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32 results on '"Zhao, Zhenhong"'

4. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Published
2015
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5. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Author

Wang, Zhaoming, Seow, Wei Jie, Shiraishi, Kouya, Hsiung, Chao A., Matsuo, Keitaro, Liu, Jie, Chen, Kexin, Yamji, Taiki, Yang, Yang, Chang, I-Shou, Wu, Chen, Hong, Yun-Chul, Burdett, Laurie, Wyatt, Kathleen, Chung, Charles C., Li, Shengchao A., Yeager, Meredith, Hutchinson, Amy, Hu, Wei, Caporaso, Neil, Landi, Maria T., Chatterjee, Nilanjan, Song, Minsun, Fraumeni, Joseph F., Jr, Kohno, Takashi, Yokota, Jun, Kunitoh, Hideo, Ashikawa, Kyota, Momozawa, Yukihide, Daigo, Yataro, Mitsudomi, Tetsuya, Yatabe, Yasushi, Hida, Toyoaki, Hu, Zhibin, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Yin, Zhihua, Li, Xuelian, Ren, Yangwu, Guan, Peng, Chang, Jiang, Tan, Wen, Chen, Chien-Jen, Chang, Gee-Chen, Tsai, Ying-Huang, Su, Wu-Chou, Chen, Kuan-Yu, Huang, Ming-Shyan, Chen, Yuh-Min, Zheng, Hong, Li, Haixin, Cui, Ping, Guo, Huan, Xu, Ping, Liu, Li, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Park, Jae Yong, Kim, Yeul Hong, Sung, Jae Sook, Park, Kyong Hwa, Kim, Young Tae, Jung, Yoo Jin, Kang, Chang Hyun, Park, In Kyu, Kim, Hee Nam, Jeon, Hyo-Sung, Choi, Jin Eun, Choi, Yi Young, Kim, Jin Hee, Oh, In-Jae, Kim, Young-Chul, Sung, Sook Whan, Kim, Jun Suk, Yoon, Ho-Il, Kweon, Sun-Seog, Shin, Min-Ho, Seow, Adeline, Chen, Ying, Lim, Wei-Yen, Liu, Jianjun, Wong, Maria Pik, Lee, Victor Ho Fun, Bassig, Bryan A., Tucker, Margaret, Berndt, Sonja I., Chow, Wong-Ho, Ji, Bu-Tian, Wang, Junwen, Xu, Jun, Sihoe, Alan Dart Loon, Ho, James C.M., Chan, John K.C., Wang, Jiu-Cun, Lu, Daru, Zhao, Xueying, Zhao, Zhenhong, Wu, Junjie, Chen, Hongyan, Jin, Li, Wei, Fusheng, Wu, Guoping, An, She-Juan, Zhang, Xu-Chao, Su, Jian, Wu, Yi-Long, Gao, Yu-Tang, Xiang, Yong-Bing, He, Xingzhou, Li, Jihua, Zheng, Wei, Shu, Xiao-Ou, Cai, Qiuyin, Klein, Robert, Pao, William, Lawrence, Charles, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Chien, Li-Hsin, Chen, Ying-Hsiang, Chen, Chung-Hsing, Wang, Wen-Chang, Chen, Chih-Yi, Wang, Chih-Liang, Yu, Chong-Jen, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Li, Yao-Jen, Yang, Tsung-Ying, Lin, Chien-Chung, Yang, Pan-Chyr, Wu, Tangchun, Lin, Dongxin, Zhou, Baosen, Yu, Jinming, Shen, Hongbing, Kubo, Michiaki, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2016
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6. Modeling and Analysis of Production Logistics Spatio-Temporal Graph Network Driven by Digital Twin.

