Search

Your search keyword '"Zhao, Yinhuan"' showing total 18 results
Start Over Author "Zhao, Yinhuan"
18 results on '"Zhao, Yinhuan"'

1. miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades

Author

Chen, Yahui, Gong, Yiyi, Shi, Mengkun, Zhu, Haoxing, Tang, Yulong, Huang, Delin, Wang, Wei, Shi, Chenyi, Xia, Xueyi, Zhang, Ying, Liu, Jianlan, Huang, Jia, Liu, Mengguo, Chen, Huyan, Ma, Yanyun, Wang, Ziyu, Wang, Lei, Tu, Wenzhen, Zhao, Yinhuan, Lin, Jinran, Jin, Li, Distler, Jörg HW, Wu, Wenyu, Wang, Jiucun, and Shi, Xiangguang

Published
2024
Full Text
View/download PDF

3. Exome-Wide Association Analysis Suggests LRP2BP as a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population

Author

Pu, Weilin, Wu, Wenyu, Liu, Qingmei, Ma, Yanyun, Tu, Wenzhen, Zuo, Xianbo, Guo, Gang, Jiang, Shuai, Zhao, Yinhuan, Zuo, Xiaoxia, Wang, Qingwen, Yang, Li, Xiao, Rong, Chu, Haiyan, Wang, Lei, Sun, Liangdan, Cui, Jimin, Yu, Ling, Li, Huiyun, Li, Yisha, Shi, Yaqian, Zhang, Jiaqian, Zhang, Haishun, Liang, Minrui, Chen, Dongdong, Ding, Yue, Chen, Xiangxiang, Chen, Yuanyuan, Zhang, Rui, Zhao, Han, Li, Yuan, Qi, Qing, Bai, Peng, Zhao, Liang, Reveille, John D., Mayes, Maureen D., Jin, Li, Lee, Eun Bong, Zhang, Xuejun, Xu, Jinhua, Zhang, Zheng, Zhou, Xiaodong, Zou, Hejian, and Wang, Jiucun

Published
2021
Full Text
View/download PDF

4. TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.

Author

Kong, Xiangzhen, Jiang, Shuai, He, Qiuyu, Shi, Xiangguang, Pu, Weilin, Huang, Yan, Ma, Yanyun, Liu, Qingmei, Sun, Dayan, Huang, Delin, Wu, Fei, Li, Pengcheng, Tu, Wenzhen, Zhao, Yinhuan, Wang, Lei, Chen, Yuanyuan, Wu, Wenyu, Tang, Yulong, Zhao, Xiansheng, and Zhu, Qing

Subjects
RESEARCH funding, PLASMIDS, TOLL-like receptors, IN vivo studies, CELLULAR signal transduction, SKIN, FIBROSIS, FIBROBLASTS, GENE expression, MICE, SYSTEMIC scleroderma, ANIMAL experimentation, RECOMBINANT proteins, INFLAMMATION, INTERLEUKINS
Abstract

Objectives Innate immunity significantly contributes to SSc pathogenesis. TLR8 is an important innate immune mediator that is implicated in autoimmunity and fibrosis. However, the expression, mechanism of action, and pathogenic role of TLR8 in SSc remain unclear. The aim of this study was to explore the roles and underlying mechanisms of TLR8 in SSc. Methods The expression of TLR8 was analysed, based on a public dataset, and then verified in skin tissues and skin fibroblasts of SSc patients. The role of TLR8 in inflammation and fibrosis was investigated using a TLR8-overexpression vector, activator (VTX-2337), inhibitor (cu-cpt-8m), and TLR8 siRNA in skin fibroblasts. The pathogenic role of TLR8 in skin inflammation and fibrosis was further validated in a bleomycin (BLM)-induced mouse skin inflammation and fibrosis model. Results TLR8 levels were significantly elevated in SSc skin tissues and myofibroblasts, along with significant activation of the TLR8 pathway. In vitro studies showed that overexpression or activation of TLR8 by a recombinant plasmid or VTX-2337 upregulated IL-6, IL-1β, COL I, COL III and α-SMA in skin fibroblasts. Consistently, both TLR8-siRNA and cu-cpt-8m reversed the phenotypes observed in TLR8-activating fibroblasts. Mechanistically, TLR8 induces skin fibrosis and inflammation in a manner dependent on the MAPK, NF-κB and SMAD2/3 pathways. Subcutaneous injection of cu-cpt-8m significantly alleviated BLM-induced skin inflammation and fibrosis in vivo. Conclusion TLR8 might be a promising therapeutic target for improving the treatment strategy for skin inflammation and fibrosis in SSc. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis

