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IntroductionThe aim of this study was to document the scope of violations of the Canadian Radio-television and Telecommunications Commission (CRTC) "Code for Broadcast Advertising of Alcoholic Beverages" (CRTC Code) by drinking venues posting alcohol-related content on social media platforms, and to assess whether CRTC Code violations by drinking venues relate to their popularity among university students and to students' drinking behaviours. MethodsIn phase 1 of the study, a probability sample of 477 students from four Canadian university responded to a questionnaire about their drinking and preferred drinking venues. In phase 2, a probability sample of 78 students assessed the compliance of drinking venues' social media posts with the 17 CRTC Code guidelines. We pooled both datasets and linked them by drinking venues. ResultsPopular drinking venues were overwhelming posting alcohol-related content that contravenes the CRTC Code. Adjusted effect estimates show that a decrease in the mean level of compliance with the CRTC Code was significantly associated with a 1% increase in popularity score of drinking venues (t-test, p < .001). With regard to drinking behaviours, a 1% increase in the overall mean level of compliance with the CRTC Code was associated with 0.458 fewer drinking days per week during a semester (t-test, p = .01), 0.294 fewer drinks per occasion (t-test, p = .048) and a lesser likelihood of consuming alcohol when attending a drinking venue (t-test, p = .001). ConclusionThe results of this study serve as a reminder to territorial and provincial regulatory agencies to review their practices to ensure that alcohol advertising guidelines are applied and enforced consistently. More importantly, these results call for the adoption of federal legislation with a public health mandate that would apply to all media, including print, television and radio, digital and social.

IntroductionCette étude a pour but de documenter la portée des infractions au Code de la publicité radio diffusée en faveur de boissons alcoolisées du Conseil de la radiodiffusion et des télécommunications canadiennes (CRTC) (Code du CRTC) commises par certains établissements servant de l’alcool qui publient du contenu lié à l’alcool sur des plateformes de médias sociaux et d’évaluer si ces infractions au Code du CRTC sont en lien avec la popularité de ces établissements auprès des étudiants universitaires et avec les comportements de ces derniers en matière de consommation d’alcool. MéthodologieAu cours de la phase 1 de l’étude, un échantillon aléatoire de 477 étudiants provenant de quatre universités canadiennes ont répondu à un questionnaire portant sur leurs habitudes de consommation d’alcool et sur les établissements servant de l’alcool qu’ils préféraient. Au cours de la phase 2, nous avons évalué, auprès d’un échantillon aléatoire de 78 étudiants, si les publications de ces établissements dans les médias sociaux étaient conformes aux 17 lignes directrices du Code du CRTC. Nous avons regroupé les deux ensembles de données et nous les avons jumelés au moyen de la liste des établissements servant de l’alcool. RésultatsLes établissements populaires servant de l’alcool ont publié massivement des contenus liés à l’alcool contrevenant au Code du CRTC. Les estimations d’effet ajusté indiquent qu’une réduction du niveau moyen de conformité au Code du CRTC est associée de manière significative à une augmentation de 1 % du taux de popularité des établissements servant de l’alcool (test t, p < 0,001). En ce qui a trait aux comportements de consommation d’alcool, une augmentation de 1 % du niveau moyen global de conformité au Code du CRTC est significativement associée à une diminution de 0,458 jour de consommation par semaine pendant un semestre (test t, p = 0,01), une diminution de 0,294 consommation par occasion (test t, p = 0,048) et une probabilité plus faible que les étudiants consomment de l’alcool lorsqu’ils se trouvent dans un établissement servant de l’alcool (test t, p = 0,001). ConclusionLes résultats de notre étude sont une invitation à ce que les agences de réglementation territoriales et provinciales réévaluent leurs pratiques, afin que les lignes directrices en matière de publicité sur l’alcool soient appliquées et respectées de manière uniforme. Au­delà, ces résultats justifient l’adoption d’une loi fédérale avec un mandat en santé publique applicable à tous les médias : médias imprimés, numériques et sociaux, télévision et radio.

