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32 results on '"Zhao, Hangbin"'

14. Epigenetic Modifications Are Involved in Transgenerational Inheritance of Cadmium Reproductive Toxicity in Mouse Oocytes.

Author

Zhu, Jiaqiao, Guo, Shuai, Cao, Jiangqin, Zhao, Hangbin, Ma, Yonggang, Zou, Hui, Ju, Huiming, Liu, Zongping, and Li, Junwei

Subjects
MATERNAL exposure, HEREDITY, GERM cells, EMBRYOLOGY, GENETIC markers
Abstract

Maternal cadmium exposure during pregnancy has been demonstrated to have detrimental effects on offspring development. However, the impact of maternal cadmium exposure on offspring oocytes remains largely unknown, and the underlying mechanisms are not fully understood. In this study, we found that maternal cadmium exposure during pregnancy resulted in selective alteration in epigenetic modifications of mouse oocytes in offspring, including a decrease in H3K4me2 and H4K12ac, as well as an increase in DNA methylation of H19. Although ROS levels and mitochondrial activity remain at normal levels, the DNA damage marker γH2AX was significantly increased and the DNA repair marker DNA-PKcs was remarkably decreased in offspring oocytes from maternal cadmium exposure. These alterations are responsible for the decrease in the quality of mouse oocytes in offspring induced by maternal cadmium exposure. As a result, the meiotic maturation of oocytes and subsequent early embryonic development are influenced by maternal cadmium exposure. RNA-seq results showed that maternal cadmium exposure elicits modifications in the expression of genes associated with metabolism, signal transduction, and endocrine regulation in offspring ovaries, which also contribute to the disorders of oocyte maturation and failures in early embryonic development. Our research provides direct evidence of transgenerational epigenetic inheritance of cadmium reproductive toxicity in mouse germ cells. [ABSTRACT FROM AUTHOR]

Published
2024
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16. THz-Over-Fiber System With Orthogonal Chirp Division Multiplexing for Integrated Sensing and Communication

Author

Li, Lianyi, Zhang, Lu, Zhang, Hongqi, Lyu, Zhidong, Yang, Zuomin, Pang, Xiaodan, Bobrovs, Vjaceslavs, Ozolins, Oskars, Zhao, Hangbin, Li, Feng, Zhang, Changming, Yu, Xianbin, Li, Lianyi, Zhang, Lu, Zhang, Hongqi, Lyu, Zhidong, Yang, Zuomin, Pang, Xiaodan, Bobrovs, Vjaceslavs, Ozolins, Oskars, Zhao, Hangbin, Li, Feng, Zhang, Changming, and Yu, Xianbin

Abstract

To achieve integrated sensing and communication (ISAC) applications with high data rates and high resolution, the terahertz-over-fiber (ToF) system has been recognized as a promising solution. However, the frequency-selective fading would deteriorate the performance of the ToF-based ISAC systems. In this work, we propose the orthogonal chirp division multiplexing (OCDM) waveform-based ToF system for high-performance ISAC applications. The system encodes data with the phase of the sub-chirps and obtains radar images by processing echoes with the zero-padded matched filtering algorithm. We experimentally demonstrate a proof-of-concept OCDM-ToF system, which simultaneously achieves a 32 Gbit/s data rate and 1.875 cm range resolution after transmission over a 10 km optical fiber and a 3.14 m wireless link at the THz band, for the first time. The experimental results indicate that the OCDM-ToF system can enhance robustness against the frequency-selective fading issue, as a benefit improving communication performance with high data rates while preserving the high sensing resolution of OFDM in the THz ISAC applications., QC 20240201

Published
2024
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27. Reshaping WiFi ISAC with High-Coherence Hardware Capabilities

Author

Li, Rui, Duan, Yu, Du, Rui, Xu, Fangxin, Zhao, Hangbin, Sun, Yang, Zhang, Yiyan, Zhang, Daiyang, Liu, Yiming, Jiang, Zhiping, and Han, Tony Xiao

Abstract

WiFi shows great promise for integrated sensing and communication (ISAC), but its wider application is hampered by two pivotal challenges: the low-quality channel state information (CSI) and inadequate hardware capabilities. This article introduces a paradigm shift with high-coherence hardware capabilities to fundamentally overcome these two challenges. Our approach is realized through four key break-throughs. First, we uncover a novel category of CSI error sources, termed CODEs, which pose core challenges for WiFi ISAC. The CODEs stem from the WiFi hardware design, and addressing them requires hardware-level modifications. Then, we propose a list of high-coherence hardware capabilities aimed at eliminating these errors. Our analysis indicates that the majority of these capabilities can be implemented at the firmware level, with a minority requiring chip-level changes. Next, we introduce two robust and synergistic incentives to encourage vendors to integrate these capabilities into their hardware: the 802.11bf standard and its certification program, and the large-scale carrier-grade purchasing. Finally, we present two demonstrations: a sub-nanosecond level time-of-flight (ToF) estimation system and a WiFi-based phased array. Both demonstrations show that remarkable sensing precision is achievable with the proposed high-coherence capabilities.

Published
2024
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32. Fast 3D positioning based on a simplified THz photonic stereo ISAR system.

Author

Yang Z, Zhang H, Lyu Z, Yang H, Zhang L, Zhao H, Li F, Zhang C, and Yu X

Abstract

In this work, a THz stereo inverse synthetic aperture radar scheme based on photonics is proposed, and proof-of-concept experimentally demonstrated, achieving high resolution and fast three-dimensional (3D) positioning of multiple targets. An optical frequency comb and a uni-traveling carrier photodiode are employed to photonically generate a linear frequency-modulation signal at 300-320 GHz. By two incoherent measurements at different angles with one pair of antennas, 3D positioning of plane reflectors over a distance of 0.6 m is successfully accomplished, achieving a resolution of 7.5 mm for both range and azimuth dimensions, and a maximum experimental height error of 4 mm.

Published
2024
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