Author

Kong, Xiangzhen, primary, Jiang, Shuai, additional, He, Qiuyu, additional, Shi, Xiangguang, additional, Pu, Weilin, additional, Huang, Yan, additional, Ma, Yanyun, additional, Liu, Qingmei, additional, Sun, Dayan, additional, Huang, Delin, additional, Wu, Fei, additional, Li, Pengcheng, additional, Tu, Wenzhen, additional, Zhao, Yinhuan, additional, Wang, Lei, additional, Chen, Yuanyuan, additional, Wu, Wenyu, additional, Tang, Yulong, additional, Zhao, Xiansheng, additional, Zhu, Qing, additional, Gao, Jian, additional, Xu, Weihong, additional, Shui, Xiaochuan, additional, Qian, Feng, additional, and Wang, Jiucun, additional

Published
2023
Full Text
View/download PDF

9. Genetic Associations of Non–Major Histocompatibility Complex Susceptibility Loci with Systemic Sclerosis in a Han Chinese Population

Author

Pu, Weilin, primary, Zhang, Rui, additional, Ma, Yanyun, additional, Liu, Qingmei, additional, Jiang, Shuai, additional, Liu, Jing, additional, Zhao, Yinhuan, additional, Tu, Wenzhen, additional, Guo, Gang, additional, Zuo, Xiaoxia, additional, Wang, Qingwen, additional, Chen, Yuanyuan, additional, Wu, Wenyu, additional, Zhou, Xiaodong, additional, Distler, Jörg H.W., additional, Reveille, John D., additional, Zou, Hejian, additional, Jin, Li, additional, Mayes, Maureen D., additional, and Wang, Jiucun, additional

Published
2022
Full Text
View/download PDF

10. LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis

Author

Shi, Xiangguang, primary, Chen, Yahui, additional, Liu, Qingmei, additional, Mei, Xueqian, additional, Liu, Jing, additional, Tang, Yulong, additional, Luo, Ruoyu, additional, Sun, Dayan, additional, Ma, Yanyun, additional, Wu, Wenyu, additional, Tu, Wenzhen, additional, Zhao, Yinhuan, additional, Xu, Weihong, additional, Ke, Yuehai, additional, Jiang, Shuai, additional, Huang, Yan, additional, Zhang, Rui, additional, Wang, Lei, additional, Chen, Yuanyuan, additional, Xia, Jingjing, additional, Pu, Weilin, additional, Zhu, Honglin, additional, Zuo, Xiaoxia, additional, Li, Yisha, additional, Xu, Jinhua, additional, Gao, Fei, additional, Wei, Dong, additional, Chen, Jingyu, additional, Yin, Wenguang, additional, Wang, Qingwen, additional, Dai, Huaping, additional, Yang, Libing, additional, Guo, Gang, additional, Cui, Jimin, additional, Song, Nana, additional, Zou, Hejian, additional, Zhao, Shimin, additional, Distler, Jörg H.W., additional, Jin, Li, additional, and Wang, Jiucun, additional

Published
2022
Full Text
View/download PDF

12. The relationship between cerebrospinal fluid metastasis and gene mutations in non-small-cell lung cancer patients

Author

Ji, Xiaokun, Du, Yun, Liu, Ying, Zhao, Yinhuan, Wang, Rui, Ma, Yang, Wu, Juan, Guo, Xiao, and Zhang, Yan

