central mechanisms in the progression of AF. However, artificially caused inflammatory cell death by catheter ablation may have a significant impact on structural and electrical remodeling, which may affect the long-term prognosis. This review first focused on the inflammatory response induced by apoptosis, necrosis, necroptosis, pyroptosis, ferroptosis and their interaction with arrhythmia. Then, we compared the differences in cell death induced by radiofrequency ablation, cryoballoon ablation and pulsed-field ablation. Finally, we discussed the structural and electrical remodeling caused by inflammation and the association between inflammation and the recurrence of AF after catheter ablation. Collectively, pulsed-field ablation will be a revolutionary innovation with faster, safer, better tissue selectivity an

Published
2023

29. Atrial fibroblasts secrete exosomal miR-21 that up-regulates KCa3.1 channels in atrial myocytes via the PI3K-Akt pathway

Author

Fu, Yuntao, primary, Chen, Huiyu, additional, Liu, Dishiwen, additional, Cao, Zhen, additional, Wang, Youcheng, additional, Wang, Xuewen, additional, Shanqing, *, additional, Yao, Yajun, additional, Jiang, Jiawei, additional, Ke, Yuanjia, additional, Cheng, Yanni, additional, Guo, Kexin, additional, Liu, Hua Fen, additional, and Zhao, Qingyan, additional

Published
2022
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30. Dapagliflozin Protects Methamphetamine-Induced Cardiomyopathy by Alleviating Mitochondrial Damage and Reducing Cardiac Function Decline in a Mouse Model

Author

He, Shanqing, Yao, Yajun, Yang, Nan, Wang, Youcheng, Liu, Dishiwen, Cao, Zhen, Chen, Huiyu, Fu, Yuntao, Yang, Mei, Wang, Songjun, He, Guangjie, and Zhao, Qingyan

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Background: Methamphetamine (METH)-induced cardiovascular toxicity has been attributed to its destructive effect on mitochondrial function at least to some extent. Previous studies highlighted the benefits of dapagliflozin (DAPA) on the cardiovascular system, but the response of METH-induced cardiomyopathy to DAPA is never addressed before. The present study aimed to investigate the potential ability of DAPA in preventing METH-induced cardiomyopathy.Materials and Methods: C57BL/6 mice were randomly divided into control group (n = 24), METH group (n = 24), and METH + DAPA group (n = 24). The METH-induced cardiomyopathy group received intraperitoneal METH injections at gradually increasing doses thrice weekly for 14 weeks. Mice in the METH + DAPA group were simultaneously treated with DAPA 1 mg/kg/day by intragastric administration. Echocardiography was performed to assess cardiac function. Reactive oxygen species (ROS), JC-1, and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assays were performed to evaluate oxidative stress, mitochondrial damage, and apoptosis, respectively. Mitochondrial and apoptosis-related protein expression was measured by western blotting.Results: Mice exposed to METH exhibited reduced cardiac function (left ventricular ejection fraction [LVEF]: 56.51 ± 6.49 vs. 73.62 ± 1.42, p < 0.01), fibrotic remodeling, and mitochondrial dysfunction, leading to apoptosis (apoptotic cells%: 7.4 ± 1.3 vs. 1.3 ± 0.5, p < 0.01). DAPA significantly reduced mitochondrial dynamics and function, ROS, apoptosis (apoptotic cells%: 2.4 ± 0.8 vs. 7.4 ± 1.3, p < 0.01), cardiac function decline (LVEF: 70.99 ± 4.936 vs. 56.51 ± 6.49, p < 0.01), and fibrotic remodeling. These results indicated that DAPA could be considered as an effective therapeutic agent in the protection against METH-associated cardiomyopathy.Conclusion: DAPA protects against METH-induced cardiomyopathy in mice by decreasing mitochondrial damage and apoptosis.