Author

ZHENG Longhui, SUN Yicheng, ZHANG Huihui, BAO Jinsong, CHEN Xiaochuan, ZHAO Zhenhong, CHEN Zhonghao, and GUAN Ruifeng

Subjects
LOGISTICS, GRAPH theory, DIGITAL twins, PRODUCTION scheduling, DIFFERENTIAL algebra
Abstract

In the process of logistics distribution of manufacturing enterprises, the automatic scheduling method based on the algorithm model has the advantages of accurate calculation and stable operation, but it excessively relies on the results of data calculation, ignores historical information and empirical data in the solving process, and has the bottleneck of low processing dimension and small processing scale. Therefore, in the digital twin (DT) system based on virtual and real fusion, a modeling and analysis method of production logistics spatio-temporal graph network model is proposed, considering the characteristics of road network topology and time-varying data. In the DT system, the temporal graph network model of the production logistics task is established and combined with the network topology, and the historical scheduling information about logistics elements is stored in the nodes. When the dynamic task arrives, a multi-stage links probability prediction method is adopted to predict the possibility of loading, driving, and other link relationships between task-related entity nodes at each stage. Several experiments are carried out, and the prediction accuracy of the digital twin-based temporal graph network ( DTGN) model trained by historical scheduling information reaches 99.2% when the appropriate batch size is selected. Through logistics simulation experiments, the feasibility and the effectiveness of production logistics spatiotemporal graph network analysis methods based on historical scheduling information are verified. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Changes of autoantibodies and intercellular adhesion molecule-1 in patients with Graves disease after clinical treatment

Author

Zhang, Jing, Zhang, Rongrong, and Zhao, Zhenhong

Subjects
Original Article
Abstract

Objective: To study the changes of autoantibodies and intercellular adhesion molecule-1 (ICAM-1) in patients with Graves disease (GD) after clinical treatment. Methods: A total of 68 patients with GD admitted to our hospital from August 2018 to August 2019 were selected as the research objects. The thyroid peroxidase antibody (TPOAb), thyroid stimulating antibody (TSAb), and antithyroglobulin antibody (TgAb), ICAM-1, insulin-like growth factor 1 (IGF-1), Interleukin-6 (IL-6), Interleukin 17 (IL-17) before and after treatment were examined. Results: The levels of TSAb, TgAb and TPOAb after treatment were remarkably lower than those before treatment (P

Published
2021

9. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, Dean H., III, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E., Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A., Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J., Chung, Charles C., Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I., Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C.H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K. C., Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F., Jr., Zheng, Wei, Lin, Dongxin, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2015
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10. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Author

Hosgood, III, H. Dean, Wang, Wen-Chang, Hong, Yun-Chul, Wang, Jiu-Cun, Chen, Kexin, Chang, I-Shou, Chen, Chien-Jen, Lu, Daru, Yin, Zhihua, Wu, Chen, Zheng, Wei, Qian, Biyun, Park, Jae Yong, Kim, Yeul Hong, Chatterjee, Nilanjan, Chen, Ying, Chang, Gee-Chen, Hsiao, Chin-Fu, Yeager, Meredith, Tsai, Ying-Huang, Wei, Hu, Kim, Young Tae, Wu, Wei, Zhao, Zhenhong, Chow, Wong-Ho, Zhu, Xiaoling, Lo, Yen-Li, Sung, Sook Whan, Chen, Kuan-Yu, Yuenger, Jeff, Kim, Joo Hyun, Huang, Liming, Chen, Ying-Hsiang, Gao, Yu-Tang, Kim, Jin Hee, Huang, Ming-Shyan, Jung, Tae Hoon, Caporaso, Neil, Zhao, Xueying, Huan, Zhang, Yu, Dianke, Kim, Chang Ho, Su, Wu-Chou, Shu, Xiao-Ou, Kim, In-San, Bassig, Bryan, Chen, Yuh-Min, Cha, Sung Ick, Tan, Wen, Chen, Hongyan, Yang, Tsung-Ying, Sung, Jae Sook, Wang, Chih-Liang, Li, Xuelian, Park, Kyong Hwa, Yu, Chong-Jen, Ryu, Jeong-Seon, Xiang, Yongbing, Hutchinson, Amy, Kim, Jun Suk, Cai, Qiuyin, Landi, Maria Teresa, Lee, Kyoung-Mu, Hung, Jen-Yu, Park, Ju-Yeon, Tucker, Margaret, Lin, Chien-Chung, Ren, Yangwu, Perng, Reury-Perng, Chen, Chih-Yi, Jin, Li, Chen, Kun-Chieh, Li, Yao-Jen, Chiu, Yu-Fang, Tsai, Fang-Yu, Yang, Pan-Chyr, Fraumeni, Jr., Joseph F., Seow, Adeline, Lin, Dongxin, Zhou, Baosen, Chanock, Stephen, Hsiung, Chao Agnes, Rothman, Nathaniel, and Lan, Qing