Subjects
Original Article
Abstract

Objective: The aim of this study was to use cerebrospinal fluid (CSF) cytology to give undiagnosed patients admitted to the hospital with severe neurological symptoms and without any anti-tumor treatment history a definitive diagnosis. Further, the aim was to explore the relationship between the frequency of gene mutations and mortality on the incidence of CSF metastasis in advanced non-small-cell lung cancer (NSCLC). Materials and methods: 30 patients diagnosed with NSCLC through CSF cytology were retrospectively analyzed. We analyzed 30 CSF metastasis patients and a control group of 20 advanced NSCLC patients without CSF metastasis. Results: 30 patients were diagnosed with CSF metastasis using CSF cytology and immunocytopathology. The frequencies of EGFR mutations and ALK fusion in the CSF metastasis group were higher than they were in the non-CSF metastasis group (80% and 50% respectively, P

Published
2020

16. Multicenter, randomized, double-blind, controlled trial of treatment of active rheumatoid arthritis with T-614 compared with methotrexate

Author

Lu, Liangjing, Bao, Chunde, Dai, Min, Teng, Jialin, Fan, Wei, Du, Fang, Yang, Nanping, Zhao, Yinhuan, Chen, Zhiwei, Xu, Jianhua, He, Peigen, Wu, Huaxiang, Tao, Yi, Zhang, Miaojia, Han, Xinghai, Li, Xingfu, Gu, Jieruo, Li, Jianhua, and Yu, Hao

Abstract

ObjectiveTo assess the efficacy and safety of T614 versus methotrexate MTX in patients with active rheumatoid arthritis RA.MethodsIn this multicenter, doubleblind trial, 489 patients randomly received either T614 25 mgday for the first 4 weeks and 50 mgday for the subsequent 20 weeks group 1, n 163, T614 50 mgday for 24 weeks group 2, n 163, or MTX 10 mgweek for the first 4 weeks and 15 mgweek for the subsequent 20 weeks n 163. Clinical and laboratory parameters were analyzed at baseline and at 4, 10, 17, and 24 weeks.ResultsAfter 24 weeks of treatment, the American College of Rheumatology 20 improvement criteria response rate for patients in T614 group 2 63.8 was not statistically significantly different from that for patients receiving MTX treatment 62.0, and was superior to that for patients in T614 group 1 50.9. The result of the noninferiority analysis indicated that the efficacy of T614 50 mgday was not lower than that of MTX by <10. Rheumatoid factor and IgA, IgG, and IgM demonstrated a statistically significant decrease in all groups. Frequently reported adverse events included hematologic disorder, skin reactions, gastrointestinal symptoms, and transient liver enzyme elevations in the T614 therapy groups. Side effects in the T614 groups were generally fewer and milder than in the MTX group, except for skin reactions. There were no prominent cardiovascular adverse events and gastrointestinal ulcers found in the T614 groups.ConclusionResults indicate that T614 therapy 50 mgday is effective and well tolerated, and represents a new option for the treatment of patients with active RA.

Published
2009
Full Text
View/download PDF

17. Exome-Wide Association Analysis Suggests LRP2BPas a Susceptibility Gene for Endothelial Injury in Systemic Sclerosis in the Han Chinese Population

Author

Pu, Weilin, Wu, Wenyu, Liu, Qingmei, Ma, Yanyun, Tu, Wenzhen, Zuo, Xianbo, Guo, Gang, Jiang, Shuai, Zhao, Yinhuan, Zuo, Xiaoxia, Wang, Qingwen, Yang, Li, Xiao, Rong, Chu, Haiyan, Wang, Lei, Sun, Liangdan, Cui, Jimin, Yu, Ling, Li, Huiyun, Li, Yisha, Shi, Yaqian, Zhang, Jiaqian, Zhang, Haishun, Liang, Minrui, Chen, Dongdong, Ding, Yue, Chen, Xiangxiang, Chen, Yuanyuan, Zhang, Rui, Zhao, Han, Li, Yuan, Qi, Qing, Bai, Peng, Zhao, Liang, Reveille, John D., Mayes, Maureen D., Jin, Li, Lee, Eun Bong, Zhang, Xuejun, Xu, Jinhua, Zhang, Zheng, Zhou, Xiaodong, Zou, Hejian, and Wang, Jiucun