Published
2022

36. Blocking Intermediate-Conductance Calcium-Activated Potassium Channels in the Macrophages Around Ganglionated Plexi Suppresses Atrial Fibrillation Vulnerability in Canines With Rapid Atrial Pacing

Author

Ma, Yazhe, Fu, Yuntao, Wang, Youcheng, Yang, Mei, Yao, Yajun, He, Shanqing, Liu, Dishiwen, Cao, Zhen, Wang, Xi, Tang, Yanhong, Zhao, Qingyan, and Huang, Congxin

Subjects
Physiology, Physiology (medical)
Abstract

Previous studies have indicated that ganglionated plexi (GP) function influences atrial fibrillation (AF) vulnerability, and intermediate-conductance calcium-activated potassium channels (SK4) have a close relationship with cardiomyocyte automaticity and the induction of AF. However, the effects of the SK4 inhibitor on GP function and AF vulnerability are unknown. Eighteen beagles were randomly divided into a control group (n = 6), rapid atrial pacing (RAP) group (n = 6), and triarylmethane-34 (TRAM-34, an SK4 inhibitor) group (n = 6). TRAM-34 (0.3 ml, 15 mmol/L) and saline were locally injected into GPs in the TRAM-34 group dogs and dogs from the other groups, respectively. After that, dogs in the RAP and TRAM-34 groups were subjected to RAP, and the neural activity of anterior right GP (ARGP) and atrial electrophysiology were measured. The levels of inflammatory cytokines and function of macrophages in the ARGP were measured in the three groups. At 10 min after TRAM-34 injection, ARGP activity and atrial electrophysiology did not significantly change. The atrial pacing shortened effective refractory period (ERP) values at all sites and increased the AF vulnerability and ARGP neural activity, while TRAM-34 reversed these changes. The levels of CD68 + cells, induced nitric oxide synthase (iNOS), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the ARGP tissues were higher in the RAP group and TRAM-34 group than they were in the control group. Furthermore, the levels of the CD68 + cells, iNOS, and inflammatory cytokines in the ARGP tissues were higher in the pacing group than those in the TRAM-34 group. Based on these results, administration of TRAM-34 into the atrial GP can suppress GP activity and AF vulnerability during atrial pacing. The effects of TRAM-34 might be related to macrophage polarization and the inflammatory response of GP.

Published
2022

37. Inhibition of intermittent calcium‐activated potassium channel (SK4) attenuates Ang II‐induced hypertrophy of human‐induced stem cell‐derived cardiomyocytes via targeting Ras–Raf–MEK1/2–ERK1/2 and CN–NFAT signaling pathways

Author

Zhao, Hongyi, Wang, Xi, Tang, Yanhong, Zhao, Qingyan, and Huang, Congxin

Subjects
CALCIUM-dependent potassium channels, POTASSIUM channels, ATRIAL natriuretic peptides, CARDIAC hypertrophy, BRAIN natriuretic factor, CELLULAR signal transduction, WESTERN immunoblotting
Abstract

Cardiac hypertrophy caused by angiotensin II (Ang II) is essential for the pathological process of heart failure. The intermediate calcium‐activated potassium channel (SK4) has been shown to be involved in the process of the inflammatory response, cell proliferation, and apoptosis. However, the role of SK4 in cardiac hypertrophy has not been elucidated. Cardiac hypertrophy in human‐induced pluripotent stem cells‐derived cardiomyocytes (HiPSC‐CMs) was induced by Ang II. Cells were transfected with SK4 adenovirus or treated with SK4 inhibitor (TRAM‐34). TUNEL staining was used to assess the levels of apoptosis. Real‐time polymerase chain reaction and Western blot analysis were used to measure messenger RNA (mRNA) and protein levels, respectively. The present results showed that SK4 expression was upregulated in HiPSC‐CMs stimulated by Ang II. The downregulation of SK4 by a specific inhibitor TRAM‐34 markedly ameliorated cardiac hypertrophy (reflected by the mRNA levels of atrial natriuretic peptide, brain natriuretic peptide, and β‐myosin heavy chain) and apoptosis (reflected by the level of Caspase 3, Bax, and Bcl‐2) induced by Ang II treatment. The action of SK4 in cardiac hypertrophy was mediated by Ras–Raf–mitogen‐activated protein kinases 1/2 (MEK1/2)–extracellular‐regulated protein kinases 1/2 (ERK1/2) and calcineurin (CN)–nuclear factors of activated T cells (NFAT) activation. Our studies demonstrated that inhibition of SK4 significantly alleviated cardiac hypertrophy induced by Ang II in hiPSC‐CMs by targeting Ras–Raf–MEK1/2–ERK1/2 signaling and CN–NFAT signaling pathway. Our studies suggest that SK4 may serve as a potential therapeutic target that could delay hypertrophy. [ABSTRACT FROM AUTHOR]

Published
2023
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