Published
2012
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11. Novel carbazole-based multifunctional materials with a hybridized local and charge-transfer excited state acting as deep-blue emitters and phosphorescent hosts for highly efficient organic light-emitting diodes

Author

Zhou, Haitao, primary, Yin, Mengna, additional, Zhao, Zhenhong, additional, Miao, Yanqin, additional, Jin, Xin, additional, Huang, Jinhai, additional, Gao, Zhixiang, additional, Wang, Hua, additional, Su, Jianhua, additional, and Tian, He, additional

Published
2021
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15. Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population

Author

Fan, Lixia, primary, Chen, Linqi, additional, Ni, Xiaoling, additional, Guo, Shicheng, additional, Zhou, Yinghui, additional, Wang, Chenji, additional, Zheng, Yabiao, additional, Shen, Fangyuan, additional, Kolluri, Vijay Kumar, additional, Muktiali, Merlin, additional, Zhao, Zhenhong, additional, Wu, Junjie, additional, Zhao, Dunmei, additional, He, Zhenglei, additional, Feng, Xulong, additional, Yuan, Ziyu, additional, Zhang, Juan, additional, Jin, Li, additional, Wang, Jiucun, additional, and Wang, Minghua, additional

Published
2017
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16. Changes of δ18O and δD along the Dousitu River, Inner Mongolia, China, and their evidence of river water evaporation

Author

Li Meng-yao, Qian Hui, Zhao Zhenhong, Ji Yadong, and Yang Bingchao

Subjects
Hydrology, Geophysics, Hydrogeology, Geochemistry and Petrology, δ18O, Water flow, Kinetic fractionation, Groundwater recharge, Structural basin, Surface water, Groundwater, Geology
Abstract

On the basis of the hydrogeology of the Dousitu River drainage basin, the changes of water flow rate, δ18O and δD along the Dousitu River are discussed according to measured and analytical results. Changes of flow rate along the Dousitu River agree well with groundwater level contours and the recharge and discharge of groundwater to the river. When compared with other types of water in the area, it is obvious that the 18O and D of river waters have experienced evaporation. The changes of δ18O and δD along the Dousitu River are mainly caused by combined effects of groundwater recharge and river water evaporation. The recharge of groundwater makes δ18O and δD of the river water decrease. Evaporation makes δ18O and δD of the river water increase. The evaporation fractions of the river water are calculated using the kinetic fractionation theory. Results showed as much as 10–30% of water was evaporated in different segments of Dousitu River.

Published
2007

17. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. and Gaziano, J. Michael Giffen, Carol Giles, Graham G. and Giovannucci, Edward Glimelius, Bengt Goggins, Michael and Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, III, Robert Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. and Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy and Henderson, Brian Henriksson, Roger Hjalgrim, Henrik and Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. and Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. and Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, III, H. Dean and Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy and Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. and Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu and Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin and Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee and Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk and Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis and Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles and Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles and Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin and Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. and Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung and Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic and Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe and Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca and Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra and North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth and Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William and Park, In Kyu Park, Jae Yong Park, Kyong Hwa and Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. and Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer and Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. and Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine and Schned, Alan Schumacher, Fredrick Schwartz, Kendra and Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol and Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy and Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. and Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya and Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. and Southey, Melissa C. Spinelli, John J. Staines, Anthony and Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. and Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei and Tardon, Adonina Thomas, David Thompson, Carrie A. and Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne and Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. and Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo and Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. and Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping and Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping and Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua and Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert and Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. and Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. and Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. and Kraft, Peter Rothman, Nathaniel Silverman, Debra T. and Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

18. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Sampson, Joshua N., primary, Wheeler, William A., additional, Yeager, Meredith, additional, Panagiotou, Orestis, additional, Wang, Zhaoming, additional, Berndt, Sonja I., additional, Lan, Qing, additional, Abnet, Christian C., additional, Amundadottir, Laufey T., additional, Figueroa, Jonine D., additional, Landi, Maria Teresa, additional, Mirabello, Lisa, additional, Savage, Sharon A., additional, Taylor, Philip R., additional, Vivo, Immaculata De, additional, McGlynn, Katherine A., additional, Purdue, Mark P., additional, Rajaraman, Preetha, additional, Adami, Hans-Olov, additional, Ahlbom, Anders, additional, Albanes, Demetrius, additional, Amary, Maria Fernanda, additional, An, She-Juan, additional, Andersson, Ulrika, additional, Andriole, Gerald, additional, Andrulis, Irene L., additional, Angelucci, Emanuele, additional, Ansell, Stephen M., additional, Arici, Cecilia, additional, Armstrong, Bruce K., additional, Arslan, Alan A., additional, Austin, Melissa A., additional, Baris, Dalsu, additional, Barkauskas, Donald A., additional, Bassig, Bryan A., additional, Becker, Nikolaus, additional, Benavente, Yolanda, additional, Benhamou, Simone, additional, Berg, Christine, additional, Van Den Berg, David, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Birmann, Brenda M., additional, Black, Amanda, additional, Boeing, Heiner, additional, Boffetta, Paolo, additional, Boutron-Ruault, Marie-Christine, additional, Bracci, Paige M., additional, Brinton, Louise, additional, Brooks-Wilson, Angela R., additional, Bueno-de-Mesquita, H. Bas, additional, Burdett, Laurie, additional, Buring, Julie, additional, Butler, Mary Ann, additional, Cai, Qiuyin, additional, Cancel-Tassin, Geraldine, additional, Canzian, Federico, additional, Carrato, Alfredo, additional, Carreon, Tania, additional, Carta, Angela, additional, Chan, John K. C., additional, Chang, Ellen T., additional, Chang, Gee-Chen, additional, Chang, I-Shou, additional, Chang, Jiang, additional, Chang-Claude, Jenny, additional, Chen, Chien-Jen, additional, Chen, Chih-Yi, additional, Chen, Chu, additional, Chen, Chung-Hsing, additional, Chen, Constance, additional, Chen, Hongyan, additional, Chen, Kexin, additional, Chen, Kuan-Yu, additional, Chen, Kun-Chieh, additional, Chen, Ying, additional, Chen, Ying-Hsiang, additional, Chen, Yi-Song, additional, Chen, Yuh-Min, additional, Chien, Li-Hsin, additional, Chirlaque, María-Dolores, additional, Choi, Jin Eun, additional, Choi, Yi Young, additional, Chow, Wong-Ho, additional, Chung, Charles C., additional, Clavel, Jacqueline, additional, Clavel-Chapelon, Françoise, additional, Cocco, Pierluigi, additional, Colt, Joanne S., additional, Comperat, Eva, additional, Conde, Lucia, additional, Connors, Joseph M., additional, Conti, David, additional, Cortessis, Victoria K., additional, Cotterchio, Michelle, additional, Cozen, Wendy, additional, Crouch, Simon, additional, Crous-Bou, Marta, additional, Cussenot, Olivier, additional, Davis, Faith G., additional, Ding, Ti, additional, Diver, W. Ryan, additional, Dorronsoro, Miren, additional, Dossus, Laure, additional, Duell, Eric J., additional, Ennas, Maria Grazia, additional, Erickson, Ralph L., additional, Feychting, Maria, additional, Flanagan, Adrienne M., additional, Foretova, Lenka, additional, Fraumeni, Joseph F., additional, Freedman, Neal D., additional, Beane Freeman, Laura E., additional, Fuchs, Charles, additional, Gago-Dominguez, Manuela, additional, Gallinger, Steven, additional, Gao, Yu-Tang, additional, Gapstur, Susan M., additional, Garcia-Closas, Montserrat, additional, García-Closas, Reina, additional, Gascoyne, Randy D., additional, Gastier-Foster, Julie, additional, Gaudet, Mia M., additional, Gaziano, J. Michael, additional, Giffen, Carol, additional, Giles, Graham G., additional, Giovannucci, Edward, additional, Glimelius, Bengt, additional, Goggins, Michael, additional, Gokgoz, Nalan, additional, Goldstein, Alisa