Abstract

Genetic factors play a key role in the pathogenesis of autoimmune diseases, whereas the disease-causing variants remain largely unknown. Herein, we performed an exome-wide association study of systemic sclerosis in a Han Chinese population. In the discovery stage, 527 patients with systemic sclerosis and 5,024 controls were recruited and genotyped. In the validation study, an independent sample set of 479 patients and 1,096 controls were examined. In total, we found that four independent signals reached genome-wide significance. Among them, rs7574865 (Pcombined = 3.87 × 10−12) located within signal transducer and activator of transcription 4gene was identified previously using samples of European ancestry. Additionally, another signal including three SNPs in linkage disequilibrium might be unreported susceptibility loci located in the epidermis differentiation complex region. Furthermore, two SNPs located within exon 3 of IGHM(rs45471499, Pcombined = 1.15 × 10−9) and upstream of LRP2BP(rs4317244, Pcombined = 4.17 × 10−8) were found. Moreover, rs4317244 was identified as an expression quantitative trait locus for LRP2BPthat regulates tight junctions, cell cycle, and apoptosis in endothelial cell lines. Collectively, our results revealed three signals associated with systemic sclerosis in Han Chinese and suggested the importance of LRP2BP in systemic sclerosis pathogenesis. Given the limited sample size and discrepancies between previous results and our study, further studies in multiethnic populations are required for verification.

Published
2021
Full Text
View/download PDF

18. The relationship between cerebrospinal fluid metastasis and gene mutations in non-small-cell lung cancer patients.

Author

Ji X, Du Y, Liu Y, Zhao Y, Wang R, Ma Y, Wu J, Guo X, and Zhang Y

Abstract

Objective: The aim of this study was to use cerebrospinal fluid (CSF) cytology to give undiagnosed patients admitted to the hospital with severe neurological symptoms and without any anti-tumor treatment history a definitive diagnosis. Further, the aim was to explore the relationship between the frequency of gene mutations and mortality on the incidence of CSF metastasis in advanced non-small-cell lung cancer (NSCLC)., Materials and Methods: 30 patients diagnosed with NSCLC through CSF cytology were retrospectively analyzed. We analyzed 30 CSF metastasis patients and a control group of 20 advanced NSCLC patients without CSF metastasis., Results: 30 patients were diagnosed with CSF metastasis using CSF cytology and immunocytopathology. The frequencies of EGFR mutations and ALK fusion in the CSF metastasis group were higher than they were in the non-CSF metastasis group (80% and 50% respectively, P <0.05). The incidence of CSF metastasis with gene mutations was higher than it was with wild-type genes (70.6% and 37.5%, P <0.05), OR 4.0 (95% CI 1.14~13.99). The median survival time of the CSF metastasis group was 4.8 months (95% CI 4.2~5.3). However, the median survival time in the non-CSF metastasis group was 9.2 months (95% CI 3.3~15.1). The mortality of the CSF metastasis group (n=13, 43.3%) was significantly higher than it was in the non-CSF metastasis group (n=6, 30%)., Conclusions: CSF metastasis in NSCLC patients has a higher frequency of gene mutations and mortality. EGFR mutation and ALK fusion patients have a higher incidence of CSF metastasis. EGFR mutations and ALK fusion may promote CSF metastasis and may be a predictor of prognosis in NSCLC patients., Competing Interests: None., (IJCEP Copyright © 2020.)

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results