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Your search keyword '"Zhao, Jungong"' showing total 38 results
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38 results on '"Zhao, Jungong"'

1. Development and Validation of a Deep Learning Model to Reduce the Interference of Rectal Artifacts in MRI-based Prostate Cancer Diagnosis

Author

Hu, Lei, primary, Guo, Xiangyu, additional, Zhou, Dawei, additional, Wang, Zhen, additional, Dai, Lisong, additional, Li, Liang, additional, Li, Ying, additional, Zhang, Tian, additional, Long, Haining, additional, Yu, Chengxin, additional, Shi, Zhen-wei, additional, Han, Chu, additional, Lu, Cheng, additional, Zhao, Jungong, additional, Li, Yuehua, additional, Zha, Yunfei, additional, and Liu, Zaiyi, additional

Published
2024
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21. Comparison of endothelial cell- and endothelial progenitor cell-derived exosomes in promoting vascular endothelial cell repair

Author

Hu, Hui, Jiang, Chunyu, Li, Ruiting, and Zhao, Jungong

Subjects
embryonic structures, cardiovascular system, Original Article
Abstract

Background: Timely endothelial repair after intervention-associated vascular injury is critical to prevent restenosis and thrombosis. Compared to living cell therapies, exosomes may be a better alternative. Thus, we aimed to compare the role of exosomes derived from human umbilical vein endothelial cells (HUVECs) versus those derived from endothelial progenitor cells (EPCs) in vascular endothelial repair. Material/methods: Exosomes secreted from HUVECs and EPCs were isolated and characterized respectively. In vitro, the effects of the two types of exosomes on migration and proliferation of endothelial cells were studied. In vivo, rats were systemically treated with the two exosome groups respectively after carotid artery endothelial injury induced by a balloon. The efficacy in promoting re-endothelialization was measured by Evans blue dye and histological examination. Results: Both types of exosomes, sized from 30 nm to 100 nm, had sphere-shaped or cupped morphology, and expressed CD63, CD9, and CD81; but the total yield of exosomes (particles/mL) based on number of cells, was 4.2 times higher from EPCs than HUVECs. Compared with control treatment, both exosome treated groups manifested significant enhancement of migration and proliferation in vitro and vascular recovery at an early stage in vivo. The two exosome-treated groups, however, did not statistically significantly differ. Conclusion: In conclusion, our results indicated that exosomes derived from HUVECs and EPCs had similar morphology, size distributions and characteristics, but those derived from EPCs were more abundant with comparable biologic activity. Therefore, EPCs may be a robust source of exosomes to promote vascular repair.

Published
2019

23. Microvessel changes after post-ischemic benign and malignant hyperemia: experimental study in rats

Author

You Xiaofang, Li Yongdong, Cheng Yingsheng, Li Minghua, Zhao Jungong, Lu Haitao, and Zhao Yuwu

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background The present investigation was designed to elucidate the use of dynamic contrast enhanced perfusion MR imaging (DCE pMRI) in characterizing hyperemia, including microvessel changes, and to examine whether DCE pMRI can predict benign or malignant hyperemia. Methods Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO) by intraluminal suture placement. All rats were randomized to 4 groups: MCAO for 0.5 hours followed by saline treatment (10 ml/kg; group 1); MCAO for 3 hours followed by treatment with saline (group 2) or urokinase (25000 IU/kg; group 3); and MCAO for 6 hours followed by urokinase treatment (group 4). Relative cerebral blood volume (rCBV) and relative maximum slope of increase of the signal intensity time curve (rMSI) were quantitatively analyzed from MRI. Microvessel diameter and blood-brain barrier disruption obtained by laser scanning confocal microscopy (LSCM) as well as transmission electron microscopy (TEM) were obtained for correlative study. Results Benign hyperemia was noticed only in group 1; malignant hyperemia was seen in group 3. Although the rCBV of malignant hyperemia was slightly higher than in benign hyperemia (P > 0.05), the rMSI, on the other hand, was significantly lower (P < 0.05). Fluoro-isothiocyanate dextran (FITC-dextran) extravasations, marked glial end-foot process swelling, and significant vasodilatation were seen in malignant hyperemia, while no or mild leakage of FITC-dextran and slight glial end-foot process swelling occurred in benign hyperemia. Conclusion Our findings indicate that DCE pMRI can characterize post-ischemic hyperemia and correlates well with microvascular damage.

Published
2010
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38. The value of ankle-branchial index screening for cardiovascular disease in type 2 diabetes.

Author

Xu, Lei, He, Rui, Hua, Xiaohan, Zhao, Jun, Zhao, Jungong, Zeng, Hui, Li, Lianxi, Liu, Fang, and Jia, Weiping

Subjects
CARDIOVASCULAR disease diagnosis, TYPE 2 diabetes complications, CARDIOVASCULAR diseases, COMPARATIVE studies, CORONARY disease, RESEARCH methodology, MEDICAL cooperation, TYPE 2 diabetes, RESEARCH, EVALUATION research, CROSS-sectional method, ANKLE brachial index, DIABETIC cardiomyopathy
Abstract

Objective: To investigate the relationship between ankle-branchial index (ABI) and cardiovascular disease in type 2 diabetes patients.Methods: A total of 634 inpatients with type 2 diabetes were recruited in this cross-sectional study. All patients were measured with ABI and computed tomography angiography (CTA) scan for coronary artery disease (CAD). According to ABI values, patients were divided into three groups: low-ABI group (ABI < 0.9, n = 259), normal-ABI group (ABI = 0.9-1.3, n = 272), and high-ABI group (ABI > 1.3, n = 103). According to the manifestation of coronary CTA, the patients were divided into CAD group (n = 348) and non-CAD group (n = 286). Their clinical data and biochemical parameters were compared and analysed.Results: The prevalence of CAD in low-ABI group (90%) was significantly higher than that of normal-ABI group (33%) and high-ABI group (25%) (both P < 0.01). Spearman correlation analysis showed that age, sex, duration, spontaneous bacterial peritonitis, total cholesterol (TC), triglyceride, low-density lipoprotein cholesterol (LDL-C), serum creatinine, and glycosylated haemoglobin (HbA1c ) were positively correlated with CAD, and high-density lipoprotein cholesterol (HDL-C), glomerular filtration rate, and ABI were negatively correlated with CAD. Logistic regression analysis further revealed that age, sex, duration, TC, HDL-C, LDL-C, HbA1c , and ABI were independent risk factors of CAD. After all potential confounders is adjusted, the risk of CAD in low-ABI group still increased over four times than the normal-ABI group (odds ratio [OR], 5.32; 95% CI, 1.973-16.5; P < 0.001). In female patients, this risk increased more than nine times (OR, 10.63; 95% CI, 3.416-17.8; P < 0.001). Receiver-operating characteristic analysis indicated that ABI < 1.045 predicted the occurrence of CAD (sensitivity, 79.7%; specificity, 71.5%; P < 0.01).Conclusions: ABI is an independent risk factor for CAD and may be a potential simple screening instrument for CAD in Chinese type 2 diabetic patients, especially in elder women. [ABSTRACT FROM AUTHOR]

Published
2019
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