M., additional, Gorlick, Richard, additional, Gross, Myron, additional, Grubb, Robert, additional, Gu, Jian, additional, Guan, Peng, additional, Gunter, Marc, additional, Guo, Huan, additional, Habermann, Thomas M., additional, Haiman, Christopher A., additional, Halai, Dina, additional, Hallmans, Goran, additional, Hassan, Manal, additional, Hattinger, Claudia, additional, He, Qincheng, additional, He, Xingzhou, additional, Helzlsouer, Kathy, additional, Henderson, Brian, additional, Henriksson, Roger, additional, Hjalgrim, Henrik, additional, Hoffman-Bolton, Judith, additional, Hohensee, Chancellor, additional, Holford, Theodore R., additional, Holly, Elizabeth A., additional, Hong, Yun-Chul, additional, Hoover, Robert N., additional, Horn-Ross, Pamela L., additional, Hosain, G. M. Monawar, additional, Hosgood, H. Dean, additional, Hsiao, Chin-Fu, additional, Hu, Nan, additional, Hu, Wei, additional, Hu, Zhibin, additional, Huang, Ming-Shyan, additional, Huerta, Jose-Maria, additional, Hung, Jen-Yu, additional, Hutchinson, Amy, additional, Inskip, Peter D., additional, Jackson, Rebecca D., additional, Jacobs, Eric J., additional, Jenab, Mazda, additional, Jeon, Hyo-Sung, additional, Ji, Bu-Tian, additional, Jin, Guangfu, additional, Jin, Li, additional, Johansen, Christoffer, additional, Johnson, Alison, additional, Jung, Yoo Jin, additional, Kaaks, Rudolph, additional, Kamineni, Aruna, additional, Kane, Eleanor, additional, Kang, Chang Hyun, additional, Karagas, Margaret R., additional, Kelly, Rachel S., additional, Khaw, Kay-Tee, additional, Kim, Christopher, additional, Kim, Hee Nam, additional, Kim, Jin Hee, additional, Kim, Jun Suk, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Kim, Young-Chul, additional, Kitahara, Cari M., additional, Klein, Alison P., additional, Klein, Robert J., additional, Kogevinas, Manolis, additional, Kohno, Takashi, additional, Kolonel, Laurence N., additional, Kooperberg, Charles, additional, Kricker, Anne, additional, Krogh, Vittorio, additional, Kunitoh, Hideo, additional, Kurtz, Robert C., additional, Kweon, Sun-Seog, additional, LaCroix, Andrea, additional, Lawrence, Charles, additional, Lecanda, Fernando, additional, Lee, Victor Ho Fun, additional, Li, Donghui, additional, Li, Haixin, additional, Li, Jihua, additional, Li, Yao-Jen, additional, Li, Yuqing, additional, Liao, Linda M., additional, Liebow, Mark, additional, Lightfoot, Tracy, additional, Lim, Wei-Yen, additional, Lin, Chien-Chung, additional, Lin, Dongxin, additional, Lindstrom, Sara, additional, Linet, Martha S., additional, Link, Brian K., additional, Liu, Chenwei, additional, Liu, Jianjun, additional, Liu, Li, additional, Ljungberg, Börje, additional, Lloreta, Josep, additional, Lollo, Simonetta Di, additional, Lu, Daru, additional, Lund, Eiluv, additional, Malats, Nuria, additional, Mannisto, Satu, additional, Marchand, Loic Le, additional, Marina, Neyssa, additional, Masala, Giovanna, additional, Mastrangelo, Giuseppe, additional, Matsuo, Keitaro, additional, Maynadie, Marc, additional, McKay, James, additional, McKean-Cowdin, Roberta, additional, Melbye, Mads, additional, Melin, Beatrice S., additional, Michaud, Dominique S., additional, Mitsudomi, Tetsuya, additional, Monnereau, Alain, additional, Montalvan, Rebecca, additional, Moore, Lee E., additional, Mortensen, Lotte Maxild, additional, Nieters, Alexandra, additional, North, Kari E., additional, Novak, Anne J., additional, Oberg, Ann L., additional, Offit, Kenneth, additional, Oh, In-Jae, additional, Olson, Sara H., additional, Palli, Domenico, additional, Pao, William, additional, Park, In Kyu, additional, Park, Jae Yong, additional, Park, Kyong Hwa, additional, Patiño-Garcia, Ana, additional, Pavanello, Sofia, additional, Peeters, Petra H. M., additional, Perng, Reury-Perng, additional, Peters, Ulrike, additional, Petersen, Gloria M., additional, Picci, Piero, additional, Pike, Malcolm