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Your search keyword '"Zhao, Pei-Wen"' showing total 12 results
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12 results on '"Zhao, Pei-Wen"'

3. Xin-Ji-Er-Kang protects heart from ischemia-reperfusion injury by rebalancing lipid metabolism

Author

Sun, Li-Jun, primary, Wang, Xiao-Yu, additional, Xia, Jie, additional, Xu, Yan-Mei, additional, Liao, Yu-Feng, additional, Qin, Yuan-Yuan, additional, Ge, Xue-Wan, additional, Zhao, Pei-Wen, additional, Xu, Tong, additional, Zhu, Xiao-Ling, additional, Gao, Shan, additional, Xiao, Rui, additional, Liu, Xue-Sheng, additional, and Zhou, Kai, additional

Published
2022
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7. Piperlongumine, a Potent Anticancer Phytotherapeutic, Induces Cell Cycle Arrest and Apoptosis In Vitro and In Vivo through the ROS/Akt Pathway in Human Thyroid Cancer Cells

Author

Kung, Fang-Ping, primary, Lim, Yun-Ping, additional, Chao, Wen-Ying, additional, Zhang, Yi-Sheng, additional, Yu, Hui-I, additional, Tai, Tsai-Sung, additional, Lu, Chieh-Hsiang, additional, Chen, Shu-Hsin, additional, Li, Yi-Zhen, additional, Zhao, Pei-Wen, additional, Yen, Yu-Pei, additional, and Lee, Ying-Ray, additional

Published
2021
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12. Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells.

Author

Liao KS, Lee YR, Chao WY, Huang YJ, Chung HC, Chen SH, Li YZ, Zhao PW, and Chang HY

Abstract

Background: Honokiol is a natural polyphenolic compound extracted from Magnolia officinali, which is commonly used material in Chinese herbal medicine, has a variety of biological functions, including anti-tumor, anti-oxidant, anti-inflammation, anti-microbial and anti-allergy. Although honokiol has numerous beneficial effects on human diseases, the underlying mechanisms of tumor metastasis are still unclear. Previously, we reported that honokiol suppresses thyroid cancer cell proliferation with cytotoxicity through cell cycle arrest, apoptosis, and dysregulation of intracellular hemostasis. Herein, we hypothesized that the antioxidant effect of honokiol might play a critical role in thyroid cancer cell proliferation and migration., Methods: The cell viability assays, cellular reactive oxygen species (ROS) activity, cell migration, and immunoblotting were performed after cells were treated with honokiol., Results: Based on this hypothesis, we first demonstrated that honokiol suppresses cell proliferation in two human anaplastic thyroid carcinoma (ATC) cell lines, KMH-2 and ASH-3, within a dosage- and time-dependent manner by cell counting kit-8 (CCK-8) assay. Next, we examined that honokiol induced ROS activation and could be suppressed by pre-treated with an antioxidant agent, N-acetyl-l-cysteine (NAC). Furthermore, the honokiol suppressed cell proliferation can be rescued by pre-treated with NAC. Finally, we demonstrated that honokiol inhibited ATC cell migration by modulating epithelial-mesenchymal transition (EMT)-related markers by Western blotting., Conclusion: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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