BackgroundAlcohol warning labels are a promising, well-targeted strategy to increase public awareness of alcohol-related health risks and support more informed and safer use. However, evidence of their effectiveness in real-world settings remains limited and inconclusive. ObjectiveThis paper presents a protocol for a real-world study examining the population-level impact of enhanced alcohol warning labels with a cancer message; national drinking guidelines; and standard drink information on attention, processing, and alcohol-related behaviors among consumers in Canada. Postimplementation modifications to the original protocol due to interference by national alcohol industry representatives are also described. MethodsThis quasi-experimental study involved partnering with local governments in two northern Canadian territories already applying alcohol warning labels on alcohol containers for sale in liquor stores. The study tested an 8-month intervention consisting of three new enhanced, rotating alcohol warning labels in an intervention site (Whitehorse, Yukon) relative to a comparison site (Yellowknife, Northwest Territories) where labelling practices would remain unchanged. Pre-post surveys were conducted at both sites to measure changes in awareness and processing of label messages, alcohol-related knowledge, and behaviors. Liquor store transaction data were collected from both sites to assess changes in population-level alcohol consumption. The intervention was successfully implemented for 1 month before it was halted due to complaints from the alcohol industry. The government of the intervention site allowed the study to proceed after a 2-month pause, on the condition that the cancer warning label was removed from rotation. Modifications to the protocol included applying the two remaining enhanced labels for the balance of the intervention and adding a third wave of surveys during the 2-month pause to capture any impact of the cancer label. ResultsThis study protocol describes a real-world quasi-experimental study that aimed to test the effectiveness of new enhanced alcohol warning labels as a tool to support consumers in making more informed and safer alcohol choices. Alcohol industry interference shortly after implementation compromised both the intervention and the original study design; however, the study design was modified to enable completion of three waves of surveys with cohort participants (n=2049) and meet the study aims. ConclusionsFindings from this study will directly inform alcohol labelling policies in Canada and internationally and provide further insight into the alcohol industry’s attempts to disrupt research in this area. Additional unimpeded real-world evaluations of enhanced alcohol warning labels are recommended. International Registered Report Identifier (IRRID)RR1-10.2196/16320

Background Chimeric antigen receptor T cell (CAR-T) therapy stands as a precise and targeted approach in the treatment of malignancies. In this study, we investigated the feasibility of targeting Cadherin 17 (CDH17) with CDH17 CAR-T cells as a therapeutic modality for small cell lung cancer (SCLC). Methods CDH17 expression levels were assessed in human SCLC tumor tissues and cell lines using qPCR and Western blot. Subsequently, we established CDH17 CAR-T cells and assessed their cytotoxicity by co-culturing them with various SCLC cell lines at different effector-to-target (E:T) ratios, complemented by ELISA assays. To ascertain the specificity of CDH17 CAR-T cells, we conducted experiments on SCLC cells with and without CDH17 expression (shRNAs). Furthermore, we employed an SCLC xenograft model to evaluate the in vivo efficacy of CDH17 CAR-T cells. Results Our results revealed a significant upregulation of CDH17 in both SCLC tissues and cell lines. CDH17 CAR-T cells exhibited robust cytotoxic activity against SCLC cells in vitro, while demonstrating no cytotoxicity towards CDH17-deficient SCLC cells and HEK293 cells that lack CDH17 expression. Importantly, the production of IFN-[gamma] and TNF-[alpha] by CDH17 CAR-T cells correlated with their cytotoxic potency. Additionally, treatment with CDH17 CAR-T cells significantly decelerated the growth rate of SCLC-derived xenograft tumors in vivo. Remarkably, no significant difference in body weight was observed between the control group and the group treated with CDH17 CAR-T cells. Conclusions The preclinical data open further venues for the clinical use of CDH17 CAR-T cells as an immunotherapeutic strategy for SCLC treatment., Author(s): Wen Tian [sup.1], Jinhui Zhao [sup.2], Wenzhong Wang [sup.3] Author Affiliations: (1) https://ror.org/016m2r485, grid.452270.6, 0000 0004 0614 4777, Second Department of Oncology, Cangzhou Central Hospital, , NO.16 Xinhua West [...]

The high-temperature deformation behavior of Ti–6.5Al–2Sn–4Zr–4Mo–1W–0.2Si alloy with initial lamellar microstructure was investigated through performing hot compression experiments at temperatures of 940–1,030°C and strain rates of 0.001–10 s−1 on the Gleeble-3500 simulator. Three kinds of typical flow curves corresponding to different strain rates were distinguished. The deformation activation energy and Zener–Hollomon parameter were obtained through kinetic analysis. By comparing saturated dislocation density with the critical density for dynamic recrystallization, dynamic softening behaviors were identified and verified by the Poliak–Jonas criterion. Furthermore, a piecewise physical-based constitutive model incorporating dynamic softening behaviors was constructed. Finally, microstructures deformed under different deformation conditions were analyzed to further verify the softening behaviors determined by identification criterions.

Students have access to the Internet at their fingertips via e-tablets and smart phones. However, the STEM fields are struggling to remain relevant in students' lives outside the classroom. In an effort to improve high school science curricula and to keep students engaged in the classroom, we developed a technology-rich bioengineering summer program for high school students in grades 9-12. The program utilized touch screen technology in conjunction with hands-on experiments and traditional lecturing to create an entertaining, relevant, and effective classroom experience.

Because antibiotics are regularly used for chicken, food safety is of utmost importance, and health experts pay attention to the effect antibiotics could have on human health. This study examines [...]