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To ensure the reliability of DNN systems and address the test generation problem for neural networks, this paper proposes a fuzzing test generation technique based on many-objective optimization algorithms. Traditional fuzz testing employs random search, leading to lower testing efficiency and tends to generate numerous invalid test cases. By utilizing many-objective optimization techniques, effective test cases can be generated. To achieve high test coverage, this paper proposes several improvement strategies. The frequency-based fuzz sampling strategy assigns priorities based on the frequency of selection of initial data, avoiding the repetitive selection of the same data and enhancing the quality of initial data better than random sampling strategies. To address the issue that global search may yield test not satisfying semantic constraints, a local search strategy based on the Monte Carlo tree search is proposed to enhance the algorithm's local search capabilities. Furthermore, we improve the diversity of the population and the algorithm's global search capability by updating SPEA2's external archive based on a decomposition-based archiving strategy. To validate the effectiveness of the proposed approach, experiments were conducted on several public datasets and various neural network models. The results reveal that, compared to random and clustering-based sampling, the frequency-based fuzz sampling strategy provides a greater improvement in coverage rate in the later stages of iterations. On complex networks like VGG16, the improved SPEA2 algorithm increased the coverage rate by about 12% across several coverage metrics, and by approximately 40% on LeNet series networks. The experimental results also indicates that the newly generated test cases not only exhibit higher coverage rates but also generate adversarial samples that reveal model errors.

We propose TG-LMM (Text-Guided Large Multi-Modal Model), a novel approach that leverages textual descriptions of organs to enhance segmentation accuracy in medical images. Existing medical image segmentation methods face several challenges: current medical automatic segmentation models do not effectively utilize prior knowledge, such as descriptions of organ locations; previous text-visual models focus on identifying the target rather than improving the segmentation accuracy; prior models attempt to use prior knowledge to enhance accuracy but do not incorporate pre-trained models. To address these issues, TG-LMM integrates prior knowledge, specifically expert descriptions of the spatial locations of organs, into the segmentation process. Our model utilizes pre-trained image and text encoders to reduce the number of training parameters and accelerate the training process. Additionally, we designed a comprehensive image-text information fusion structure to ensure thorough integration of the two modalities of data. We evaluated TG-LMM on three authoritative medical image datasets, encompassing the segmentation of various parts of the human body. Our method demonstrated superior performance compared to existing approaches, such as MedSAM, SAM and nnUnet., Comment: 11 pages, 2 figures

The delineation of tumor target and organs-at-risk is critical in the radiotherapy treatment planning. Automatic segmentation can be used to reduce the physician workload and improve the consistency. However, the quality assurance of the automatic segmentation is still an unmet need in clinical practice. The patient data used in our study was a standardized dataset from AAPM Thoracic Auto-Segmentation Challenge. The OARs included were left and right lungs, heart, esophagus, and spinal cord. Two groups of OARs were generated, the benchmark dataset manually contoured by experienced physicians and the test dataset automatically created using a software AccuContour. A resnet-152 network was performed as feature extractor, and one-class support vector classifier was used to determine the high or low quality. We evaluate the model performance with balanced accuracy, F-score, sensitivity, specificity and the area under the receiving operator characteristic curve. We randomly generated contour errors to assess the generalization of our method, explored the detection limit, and evaluated the correlations between detection limit and various metrics such as volume, Dice similarity coefficient, Hausdorff distance, and mean surface distance. The proposed one-class classifier outperformed in metrics such as balanced accuracy, AUC, and others. The proposed method showed significant improvement over binary classifiers in handling various types of errors. Our proposed model, which introduces residual network and attention mechanism in the one-class classification framework, was able to detect the various types of OAR contour errors with high accuracy. The proposed method can significantly reduce the burden of physician review for contour delineation., Comment: 14 pages,5 figures, 3 tables