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Your search keyword '"Zhao, Huiyue"' showing total 20 results
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20 results on '"Zhao, Huiyue"'

2. Epi‐Endocytic Performance Engineering through Nanomaterials Co‐Challenging: A Study of Mechanism and Implication in Radiotherapy.

Author

Zhao, Huiyue, Zheng, Liuting, Ma, Ruxuan, Ding, Chengjin, Wang, Fei, Qin, Shuheng, Ding, Qingqing, Jiang, Guangliang, Hu, Yong, and Huo, Da

Subjects
*PRECIOUS metals, *MASS spectrometry, *DRUG therapy, *NANOSTRUCTURED materials, *DOPING agents (Chemistry)
Abstract

While the influence of size on nanomaterial uptake has been extensively explored, it remains elusive how cells simultaneously respond to multiple, size‐varying particles due to the lack of a proper quantitative assay. In this study, a strategy named "metal‐doping engineering" is developed, and constructed a library of multi‐elemental alloys (MEAs) features precisely controlled size and dopant dosage for quantification with mass spectra. Next a comprehensive study of cellular uptake behaviors is conducted when treated with dual‐, triple‐, and quadra‐, size‐differing nanoparticles. Specifically, the exposure to triple‐, and quadra‐, size‐differing MEAs resulted in an unprecedented, enhanced uptake of counterpart in the middle size as 10/20 nm. Further efforts including RNA‐sequencing and photo‐affinity labeling‐assisted proteomics are devoted to uncovering the underlying mechanism, wherein the role of nonconical endocytic pathways in fast‐endophilin‐mediated endocytosis is uncovered. Given the capacity of MEAs as chaperones to facilitate the uptake of one featuring a predetermined size promoted to propose a straightforward, "bystander nanomaterials"‐assisted drug delivery strategy, whose superior dosage‐reduced radio‐sensitization performance and anti‐tumoral outcome are confirmed in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Doxorubicin loaded chitosan–ZnO hybrid nanospheres combining cell imaging and cancer therapy

Author

Peipei Xu, Yin Ding, Yong Hu, Zhao Huiyue, Chao Zhang, Da Huo, and Pin Lv

Subjects
Materials science, Photoluminescence, General Chemical Engineering, Cell, technology, industry, and agriculture, Cancer therapy, Nanoparticle, Nanotechnology, General Chemistry, Chitosan, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, medicine, Distribution (pharmacology), Doxorubicin, Retention time, medicine.drug
Abstract

We report chitosan–ZnO nanoparticles (CZNPs), which have enhanced photoluminescence stability and longer retention time in cells compared with pure ZnO QDs. These CZNPs can illuminate the cells, show the distribution of the nanospheres in the cell, and thus monitor the fate of the loaded drug, which enable these CZNPs to have a promising future in cell imaging and cancer therapy.

Published
2015

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