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2,922 results on '"Zhao, Yuliang"'

12. Data-Folding and Hyperspace Coding for Multi-Dimensonal Time-Series Data Imaging

Author

Lian, Chao, Zhao, Yuliang, Zhan, Zhikun, and Li, Wen J.

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

Multi-Dimensional time series classification and prediction has been widely used in many fields, such as disease prevention, fault diagnosis and action recognition. However, the traditional method needs manual intervention and inference, and cannot realize the figurative expression of multi-Dimensional data, which lead to inadequate information mining. Inspired by the strong power of deep learning technology in image processing, we propose a unified time-series image fusion framework to transform multi-modal data into 2D-image, and then realize automatic feature extraction and classification based on a lightweight convolutional neural network. We present two basic image coding methods, Gray image coding, RGB image coding, and their step coding methods. Considering the universality of different application fields, we extended the coding method and propose two types transform coding, Transform-RGB coding and RGB-Transform coding, to improve the multi-domain representation ability. By applying to three typical scenes of Parkinson's disease diagnosis, bearing fault detection and gymnastics action recognition, we obtained the highest classification accuracy of 100%, 92.86% and 99.70% respectively, which were all higher than the classical processing methods. It proves the strong classification ability and universality of our coding framework to different multi-dimensional scenes. We expect that this method can be used and perform well in other scenarios, and be potential to facilitate the progress of related technology.

Published
2022

35. Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities

Author

Wang Jing, Zhao Yuliang, and Nie Guangjun

Subjects
intelligent nanomedicine, anti-cancer nanomaterials, tumor microenvironment, tumor vaccines, immunotherapy, personalized medication, Medicine
Abstract

Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy development. Empowered by the recent progresses of nanobiotechnology, a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated nature of cancer. With rationally designed multifunctionality and programmable assembly of functional subunits, the in vivo behaviors of intelligent nanosystems have become increasingly tunable, making them more efficient in performing sophisticated actions in physiological and pathological microenvironments. In recent years, intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery, biological barrier circumvention, multi-responsive tumor sensing and drug release, as well as convergence with precise medication approaches such as personalized tumor vaccines. On the other hand, the increasing system complexity of anti-cancer nanomedicines also pose significant challenges in characterization, monitoring and clinical use, requesting a more comprehensive and dynamic understanding of nano-bio interactions. This review aims to briefly summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery, tumor immunotherapy and temporospatially specific tumor imaging, as well as important advances of our knowledge on their interaction with biological systems. In the perspective of clinical translation, we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nanomaterials, highlighting the critical importance clinically-oriented system design.

Published
2023
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40. Immunogenicity and safety of a SARS-CoV-2 mRNA vaccine (SYS6006) in healthy Chinese participants: A randomized, observer-blinded, placebo-controlled phase 2 clinical trial

Author

Jin, Fei, Qiu, Yuanzheng, Wu, Zhiwei, Wang, Yuan-Hui, Cai, Chengye, Fu, Liangcai, Jiao, Wenbin, Wang, Huixian, Gao, Ming, Su, Chang, Ma, Jun-Heng, Xu, Yan, Huang, Chao-Chao, Zhang, Qing, Ni, Shaonan, Zhao, Maosheng, Guo, Lixian, Ji, Li, Yang, Hanyu, Zhao, Yuliang, Li, Chunlei, Lu, Xiang, Su, Yu-Wen, and Li, Qi

Published
2024
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45. Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade

Author

Bondarenko, Olesja, Mortimer, Monika, Kahru, Anne, Feliu, Neus, Javed, Ibrahim, Kakinen, Aleksandr, Lin, Sijie, Xia, Tian, Song, Yang, Davis, Thomas P, Lynch, Iseult, Parak, Wolfgang J, Leong, David Tai, Ke, Pu Chun, Chen, Chunying, and Zhao, Yuliang

Subjects
Nanotechnology, Bioengineering, Nanotoxicology, Nanomedicine, Microbiome, Coronavirus, Protein corona, NanoEL, coronavirus, microbiome, nanomedicine, nanotoxicology, protein corona, Biomedical Engineering, Nanoscience & Nanotechnology
Abstract

Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials - the main subjects of nanotoxicology - have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.

Published
2021

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