C., additional, Porru, Stefano, additional, Prescott, Jennifer, additional, Prokunina-Olsson, Ludmila, additional, Qian, Biyun, additional, Qiao, You-Lin, additional, Rais, Marco, additional, Riboli, Elio, additional, Riby, Jacques, additional, Risch, Harvey A., additional, Rizzato, Cosmeri, additional, Rodabough, Rebecca, additional, Roman, Eve, additional, Roupret, Morgan, additional, Ruder, Avima M., additional, Sanjose, Silvia de, additional, Scelo, Ghislaine, additional, Schned, Alan, additional, Schumacher, Fredrick, additional, Schwartz, Kendra, additional, Schwenn, Molly, additional, Scotlandi, Katia, additional, Seow, Adeline, additional, Serra, Consol, additional, Serra, Massimo, additional, Sesso, Howard D., additional, Setiawan, Veronica Wendy, additional, Severi, Gianluca, additional, Severson, Richard K., additional, Shanafelt, Tait D., additional, Shen, Hongbing, additional, Shen, Wei, additional, Shin, Min-Ho, additional, Shiraishi, Kouya, additional, Shu, Xiao-Ou, additional, Siddiq, Afshan, additional, Sierrasesúmaga, Luis, additional, Sihoe, Alan Dart Loon, additional, Skibola, Christine F., additional, Smith, Alex, additional, Smith, Martyn T., additional, Southey, Melissa C., additional, Spinelli, John J., additional, Staines, Anthony, additional, Stampfer, Meir, additional, Stern, Marianna C., additional, Stevens, Victoria L., additional, Stolzenberg-Solomon, Rachael S., additional, Su, Jian, additional, Su, Wu-Chou, additional, Sund, Malin, additional, Sung, Jae Sook, additional, Sung, Sook Whan, additional, Tan, Wen, additional, Tang, Wei, additional, Tardón, Adonina, additional, Thomas, David, additional, Thompson, Carrie A., additional, Tinker, Lesley F., additional, Tirabosco, Roberto, additional, Tjønneland, Anne, additional, Travis, Ruth C., additional, Trichopoulos, Dimitrios, additional, Tsai, Fang-Yu, additional, Tsai, Ying-Huang, additional, Tucker, Margaret, additional, Turner, Jenny, additional, Vajdic, Claire M., additional, Vermeulen, Roel C. H., additional, Villano, Danylo J., additional, Vineis, Paolo, additional, Virtamo, Jarmo, additional, Visvanathan, Kala, additional, Wactawski-Wende, Jean, additional, Wang, Chaoyu, additional, Wang, Chih-Liang, additional, Wang, Jiu-Cun, additional, Wang, Junwen, additional, Wei, Fusheng, additional, Weiderpass, Elisabete, additional, Weiner, George J., additional, Weinstein, Stephanie, additional, Wentzensen, Nicolas, additional, White, Emily, additional, Witzig, Thomas E., additional, Wolpin, Brian M., additional, Wong, Maria Pik, additional, Wu, Chen, additional, Wu, Guoping, additional, Wu, Junjie, additional, Wu, Tangchun, additional, Wu, Wei, additional, Wu, Xifeng, additional, Wu, Yi-Long, additional, Wunder, Jay S., additional, Xiang, Yong-Bing, additional, Xu, Jun, additional, Xu, Ping, additional, Yang, Pan-Chyr, additional, Yang, Tsung-Ying, additional, Ye, Yuanqing, additional, Yin, Zhihua, additional, Yokota, Jun, additional, Yoon, Ho-Il, additional, Yu, Chong-Jen, additional, Yu, Herbert, additional, Yu, Kai, additional, Yuan, Jian-Min, additional, Zelenetz, Andrew, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xu-Chao, additional, Zhang, Yawei, additional, Zhao, Xueying, additional, Zhao, Zhenhong, additional, Zheng, Hong, additional, Zheng, Tongzhang, additional, Zheng, Wei, additional, Zhou, Baosen, additional, Zhu, Meng, additional, Zucca, Mariagrazia, additional, Boca, Simina M., additional, Cerhan, James R., additional, Ferri, Giovanni M., additional, Hartge, Patricia, additional, Hsiung, Chao Agnes, additional, Magnani, Corrado, additional, Miligi, Lucia, additional, Morton, Lindsay M., additional, Smedby, Karin E., additional, Teras, Lauren R., additional, Vijai, Joseph, additional, Wang, Sophia S., additional, Brennan, Paul, additional, Caporaso, Neil E., additional, Hunter, David J., additional, Kraft, Peter, additional, Rothman, Nathaniel, additional, Silverman, Debra T., additional, Slager, Susan L., additional, Chanock, Stephen J., additional, and Chatterjee, Nilanjan, additional

