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Your search keyword '"Zhao, Cuiting"' showing total 25 results
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25 results on '"Zhao, Cuiting"'

16. LncRNA NEAT1 Promote Inflammatory Responses in Coronary Slow Flow Through Regulating miR-148b-3p/ICAM-1 Axis

Author

Zhu,Qing, Zhao,Cuiting, Wang,Yonghuai, Li,Xinxin, Xue,Yixue, Ma,Chunyan, Zhu,Qing, Zhao,Cuiting, Wang,Yonghuai, Li,Xinxin, Xue,Yixue, and Ma,Chunyan

Abstract

Qing Zhu,1 Cuiting Zhao,1 Yonghuai Wang,1 Xinxin Li,1 Yixue Xue,2– 4 Chunyan Ma1 1Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Neurobiology, School of Life Sciences, China Medical University, Shenyang, People’s Republic of China; 3Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, Shenyang, People’s Republic of China; 4Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chunyan MaDepartment of Cardiovascular Ultrasound, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Shenyang, Liaoning, 110001, People’s Republic of ChinaTel +86 2483282129Email cmu1h_mcy@126.comBackground: Coronary slow flow (CSF) is an angiographic phenomenon characterized by delayed coronary opacification with normal or near-normal epicardial coronary arteries. The pathogenesis of CSF is closely related to inflammatory response. Accumulating evidence shows that long non-coding RNAs (lncRNAs) play an important role in cardiovascular disease. However, the mechanism underlying the influence of the lncRNA nuclear enriched abundant transcripts 1 (NEAT1) on CSF is still unknown.Patients and Methods: Forty CSF patients and forty control subjects were included in the study and underwent coronary angiography, Seattle angina questionnaire (SAQ) and echocardiography. The plasma levels of the inflammatory factors soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were determined by ELISA. The expression levels of NEAT1, miR-148b-3p and ICAM-1 in cells were measured by qRT-PCR or Western blotting. Cell proliferation was measured by 5‐Ethynyl‐2ʹ‐deoxyuridine (EdU) and Cell Counting Kit-8 (CCK-8) assay. Cell apoptos

Published
2021

24. N-doped graphene anchored ultrasmall Ir nanoparticles as bifunctional electrocatalyst for overall water splitting

Author

Yao, Wenqing, Jiang, Xian, Li, Yulian, Zhao, Cuiting, Ding, Linfei, Sun, Dongmei, and Tang, Yawen

Abstract

Seeking for extremely active and durable bifunctional electrocatalysts towards the overall water splitting possesses a strategic significance on the development of sustainable and clean energy for the replacement of fossil fuels. Ir-based nanomaterials are deemed as one of the most high-efficiency oxygen evolution reaction electrocatalysts while the hydrogen evolution reaction performance is unfavorable. In this work, we report a one-pot hydrothermal synthesis of N-doped graphene anchored Ir nanoparticles (Ir/N-rGO) with ultrasmall particle size (∼2.0 nm). Apart from the predictably superior OER performance, the resultant Ir/N-rGO also displays excellent hydrogen evolution reaction (HER) performance, requiring merely 76 and 260 mV overpotentials to achieve the current density of 10 mA cm−2towards HER and OER, respectively. When applied as the bifunctional electrodes for overall water splitting, Ir/N-rGO needs a lower overpotential (1.74 V) to achieve a current density of 50 mA cm−2in alkaline solution, exceeding that of Pt/C and RuO2couple (1.85 V). Thus, the as-fabricated Ir/N-rGO has a commendable prospect in the practical application of alkaline water electrocatalysis.

Published
2021
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25. Usefulness of soluble endothelial protein C receptor combined with left ventricular global longitudinal strain for predicting slow coronary flow: A case-control study.

Author

Wang Y, Yu H, Zhao C, Li G, Yang J, Jia D, and Ma C

Subjects
Case-Control Studies, Echocardiography methods, Endothelial Protein C Receptor, Humans, Inflammation, Ventricular Function, Left, Coronary Vessels diagnostic imaging, Ventricular Dysfunction, Left
Abstract

Background: Slow coronary flow (SCF) is an angiographic entity characterized by delayed coronary opacification without an evident obstructive lesion in the epicardial coronary artery. However, patients with SCF have decreased left ventricular (LV) global longitudinal strain (GLS). SCF is associated with inflammation, and soluble endothelial protein C receptor (sEPCR) is a potential biomarker of inflammation. Therefore, under evaluation herein, was the relationship between SCF and sEPCR and the predictive value of sEPCR and LV GLS for SCF was investigated., Methods: Twenty-eight patients with SCF and 34 controls were enrolled. SCF was diagnosed by the thrombolysis in myocardial infarction frame count (TFC). The plasma level of sEPCR was quantified using enzyme-linked immunosorbent assay. LV GLS was measured by two-dimensional speckle-tracking echocardiography., Results: Plasma sEPCR was significantly higher in patients with SCF than in controls and was positively correlated with the mean TFC (r = 0.67, p < 0.001) and number of involved vessels (r = 0.61, p < 0.001). LV GLS was decreased in patients with SCF compared to that in controls. sEPCR level (OR = 3.14, 95% CI 1.55-6.36, p = 0.001) and LV GLS (OR = 1.44, 95% CI 1.02-2.04, p = 0.04) were independent predictors of SCF. sEPCR predicted SCF (area under curve [AUC]: 0.83); however, sEPCR > 9.63 ng/mL combined with LV GLS > -14.36% demonstrated better predictive power (AUC: 0.89; sensitivity: 75%; specificity: 91%)., Conclusions: Patients with SCF have increased plasma sEPCR and decreased LV GLS. sEPCR may be a useful potential biomarker for SCF, and sEPCR combined with LV GLS can better predict SCF.

Published
2022
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