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437 results on '"Zhao, Yongzhi"'

26. Synergistic Coupling of Sulfide Electrolyte and Integrated 3D FeS2 Electrode Toward Long‐Cycling All‐Solid‐State Lithium Batteries.

Author

Liu, Wenyi, Zhao, Yongzhi, Yi, Chengjun, Hu, Weifei, Xia, Jiale, Li, Yuanyuan, and Liu, Jinping

Subjects
LITHIUM cells, CHEMICAL kinetics, ELECTRON transport, NANOSTRUCTURED materials, ELECTRODES
Abstract

FeS2 cathode is promising for all‐solid‐state lithium batteries due to its ultra‐high capacity, low cost, and environmental friendliness. However, the poor performances, induced by limited electrode‐electrolyte interface, severe volume expansion, and polysulfide shuttle, hinder the application of FeS2 in all‐solid‐state lithium batteries. Herein, an integrated 3D FeS2 electrode with full infiltration of Li6PS5Cl sulfide electrolytes is designed to address these challenges. Such a 3D integrated design not only achieves intimate and maximized interfacial contact between electrode and sulfide electrolytes, but also effectively buffers the inner volume change of FeS2 and completely eliminates the polysulfide shuttle through direct solid–solid conversion of Li2S/S. Besides, the vertical 3D arrays guarantee direct electron transport channels and horizontally shortened ion diffusion paths, endowing the integrated electrode with a remarkably reduced interfacial impedance and enhanced reaction kinetics. Benefiting from these synergies, the integrated all‐solid‐state lithium battery exhibits the largest reversible capacity (667 mAh g−1), best rate performance, and highest capacity retention of 82% over 500 cycles at 0.1 C compared to both a liquid battery and non‐integrated all‐solid‐state lithium battery. The cycling performance is among the best reported for FeS2‐based all‐solid‐state lithium batteries. This work presents an innovative synergistic strategy for designing long‐cycling high‐energy all‐solid‐state lithium batteries, which can be readily applied to other battery systems, such as lithium‐sulfur batteries. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Oncogenic Roles of Laminin Subunit Gamma‐2 in Intrahepatic Cholangiocarcinoma via Promoting EGFR Translation.

Author

Zhang, Jianjuan, Ji, Fubo, Tan, Yaqi, Zhao, Lei, Zhao, Yongzhi, Liu, Jiaxin, Shao, Liyuan, Shi, Jiong, Ye, Meihua, He, Xianglei, Jin, Jianping, Zhao, Bin, Huang, Jun, Roessler, Stephanie, Zheng, Xin, and Ji, Junfang

Subjects
INTRAHEPATIC bile ducts, EPIDERMAL growth factor receptors, CHOLANGIOCARCINOMA, PROTEIN-tyrosine kinase inhibitors, LIVER cancer, BILE ducts
Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma‐2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82% of iCCA patients) across four independent cohorts, LAMC2 is significantly more abundant in iCCA tumor tissue compared to normal bile duct and non‐tumor liver. Among 26.3% of iCCA patients, LAMC2 gene is amplified, contributing to its over‐expression. Functionally, silencing LAMC2 significantly blocks tumor formation in orthotopic iCCA mouse models. Mechanistically, it promotes EGFR protein translation via interacting with nascent unglycosylated EGFR in the endoplasmic reticulum (ER), resulting in activated EGFR signaling. LAMC2‐mediated EGFR translation also depends on its interaction with the ER chaperone BiP via their C‐terminus. Together LAMC2 and BiP generate a binding "pocket" of nascent EGFR and facilitate EGFR translation. Consistently, LAMC2‐high iCCA patients have poor prognosis in two iCCA cohorts. LAMC2‐high iCCA cells are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs) treatment both in vitro and in vivo. Together, these data demonstrate LAMC2 as an oncogenic player in iCCA by promoting EGFR translation and an indicator to identify iCCA patients who may benefit from available EGFR‐targeted TKIs therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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