Published
2015
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21. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., primary, Hsiung, Chao Agnes, additional, Shu, Xiao-Ou, additional, Seow, Wei Jie, additional, Wang, Zhaoming, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wu, Chen, additional, Hosgood, H. Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Wen, Wanqing, additional, Cawthon, Richard, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Caporaso, Neil E., additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A., additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert J., additional, Chung, Charles C., additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I., additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel C.H, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K. C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wong, Maria Pik, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F., additional, Zheng, Wei, additional, Lin, Dongxin, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2014
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23. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Author

Lan, Qing, primary, Hsiung, Chao A, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wang, Zhaoming, additional, Hosgood, H Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Wong, Maria Pik, additional, Zheng, Wei, additional, Caporaso, Neil, additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Yuenger, Jeffrey, additional, Jacobs, Kevin B, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A, additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, Wu, Chen, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert, additional, Chung, Charles C, additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I, additional, He, Xingzhou, additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Shu, Xiao-Ou, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K C, additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F, additional, Lin, Dongxin, additional, Chanock, Stephen J, additional, and Rothman, Nathaniel, additional

Published
2012
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29. Significant association of 5p15.33 ( TERT-CLPTM1L genes) with lung cancer in Chinese Han population.

Author

Zhao, Zhenhong, Li, Cong, Yang, Lixin, Zhang, Xiaobo, Zhao, Xueying, Song, Xiao, Li, Xiaoying, Wang, Jiucun, Qian, Ji, Yang, Yajun, Jin, Li, Chen, Hongyan, and Lu, Daru

Abstract

Lung cancer is a leading cause of cancer-related deaths throughout the world. Recent genome-wide association studies and consecutive validation supported that the 5p15.33 region containing telomerase reverse transcriptase gene ( TERT) and cleft lip and palate transmembrane protein 1-like ( CLPTM1L) gene showed significant association with lung cancer in multiple populations. Here we studied a large Chinese Han cohort consisting of 1759 cases and 1804 controls. In the 1st stage (784 cases versus 782 controls) we genotyped 13 tag SNPs within 5p15.33 region to further investigate the association. After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer ( P = 4 × 10−3 in the 1st stage association, P = 4 × 10−4 in the 2nd stage validation, and P = 1 × 10−5, odds ratio = 1.24 in the combined population). The results provided the evidence of a cross-race susceptibility of the lung cancer locus. [ABSTRACT FROM AUTHOR]

Published
2013
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30. Distribution of δ34S and δ18O in SO2−4 in Groundwater from the Ordos Cretaceous Groundwater Basin and Geological Implications.

Author

YANG, Yuncheng, SHEN, Zhaoli, WEN, Dongguang, HOU, Guangcai, SHE, Hongquan, ZHAO, Zhenhong, WANG, Dong, and LI, Jingwen

Subjects
GROUNDWATER, CRETACEOUS Period, GYPSUM, SULFATES, PRECIPITATION variability
Abstract

The Ordos Cretaceous Groundwater Basin, located in an arid-semiarid area in northwestern China, is a large-style groundwater basin. SO2−4 is one of the major harmful components in groundwater. Dissolved SO2−4 concentrations, and δ34S-SO2−4 and δ18O-SO2−4 in groundwater from 14 boreholes and in gypsum from aquifer were analyzed. Results show that SO2−4 in shallow groundwaters originates from precipitation, sulfide oxidation, and dissolution of stratum sulphate, with a big range of δ34S values, from −10.7‰ to 9.2‰, and addition of SO2−4 in deep groundwater results from dissolution of stratum sulphate, with bigger δ34S values, from 7.8‰ to 18.5‰, compared with those in shallow groundwater. This research also indicates that three types of sulphate are present in the strata, and characterized by high δ34S values and high δ18O values-style, high δ34S values and middle δ18O values-style, middle δ34S values and low δ18O values-style, respectively. The δ34S-SO2−4 and δ18O-SO2−4 in groundwater have a good perspective for application in distinguishing different groundwater systems and determining groundwater circulation and evolution in this area. [ABSTRACT FROM AUTHOR]

Published
2010
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31. Changes of δ18O and δD along the Dousitu River, Inner Mongolia, China, and their evidence of river water evaporation.

Author

Qian Hui, Li Mengyao, Ji Yadong, Yang Bingchao, and Zhao Zhenhong

Abstract

Abstract  On the basis of the hydrogeology of the Dousitu River drainage basin, the changes of water flow rate, δ18O and δD along the Dousitu River are discussed according to measured and analytical results. Changes of flow rate along the Dousitu River agree well with groundwater level contours and the recharge and discharge of groundwater to the river. When compared with other types of water in the area, it is obvious that the 18O and D of river waters have experienced evaporation. The changes of δ18O and δD along the Dousitu River are mainly caused by combined effects of groundwater recharge and river water evaporation. The recharge of groundwater makes δ18O and δD of the river water decrease. Evaporation makes δ18O and δD of the river water increase. The evaporation fractions of the river water are calculated using the kinetic fractionation theory. Results showed as much as 10–30% of water was evaporated in different segments of Dousitu River. [ABSTRACT FROM AUTHOR]

Published
2007
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32. Changes of autoantibodies and intercellular adhesion molecule-1 in patients with Graves disease after clinical treatment.

Author

Zhang J, Zhang R, and Zhao Z

Abstract

Objective: To study the changes of autoantibodies and intercellular adhesion molecule-1 (ICAM-1) in patients with Graves disease (GD) after clinical treatment., Methods: A total of 68 patients with GD admitted to our hospital from August 2018 to August 2019 were selected as the research objects. The thyroid peroxidase antibody (TPOAb), thyroid stimulating antibody (TSAb), and antithyroglobulin antibody (TgAb), ICAM-1, insulin-like growth factor 1 (IGF-1), Interleukin-6 (IL-6), Interleukin 17 (IL-17) before and after treatment were examined., Results: The levels of TSAb, TgAb and TPOAb after treatment were remarkably lower than those before treatment (P<0.001); the levels of ICAM-1, IGF-1, IL-17 and IL-6 after treatment were noticeably lower than those before treatment (P<0.001); the FT3 and FT4 levels of patients after treatment were significantly lower than those before treatment (P<0.001), and the FSH level was significantly higher than that before treatment (P<0.001)., Conclusion: Clinical treatment can remarkably reduce the levels of autoantibodies, ICAM-1 and IGF-1 in GD patients, improve thyroid function, and relieve inflammation. The detection of the above indicators can provide guidance for the progression and treatment of GD., Competing Interests: None., (AJTR Copyright © 2021.)

Published
2021

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